Intracellular proton-mediated activation of TRPV3 channels accounts for the exfoliation effect of α-hydroxyl acids on keratinocytes

Journal of Biological Chemistry

Volumn 287, Issue 31, 2012, Pages 25905-25916

  Cao, Xu ^a,b   Yang, Fan ^b   Zheng, Jie ^b   Wang, KeWei ^a,c  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PEKING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COSMETIC INDUSTRY; DIRECT ACTIVATION; GLYCOLIC ACIDS; HEK293 CELLS; HISTIDINE RESIDUES; INTRACELLULAR PROTONS; KERATINOCYTES; MOLECULAR BASIS; N-TERMINALS; NATURAL SOURCES; PATCH CLAMP RECORDING; PROTON DONORS; SITE DIRECTED MUTAGENESIS; SKIN DISORDERS; THERAPEUTIC POTENTIALS; TRANSIENT RECEPTOR POTENTIAL VANILLOID;

ACIDIFICATION; AMINO ACIDS; CELL DEATH; CHEMICAL COMPOUNDS; ELECTROPHYSIOLOGY; PROTONS;

ENZYME ACTIVITY;

ALPHA HYDROXYL ACID; DERMATOLOGICAL AGENT; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 3;

ACIDIFICATION; APOPTOSIS; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; KERATINIZATION; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTON TRANSPORT; RECEPTOR UPREGULATION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BORON COMPOUNDS; CELL LINE; CELL SURVIVAL; COSMETICS; GLYCOLATES; HUMANS; HYDROGEN-ION CONCENTRATION; KERATINOCYTES; KERATOLYTIC AGENTS; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, TERTIARY; SKIN; TRPV CATION CHANNELS;

EID: 84864390249     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.364869     Document Type: Article

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