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Volumn 9, Issue 1, 2014, Pages

Activation of p38/JNK pathway is responsible for embelin induced apoptosis in lung cancer cells: Transitional role of reactive oxygen species

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; EMBELIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; X LINKED INHIBITOR OF APOPTOSIS;

EID: 84899567691     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0087050     Document Type: Article
Times cited : (65)

References (34)
  • 1
    • 0028180470 scopus 로고
    • Antitumor, anti-inflammatory and analgesic property of embelin, a plant product
    • Chitra M, Sukumar E, Suja V, Devi CS (1994) Antitumor, anti-inflammatory and analgesic property of embelin, a plant product. Chemotherapy 40 (2): 109-113.
    • (1994) Chemotherapy , vol.40 , Issue.2 , pp. 109-113
    • Chitra, M.1    Sukumar, E.2    Suja, V.3    Devi, C.S.4
  • 2
    • 84868708334 scopus 로고    scopus 로고
    • Insulin sensitization via partial agonism of PPARγ and glucose uptake through translocation and activation of GLUT4 in PI3K/p-AKT signalling pathway by embelin in type 2 diabetic rats
    • Gandhi GR, Stalin A, Balakrishna K, Ignacimuthu S, Paulraj MG, et al. (2013) Insulin sensitization via partial agonism of PPARγ and glucose uptake through translocation and activation of GLUT4 in PI3K/p-AKT signalling pathway by embelin in type 2 diabetic rats. Biochim Biophys Acta. 1830 (1): 2243-2255.
    • (2013) Biochim Biophys Acta. , vol.1830 , Issue.1 , pp. 2243-2255
    • Gandhi, G.R.1    Stalin, A.2    Balakrishna, K.3    Ignacimuthu, S.4    Paulraj, M.G.5
  • 3
    • 84930486742 scopus 로고    scopus 로고
    • Preventive effects of embelin from Embelia ribes on lipid metabolism and oxidative stress in high-fat dietinduced obesity in rats
    • Chaudhari HS, Bhandari U, Khanna G (2012) Preventive effects of embelin from Embelia ribes on lipid metabolism and oxidative stress in high-fat dietinduced obesity in rats. Planta Med. 78(7): 651-657.
    • (2012) Planta Med. , vol.78 , Issue.7 , pp. 651-657
    • Chaudhari, H.S.1    Bhandari, U.2    Khanna, G.3
  • 4
    • 0025836786 scopus 로고
    • Determination of estrogenic/antiestrogenic potential of antifertility substances using rat uterine peroxidise assay
    • Johri RK, Pahwa GS, Sharma SC, Zutshi U (1991) Determination of estrogenic/antiestrogenic potential of antifertility substances using rat uterine peroxidise assay. Contraception 44 (5): 549-557.
    • (1991) Contraception , vol.44 , Issue.5 , pp. 549-557
    • Johri, R.K.1    Pahwa, G.S.2    Sharma, S.C.3    Zutshi, U.4
  • 5
    • 0346056906 scopus 로고    scopus 로고
    • Evaluation of anthelmintic properties of extracts from some plants used as livestock dewormers by pastoralist and smallholder farmers in Kenya against Heligmosomoides polygyrus infections in mice
    • DOI 10.1016/j.vetpar.2003.10.006
    • Githiori JB, Höglund J, Waller PJ, Leyden Baker R (2003) Evaluation of anthelmintic properties of extracts from some plants used as livestock dewormers by pastoralist and smallholder farmers in Kenya against Heligmosomoides polygyrus infections in mice. Vet Parasitol. 118(3-4): 215-226. (Pubitemid 38068283)
    • (2003) Veterinary Parasitology , vol.118 , Issue.3-4 , pp. 215-226
    • Githiori, J.B.1    Hoglund, J.2    Waller, P.J.3    Baker, R.L.4
  • 7
    • 84870667706 scopus 로고    scopus 로고
    • PEG-derivatized embelin as a nanomicellar carrier for delivery of paclitaxel to breast and prostate cancers
    • Lu J, Huang Y, Zhao W, Marquez RT, Meng X, et al. (2013) PEG-derivatized embelin as a nanomicellar carrier for delivery of paclitaxel to breast and prostate cancers. Biomaterials 34(5): 1591-1600.
    • (2013) Biomaterials , vol.34 , Issue.5 , pp. 1591-1600
    • Lu, J.1    Huang, Y.2    Zhao, W.3    Marquez, R.T.4    Meng, X.5
  • 8
    • 84877292795 scopus 로고    scopus 로고
    • Embelin induces apoptosis in human glioma cells through inactivating NF-κB
    • Park SY, Lim SL, Jang HJ, Lee JH, Um JY, et al. (2013) Embelin induces apoptosis in human glioma cells through inactivating NF-κB. J Pharmacol Sci. 121(3): 192-199.
    • (2013) J Pharmacol Sci. , vol.121 , Issue.3 , pp. 192-199
    • Park, S.Y.1    Lim, S.L.2    Jang, H.J.3    Lee, J.H.4    Um, J.Y.5
  • 9
    • 79958095970 scopus 로고    scopus 로고
    • Embelin suppresses STAT3 signalling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN
    • Heo JY, Kim HJ, Kim SM, Park KR, Park SY, et al. (2011) Embelin suppresses STAT3 signalling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN. Cancer Lett. 308(1): 71-80.
    • (2011) Cancer Lett. , vol.308 , Issue.1 , pp. 71-80
    • Heo, J.Y.1    Kim, H.J.2    Kim, S.M.3    Park, K.R.4    Park, S.Y.5
  • 10
    • 84884902697 scopus 로고    scopus 로고
    • Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin
    • Schaible AM, Traber H, Temml V, Noha SM, Filosa R, et al. (2013) Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin. Biochem Pharmacol. 86 (4): 476-486.
    • (2013) Biochem Pharmacol. , vol.86 , Issue.4 , pp. 476-486
    • Schaible, A.M.1    Traber, H.2    Temml, V.3    Noha, S.M.4    Filosa, R.5
  • 11
    • 84879756597 scopus 로고    scopus 로고
    • Probing p300/CBP Associated Factor (PCAF)-Dependent Pathways with a Small Molecule Inhibitor
    • May 9. doi: 10.1021/cb4000597 [Epub ahead of print]
    • Modak R, Basha J, Bharathy N, Maity K, Mizar P, et al. (2013) Probing p300/CBP Associated Factor (PCAF)-Dependent Pathways with a Small Molecule Inhibitor. ACS Chem Biol. May 9. doi: 10.1021/cb4000597 [Epub ahead of print].
    • (2013) ACS Chem Biol.
    • Modak, R.1    Basha, J.2    Bharathy, N.3    Maity, K.4    Mizar, P.5
  • 12
    • 84874340538 scopus 로고    scopus 로고
    • Structural insight into inactivation of plasminogen activator inhibitor-1 by a small-molecule antagonist
    • Lin Z, Jensen JK, Hong Z, Shi X, Hu L, et al. (2013) Structural insight into inactivation of plasminogen activator inhibitor-1 by a small-molecule antagonist. Chem Biol. 20 (2): 253-261.
    • (2013) Chem Biol. , vol.20 , Issue.2 , pp. 253-261
    • Lin, Z.1    Jensen, J.K.2    Hong, Z.3    Shi, X.4    Hu, L.5
  • 13
    • 67349279226 scopus 로고    scopus 로고
    • Formation of semiquinone radical in the reaction of embelin (2,5-dihydroxy-3-undecyl-1,4-benzoquinone) with reductants as well as oxidants. Characterization by pulse radiolysis and structure investigation by quantum chemical study
    • Joshi R, Ghanty TR, Mukherjee T (2009) Formation of semiquinone radical in the reaction of embelin (2,5-dihydroxy-3-undecyl-1,4-benzoquinone) with reductants as well as oxidants. Characterization by pulse radiolysis and structure investigation by quantum chemical study. J Mol Struct. 928: 46-53.
    • (2009) J Mol Struct. , vol.928 , pp. 46-53
    • Joshi, R.1    Ghanty, T.R.2    Mukherjee, T.3
  • 14
    • 0025341285 scopus 로고
    • Interaction of benzoquinones with mitochondria interferes with oxidative phosphorylation characteristics
    • DOI 10.1016/0014-5793(90)81497-C
    • Makawiti DW, Konji VN, Olowookere JO (1990) Interaction of benzoquinones with mitochondria interferes with oxidative phosphorylation characteristics. FEBS Lett. 266(1-2): 26-28. (Pubitemid 20194164)
    • (1990) FEBS Letters , vol.266 , Issue.1-2 , pp. 26-28
    • Makawiti, D.W.1    Konji, V.N.2    Olowookere, J.O.3
  • 15
    • 77951655077 scopus 로고    scopus 로고
    • Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin-induced apoptosis
    • Joy B, Sivadasan R, Abraham TE, John M, Sobhan PK, et al. (2010) Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin-induced apoptosis. Mol Carcinog. 49(4): 324-336.
    • (2010) Mol Carcinog. , vol.49 , Issue.4 , pp. 324-336
    • Joy, B.1    Sivadasan, R.2    Abraham, T.E.3    John, M.4    Sobhan, P.K.5
  • 16
    • 77957961226 scopus 로고    scopus 로고
    • Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling
    • Hussain AR, Uddin S, Ahmed M, Bu R, Ahmed SO, et al. (2010) Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling. J Pathol. 222(2): 180-190.
    • (2010) J Pathol. , vol.222 , Issue.2 , pp. 180-190
    • Hussain, A.R.1    Uddin, S.2    Ahmed, M.3    Bu, R.4    Ahmed, S.O.5
  • 17
    • 66349089835 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of Embelin on colon carcinogenesis
    • Dai Y, Qiao L, Chan KW, Yang M, Ye J, et al. (2009) Peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of Embelin on colon carcinogenesis. Cancer Res. 69(11): 4776-4783.
    • (2009) Cancer Res. , vol.69 , Issue.11 , pp. 4776-4783
    • Dai, Y.1    Qiao, L.2    Chan, K.W.3    Yang, M.4    Ye, J.5
  • 18
    • 0038361015 scopus 로고    scopus 로고
    • Antibacterial activity of embelin
    • DOI 10.1016/S0367-326X(03)00066-2
    • Chitra M, Devi CS, Viswanathan S, Sukumar E (2003) Antibacterial activity of embelin. Fitoterapia 74: 401-403. (Pubitemid 36623308)
    • (2003) Fitoterapia , vol.74 , Issue.4 , pp. 401-403
    • Chitra, M.1    Shyamala, D.C.S.2    Sukumar, E.3
  • 20
    • 34347230544 scopus 로고    scopus 로고
    • Sulphorhodamine B colorimetric assay for cytotoxicity screening
    • Vichai V, Kirtikira K (2006) Sulphorhodamine B colorimetric assay for cytotoxicity screening. Nat. Protoc. 1(3): 1112-1116.
    • (2006) Nat. Protoc. , vol.1 , Issue.3 , pp. 1112-1116
    • Vichai, V.1    Kirtikira, K.2
  • 21
    • 0031571676 scopus 로고    scopus 로고
    • Fluorometric and colorimetric detection of caspase activity associated with apoptosis
    • DOI 10.1006/abio.1997.2220
    • Gurtu V, Kain SR, Zhang G (1997) Fluorometric and colorimetric detection of caspase activity associated with apoptosis. Anal Biochem. 251(1): 98-102. (Pubitemid 27352149)
    • (1997) Analytical Biochemistry , vol.251 , Issue.1 , pp. 98-102
    • Gurtu, V.1    Kain, S.R.2    Zhang, G.3
  • 22
    • 4444315545 scopus 로고    scopus 로고
    • Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis
    • DOI 10.1074/jbc.M404003200
    • Dhanasekaran A, Kotamraju S, Kalivendi SV, Matsunaga T, Shang T, et al. (2004) Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis. J Biol Chem. 279(36): 37575-37587. (Pubitemid 39195471)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.36 , pp. 37575-37587
    • Dhanasekaran, A.1    Kotamraju, S.2    Kalivendi, S.V.3    Matsunaga, T.4    Shang, T.5    Keszler, A.6    Joseph, J.7    Kalyanaraman, B.8
  • 23
    • 22544466964 scopus 로고    scopus 로고
    • Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: Role of mitochondrial reactive oxygen species and calcium
    • DOI 10.1042/BJ20050285
    • Kalivendi SV, Konorev EA, Cunningham S, Vanamala SK, Kaji EH, et al. (2005) Doxorubicin activates nuclear factor of activated T lymphocytes and Fas ligand transcription: role of mitochondrial reactive oxygen species and calcium. Biochem J. 389 (Pt 2): 527-539. (Pubitemid 41021156)
    • (2005) Biochemical Journal , vol.389 , Issue.2 , pp. 527-539
    • Kalivendi, S.V.1    Konorev, E.A.2    Cunningham, S.3    Vanamala, S.K.4    Kaji, E.H.5    Joseph, J.6    Kalyanaraman, B.7
  • 24
    • 48249140223 scopus 로고    scopus 로고
    • Smac/DIABLO enhances the therapeutic potential of chemotherapeutic drugs and irradiation, and sensitizes TRAIL-resistant breast cancer cells
    • Fandy TE, Shankar S, Srivastava RK (2008) Smac/DIABLO enhances the therapeutic potential of chemotherapeutic drugs and irradiation, and sensitizes TRAIL-resistant breast cancer cells. Mol. Cancer 7: 60.
    • (2008) Mol. Cancer , vol.7 , pp. 60
    • Fandy, T.E.1    Shankar, S.2    Srivastava, R.K.3
  • 25
    • 56349128620 scopus 로고    scopus 로고
    • Differences in doxorubicin-induced apoptotic signalling in adult and immature cardiomyocytes
    • Konorev EA, Vanamala S, Kalyanaraman B (2008) Differences in doxorubicin-induced apoptotic signalling in adult and immature cardiomyocytes. Free Radic Biol Med. 45 (12): 1723-1728.
    • (2008) Free Radic Biol Med. , vol.45 , Issue.12 , pp. 1723-1728
    • Konorev, E.A.1    Vanamala, S.2    Kalyanaraman, B.3
  • 27
    • 0033766405 scopus 로고    scopus 로고
    • Stimulation of MAPK cascades by insulin and osmotic shock: Lack of an involvement of p38 mitogen-activated protein kinase in glucose transport in 3T3-L1 adipocytes
    • Kayali AG, Austin DA, Webster NJ (2000) Stimulation of MAPK cascades by insulin and osmotic shock: lack of an involvement of p38 mitogen-activated protein kinase in glucose transport in 3T3-L1 adipocytes. Diabetes 49(11): 1783-1793.
    • (2000) Diabetes , vol.49 , Issue.11 , pp. 1783-1793
    • Kayali, A.G.1    Austin, D.A.2    Webster, N.J.3
  • 29
    • 84863790379 scopus 로고    scopus 로고
    • XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells
    • Allensworth JL, Aird KM, Aldrich AJ, Batinic-Haberle I, Devi GR (2012) XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells. Mol Cancer Ther. 11(7): 1518-1527.
    • (2012) Mol Cancer Ther. , vol.11 , Issue.7 , pp. 1518-1527
    • Allensworth, J.L.1    Aird, K.M.2    Aldrich, A.J.3    Batinic-Haberle, I.4    Devi, G.R.5
  • 30
    • 33845883544 scopus 로고    scopus 로고
    • Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-κB (NF-κB) signaling pathway leading to suppression of NF-κB-regulated antiapoptotic and metastatic gene products
    • DOI 10.1124/mol.106.028787
    • Ahn KS, Sethi G, Aggarwal BB (2007) Embelin, an inhibitor of X chromosomelinked inhibitor-of-apoptosis protein, blocks nuclear factor-κB (NF-κB) signaling pathway leading to suppression of NF-κB-regulated antiapoptotic and metastatic gene products. Mol Pharmacol. 71(1): 209-219. (Pubitemid 46020991)
    • (2007) Molecular Pharmacology , vol.71 , Issue.1 , pp. 209-219
    • Kwang, S.A.1    Sethi, G.2    Aggarwal, B.B.3
  • 31
    • 84872765772 scopus 로고    scopus 로고
    • Embelin inhibits growth and induces apoptosis through the suppression of Akt/mTOR/S6K1 signaling cascades
    • Kim SW, Kim SM, Bae H, Nam D, Lee JH, et al. (2013) Embelin inhibits growth and induces apoptosis through the suppression of Akt/mTOR/S6K1 signaling cascades. Prostate 73(3): 296-305.
    • (2013) Prostate , vol.73 , Issue.3 , pp. 296-305
    • Kim, S.W.1    Kim, S.M.2    Bae, H.3    Nam, D.4    Lee, J.H.5
  • 32
    • 2342562556 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases in apoptosis regulation
    • DOI 10.1038/sj.onc.1207556
    • Wada T, Penninger JM (2004) Mitogen-activated protein kinases in apoptosis regulation. Oncogene 23: 2838-2849. (Pubitemid 38638846)
    • (2004) Oncogene , vol.23 , Issue.16 REV. ISS. 2 , pp. 2838-2849
    • Wada, T.1    Penninger, J.M.2
  • 33
    • 60849112820 scopus 로고    scopus 로고
    • Tumour cell survival signalling by the ERK 1/2 pathway
    • 2009
    • Balmanno K, Cook SJ (2009) Tumour cell survival signalling by the ERK 1/2 pathway. Cell Death Differ. 2009; 16(3): 368-77.
    • (2009) Cell Death Differ. , vol.16 , Issue.3 , pp. 368-377
    • Balmanno, K.1    Cook, S.J.2
  • 34
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270(5240): 1326-1331.
    • (1995) Science , vol.270 , Issue.5240 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5


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