1,25-Dihydroxyvitamin D3 prevents puromycin aminonucleoside-Induced apoptosis of glomerular podocytes by activating the phosphatidylinositol 3-Kinase/Akt-Signaling pathway

American Journal of Nephrology

Volumn 30, Issue 1, 2009, Pages 34-43

  Xiao, Houqin ^a,b   Shi, Wei ^a   Liu, Shuangxin ^a   Wang, Wenjian ^a   Zhang, Bin ^a   Zhang, Yong ^b   Xu, Lixia ^a   Liang, Xinling ^a   Liang, Yongzheng ^a  

^a GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

Akt; Apoptosis; Phosphatidylinositol 3 kinase; Podocytes; Vitamin D

Indexed keywords

ALBUMIN; CALCITRIOL; CALCIUM; CREATININE; MESSENGER RNA; NEPHRIN; PHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PUROMYCIN AMINONUCLEOSIDE; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM BLOOD LEVEL; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION; GLOMERULUS; HISTOPATHOLOGY; KIDNEY FUNCTION TEST; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOSPHATE BLOOD LEVEL; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN URINE LEVEL; PROTEINURIA; RAT; RENAL PROTECTION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CALCITRIOL; ENZYME ACTIVATION; KIDNEY GLOMERULUS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; PODOCYTES; PROTO-ONCOGENE PROTEINS C-AKT; PUROMYCIN AMINONUCLEOSIDE; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 59449105533     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000200769     Document Type: Article

References (36)

1. Toyoda M, Najafian B, Kim Y, et al: Podocyte detachment and reduced glomerular capillary endothelial fenestration in human type 1 diabetic nephropathy. Diabetes 2007;56:2155-2160.
2. White KE, Bilous RW, Marshall SM, et al: Podocyte number in normotensive type 1 diabetic patients with albuminuria. Diabetes 2002;51:3083-3089.
3. Wharram BL, Goyal M, Wiggins JE, et al: Podocyte depletion causes glomerulosclero-sis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol 2005;16:2941-2952.
4. Kim YH, Goyal M, Kurnit D, et al: Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat. Kidney Int 2001;60:957-968.
5. Dusso AS, Brown AJ, Slatopolsky E: Vitamin D: Am J Physiol Renal Physiol 2005;289: 8-28.
6. Shoben AB, Rudser KD, de Boer IH, el al: Association of oral calcitriol with improved survival in nondialyzed CKD. J Am Soc Nephrol 2008;19:1613-1619.
7. Teng M, Wolf M, Lowrie E, et al: Survival of patients undergoing hemodialysis with pari-calcitol or calcitriol therapy. N Engl J Med 2003;349:446-456.
8. Levin A, Li YC, et al: Vitamin D and its analogues: Do they protect against cardiovascular disease in patients with kidney disease? Kidney Int 2005;68:1973-1981.
9. Alborzi P, Patel NA, Peterson C, et al: Pari-calcitol reduces albuminuria and inflammation in chronic kidney disease: a randomized double-blind pilot trial. Hypertension 2008;52:249-255.
10. 3 decreases podocyte loss and podocyte hypertrophy in the subtotally nephrectomized rat. Am J Physiol Renal Physiol 20 04;286: 526 -533.
11. Mizobuchi M, Morrissey J, Finch JL, et al: Combination therapy with an angiotensin-converting enzyme inhibitor and a vitamin D analog suppresses the progression of renal insufficiency in uremic rats. J Am Soc Nephrol 2007;18:1796-1806.
12. Hirata M, Makibayashi K, Katsumata K, et al:22-Oxacalcitriol prevents progressive glomerulosclerosis without adversely affecting calcium and phosphorus metabolism in subtotally nephrectomized rats. Nephrol Dial Transplant 2002;17:2132-2137.
13. Li Y, Spataro BC, Yang J, et al:1,25-Dihy-droxyvitamin D inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expression. Kidney Int 2005;68:1500-1510.
14. Tan X, Li Y, Liu Y: Paricalcitol attenuates renal interstitial fibrosis in obstructive ne-phropat hy. J Am Soc Nephrol 20 06;17:3382-3393.
15. Makibayashi K, Tatematsu M, Hirata M, et al: A vitamin D analog ameliorates glomeru-lar injury on rat glomerulonephritis. Am J Pathol 2001;158:1733-1741.
16. 3 inexperime ntal mesangial proliferative nephritis in rats. Kidney Int 2001;60:87-95.
17. Ya mauchi K, Takano Y, Kasai A, et al: Screening and identification of substances that regulate nephrin gene expression using engineered reporter podocytes. Kidney Int 2006;70: 892-900.
18. Wang Y, Zhou J, Minto AW, et al: Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy. Kidney Int 2006;70: 882-891.
19. Takano Y, Yamauchi K, Hiramatsu N, et al: Recovery and maintenance of nephrin expression in cultured podocytes and identification of HGF as a repressor of nephrin. Am J Physiol Renal Physiol 2007;292:1573-1582.
20. Ma Y, Yu WD, Kong RX, et al: Role of nongenomic activation of phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated ki-nase1/2 pathways in 1,25D3-mediated apop-tosis in squamous cell carcinoma cells. Cancer Res 2006;66:8131-8138.
21. 3-induced anti-apoptotic PI3K/Akt signaling in osteoblasts. J Bone Miner Res 2008;23:1238-1248.
22. Gross ML, El-Shakmak A, Ziebart H, el al: ACE inhibitors but not endothelin receptor blockers prevent podocyte loss in early diabetic nephropathy. Diabetologia 2003;46: 856-868.
23. Baker AJ, Mooney A, Hughes J, et al: Mesan-gial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis. J Clin Invest 1994;94:2105-2116.
24. Macconi D, Bonomelli M, Benigni A, et al: Pathophysiologic implications of reduced podocyte number in a rat model of progressive glomerular injury. Am J Pathol 2006;168:42-54.
25. 3 alters the transforming growth factor- β signaling pathway in renal tissue. J Surg Res 2001;100:171-175.
26. 3 targeting of NF-κB suppresses high glucose-induced MCP-1 expression in mesangial cells. Kidney Int 2007;72:193-201.
27. Li YC, Kong J, Wei M, et al: Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure. J Steroid Biochem Mol Biol 2004;90:387-392.
28. Kawachi H, Koike H, Kurihara H, et al: Cloning of rat nephrin: expression in developing glomeruli and in proteinuric states. Kidney Int 2000;57:1949-1961.
29. Luimula P, Ahola H, Wang SX, et al: Nephrin in experimental glomerular disease. Kidney Int 2000;58:1461-1468.
30. Elias J, Marian B, Edling C, et al: Induction of apoptosis by vitamin D metabolites and analogs in a glioma cell line. Recent Results Cancer Res 2003;164:319-332.
31. Valrance ME, Welsh J: Breast cancer cell regulation by high-dose vitamin D compounds in the absence of nuclear vitamin D receptor. J Steroid Biochem Mol Biol 2004;89-90:221-225.
32. 3 in primary human melanocytes. Melanoma Res 2003;13:339-347.
33. Diker-Cohen T, Koren R, Liberman UA, et al: Vitamin D protects keratinocytes from apoptosis induced by osmotic shock, oxidative stress, and tumor necrosis factor. Ann NY Acad Sci 2003;1010:350-353.
34. Huber TB, Hartleben B, Kim J, et al: Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate Akt-dependent signaling. Mol Cell Biol 2003;23:4917-4928.
35. Zhu J, Sun N, Aoudjit L, Li H, et al: Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes. Kidney Int 2008;73: 556-566.
36. Schiffer M, Bitzer M, Roberts IS, et al: Apoptosis in podocytes induced by TGF-β and Smad7. J Clin Invest 2001;108:807-816.