Sensitizing the slit diaphragm with TRPC6 ion channels

Journal of the American Society of Nephrology

Volumn 20, Issue 5, 2009, Pages 950-953

  Möller, Clemens C ^a   Flesche, Jan ^a   Reiser, Jochen ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CALCIUM; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; MEMBRANE PROTEIN; PODOCIN; SIGNAL PEPTIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC6 PROTEIN, HUMAN; TRPC6 PROTEIN, MOUSE;

ARTICLE; CELL DAMAGE; CYTOSKELETON; DIAPHRAGM; DISEASE COURSE; GENE MUTATION; GLOMERULOPATHY; GLOMERULUS CAPILLARY; GLOMERULUS FILTRATION; HUMAN; KIDNEY FAILURE; MEMBRANE PERMEABILITY; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEINURIA; ANIMAL; BASEMENT MEMBRANE; CAENORHABDITIS ELEGANS; CAPILLARY; GENETICS; GLOMERULUS; KIDNEY DISEASE; MOUSE; MOUSE MUTANT; NEPHROTIC SYNDROME; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; VASCULARIZATION;

ANIMALS; BASEMENT MEMBRANE; CAENORHABDITIS ELEGANS; CAPILLARIES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY DISEASES; KIDNEY GLOMERULUS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NEPHROTIC SYNDROME; PODOCYTES; PROTEINURIA; RATS; TRPC CATION CHANNELS;

EID: 65649133663     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2008030329     Document Type: Article

References (16)

1. Clapham DE: Calcium signaling. Cell 131: 1047-1058, 2007
2. Reiser J, Polu KR, Moller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, Clapham DE, Pollak MR: TRPC6 is a glomerular glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet 37: 739-744, 2005 (Pubitemid 41754891)
3. Winn MP, Conlon PJ, Lynn KL, Farrington MK, Creazzo T, Hawkins AF, Daskalakis N, Kwan SY, Ebersviller S, Burchette JL, Pericak-Vance MA, Howell DN, Vance JM, Rosenberg PB: A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 308: 1801-1804, 2005 (Pubitemid 40848011)
4. Moller CC, Wei C, Altintas MM, Li J, Greka A, Ohse T, Pippin JW, Rastaldi MP, Wawersik S, Schiavi S, Henger A, Kretzler M, Shankland SJ, Reiser J: Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. J Am Soc Nephrol 18: 29-36, 2007 (Pubitemid 46053419)
5. Huber TB, Schermer B, Muller RU, Hohne M, Bartram M, Calixto A, Hagmann H, Reinhardt C, Koos F, Kunzelmann K, Shirokova E, Krautwurst D, Harteneck C, Simons M, Pavenstadt H, Kerjaschki D, Thiele C, Walz G, Chalfie M, Benzing T: Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A 103: 17079-17086, 2006
6. Spassova MA, Hewavitharana T, Xu W, Soboloff J, Gill DL: A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc Natl Acad Sci U S A 103: 16586-16591, 2006
7. Benzing T: Signaling at the slit diaphragm. J Am Soc Nephrol 15: 1382-1391, 2004
8. Zhu J, Sun N, Aoudjit L, Li H, Kawachi H, Lemay S, Takano T: Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes. Kidney Int 73: 556-566, 2008
9. Verma R, Wharram B, Kovari I, Kunkel R, Nihalani D, Wary KK, Wiggins RC, Killen P, Holzman LB: Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin. J Biol Chem 278: 20716-20723, 2003 (Pubitemid 36806374)
10. Hisatsune C, Kuroda Y, Nakamura K, Inoue T, Nakamura T, Michikawa T, Mizutani A, Mikoshiba K: Regulation of TRPC6 channel activity by tyrosine phosphorylation. J Biol Chem 279: 18887-18894, 2004 (Pubitemid 38623316)
11. Faul C, Asanuma K, Yanagida-Asanuma E, Kim K, Mundel P: Actin up: Regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol 17: 428-437, 2007 (Pubitemid 47499042)
12. Kuwahara K, Wang Y, McAnally J, Richardson JA, Bassel-Duby R, Hill JA, Olson EN: TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. J Clin Invest 116: 3114-3126, 2006
13. Dietrich A, Mederos YS, Gollasch M, Gross V, Storch U, Dubrovska G, Obst M, Yildirim E, Salanova B, Kalwa H, Essin K, Pinkenburg O, Luft FC, Gudermann T, Birnbaumer L: Increased vascular smooth muscle contractility in TRPC6-/- mice. Mol Cell Biol 25: 6980-6989, 2005 (Pubitemid 41105898)
14. Moller CC, Mangos S, Drummond IA, Reiser J: Expression of trpC1 and trpC6 orthologs in zebrafish. Gene Expr Patterns 8: 291-296, 2008
15. Huber TB, Kwoh C, Wu H, Asanuma K, Godel M, Hartleben B, Blumer KJ, Miner JH, Mundel P, Shaw AS: Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin. J Clin Invest 116: 1337-1345, 2006
16. Gawlik A, Quaggin SE: Conditional gene targeting in the kidney. Curr Mol Med 5: 527-536, 2005 (Pubitemid 41086777)