메뉴 건너뛰기




Volumn 21, Issue 11, 2014, Pages 1805-1814

Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXIDOREDUCTASE; TUMOR SUPPRESSOR PROTEIN; WWOX PROTEIN, HUMAN; WWOX PROTEIN, MOUSE;

EID: 84932091996     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2014.95     Document Type: Article
Times cited : (68)

References (48)
  • 2
    • 34347371806 scopus 로고    scopus 로고
    • WWOX in biological control and tumorigenesis
    • Aqeilan RI, Croce CM. WWOX in biological control and tumorigenesis. J Cell Physiol 2007; 212: 307-310.
    • (2007) J Cell Physiol , vol.212 , pp. 307-310
    • Aqeilan, R.I.1    Croce, C.M.2
  • 3
    • 84896035949 scopus 로고    scopus 로고
    • WW domain-containing oxidoreductase's role in myriad cancers: Clinical significance and future implications
    • Gardenswartz A, Aqeilan RI. WW domain-containing oxidoreductase's role in myriad cancers: clinical significance and future implications. Exp Biol Med 2014; 239: 253-263.
    • (2014) Exp Biol Med , vol.239 , pp. 253-263
    • Gardenswartz, A.1    Aqeilan, R.I.2
  • 5
    • 52049102904 scopus 로고    scopus 로고
    • The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
    • Aqeilan RI, Hassan MQ, de Bruin A, Hagan JP, Volinia S, Palumbo T et al. The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism. J Biol Chem 2008; 283: 21629-21639.
    • (2008) J Biol Chem , vol.283 , pp. 21629-21639
    • Aqeilan, R.I.1    Hassan, M.Q.2    De Bruin, A.3    Hagan, J.P.4    Volinia, S.5    Palumbo, T.6
  • 7
    • 84875536891 scopus 로고    scopus 로고
    • Conditional inactivation of the mouse Wwox tumor suppressor gene recapitulates the null phenotype
    • Abdeen SK, Del Mare S, Hussain S, Remaileh M.A, Salah Z, Hagan J et al. Conditional inactivation of the mouse Wwox tumor suppressor gene recapitulates the null phenotype. J Cell Physiol 2012; 228: 1377-1382.
    • (2012) J Cell Physiol , vol.228 , pp. 1377-1382
    • Abdeen, S.K.1    Del Mare, S.2    Hussain, S.3    Remaileh, M.A.4    Salah, Z.5    Hagan, J.6
  • 10
    • 8544283814 scopus 로고    scopus 로고
    • Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor
    • Aqeilan RI, Palamarchuk A, Weigel RJ, Herrero JJ, Pekarsky Y, Croce CM. Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor. Cancer Res 2004; 64: 8256-8261.
    • (2004) Cancer Res , vol.64 , pp. 8256-8261
    • Aqeilan, R.I.1    Palamarchuk, A.2    Weigel, R.J.3    Herrero, J.J.4    Pekarsky, Y.5    Croce, C.M.6
  • 13
    • 77952536450 scopus 로고    scopus 로고
    • WWOX gene and gene product: Tumor suppression through specific protein interactions
    • Salah Z, Aqeilan R, Huebner K. WWOX gene and gene product: tumor suppression through specific protein interactions. Future Oncol 2010; 6: 249-259.
    • (2010) Future Oncol , vol.6 , pp. 249-259
    • Salah, Z.1    Aqeilan, R.2    Huebner, K.3
  • 14
    • 84897401786 scopus 로고    scopus 로고
    • Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks
    • Abu-Odeh M, Bar-Mag T, Huang H, Kim T, Salah Z, Abdeen SK et al. Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. J Biol Chem 2014; 289: 8865-8880.
    • (2014) J Biol Chem , vol.289 , pp. 8865-8880
    • Abu-Odeh, M.1    Bar-Mag, T.2    Huang, H.3    Kim, T.4    Salah, Z.5    Abdeen, S.K.6
  • 15
    • 78651079527 scopus 로고    scopus 로고
    • Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species
    • O'Keefe LV, Colella A, Dayan S, Chen Q, Choo A, Jacob R et al. Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. Hum Mol Genet 2011; 20: 497-509.
    • (2011) Hum Mol Genet , vol.20 , pp. 497-509
    • O'Keefe, L.V.1    Colella, A.2    Dayan, S.3    Chen, Q.4    Choo, A.5    Jacob, R.6
  • 16
    • 84880513475 scopus 로고    scopus 로고
    • Common chromosomal fragile site FRA16D tumor suppressor WWOX gene expression and metabolic reprograming in cells
    • Dayan S, O'Keefe LV, Choo A, Richards RI. Common chromosomal fragile site FRA16D tumor suppressor WWOX gene expression and metabolic reprograming in cells. Genes Chromosomes Cancer 2013; 52: 823-831.
    • (2013) Genes Chromosomes Cancer , vol.52 , pp. 823-831
    • Dayan, S.1    O'Keefe, L.V.2    Choo, A.3    Richards, R.I.4
  • 17
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 18
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 19
    • 80054046029 scopus 로고    scopus 로고
    • Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation
    • Lunt SY, Vander Heiden MG. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol 2011; 27: 441-464.
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 441-464
    • Lunt, S.Y.1    Vander Heiden, M.G.2
  • 20
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956; 123: 309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 21
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg O. On respiratory impairment in cancer cells. Science 1956; 124: 269-270.
    • (1956) Science , vol.124 , pp. 269-270
    • Warburg, O.1
  • 22
    • 34247631690 scopus 로고    scopus 로고
    • The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis
    • Lum JJ, Bui T, Gruber M, Gordan JD, DeBerardinis RJ, Covello KL et al. The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev 2007; 21: 1037-1049.
    • (2007) Genes Dev , vol.21 , pp. 1037-1049
    • Lum, J.J.1    Bui, T.2    Gruber, M.3    Gordan, J.D.4    Deberardinis, R.J.5    Covello, K.L.6
  • 24
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008; 7: 11-20.
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • Deberardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 25
    • 61849135453 scopus 로고    scopus 로고
    • Tumor suppressors and cell metabolism: A recipe for cancer growth
    • Jones RG, Thompson CB. Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev 2009; 23: 537-548.
    • (2009) Genes Dev , vol.23 , pp. 537-548
    • Jones, R.G.1    Thompson, C.B.2
  • 26
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 2006; 3: 187-197.
    • (2006) Cell Metab , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 27
    • 84855453655 scopus 로고    scopus 로고
    • Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells
    • Le A, Lane AN, Hamaker M, Bose S, Gouw A, Barbi J et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab 2012; 15: 110-121.
    • (2012) Cell Metab , vol.15 , pp. 110-121
    • Le Lane A, A.N.1    Hamaker, M.2    Bose, S.3    Gouw, A.4    Barbi, J.5
  • 28
    • 84875890762 scopus 로고    scopus 로고
    • Targeting cellular metabolism to improve cancer therapeutics
    • Zhao Y, Butler EB, Tan M. Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis 2013; 4: e532.
    • (2013) Cell Death Dis , vol.4 , pp. 532
    • Zhao, Y.1    Butler, E.B.2    Tan, M.3
  • 29
    • 40949114950 scopus 로고    scopus 로고
    • Role and regulation of prolyl hydroxylase domain proteins
    • Fong GH, Takeda K. Role and regulation of prolyl hydroxylase domain proteins. Cell Death Differ 2008; 15: 635-641.
    • (2008) Cell Death Differ , vol.15 , pp. 635-641
    • Fong, G.H.1    Takeda, K.2
  • 31
  • 32
    • 84870874690 scopus 로고    scopus 로고
    • The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
    • Sebastian C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L et al. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell 2012; 151: 1185-1199.
    • (2012) Cell , vol.151 , pp. 1185-1199
    • Sebastian, C.1    Zwaans, B.M.2    Silberman, D.M.3    Gymrek, M.4    Goren, A.5    Zhong, L.6
  • 33
    • 77950799838 scopus 로고    scopus 로고
    • MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis
    • Cha ST, Chen PS, Johansson G, Chu CY, Wang MY, Jeng YM et al. MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis. Cancer Res 2010; 70: 2675-2685.
    • (2010) Cancer Res , vol.70 , pp. 2675-2685
    • Cha, S.T.1    Chen, P.S.2    Johansson, G.3    Chu, C.Y.4    Wang, M.Y.5    Jeng, Y.M.6
  • 34
    • 48649102010 scopus 로고    scopus 로고
    • Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster
    • Taguchi A, Yanagisawa K, Tanaka M, Cao K, Matsuyama Y, Goto H et al. Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster. Cancer Res 2008; 68: 5540-5545.
    • (2008) Cancer Res , vol.68 , pp. 5540-5545
    • Taguchi, A.1    Yanagisawa, K.2    Tanaka, M.3    Cao, K.4    Matsuyama, Y.5    Goto, H.6
  • 35
    • 79951678403 scopus 로고    scopus 로고
    • MiR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity
    • Puissegur MP, Mazure NM, Bertero T, Pradelli L, Grosso S, Robbe-Sermesant K et al. miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity. Cell Death Differ 2011; 18: 465-478.
    • (2011) Cell Death Differ , vol.18 , pp. 465-478
    • Puissegur, M.P.1    Mazure, N.M.2    Bertero, T.3    Pradelli, L.4    Grosso, S.5    Robbe-Sermesant, K.6
  • 36
    • 84866689485 scopus 로고    scopus 로고
    • Hypoxia in the eye: A two-sided coin
    • Grimm C, Willmann G. Hypoxia in the eye: a two-sided coin. High Alt Med Biol 2012; 13: 169-175.
    • (2012) High Alt Med Biol , vol.13 , pp. 169-175
    • Grimm, C.1    Willmann, G.2
  • 37
    • 58149374576 scopus 로고    scopus 로고
    • Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth
    • Zhang H, Qian DZ, Tan YS, Lee K, Gao P, Ren YR et al. Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc Natl Acad Sci USA 2008; 105: 19579-19586.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19579-19586
    • Zhang, H.1    Qian, D.Z.2    Tan, Y.S.3    Lee, K.4    Gao, P.5    Ren, Y.R.6
  • 38
    • 77953515701 scopus 로고    scopus 로고
    • Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization
    • Yoshida T, Zhang H, Iwase T, Shen J, Semenza GL, Campochiaro PA. Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization. FASEB J 2010; 24: 1759-1767.
    • (2010) FASEB J , vol.24 , pp. 1759-1767
    • Yoshida, T.1    Zhang, H.2    Iwase, T.3    Shen, J.4    Semenza, G.L.5    Campochiaro, P.A.6
  • 39
    • 84862777480 scopus 로고    scopus 로고
    • Digoxin inhibits blood vessel density and HIF-1a expression in castration-resistant C4-2 xenograft prostate tumors
    • Gayed BA, O'Malley KJ, Pilch J, Wang Z. Digoxin inhibits blood vessel density and HIF-1a expression in castration-resistant C4-2 xenograft prostate tumors. Clin Transl Sci 2012; 5: 39-42.
    • (2012) Clin Transl Sci , vol.5 , pp. 39-42
    • Gayed, B.A.1    O'Malley, K.J.2    Pilch, J.3    Wang, Z.4
  • 40
    • 84859469406 scopus 로고    scopus 로고
    • Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-beta signaling
    • Wei H, Bedja D, Koitabashi N, Xing D, Chen J, Fox-Talbot K et al. Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-beta signaling. Proc Natl Acad Sci USA 2012; 109: E841-E850.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. E841-E850
    • Wei, H.1    Bedja, D.2    Koitabashi, N.3    Xing, D.4    Chen, J.5    Fox-Talbot, K.6
  • 41
    • 84879004119 scopus 로고    scopus 로고
    • Tumor suppressor WWOX binds to DeltaNp63alpha and sensitizes cancer cells to chemotherapy
    • Salah Z, Bar-mag T, Kohn Y, Pichiorri F, Palumbo T, Melino G et al. Tumor suppressor WWOX binds to DeltaNp63alpha and sensitizes cancer cells to chemotherapy. Cell Death Dis 2013; 4: e480.
    • (2013) Cell Death Dis , vol.4 , pp. 480
    • Salah, Z.1    Bar-Mag, T.2    Kohn, Y.3    Pichiorri, F.4    Palumbo, T.5    Melino, G.6
  • 42
    • 70350463840 scopus 로고    scopus 로고
    • WWOX: Its genomics, partners, and functions
    • Del Mare S, Salah Z, Aqeilan RI. WWOX: its genomics, partners, and functions. J Cell Biochem 2009; 108: 737-745.
    • (2009) J Cell Biochem , vol.108 , pp. 737-745
    • Del Mare, S.1    Salah, Z.2    Aqeilan, R.I.3
  • 43
    • 0141815741 scopus 로고    scopus 로고
    • Production of reactive oxygen species by mitochondria: Central role of complex III
    • Chen Q, Vazquez EJ, Moghaddas S, Hoppel CL, Lesnefsky EJ. Production of reactive oxygen species by mitochondria: central role of complex III. J Biol Chem 2003; 278: 36027-36031.
    • (2003) J Biol Chem , vol.278 , pp. 36027-36031
    • Chen, Q.1    Vazquez, E.J.2    Moghaddas, S.3    Hoppel, C.L.4    Lesnefsky, E.J.5
  • 44
    • 33745155010 scopus 로고    scopus 로고
    • TSGA10 prevents nuclear localization of the hypoxia-inducible factor (HIF)-1alpha
    • Hagele S, Behnam B, Borter E, Wolfe J, Paasch U, Lukashev D et al. TSGA10 prevents nuclear localization of the hypoxia-inducible factor (HIF)-1alpha. FEBS Lett 2006; 580: 3731-3738.
    • (2006) FEBS Lett , vol.580 , pp. 3731-3738
    • Hagele, S.1    Behnam, B.2    Borter, E.3    Wolfe, J.4    Paasch, U.5    Lukashev, D.6
  • 45
    • 84872258004 scopus 로고    scopus 로고
    • Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling
    • Pientka FK, Hu J, Schindler SG, Brix B, Thiel A, Johren O et al. Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling. J Cell Sci 2012; 125(Pt 21): 5168-5176.
    • (2012) J Cell Sci , vol.125 , pp. 5168-5176
    • Pientka, F.K.1    Hu, J.2    Schindler, S.G.3    Brix, B.4    Thiel, A.5    Johren, O.6
  • 46
    • 40949142209 scopus 로고    scopus 로고
    • The role of hypoxia-inducible factors in tumorigenesis
    • Rankin EB, Giaccia AJ. The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ 2008; 15: 678-685.
    • (2008) Cell Death Differ , vol.15 , pp. 678-685
    • Rankin, E.B.1    Giaccia, A.J.2
  • 47
    • 84878679199 scopus 로고    scopus 로고
    • A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
    • Kaplon J, Zheng L, Meissl K, Chaneton B, Selivanov VA, Mackay G et al. A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature 2013; 498: 109-112.
    • (2013) Nature , vol.498 , pp. 109-112
    • Kaplon, J.1    Zheng, L.2    Meissl, K.3    Chaneton, B.4    Selivanov, V.A.5    MacKay, G.6
  • 48
    • 79951699777 scopus 로고    scopus 로고
    • Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
    • Wolf A, Agnihotri S, Micallef J, Mukherjee J, Sabha N, Cairns R et al. Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme. J Exp Med 2011; 208: 313-326.
    • (2011) J Exp Med , vol.208 , pp. 313-326
    • Wolf, A.1    Agnihotri, S.2    Micallef, J.3    Mukherjee, J.4    Sabha, N.5    Cairns, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.