TRP channel cannabinoid receptors in skin sensation, homeostasis, and inflammation

ACS Chemical Neuroscience

Volumn 5, Issue 11, 2014, Pages 1107-1116

  Caterina, Michael J ^a  

^a Center for Sensory Biology   (United States)

Author keywords

Cannabinoids; Dermatitis; Ion channel; Nociception; Pruritis; Transient receptor potential

Indexed keywords

CANNABINOID; CANNABINOID RECEPTOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 2; VANILLOID RECEPTOR 3; VANILLOID RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL TYPE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DERMATITIS; EPIDERMIS; HAIR FOLLICLE; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NOCICEPTION; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PRURITUS; REVIEW; SEBACEOUS GLAND; SIGNAL TRANSDUCTION; SKIN SENSATION; SKIN TEMPERATURE; TASTE DISCRIMINATION; ANIMAL; CHEMICAL STRUCTURE; DRUG EFFECTS; INFLAMMATION; INNERVATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; SENSATION; SKIN;

ANIMALS; HOMEOSTASIS; HUMANS; INFLAMMATION; MODELS, MOLECULAR; SENSATION; SKIN; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84913596802     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn5000919     Document Type: Review

References (107)

1. Pacher, P., Batkai, S., and Kunos, G. (2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev. 58, 389-462.
2. Akopian, A. N., Ruparel, N. B., Jeske, N. A., Patwardhan, A., and Hargreaves, K. M. (2009) Role of ionotropic cannabinoid receptors in peripheral antinociception and antihyperalgesia. Trends Pharmacol. Sci. 30, 79-84.
3. Pertwee, R. G., Howlett, A. C., Abood, M. E., Alexander, S. P., Di Marzo, V., Elphick, M. R., Greasley, P. J., Hansen, H. S., Kunos, G., Mackie, K., Mechoulam, R., and Ross, R. A. (2010) International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and Their Ligands: Beyond CB(1) and CB(2). Pharmacol Rev. 62, 588-631.
4. Biro, T., Toth, B. I., Hasko, G., Paus, R., and Pacher, P. (2009) The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. Trends Pharmacol. Sci. 30, 411-420.
5. Pucci, M., Pirazzi, V., Pasquariello, N., and Maccarrone, M. (2011) Endocannabinoid signaling and epidermal differentiation. Eur. J. Dermatol 21 (Suppl2), 29-34.
6. Ahluwalia, J., Urban, L., Bevan, S., and Nagy, I. (2003) Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro. Eur. J. Neurosci 17, 2611-2618.
7. Lever, I. J., Robinson, M., Cibelli, M., Paule, C., Santha, P., Yee, L., Hunt, S. P., Cravatt, B. F., Elphick, M. R., Nagy, I., and Rice, A. S. (2009) Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury. J. Neurosci. 29, 3766-3780.
8. Bridges, D., Rice, A. S., Egertova, M., Elphick, M. R., Winter, J., and Michael, G. J. (2003) Localisation of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridisation and immunohistochemistry. Neuroscience 119, 803-812.
9. Ibrahim, M. M., Porreca, F., Lai, J., Albrecht, P. J., Rice, F. L., Khodorova, A., Davar, G., Makriyannis, A., Vanderah, T. W., Mata, H. P., and Malan, T. P., Jr. (2005) CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proc. Natl. Acad. Sci. U.S.A. 102, 3093-3098.
10. Anand, U., Otto, W. R., Sanchez-Herrera, D., Facer, P., Yiangou, Y., Korchev, Y., Birch, R., Benham, C., Bountra, C., Chessell, I. P., and Anand, P. (2008) Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons. Pain 138, 667-680.
11. Stander, S., Schmelz, M., Metze, D., Luger, T., and Rukwied, R. (2005) Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin. J. Dermatol. Sci. 38, 177-188.
12. Pucci, M., Rapino, C., Di Francesco, A., Dainese, E., D'Addario, C., and Maccarrone, M. (2013) Epigenetic control of skin differentiation genes by phytocannabinoids. Br. J. Pharmacol. 170, 581-591.
13. Toth, B. I., Dobrosi, N., Dajnoki, A., Czifra, G., Olah, A., Szollosi, A. G., Juhasz, I., Sugawara, K., Paus, R., and Biro, T. (2011) Endocannabinoids modulate human epidermal keratinocyte proliferation and survival via the sequential engagement of cannabinoid receptor-1 and transient receptor potential vanilloid-1. J. Invest. Dermatol. 131, 1095-1104.
14. Ramot, Y., Sugawara, K., Zakany, N., Toth, B. I., Biro, T., and Paus, R. (2013) A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ. PeerJ. 1, e40.
15. Casanova, M. L., Blazquez, C., Martinez-Palacio, J., Villanueva, C., Fernandez-Acenero, M. J., Huffman, J. W., Jorcano, J. L., and Guzman, M. (2003) Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J. Clin. Invest. 111, 43-50.
16. Lau, B. K., and Vaughan, C. W. (2014) Targeting the endogenous cannabinoid system to treat neuropathic pain. Front. Pharmacol. 5, 28.
17. Walker, J. M., and Hohmann, A. G. (2005) Cannabinoid mechanisms of pain suppression. Handb. Exp. Pharmacol., 509-554.
18. Movahed, P., Evilevitch, V., Andersson, T. L., Jonsson, B. A., Wollmer, P., Zygmunt, P. M., and Hogestatt, E. D. (2005) Vascular effects of anandamide and N-acylvanillylamines in the human forearm and skin microcirculation. Br. J. Pharmacol. 146, 171-179.
19. Walker, J. M., Krey, J. F., Chen, J. S., Vefring, E., Jahnsen, J. A., Bradshaw, H., and Huang, S. M. (2005) Targeted lipidomics: fatty acid amides and pain modulation. Prostaglandins Other Lipid Mediators 77, 35-45.
20. Hohmann, A. G., Suplita, R. L., Bolton, N. M., Neely, M. H., Fegley, D., Mangieri, R., Krey, J. F., Walker, J. M., Holmes, P. V., Crystal, J. D., Duranti, A., Tontini, A., Mor, M., Tarzia, G., and Piomelli, D. (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature 435, 1108-1112.
21. Schlosburg, J. E., O'Neal, S. T., Conrad, D. H., and Lichtman, A. H. (2011) CB1 receptors mediate rimonabant-induced pruritic responses in mice: investigation of locus of action. Psychopharmacology 216, 323-331.
22. Klein, T. W., and Newton, C. A. (2007) Therapeutic potential of cannabinoid-based drugs. Adv. Exp. Med. Biol. 601, 395-413.
23. Karsak, M., Gaffal, E., Date, R., Wang-Eckhardt, L., Rehnelt, J., Petrosino, S., Starowicz, K., Steuder, R., Schlicker, E., Cravatt, B., Mechoulam, R., Buettner, R., Werner, S., Di Marzo, V., Tuting, T., and Zimmer, A. (2007) Attenuation of allergic contact dermatitis through the endocannabinoid system. Science 316, 1494-1497.
24. Gaffal, E., Cron, M., Glodde, N., and Tuting, T. (2013) Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors. Allergy 68, 994-1000.
25. Petrosino, S., Cristino, L., Karsak, M., Gaffal, E., Ueda, N., Tuting, T., Bisogno, T., De Filippis, D., D'Amico, A., Saturnino, C., Orlando, P., Zimmer, A., Iuvone, T., and Di Marzo, V. (2010) Protective role of palmitoylethanolamide in contact allergic dermatitis. Allergy 65, 698-711.
26. Venkatachalam, K., and Montell, C. (2007) TRP channels. Annu. Rev. Biochem. 76, 387-417.
27. Nilius, B., and Owsianik, G. (2010) Transient receptor potential channelopathies. Pfluegers Arch. 460, 437-450.
28. Caterina, M. J., and Julius, D. (2001) The vanilloid receptor: a molecular gateway to the pain pathway. Annu. Rev. Neurosci. 24, 487-517.
29. Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H., Sorgard, M., Di Marzo, V., Julius, D., and Hogestatt, E. D. (1999) Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400, 452-457.
30. Zygmunt, P. M., Ermund, A., Movahed, P., Andersson, D. A., Simonsen, C., Jonsson, B. A., Blomgren, A., Birnir, B., Bevan, S., Eschalier, A., Mallet, C., Gomis, A., and Hogestatt, E. D. (2013) Monoacylglycerols activate TRPV1 - a link between phospholipase C and TRPV1. PLoS One 8, e81618.
31. Bisogno, T., Hanus, L., De Petrocellis, L., Tchilibon, S., Ponde, D. E., Brandi, I., Moriello, A. S., Davis, J. B., Mechoulam, R., and Di Marzo, V. (2001) Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br. J. Pharmacol. 134, 845-852.
32. Ruparel, N. B., Patwardhan, A. M., Akopian, A. N., and Hargreaves, K. M. (2011) Desensitization of transient receptor potential ankyrin 1 (TRPA1) by the TRP vanilloid 1-selective cannabinoid arachidonoyl-2 chloroethanolamine. Mol. Pharmacol. 80, 117-123.
33. Shim, W. S., Tak, M. H., Lee, M. H., Kim, M., Koo, J. Y., Lee, C. H., and Oh, U. (2007) TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase. J. Neurosci. 27, 2331-2337.
34. Geppetti, P., Nassini, R., Materazzi, S., and Benemei, S. (2008) The concept of neurogenic inflammation. BJU Int. 101 (Suppl 3), 2-6.
35. Yun, J. W., Seo, J. A., Jang, W. H., Koh, H. J., Bae, I. H., Park, Y. H., and Lim, K. M. (2011) Antipruritic effects of TRPV1 antagonist in murine atopic dermatitis and itching models. J. Invest. Dermatol. 131, 1576-1579.
36. Yun, J. W., Seo, J. A., Jeong, Y. S., Bae, I. H., Jang, W. H., Lee, J., Kim, S. Y., Shin, S. S., Woo, B. Y., Lee, K. W., Lim, K. M., and Park, Y. H. (2011) TRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery. J. Dermatol. Sci. 62, 8-15.
37. Banvolgyi, A., Palinkas, L., Berki, T., Clark, N., Grant, A. D., Helyes, Z., Pozsgai, G., Szolcsanyi, J., Brain, S. D., and Pinter, E. (2005) Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model. J. Neuroimmunol. 169, 86-96.
38. Engel, M. A., Izydorczyk, I., Mueller-Tribbensee, S. M., Becker, C., Neurath, M. F., and Reeh, P. W. (2011) Inhibitory CB1 and activating/desensitizing TRPV1-mediated cannabinoid actions on CGRP release in rodent skin. Neuropeptides 45, 229-237.
39. Fioravanti, B., De Felice, M., Stucky, C. L., Medler, K. A., Luo, M. C., Gardell, L. R., Ibrahim, M., Malan, T. P., Jr., Yamamura, H. I., Ossipov, M. H., King, T., Lai, J., Porreca, F., and Vanderah, T. W. (2008) Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists. J. Neurosci. 28, 11593-11602.
40. Gunthorpe, M. J., and Chizh, B. A. (2009) Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway. Drug Discovery Today 14, 56-67.
41. Axelsson, H. E., Minde, J. K., Sonesson, A., Toolanen, G., Hogestatt, E. D., and Zygmunt, P. M. (2009) Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without Norrbottnian congenital insensitivity to pain. Neuroscience 162, 1322-1332.
42. Bodo, E., Biro, T., Telek, A., Czifra, G., Griger, Z., Toth, B. I., Mescalchin, A., Ito, T., Bettermann, A., Kovacs, L., and Paus, R. (2005) A hot new twist to hair biology: involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control. Am. J. Pathol. 166, 985-998.
43. Stander, S., Moormann, C., Schumacher, M., Buddenkotte, J., Artuc, M., Shpacovitch, V., Brzoska, T., Lippert, U., Henz, B. M., Luger, T. A., Metze, D., and Steinhoff, M. (2004) Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp. Dermatol. 13, 129-139.
44. Toth, B. I., Benko, S., Szollosi, A. G., Kovacs, L., Rajnavolgyi, E., and Biro, T. (2009) Transient receptor potential vanilloid-1 signaling inhibits differentiation and activation of human dendritic cells. FEBS Lett. 583, 1619-1624.
45. Sulk, M., Seeliger, S., Aubert, J., Schwab, V. D., Cevikbas, F., Rivier, M., Nowak, P., Voegel, J. J., Buddenkotte, J., and Steinhoff, M. (2012) Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea. J. Invest. Dermatol. 132, 1253-1262.
46. Nilius, B., Appendino, G., and Owsianik, G. (2012) The transient receptor potential channel TRPA1: from gene to pathophysiology. Pfluegers Arch. 464, 425-458.
47. Jordt, S. E., Bautista, D. M., Chuang, H. H., McKemy, D. D., Zygmunt, P. M., Hogestatt, E. D., Meng, I. D., and Julius, D. (2004) Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427, 260-265.
48. Patil, M., Patwardhan, A., Salas, M. M., Hargreaves, K. M., and Akopian, A. N. (2011) Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons. Neuropharmacology 61, 778-788.
49. del Camino, D., Murphy, S., Heiry, M., Barrett, L. B., Earley, T. J., Cook, C. A., Petrus, M. J., Zhao, M., D'Amours, M., Deering, N., Brenner, G. J., Costigan, M., Hayward, N. J., Chong, J. A., Fanger, C. M., Woolf, C. J., Patapoutian, A., and Moran, M. M. (2010) TRPA1 contributes to cold hypersensitivity. J. Neurosci. 30, 15165-15174.
50. Petrus, M., Peier, A. M., Bandell, M., Hwang, S. W., Huynh, T., Olney, N., Jegla, T., and Patapoutian, A. (2007) A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol. Pain 3, 40.
51. Wilson, S. R., Gerhold, K. A., Bifolck-Fisher, A., Liu, Q., Patel, K. N., Dong, X., and Bautista, D. M. (2011) TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nat. Neurosci. 14, 595-602.
52. Wilson, S. R., Nelson, A. M., Batia, L., Morita, T., Estandian, D., Owens, D. M., Lumpkin, E. A., and Bautista, D. M. (2013) The ion channel TRPA1 is required for chronic itch. J. Neurosci. 33, 9283-9294.
53. Bautista, D. M., Jordt, S. E., Nikai, T., Tsuruda, P. R., Read, A. J., Poblete, J., Yamoah, E. N., Basbaum, A. I., and Julius, D. (2006) TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124, 1269-1282.
54. McNamara, C. R., Mandel-Brehm, J., Bautista, D. M., Siemens, J., Deranian, K. L., Zhao, M., Hayward, N. J., Chong, J. A., Julius, D., Moran, M. M., and Fanger, C. M. (2007) TRPA1 mediates formalin-induced pain. Proc. Natl. Acad. Sci. U.S.A. 104, 13525-13530.
55. Liu, B., Escalera, J., Balakrishna, S., Fan, L., Caceres, A. I., Robinson, E., Sui, A., McKay, M. C., McAlexander, M. A., Herrick, C. A., and Jordt, S. E. (2013) TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. FASEB J. 27, 3549-3563.
56. Oh, M. H., Oh, S. Y., Lu, J., Lou, H., Myers, A. C., Zhu, Z., and Zheng, T. (2013) TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis. J. Immunol 191, 5371-5382.
57. Atoyan, R., Shander, D., and Botchkareva, N. V. (2009) Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin. J. Invest. Dermatol. 129, 2312-2315.
58. Kwan, K. Y., Glazer, J. M., Corey, D. P., Rice, F. L., and Stucky, C. L. (2009) TRPA1 modulates mechanotransduction in cutaneous sensory neurons. J. Neurosci. 29, 4808-4819.
59. Bellono, N. W., Kammel, L. G., Zimmerman, A. L., and Oancea, E. (2013) UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes. Proc. Natl. Acad. Sci. U.S.A. 110, 2383-2388.
60. Oehler, B., Scholze, A., Schaefer, M., and Hill, K. (2012) TRPA1 is functionally expressed in melanoma cells but is not critical for impaired proliferation caused by allyl isothiocyanate or cinnamaldehyde. Naunyn-Schmiedeberg's Arch. Pharmacol. 385, 555-563.
61. Akopian, A. N. (2011) Regulation of nociceptive transmission at the periphery via TRPA1-TRPV1 interactions. Curr. Pharm. Biotechnol 12, 89-94.
62. Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J., and Julius, D. (1999) A capsaicin receptor homologue with a high threshold for noxious heat. Nature 398, 436-441.
63. Kanzaki, M., Zhang, Y. Q., Mashima, H., Li, L., Shibata, H., and Kojima, I. (1999) Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I. Nat. Cell Biol. 1, 165-170.
64. Nagasawa, M., Nakagawa, Y., Tanaka, S., and Kojima, I. (2007) Chemotactic peptide fMetLeuPhe induces translocation of the TRPV2 channel in macrophages. J. Cell Physiol. 210, 692-702.
65. Stokes, A. J., Shimoda, L. M., Koblan-Huberson, M., Adra, C. N., and Turner, H. (2004) A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells. J. Exp. Med. 200, 137-147.
66. Bang, S., Kim, K. Y., Yoo, S., Lee, S. H., and Hwang, S. W. (2007) Transient receptor potential V2 expressed in sensory neurons is activated by probenecid. Neurosci. Lett. 425, 120-125.
67. Hu, H. Z., Gu, Q., Wang, C., Colton, C. K., Tang, J., Kinoshita-Kawada, M., Lee, L. Y., Wood, J. D., and Zhu, M. X. (2004) 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J. Biol. Chem. 279, 35741-35748.
68. Neeper, M. P., Liu, Y., Hutchinson, T. L., Wang, Y., Flores, C. M., and Qin, N. (2007) Activation properties of heterologously expressed mammalian TRPV2: evidence for species dependence. J. Biol. Chem. 282, 15894-15902.
69. Qin, N., Neeper, M. P., Liu, Y., Hutchinson, T. L., Lubin, M. L., and Flores, C. M. (2008) TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J. Neurosci. 28, 6231-6238.
70. Park, U., Vastani, N., Guan, Y., Raja, S. N., Koltzenburg, M., and Caterina, M. J. (2011) TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception. J. Neurosci. 31, 11425-11436.
71. Szollosi, A. G., Olah, A., Toth, I. B., Papp, F., Czifra, G., Panyi, G., and Biro, T. (2013) Transient receptor potential vanilloid-2 mediates the effects of transient heat shock on endocytosis of human monocyte-derived dendritic cells. FEBS Lett. 587, 1440-1445.
72. Link, T. M., Park, U., Vonakis, B. M., Raben, D. M., Soloski, M. J., and Caterina, M. J. (2010) TRPV2 has a pivotal role in macrophage particle binding and phagocytosis. Nat. Immunol. 11, 232-239.
73. Yamashiro, K., Sasano, T., Tojo, K., Namekata, I., Kurokawa, J., Sawada, N., Suganami, T., Kamei, Y., Tanaka, H., Tajima, N., Utsunomiya, K., Ogawa, Y., and Furukawa, T. (2010) Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages. Biochem. Biophys. Res. Commun. 398, 284-289.
74. Compan, V., Baroja-Mazo, A., Lopez-Castejon, G., Gomez, A. I., Martinez, C. M., Angosto, D., Montero, M. T., Herranz, A. S., Bazan, E., Reimers, D., Mulero, V., and Pelegrin, P. (2012) Cell volume regulation modulates NLRP3 inflammasome activation. Immunity 37, 487-500.
75. Peier, A. M., Reeve, A. J., Andersson, D. A., Moqrich, A., Earley, T. J., Hergarden, A. C., Story, G. M., Colley, S., Hogenesch, J. B., McIntyre, P., Bevan, S., and Patapoutian, A. (2002) A heat-sensitive TRP channel expressed in keratinocytes. Science 296, 2046-2049.
76. Smith, G. D., Gunthorpe, M. J., Kelsell, R. E., Hayes, P. D., Reilly, P., Facer, P., Wright, J. E., Jerman, J. C., Walhin, J. P., Ooi, L., Egerton, J., Charles, K. J., Smart, D., Randall, A. D., Anand, P., and Davis, J. B. (2002) TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature 418, 186-190.
77. Xu, H., Ramsey, I. S., Kotecha, S. A., Moran, M. M., Chong, J. A., Lawson, D., Ge, P., Lilly, J., Silos-Santiago, I., Xie, Y., DiStefano, P. S., Curtis, R., and Clapham, D. E. (2002) TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature 418, 181-186.
78. Moqrich, A., Hwang, S. W., Earley, T. J., Petrus, M. J., Murray, A. N., Spencer, K. S., Andahazy, M., Story, G. M., and Patapoutian, A. (2005) Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science 307, 1468-1472.
79. Moussaieff, A., Rimmerman, N., Bregman, T., Straiker, A., Felder, C. C., Shoham, S., Kashman, Y., Huang, S. M., Lee, H., Shohami, E., Mackie, K., Caterina, M. J., Walker, J. M., Fride, E., and Mechoulam, R. (2008) Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain. FASEB J. 22, 3024-3034.
80. Xu, H., Delling, M., Jun, J. C., and Clapham, D. E. (2006) Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat. Neurosci. 9, 628-635.
81. De Petrocellis, L., Orlando, P., Moriello, A. S., Aviello, G., Stott, C., Izzo, A. A., and Di Marzo, V. (2012) Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation. Acta Physiol. 204, 255-266.
82. Huang, S. M., Li, X., Yu, Y., Wang, J., and Caterina, M. J. (2011) TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation. Mol. Pain 7, 37.
83. Miyamoto, T., Petrus, M. J., Dubin, A. E., and Patapoutian, A. (2011) TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin. Nat. Commun. 2, 369.
84. Yamamoto-Kasai, E., Imura, K., Yasui, K., Shichijou, M., Oshima, I., Hirasawa, T., Sakata, T., and Yoshioka, T. (2012) TRPV3 as a therapeutic target for itch. J. Invest. Dermatol. 132, 2109-2112.
85. Cheng, X., Jin, J., Hu, L., Shen, D., Dong, X. P., Samie, M. A., Knoff, J., Eisinger, B., Liu, M. L., Huang, S. M., Caterina, M. J., Dempsey, P., Michael, L. E., Dlugosz, A. A., Andrews, N. C., Clapham, D. E., and Xu, H. (2010) TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell 141, 331-343.
86. Borbiro, I., Lisztes, E., Toth, B. I., Czifra, G., Olah, A., Szollosi, A. G., Szentandrassy, N., Nanasi, P. P., Peter, Z., Paus, R., Kovacs, L., and Biro, T. (2011) Activation of transient receptor potential vanilloid-3 inhibits human hair growth. J. Invest. Dermatol. 131, 1605-1614.
87. Asakawa, M., Yoshioka, T., Matsutani, T., Hikita, I., Suzuki, M., Oshima, I., Tsukahara, K., Arimura, A., Horikawa, T., Hirasawa, T., and Sakata, T. (2006) Association of a mutation in TRPV3 with defective hair growth in rodents. J. Invest. Dermatol. 126, 2664-2672.
88. Xiao, R., Tian, J., Tang, J., and Zhu, M. X. (2008) The TRPV3 mutation associated with the hairless phenotype in rodents is constitutively active. Cell Calcium 43, 334-343.
89. Imura, K., Yoshioka, T., Hirasawa, T., and Sakata, T. (2009) Role of TRPV3 in immune response to development of dermatitis. J. Inflammation 6, 17.
90. Lin, Z., Chen, Q., Lee, M., Cao, X., Zhang, J., Ma, D., Chen, L., Hu, X., Wang, H., Wang, X., Zhang, P., Liu, X., Guan, L., Tang, Y., Yang, H., Tu, P., Bu, D., Zhu, X., Wang, K., Li, R., and Yang, Y. (2012) Exome sequencing reveals mutations in TRPV3 as a cause of Olmsted syndrome. Am. J. Hum. Genet. 90, 558-564.
91. Danso-Abeam, D., Zhang, J., Dooley, J., Staats, K. A., Van Eyck, L., Van Brussel, T., Zaman, S., Hauben, E., Van de Velde, M., Morren, M. A., Renard, M., Van Geet, C., Schaballie, H., Lambrechts, D., Tao, J., Franckaert, D., Humblet-Baron, S., Meyts, I., and Liston, A. (2013) Olmsted syndrome: exploration of the immunological phenotype. Orphanet J. Rare Dis. 8, 79.
92. Duchatelet, S., Guibbal, L., de Veer, S., Fraitag, S., Nitschke, P., Zarhrate, M., Bodemer, C., and Hovnanian, A. (2014) Olmsted syndrome with erythromelalgia caused by recessive TRPV3 mutations. Br. J. Dermatol., DOI: 10.1111/bjd.12951.
93. Eytan, O., Fuchs-Telem, D., Mevorach, B., Indelman, M., Bergman, R., Sarig, O., Goldberg, I., Adir, N., and Sprecher, E. (2014) Olmsted Syndrome Caused by a Homozygous Recessive Mutation in TRPV3. J. Invest. Dermatol., DOI: 10.1038/jid.2014.37.
94. Cao, X., Yang, F., Zheng, J., and Wang, K. (2012) Intracellular proton-mediated activation of TRPV3 channels accounts for the exfoliation effect of alpha-hydroxyl acids on keratinocytes. J. Biol. Chem. 287, 25905-25916.
95. Everaerts, W., Nilius, B., and Owsianik, G. (2010) The vanilloid transient receptor potential channel TRPV4: from structure to disease. Prog. Biophys. Mol. Biol. 103, 2-17.
96. Liedtke, W., Choe, Y., Marti-Renom, M. A., Bell, A. M., Denis, C. S., Sali, A., Hudspeth, A. J., Friedman, J. M., and Heller, S. (2000) Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103, 525-535.
97. Liedtke, W., and Friedman, J. M. (2003) Abnormal osmotic regulation in trpv4-/- mice. Proc. Natl. Acad. Sci. U.S.A. 100, 13698-13703.
98. Suzuki, M., Mizuno, A., Kodaira, K., and Imai, M. (2003) Impaired pressure sensation in mice lacking TRPV4. J. Biol. Chem. 278, 22664-22668.
99. Alessandri-Haber, N., Dina, O. A., Yeh, J. J., Parada, C. A., Reichling, D. B., and Levine, J. D. (2004) Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat. J. Neurosci. 24, 4444-4452.
100. Chen, Y., Williams, S. H., McNulty, A. L., Hong, J. H., Lee, S. H., Rothfusz, N. E., Parekh, P. K., Moore, C., Gereau, R. W. t., Taylor, A. B., Wang, F., Guilak, F., and Liedtke, W. (2013) Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion. Pain 154, 1295-1304.
101. Lee, H., Iida, T., Mizuno, A., Suzuki, M., and Caterina, M. J. (2005) Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4. J. Neurosci. 25, 1304-1310.
102. Moore, C., Cevikbas, F., Pasolli, H. A., Chen, Y., Kong, W., Kempkes, C., Parekh, P., Lee, S. H., Kontchou, N. A., Yeh, I., Jokerst, N. M., Fuchs, E., Steinhoff, M., and Liedtke, W. B. (2013) UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling. Proc. Natl. Acad. Sci. U.S.A. 110, E3225-3234.
103. Kida, N., Sokabe, T., Kashio, M., Haruna, K., Mizuno, Y., Suga, Y., Nishikawa, K., Kanamaru, A., Hongo, M., Oba, A., and Tominaga, M. (2012) Importance of transient receptor potential vanilloid 4 (TRPV4) in epidermal barrier function in human skin keratinocytes. Pfluegers Arch 463, 715-725.
104. Sokabe, T., and Tominaga, M. (2010) The TRPV4 cation channel: A molecule linking skin temperature and barrier function. Commun. Integr. Biol. 3, 619-621.
105. McKemy, D. D. (2013) The molecular and cellular basis of cold sensation. ACS Chem. Neurosci. 4, 238-247.
106. De Petrocellis, L., Vellani, V., Schiano-Moriello, A., Marini, P., Magherini, P. C., Orlando, P., and Di Marzo, V. (2008) Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8. J. Pharmacol. Exp. Ther. 325, 1007-1015.
107. Ramachandran, R., Hyun, E., Zhao, L., Lapointe, T. K., Chapman, K., Hirota, C. L., Ghosh, S., McKemy, D. D., Vergnolle, N., Beck, P. L., Altier, C., and Hollenberg, M. D. (2013) TRPM8 activation attenuates inflammatory responses in mouse models of colitis. Proc. Natl. Acad. Sci. U.S.A. 110, 7476-7481.