메뉴 건너뛰기




Volumn 399, Issue 1-2, 2015, Pages 155-165

The novel role of TRPC6 in vitamin D ameliorating podocyte injury in STZ-induced diabetic rats

Author keywords

Calcitriol; Diabetic nephropathy; Podocyte; TRPC6; Vitamin D receptor

Indexed keywords

CALCITRIOL; CALCIUM; CREATININE; DESMIN; GLUCOSE; NEPHRIN; PHOSPHORUS; PODOCIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR; STREPTOZOCIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC6 PROTEIN, RAT; WT1 PROTEIN;

EID: 84916897362     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2242-9     Document Type: Article
Times cited : (53)

References (48)
  • 2
    • 37349120735 scopus 로고    scopus 로고
    • The podocyte and diabetes mellitus: is the podocyte the key to the origins of diabetic nephropathy?
    • PID: 18090667
    • Reddy GR, Kotlyarevska K, Ransom RF, Menon RK (2008) The podocyte and diabetes mellitus: is the podocyte the key to the origins of diabetic nephropathy? Curr Opin Nephrol Hypertens 17:32–36
    • (2008) Curr Opin Nephrol Hypertens , vol.17 , pp. 32-36
    • Reddy, G.R.1    Kotlyarevska, K.2    Ransom, R.F.3    Menon, R.K.4
  • 3
    • 79952757250 scopus 로고    scopus 로고
    • The glomerular podocyte as a target of growth hormone action: implications for the pathogenesis of diabetic nephropathy
    • COI: 1:CAS:528:DC%2BC3MXisVGntrY%3D, PID: 21067510
    • Kumar PA, Brosius FC, Menon RK (2011) The glomerular podocyte as a target of growth hormone action: implications for the pathogenesis of diabetic nephropathy. Curr Diabetes Rev 7:50–55
    • (2011) Curr Diabetes Rev , vol.7 , pp. 50-55
    • Kumar, P.A.1    Brosius, F.C.2    Menon, R.K.3
  • 5
    • 77957984504 scopus 로고    scopus 로고
    • TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology
    • COI: 1:CAS:528:DC%2BC3cXhtlKlur3L, PID: 20685822
    • Dryer SE, Reiser J (2010) TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology. Am J Physiol Renal Physiol 299:F689–F701
    • (2010) Am J Physiol Renal Physiol , vol.299 , pp. F689-F701
    • Dryer, S.E.1    Reiser, J.2
  • 6
    • 84875768768 scopus 로고    scopus 로고
    • High glucose induces podocyte apoptosis by stimulating TRPC6 via elevation of reactive oxygen species
    • COI: 1:CAS:528:DC%2BC3sXlvVCmtbk%3D, PID: 23499875
    • Liu BC, Song X, Lu XY, Li DT, Eaton DC, Shen BZ, Li XQ, Ma HP (2013) High glucose induces podocyte apoptosis by stimulating TRPC6 via elevation of reactive oxygen species. Biochim Biophys Acta 1833:1434–1442
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 1434-1442
    • Liu, B.C.1    Song, X.2    Lu, X.Y.3    Li, D.T.4    Eaton, D.C.5    Shen, B.Z.6    Li, X.Q.7    Ma, H.P.8
  • 7
    • 84872004572 scopus 로고    scopus 로고
    • Wnt/beta-catenin signalling pathway mediates high glucose induced cell injury through activation of TRPC6 in podocytes
    • COI: 1:CAS:528:DC%2BC3sXmslGqtg%3D%3D, PID: 23294354
    • Li Z, Xu J, Xu P, Liu S, Yang Z (2013) Wnt/beta-catenin signalling pathway mediates high glucose induced cell injury through activation of TRPC6 in podocytes. Cell Prolif 46:76–85
    • (2013) Cell Prolif , vol.46 , pp. 76-85
    • Li, Z.1    Xu, J.2    Xu, P.3    Liu, S.4    Yang, Z.5
  • 8
    • 78549271719 scopus 로고    scopus 로고
    • Proteinuria, the podocyte, and insulin resistance
    • COI: 1:CAS:528:DC%2BC3cXhsVyktL7E, PID: 21083394
    • Fornoni A (2010) Proteinuria, the podocyte, and insulin resistance. N Engl J Med 363:2068–2069
    • (2010) N Engl J Med , vol.363 , pp. 2068-2069
    • Fornoni, A.1
  • 11
    • 84856147546 scopus 로고    scopus 로고
    • Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species
    • COI: 1:CAS:528:DC%2BC38Xjt1Gjt7o%3D, PID: 22031853
    • Kim EY, Anderson M, Dryer SE (2012) Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species. Am J Physiol Renal Physiol 302:F298–F307
    • (2012) Am J Physiol Renal Physiol , vol.302 , pp. F298-F307
    • Kim, E.Y.1    Anderson, M.2    Dryer, S.E.3
  • 12
    • 58849109774 scopus 로고    scopus 로고
    • The role of transient receptor potential channels in metabolic syndrome
    • COI: 1:CAS:528:DC%2BD1MXivVGltLc%3D, PID: 19098369
    • Liu D, Zhu Z, Tepel M (2008) The role of transient receptor potential channels in metabolic syndrome. Hypertens Res 31:1989–1995
    • (2008) Hypertens Res , vol.31 , pp. 1989-1995
    • Liu, D.1    Zhu, Z.2    Tepel, M.3
  • 13
    • 60549093179 scopus 로고    scopus 로고
    • +) influx is mediated by the 1/4/5 subgroup of the transient receptor potential proteins in cultured aortic smooth muscle cells from diabetic Goto-Kakizaki rats
    • COI: 1:CAS:528:DC%2BD1MXis1ertbY%3D, PID: 19135126
    • +) influx is mediated by the 1/4/5 subgroup of the transient receptor potential proteins in cultured aortic smooth muscle cells from diabetic Goto-Kakizaki rats. Mol Cell Endocrinol 302:49–57
    • (2009) Mol Cell Endocrinol , vol.302 , pp. 49-57
    • Evans, J.F.1    Lee, J.H.2    Ragolia, L.3
  • 14
    • 70349329587 scopus 로고    scopus 로고
    • The role of transient receptor potential channels in kidney disease
    • COI: 1:CAS:528:DC%2BD1MXpsVKgsLk%3D, PID: 19546862
    • Woudenberg-Vrenken TE, Bindels RJ, Hoenderop JG (2009) The role of transient receptor potential channels in kidney disease. Nat Rev Nephrol 5:441–449
    • (2009) Nat Rev Nephrol , vol.5 , pp. 441-449
    • Woudenberg-Vrenken, T.E.1    Bindels, R.J.2    Hoenderop, J.G.3
  • 15
    • 79960991150 scopus 로고    scopus 로고
    • Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes
    • COI: 1:CAS:528:DC%2BC3MXhtFSqur3J, PID: 21525431
    • Graham S, Gorin Y, Abboud HE, Ding M, Lee DY, Shi H, Ding Y, Ma R (2011) Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes. Am J Physiol Cell Physiol 301:C304–C315
    • (2011) Am J Physiol Cell Physiol , vol.301 , pp. C304-C315
    • Graham, S.1    Gorin, Y.2    Abboud, H.E.3    Ding, M.4    Lee, D.Y.5    Shi, H.6    Ding, Y.7    Ma, R.8
  • 16
    • 65649133663 scopus 로고    scopus 로고
    • Sensitizing the slit diaphragm with TRPC6 ion channels
    • COI: 1:CAS:528:DC%2BD1MXlvFKqsbk%3D, PID: 18784209
    • Moller CC, Flesche J, Reiser J (2009) Sensitizing the slit diaphragm with TRPC6 ion channels. J Am Soc Nephrol 20:950–953
    • (2009) J Am Soc Nephrol , vol.20 , pp. 950-953
    • Moller, C.C.1    Flesche, J.2    Reiser, J.3
  • 22
    • 84879312489 scopus 로고    scopus 로고
    • Inhibition of TGF-beta1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats
    • COI: 1:CAS:528:DC%2BC3sXhtVCgt7fF, PID: 23624380
    • Pan MM, Zhang MH, Ni HF, Chen JF, Xu M, Phillips AO, Liu BC (2013) Inhibition of TGF-beta1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats. Food Chem Toxicol 58:487–494
    • (2013) Food Chem Toxicol , vol.58 , pp. 487-494
    • Pan, M.M.1    Zhang, M.H.2    Ni, H.F.3    Chen, J.F.4    Xu, M.5    Phillips, A.O.6    Liu, B.C.7
  • 23
    • 0141790220 scopus 로고    scopus 로고
    • Evaluation of a thick and thin section method for estimation of podocyte number, glomerular volume, and glomerular volume per podocyte in rat kidney with Wilms’ tumor-1 protein used as a podocyte nuclear marker
    • PID: 14514726
    • Sanden SK, Wiggins JE, Goyal M, Riggs LK, Wiggins RC (2003) Evaluation of a thick and thin section method for estimation of podocyte number, glomerular volume, and glomerular volume per podocyte in rat kidney with Wilms’ tumor-1 protein used as a podocyte nuclear marker. J Am Soc Nephrol 14:2484–2493
    • (2003) J Am Soc Nephrol , vol.14 , pp. 2484-2493
    • Sanden, S.K.1    Wiggins, J.E.2    Goyal, M.3    Riggs, L.K.4    Wiggins, R.C.5
  • 24
    • 0037087593 scopus 로고    scopus 로고
    • WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis
    • COI: 1:CAS:528:DC%2BD38XivV2ntL4%3D, PID: 11912180
    • Guo JK, Menke AL, Gubler MC, Clarke AR, Harrison D, Hammes A, Hastie ND, Schedl A (2002) WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum Mol Genet 11:651–659
    • (2002) Hum Mol Genet , vol.11 , pp. 651-659
    • Guo, J.K.1    Menke, A.L.2    Gubler, M.C.3    Clarke, A.R.4    Harrison, D.5    Hammes, A.6    Hastie, N.D.7    Schedl, A.8
  • 25
    • 45249108429 scopus 로고    scopus 로고
    • Proteinuria in diabetic kidney disease: a mechanistic viewpoint
    • COI: 1:CAS:528:DC%2BD1cXntFymtro%3D, PID: 18418356
    • Jefferson JA, Shankland SJ, Pichler RH (2008) Proteinuria in diabetic kidney disease: a mechanistic viewpoint. Kidney Int 74:22–36
    • (2008) Kidney Int , vol.74 , pp. 22-36
    • Jefferson, J.A.1    Shankland, S.J.2    Pichler, R.H.3
  • 26
    • 34047248203 scopus 로고    scopus 로고
    • AGE, RAGE, and ROS in diabetic nephropathy
    • COI: 1:CAS:528:DC%2BD2sXlt1KrtL8%3D, PID: 17418682
    • Tan AL, Forbes JM, Cooper ME (2007) AGE, RAGE, and ROS in diabetic nephropathy. Semin Nephrol 27:130–143
    • (2007) Semin Nephrol , vol.27 , pp. 130-143
    • Tan, A.L.1    Forbes, J.M.2    Cooper, M.E.3
  • 28
    • 34447514029 scopus 로고    scopus 로고
    • Vitamin D deficiency
    • COI: 1:CAS:528:DC%2BD2sXotVejsbc%3D, PID: 17634462
    • Holick MF (2007) Vitamin D deficiency. N Engl J Med 357:266–281
    • (2007) N Engl J Med , vol.357 , pp. 266-281
    • Holick, M.F.1
  • 29
    • 53749088063 scopus 로고    scopus 로고
    • Vitamin D and kidney disease
    • COI: 1:CAS:528:DC%2BD1cXhtFensrfJ, PID: 18450926
    • Al-Badr W, Martin KJ (2008) Vitamin D and kidney disease. Clin J Am Soc Nephrol 3:1555–1560
    • (2008) Clin J Am Soc Nephrol , vol.3 , pp. 1555-1560
    • Al-Badr, W.1    Martin, K.J.2
  • 30
    • 34547208630 scopus 로고    scopus 로고
    • Expanding role for vitamin D in chronic kidney disease: importance of blood 25-OH-D levels and extra-renal 1alpha-hydroxylase in the classical and nonclassical actions of 1alpha,25-dihydroxyvitamin D(3)
    • PID: 17635821
    • Jones G (2007) Expanding role for vitamin D in chronic kidney disease: importance of blood 25-OH-D levels and extra-renal 1alpha-hydroxylase in the classical and nonclassical actions of 1alpha,25-dihydroxyvitamin D(3). Semin Dial 20:316–324
    • (2007) Semin Dial , vol.20 , pp. 316-324
    • Jones, G.1
  • 31
    • 0042343804 scopus 로고    scopus 로고
    • Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy
    • COI: 1:CAS:528:DC%2BD3sXms1Ogsrg%3D, PID: 12890843
    • Teng M, Wolf M, Lowrie E, Ofsthun N, Lazarus JM, Thadhani R (2003) Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy. N Engl J Med 349:446–456
    • (2003) N Engl J Med , vol.349 , pp. 446-456
    • Teng, M.1    Wolf, M.2    Lowrie, E.3    Ofsthun, N.4    Lazarus, J.M.5    Thadhani, R.6
  • 32
    • 78149359262 scopus 로고    scopus 로고
    • Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial
    • PID: 21055801
    • de Zeeuw D, Agarwal R, Amdahl M, Audhya P, Coyne D, Garimella T, Parving HH, Pritchett Y, Remuzzi G, Ritz E, Andress D (2010) Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial. Lancet 376:1543–1551
    • (2010) Lancet , vol.376 , pp. 1543-1551
    • de Zeeuw, D.1    Agarwal, R.2    Amdahl, M.3    Audhya, P.4    Coyne, D.5    Garimella, T.6    Parving, H.H.7    Pritchett, Y.8    Remuzzi, G.9    Ritz, E.10    Andress, D.11
  • 33
    • 84887301184 scopus 로고    scopus 로고
    • 25 (OH) vitamin D levels and renal disease progression in patients with type 2 diabetic nephropathy and blockade of the renin–angiotensin system
    • COI: 1:CAS:528:DC%2BC3sXhvVCjsLbE, PID: 24135218
    • Fernandez-Juarez G, Luno J, Barrio V, de Vinuesa SG, Praga M, Goicoechea M, Lahera V, Casas L, Oliva J (2013) 25 (OH) vitamin D levels and renal disease progression in patients with type 2 diabetic nephropathy and blockade of the renin–angiotensin system. Clin J Am Soc Nephrol 8:1870–1876
    • (2013) Clin J Am Soc Nephrol , vol.8 , pp. 1870-1876
    • Fernandez-Juarez, G.1    Luno, J.2    Barrio, V.3    de Vinuesa, S.G.4    Praga, M.5    Goicoechea, M.6    Lahera, V.7    Casas, L.8    Oliva, J.9
  • 34
    • 34249868434 scopus 로고    scopus 로고
    • Combination therapy with an angiotensin-converting enzyme inhibitor and a vitamin D analog suppresses the progression of renal insufficiency in uremic rats
    • COI: 1:CAS:528:DC%2BD2sXnt1Wjsro%3D, PID: 17513326
    • Mizobuchi M, Morrissey J, Finch JL, Martin DR, Liapis H, Akizawa T, Slatopolsky E (2007) Combination therapy with an angiotensin-converting enzyme inhibitor and a vitamin D analog suppresses the progression of renal insufficiency in uremic rats. J Am Soc Nephrol 18:1796–1806
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1796-1806
    • Mizobuchi, M.1    Morrissey, J.2    Finch, J.L.3    Martin, D.R.4    Liapis, H.5    Akizawa, T.6    Slatopolsky, E.7
  • 35
    • 78651384347 scopus 로고    scopus 로고
    • Blockade of Wnt/beta-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury
    • COI: 1:CAS:528:DC%2BC3MXhsVChsrk%3D, PID: 21030600
    • He W, Kang YS, Dai C, Liu Y (2011) Blockade of Wnt/beta-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury. J Am Soc Nephrol 22:90–103
    • (2011) J Am Soc Nephrol , vol.22 , pp. 90-103
    • He, W.1    Kang, Y.S.2    Dai, C.3    Liu, Y.4
  • 36
    • 80855144625 scopus 로고    scopus 로고
    • 2alpha-Methyl-19-nor-(20S)-1,25-dihydroxyvitamin D(3) protects the insulin 2 knockout non-obese diabetic mouse from developing type 1 diabetes without hypercalcaemia
    • COI: 1:CAS:528:DC%2BC3MXhs12gtrvE, PID: 22059989
    • Kiekhaefer CM, Weber B, Huggins M, Gorichanaz C, Nehring JA, DeLuca HF (2011) 2alpha-Methyl-19-nor-(20S)-1,25-dihydroxyvitamin D(3) protects the insulin 2 knockout non-obese diabetic mouse from developing type 1 diabetes without hypercalcaemia. Clin Exp Immunol 166:325–332
    • (2011) Clin Exp Immunol , vol.166 , pp. 325-332
    • Kiekhaefer, C.M.1    Weber, B.2    Huggins, M.3    Gorichanaz, C.4    Nehring, J.A.5    DeLuca, H.F.6
  • 37
    • 33646585142 scopus 로고    scopus 로고
    • Identification and localization of TRPC channels in the rat kidney
    • COI: 1:CAS:528:DC%2BD28XkvFSlsbY%3D, PID: 16303855
    • Goel M, Sinkins WG, Zuo CD, Estacion M, Schilling WP (2006) Identification and localization of TRPC channels in the rat kidney. Am J Physiol Renal Physiol 290:F1241–F1252
    • (2006) Am J Physiol Renal Physiol , vol.290 , pp. F1241-F1252
    • Goel, M.1    Sinkins, W.G.2    Zuo, C.D.3    Estacion, M.4    Schilling, W.P.5
  • 38
    • 34547584505 scopus 로고    scopus 로고
    • TRP channels in kidney disease
    • COI: 1:CAS:528:DC%2BD2sXosFOjtb4%3D, PID: 17346947
    • Hsu YJ, Hoenderop JG, Bindels RJ (2007) TRP channels in kidney disease. Biochim Biophys Acta 1772:928–936
    • (2007) Biochim Biophys Acta , vol.1772 , pp. 928-936
    • Hsu, Y.J.1    Hoenderop, J.G.2    Bindels, R.J.3
  • 39
    • 34447136072 scopus 로고    scopus 로고
    • Podocin organizes ion channel-lipid supercomplexes: implications for mechanosensation at the slit diaphragm
    • COI: 1:CAS:528:DC%2BD2sXmsVOisrg%3D, PID: 17570936
    • Huber TB, Schermer B, Benzing T (2007) Podocin organizes ion channel-lipid supercomplexes: implications for mechanosensation at the slit diaphragm. Nephron Exp Nephrol 106:e27–e31
    • (2007) Nephron Exp Nephrol , vol.106 , pp. e27-e31
    • Huber, T.B.1    Schermer, B.2    Benzing, T.3
  • 40
    • 65249099647 scopus 로고    scopus 로고
    • TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription
    • COI: 1:CAS:528:DC%2BD1MXjtFGrsbo%3D, PID: 19129465
    • Schlondorff J, Del Camino D, Carrasquillo R, Lacey V, Pollak MR (2009) TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription. Am J Physiol Cell Physiol 296:C558–C569
    • (2009) Am J Physiol Cell Physiol , vol.296 , pp. C558-C569
    • Schlondorff, J.1    Del Camino, D.2    Carrasquillo, R.3    Lacey, V.4    Pollak, M.R.5
  • 41
    • 84880072570 scopus 로고    scopus 로고
    • Gain-of-function mutations in transient receptor potential C6 (TRPC6) activate extracellular signal-regulated kinases 1/2 (ERK1/2)
    • COI: 1:CAS:528:DC%2BC3sXpvVGmur8%3D, PID: 23645677
    • Chiluiza D, Krishna S, Schumacher VA, Schlondorff J (2013) Gain-of-function mutations in transient receptor potential C6 (TRPC6) activate extracellular signal-regulated kinases 1/2 (ERK1/2). J Biol Chem 288:18407–18420
    • (2013) J Biol Chem , vol.288 , pp. 18407-18420
    • Chiluiza, D.1    Krishna, S.2    Schumacher, V.A.3    Schlondorff, J.4
  • 43
    • 84877125730 scopus 로고    scopus 로고
    • Nuclear factor kappaB mediates suppression of canonical transient receptor potential 6 expression by reactive oxygen species and protein kinase C in kidney cells
    • COI: 1:CAS:528:DC%2BC3sXmvF2ltrs%3D, PID: 23525112
    • Wang Y, Ding M, Chaudhari S, Ding Y, Yuan J, Stankowska D, He S, Krishnamoorthy R, Cunningham JT, Ma R (2013) Nuclear factor kappaB mediates suppression of canonical transient receptor potential 6 expression by reactive oxygen species and protein kinase C in kidney cells. J Biol Chem 288:12852–12865
    • (2013) J Biol Chem , vol.288 , pp. 12852-12865
    • Wang, Y.1    Ding, M.2    Chaudhari, S.3    Ding, Y.4    Yuan, J.5    Stankowska, D.6    He, S.7    Krishnamoorthy, R.8    Cunningham, J.T.9    Ma, R.10
  • 44
    • 84890473534 scopus 로고    scopus 로고
    • Angiotensin II activation of TRPC6 channels in rat podocytes requires generation of reactive oxygen species
    • COI: 1:CAS:528:DC%2BC3sXhvFeqtL3M, PID: 24037962
    • Anderson M, Roshanravan H, Khine J, Dryer SE (2014) Angiotensin II activation of TRPC6 channels in rat podocytes requires generation of reactive oxygen species. J Cell Physiol 229:434–442
    • (2014) J Cell Physiol , vol.229 , pp. 434-442
    • Anderson, M.1    Roshanravan, H.2    Khine, J.3    Dryer, S.E.4
  • 45
    • 84904744166 scopus 로고    scopus 로고
    • High glucose modifies transient receptor potential canonical type 6 channels via increased oxidative stress and syndecan-4 in human podocytes
    • COI: 1:CAS:528:DC%2BC2cXhtVCjtLnE, PID: 24942878
    • Thilo F, Lee M, Xia S, Zakrzewicz A, Tepel M (2014) High glucose modifies transient receptor potential canonical type 6 channels via increased oxidative stress and syndecan-4 in human podocytes. Biochem Biophys Res Commun 450:312–317
    • (2014) Biochem Biophys Res Commun , vol.450 , pp. 312-317
    • Thilo, F.1    Lee, M.2    Xia, S.3    Zakrzewicz, A.4    Tepel, M.5
  • 47
    • 59449105533 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D(3) prevents puromycin aminonucleoside-induced apoptosis of glomerular podocytes by activating the phosphatidylinositol 3-kinase/Akt-signaling pathway
    • PID: 19202327
    • Xiao H, Shi W, Liu S, Wang W, Zhang B, Zhang Y, Xu L, Liang X, Liang Y (2009) 1,25-Dihydroxyvitamin D(3) prevents puromycin aminonucleoside-induced apoptosis of glomerular podocytes by activating the phosphatidylinositol 3-kinase/Akt-signaling pathway. Am J Nephrol 30:34–43
    • (2009) Am J Nephrol , vol.30 , pp. 34-43
    • Xiao, H.1    Shi, W.2    Liu, S.3    Wang, W.4    Zhang, B.5    Zhang, Y.6    Xu, L.7    Liang, X.8    Liang, Y.9
  • 48
    • 80052197647 scopus 로고    scopus 로고
    • Vitamin D receptor (VDR)-mediated actions of 1alpha,25(OH)(2) vitamin D(3): genomic and non-genomic mechanisms
    • COI: 1:CAS:528:DC%2BC3MXhtFSru7jN, PID: 21872797
    • Haussler MR, Jurutka PW, Mizwicki M, Norman AW (2011) Vitamin D receptor (VDR)-mediated actions of 1alpha,25(OH)(2) vitamin D(3): genomic and non-genomic mechanisms. Best Pract Res Clin Endocrinol Metab 25:543–559
    • (2011) Best Pract Res Clin Endocrinol Metab , vol.25 , pp. 543-559
    • Haussler, M.R.1    Jurutka, P.W.2    Mizwicki, M.3    Norman, A.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.