WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 44, 2014, Pages E4716-E4725

  Abu Odeh, Mohammad ^a   Salah, Zaidoun ^a,b   Herbel, Christoph ^c   Hofmann, Thomas G ^c   Aqeilan, Rami I ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b AL QUDS UNIVERSITY   (Palestine)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Ataxia telangiectasia mutated; Common fragile sites; Genomic instability; ITCH; Ww domain containing oxidoreductase

Indexed keywords

ATM PROTEIN; HISTONE H2AX; LYSINE; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; WWOX PROTEIN; ATM PROTEIN, HUMAN; ATM PROTEIN, MOUSE; GAMMA-H2AX PROTEIN, MOUSE; H2AFX PROTEIN, HUMAN; HISTONE; ITCH PROTEIN, HUMAN; ITCH PROTEIN, MOUSE; OXIDOREDUCTASE; REPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE; WWOX PROTEIN, HUMAN; WWOX PROTEIN, MOUSE;

ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FRA16D GENE PRODUCT; GENE PRODUCT; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; PROTEIN DEFICIENCY; UBIQUITINATION; ANIMAL; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; MOUSE; NEOPLASM; PATHOLOGY;

ANIMALS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CELL NUCLEUS; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOMIC INSTABILITY; HEK293 CELLS; HELA CELLS; HISTONES; HUMANS; MICE; NEOPLASMS; OXIDOREDUCTASES; REPRESSOR PROTEINS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84914676110     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1409252111     Document Type: Article

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