The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192

Science Signaling

Volumn 7, Issue 355, 2014, Pages

  Granum, Stine ^a   Sundvold Gjerstad, Vibeke ^a   Gopalakrishnan, Ramakrishna Prabhu ^a   Berge, Tone ^b   Koll, Lise ^a   Abrahamsen, Greger ^a   Sorlie, Morten ^c   Spurkland, Anne ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^c NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; ADAPTOR PROTEIN; CD18 ANTIGEN; FOCAL ADHESION KINASE 2; GLUTATHIONE TRANSFERASE; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 2 INDUCIBLE TEC KINASE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PERVANADATE; PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; PROTEIN SH2; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; SMALL INTERFERING RNA; T CELL SPECIFIC ADAPTOR PROTEIN; UNCLASSIFIED DRUG; EMT PROTEIN-TYROSINE KINASE; LYMPHOCYTE ANTIGEN RECEPTOR; SH2D2A PROTEIN, HUMAN; SH2D2A PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TYROSINE;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CD4+ T LYMPHOCYTE; CELL CONJUGATE; CELL LYSATE; CHEMOLUMINESCENCE; CONJUGATION; CONTROLLED STUDY; ENZYME ACTIVITY; FLOW CYTOMETRY; IMMUNOLOGICAL SYNAPSE; IMMUNOPRECIPITATION; ISOTHERMAL TITRATION CALORIMETRY; JURKAT CELL LINE; LIGAND BINDING; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PHAGE DISPLAY; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; WESTERN BLOTTING; WILD TYPE; ANIMAL; CYTOLOGY; ENZYME SPECIFICITY; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; PHOSPHORYLATION; SRC HOMOLOGY DOMAIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGEN-PRESENTING CELLS; HUMANS; JURKAT CELLS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; SUBSTRATE SPECIFICITY; T-LYMPHOCYTES; TYROSINE;

EID: 84916607723     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2005384     Document Type: Article

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