메뉴 건너뛰기




Volumn 3, Issue , 2014, Pages 56-62

The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts

Author keywords

Carcinogenesis; Cytochrome P450 2E1; Ethanol; Etheno DNA adducts; Lipidperoxidation products; Non alcoholic fatty liver disease

Indexed keywords

ALCOHOL; CARCINOGEN; CYTOCHROME P450 2E1; ETHENO DNA ADDUCT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; DNA ADDUCT;

EID: 84912113044     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2014.08.009     Document Type: Review
Times cited : (141)

References (92)
  • 1
    • 33845927120 scopus 로고    scopus 로고
    • Alcohol, oxidative stress and free radical damage
    • Albano E. Alcohol, oxidative stress and free radical damage. Proceedings of the Nutrition Society 2006, 65:278-290. http://www.ncbi.nlm.nih.gov/pubmed/16923312, 10.1079/PNS2006496.
    • (2006) Proceedings of the Nutrition Society , vol.65 , pp. 278-290
    • Albano, E.1
  • 2
    • 34547118090 scopus 로고    scopus 로고
    • Molecular mechanisms of alcohol-mediated carcinogenesis
    • Seitz H.K., Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nature Reviews: Cancer 2007, 7:599-612. http://www.ncbi.nlm.nih.gov/pubmed/17646865, 10.1038/nrc2191.
    • (2007) Nature Reviews: Cancer , vol.7 , pp. 599-612
    • Seitz, H.K.1    Stickel, F.2
  • 3
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens L.M., Werb Z. Inflammation and cancer. Nature 2002, 420:860-867. http://www.ncbi.nlm.nih.gov/pubmed/12490959, 10.1038/nature01322.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 5
    • 33745807627 scopus 로고    scopus 로고
    • Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation
    • Kawanishi S., Hiraku Y. Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation. Antioxidants and Redox Signaling 2006, 8:1047-1058. http://www.ncbi.nlm.nih.gov/pubmed/16771694, 10.1089/ars.2006.8.1047.
    • (2006) Antioxidants and Redox Signaling , vol.8 , pp. 1047-1058
    • Kawanishi, S.1    Hiraku, Y.2
  • 6
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • Mantovani A., Allavena P., Sica A., Balkwill F. Cancer-related inflammation. Nature 2008, 454:436-444. http://www.ncbi.nlm.nih.gov/pubmed/18650914, 10.1038/nature07205.
    • (2008) Nature , vol.454 , pp. 436-444
    • Mantovani, A.1    Allavena, P.2    Sica, A.3    Balkwill, F.4
  • 7
    • 0028218474 scopus 로고
    • Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis
    • Ohshima H., Bartsch H. Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutation Research 1994, 305:253-264. http://www.ncbi.nlm.nih.gov/pubmed/7510036, 10.1016/0027-5107(94)90245-3.
    • (1994) Mutation Research , vol.305 , pp. 253-264
    • Ohshima, H.1    Bartsch, H.2
  • 8
    • 32944474237 scopus 로고    scopus 로고
    • Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer
    • Karin M., Lawrence T., Nizet V. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell 2006, 124:823-835. http://www.ncbi.nlm.nih.gov/pubmed/16497591, 10.1016/j.cell.2006.02.016.
    • (2006) Cell , vol.124 , pp. 823-835
    • Karin, M.1    Lawrence, T.2    Nizet, V.3
  • 9
    • 79952474331 scopus 로고    scopus 로고
    • Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates
    • Lonkar P., Dedon P.C. Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates. International Journal of Cancer: Journal International du Cancer 2011, 128:1999-2009. http://www.ncbi.nlm.nih.gov/pubmed/21387284, 10.1002/ijc.25815.
    • (2011) International Journal of Cancer: Journal International du Cancer , vol.128 , pp. 1999-2009
    • Lonkar, P.1    Dedon, P.C.2
  • 10
    • 33748344714 scopus 로고    scopus 로고
    • Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair
    • Bartsch H., Nair J. Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair. Langenbeck's Archives of Surgery/Deutsche Gesellschaft für Chirurgie 2006, 391:499-510. http://www.ncbi.nlm.nih.gov/pubmed/16909291, 10.1007/s00423-006-0073-1.
    • (2006) Langenbeck's Archives of Surgery/Deutsche Gesellschaft für Chirurgie , vol.391 , pp. 499-510
    • Bartsch, H.1    Nair, J.2
  • 11
    • 25844459154 scopus 로고    scopus 로고
    • NF-kappaB: linking inflammation and immunity to cancer development and progression
    • Karin M., Greten F.R. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nature Reviews: Immunology 2005, 5:749-759. http://www.ncbi.nlm.nih.gov/pubmed/16175180, 10.1038/nri1703.
    • (2005) Nature Reviews: Immunology , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 12
    • 4544327894 scopus 로고    scopus 로고
    • Cyclooxygenases in cancer: progress and perspective
    • Zha S., Yegnasubramanian V., Nelson W.G., Isaacs W.B., De Marzo A.M. Cyclooxygenases in cancer: progress and perspective. Cancer Letters 2004, 215:1-20. http://www.ncbi.nlm.nih.gov/pubmed/15374627, 10.1016/j.canlet.2004.06.014.
    • (2004) Cancer Letters , vol.215 , pp. 1-20
    • Zha, S.1    Yegnasubramanian, V.2    Nelson, W.G.3    Isaacs, W.B.4    De Marzo, A.M.5
  • 13
    • 0030606276 scopus 로고    scopus 로고
    • Self-promotion? Intimate connections between APC and prostaglandin H synthase-2
    • Prescott S.M., White R.L. Self-promotion? Intimate connections between APC and prostaglandin H synthase-2. Cell 1996, 87:783-786. http://www.ncbi.nlm.nih.gov/pubmed/8945503, 10.1016/S0092-8674(00)81983-2.
    • (1996) Cell , vol.87 , pp. 783-786
    • Prescott, S.M.1    White, R.L.2
  • 14
    • 0034039575 scopus 로고    scopus 로고
    • Increased levels of promutagenic etheno-DNA adducts in colonic polyps of FAP patients
    • Schmid K., Nair J., Winde G., Velic I., Bartsch H. Increased levels of promutagenic etheno-DNA adducts in colonic polyps of FAP patients. International Journal of Cancer: Journal International du Cancer 2000, 87:1-4. http://www.ncbi.nlm.nih.gov/pubmed/10861445, 10.1002/1097-0215(20000701)87:1<1::AID-IJC1>3.0.CO;2-C.
    • (2000) International Journal of Cancer: Journal International du Cancer , vol.87 , pp. 1-4
    • Schmid, K.1    Nair, J.2    Winde, G.3    Velic, I.4    Bartsch, H.5
  • 16
    • 33744507695 scopus 로고    scopus 로고
    • Endogenous lipid hydroperoxide-mediated DNA-adduct formation in min mice
    • Williams M.V., Lee S.H., Pollack M., Blair I.A. Endogenous lipid hydroperoxide-mediated DNA-adduct formation in min mice. Journal of Biological Chemistry 2006, 281:10127-10133. http://www.ncbi.nlm.nih.gov/pubmed/16449227, 10.1074/jbc.M600178200.
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 10127-10133
    • Williams, M.V.1    Lee, S.H.2    Pollack, M.3    Blair, I.A.4
  • 17
    • 0034676492 scopus 로고    scopus 로고
    • A causal relationship between unscheduled eicosanoid signaling and tumor development: cancer chemoprevention by inhibitors of arachidonic acid metabolism
    • Marks F., Müller-Decker K., Fürstenberger G. A causal relationship between unscheduled eicosanoid signaling and tumor development: cancer chemoprevention by inhibitors of arachidonic acid metabolism. Toxicology 2000, 153:11-26. http://www.ncbi.nlm.nih.gov/pubmed/11090944, 10.1016/S0300-483X(00)00301-2.
    • (2000) Toxicology , vol.153 , pp. 11-26
    • Marks, F.1    Müller-Decker, K.2    Fürstenberger, G.3
  • 18
    • 0033845834 scopus 로고    scopus 로고
    • Promutagenic etheno-DNA adducts in multistage mouse skin carcinogenesis: correlation with lipoxygenase-catalyzed arachidonic acid metabolism
    • Nair J., Fürstenberger G., Bürger F., Marks F., Bartsch H. Promutagenic etheno-DNA adducts in multistage mouse skin carcinogenesis: correlation with lipoxygenase-catalyzed arachidonic acid metabolism. Chemical Research in Toxicology 2000, 13:703-709. http://www.ncbi.nlm.nih.gov/pubmed/10956057, 10.1021/tx000045d.
    • (2000) Chemical Research in Toxicology , vol.13 , pp. 703-709
    • Nair, J.1    Fürstenberger, G.2    Bürger, F.3    Marks, F.4    Bartsch, H.5
  • 19
    • 0023009007 scopus 로고
    • Formation of cyclic adducts of deoxyguanosine with the aldehydes trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal in vitro
    • Winter C.K., Segall H.J., Haddon W.F. Formation of cyclic adducts of deoxyguanosine with the aldehydes trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal in vitro. Cancer Research 1986, 46:5682-5686. http://www.ncbi.nlm.nih.gov/pubmed/3756915.
    • (1986) Cancer Research , vol.46 , pp. 5682-5686
    • Winter, C.K.1    Segall, H.J.2    Haddon, W.F.3
  • 20
    • 0029824077 scopus 로고    scopus 로고
    • Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts
    • Chung F.L., Chen H.J., Nath R.G. Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts. Carcinogenesis 1996, 17:2105-2111. http://www.ncbi.nlm.nih.gov/pubmed/8895475, 10.1093/carcin/17.10.2105.
    • (1996) Carcinogenesis , vol.17 , pp. 2105-2111
    • Chung, F.L.1    Chen, H.J.2    Nath, R.G.3
  • 21
    • 0028986148 scopus 로고
    • Formation of 1,N6-ethenoadenine and 3,N4-ethenocytosine by lipid peroxidation products and nucleic acid bases
    • El Ghissassi F., Barbin A., Nair J., et al. Formation of 1,N6-ethenoadenine and 3,N4-ethenocytosine by lipid peroxidation products and nucleic acid bases. Chemical Research in Toxicology 1995, 8:278-283. http://www.ncbi.nlm.nih.gov/pubmed/7766812, 10.1021/tx00044a013.
    • (1995) Chemical Research in Toxicology , vol.8 , pp. 278-283
    • El Ghissassi, F.1    Barbin, A.2    Nair, J.3
  • 22
    • 0023841337 scopus 로고
    • Interaction of lipid peroxidation products with DNA. A review
    • Vaca C.E., Wilhelm J., Harms-Ringdahl M. Interaction of lipid peroxidation products with DNA. A review. Mutation Research 1988, 195:137-149. http://www.ncbi.nlm.nih.gov/pubmed/3277035, 10.1016/0165-1110(88)90022-X.
    • (1988) Mutation Research , vol.195 , pp. 137-149
    • Vaca, C.E.1    Wilhelm, J.2    Harms-Ringdahl, M.3
  • 23
    • 0025285284 scopus 로고
    • Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids
    • Pryor W.A., Porter N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids. Free Radical Biology and Medicine 1990, 8:541-543. http://www.ncbi.nlm.nih.gov/pubmed/2193853, 10.1016/0891-5849(90)90153-A.
    • (1990) Free Radical Biology and Medicine , vol.8 , pp. 541-543
    • Pryor, W.A.1    Porter, N.A.2
  • 24
    • 47049109950 scopus 로고    scopus 로고
    • DNA adducts with lipid peroxidation products
    • Blair I.A. DNA adducts with lipid peroxidation products. Journal of Biological Chemistry 2008, 283:15545-15549. http://www.ncbi.nlm.nih.gov/pubmed/18285329, 10.1074/jbc.R700051200.
    • (2008) Journal of Biological Chemistry , vol.283 , pp. 15545-15549
    • Blair, I.A.1
  • 25
    • 0026021690 scopus 로고
    • Stereoselective formation of in vitro nucleic acid adducts by 2,3-epoxy-4-hydroxynonanal
    • Sodum R.S., Chung F.L. Stereoselective formation of in vitro nucleic acid adducts by 2,3-epoxy-4-hydroxynonanal. Cancer Research 1991, 51:137-143. http://www.ncbi.nlm.nih.gov/pubmed/1703030.
    • (1991) Cancer Research , vol.51 , pp. 137-143
    • Sodum, R.S.1    Chung, F.L.2
  • 26
    • 34548508693 scopus 로고    scopus 로고
    • Lipid peroxidation-induced DNA damage in cancer-prone inflammatory diseases: a review of published adduct types and levels in humans
    • Nair U., Bartsch H., Nair J. Lipid peroxidation-induced DNA damage in cancer-prone inflammatory diseases: a review of published adduct types and levels in humans. Free Radical Biology and Medicine 2007, 43:1109-1120. http://www.ncbi.nlm.nih.gov/pubmed/17854706, 10.1016/j.freeradbiomed.2007.07.012.
    • (2007) Free Radical Biology and Medicine , vol.43 , pp. 1109-1120
    • Nair, U.1    Bartsch, H.2    Nair, J.3
  • 27
    • 0029824077 scopus 로고    scopus 로고
    • Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts
    • Chung F.L., Chen H.J., Nath R.G. Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts. Carcinogenesis 1996, 17:2105-2111. http://www.ncbi.nlm.nih.gov/pubmed/8895475, 10.1093/carcin/17.10.2105.
    • (1996) Carcinogenesis , vol.17 , pp. 2105-2111
    • Chung, F.L.1    Chen, H.J.2    Nath, R.G.3
  • 28
    • 84912062056 scopus 로고    scopus 로고
    • Role of nitrative DNA damage in inflammation related carcinogenesis
    • John Wiley & Sons, Hoboken, NJ, Y. Hiraku, S. Kawanishi, H. Ohshima (Eds.)
    • Hiraku Y., Kawanishi S. Role of nitrative DNA damage in inflammation related carcinogenesis. Cancer and Inflammation Mechanisms: Chemical, Biological, and Chemical Aspects 2014, 41-59. John Wiley & Sons, Hoboken, NJ. Y. Hiraku, S. Kawanishi, H. Ohshima (Eds.).
    • (2014) Cancer and Inflammation Mechanisms: Chemical, Biological, and Chemical Aspects , pp. 41-59
    • Hiraku, Y.1    Kawanishi, S.2
  • 29
    • 0024476758 scopus 로고
    • N6-etheno-2'-deoxyadenosine and 3,N4-etheno-2'-deoxycytidine detected by monoclonal antibodies in lung and liver DNA of rats exposed to vinyl chloride
    • Eberle G., Barbin A., Laib R.J., et al. N6-etheno-2'-deoxyadenosine and 3,N4-etheno-2'-deoxycytidine detected by monoclonal antibodies in lung and liver DNA of rats exposed to vinyl chloride. Carcinogenesis 1989, 10:209-212. http://www.ncbi.nlm.nih.gov/pubmed/2783395, 10.1093/carcin/10.1.209.
    • (1989) Carcinogenesis , vol.10 , pp. 209-212
    • Eberle, G.1    Barbin, A.2    Laib, R.J.3
  • 30
    • 3042739680 scopus 로고    scopus 로고
    • Immunohistochemical detection of 1,N6-ethenodeoxyadenosine in nuclei of human liver affected by diseases predisposing to hepato-carcinogenesis
    • Frank A., Seitz H.K., Bartsch H., et al. Immunohistochemical detection of 1,N6-ethenodeoxyadenosine in nuclei of human liver affected by diseases predisposing to hepato-carcinogenesis. Carcinogenesis 2004, 25:1027-1031. http://www.ncbi.nlm.nih.gov/pubmed/14742317, 10.1093/carcin/bgh089.
    • (2004) Carcinogenesis , vol.25 , pp. 1027-1031
    • Frank, A.1    Seitz, H.K.2    Bartsch, H.3
  • 31
    • 79952202355 scopus 로고    scopus 로고
    • Quantifying etheno-DNA adducts in human tissues, white blood cells, and urine by ultrasensitive (32)P-postlabeling and immunohistochemistry
    • Nair J., Nair U.J., Sun X., et al. Quantifying etheno-DNA adducts in human tissues, white blood cells, and urine by ultrasensitive (32)P-postlabeling and immunohistochemistry. Methods in Molecular Biology (Clifton, N.J.) 2011, 682:189-205. http://www.ncbi.nlm.nih.gov/pubmed/21057929, 10.1007/978-1-60327-409-8_14.
    • (2011) Methods in Molecular Biology (Clifton, N.J.) , vol.682 , pp. 189-205
    • Nair, J.1    Nair, U.J.2    Sun, X.3
  • 32
    • 0028987545 scopus 로고
    • N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytine in liver DNA from humans and untreated rodents detected by immunoaffinity/32P-postlabeling
    • Nair J., Barbin A., Guichard Y., et al. N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytine in liver DNA from humans and untreated rodents detected by immunoaffinity/32P-postlabeling. Carcinogenesis 1995, 16:613-617. http://www.ncbi.nlm.nih.gov/pubmed/7697821, 10.1093/carcin/16.3.613.
    • (1995) Carcinogenesis , vol.16 , pp. 613-617
    • Nair, J.1    Barbin, A.2    Guichard, Y.3
  • 33
    • 84855835886 scopus 로고    scopus 로고
    • Identification of 3,N(4)-etheno-5-methyl-2'-deoxycytidine in human DNA: A new modified nucleoside which may perturb genome methylation
    • Nair J., Godschalk R.W., Nair U., et al. Identification of 3,N(4)-etheno-5-methyl-2'-deoxycytidine in human DNA: A new modified nucleoside which may perturb genome methylation. Chemical Research in Toxicology 2012, 25:162-169. http://www.ncbi.nlm.nih.gov/pubmed/22148471, 10.1021/tx200392a.
    • (2012) Chemical Research in Toxicology , vol.25 , pp. 162-169
    • Nair, J.1    Godschalk, R.W.2    Nair, U.3
  • 34
    • 71549121960 scopus 로고    scopus 로고
    • High urinary excretion of lipid peroxidation-derived DNA damage in patients with cancer-prone liver diseases
    • Nair J., Srivatanakul P., Haas C., et al. High urinary excretion of lipid peroxidation-derived DNA damage in patients with cancer-prone liver diseases. Mutation Research 2010, 683:23-28. http://www.ncbi.nlm.nih.gov/pubmed/19822158, 10.1016/j.mrfmmm.2009.10.002.
    • (2010) Mutation Research , vol.683 , pp. 23-28
    • Nair, J.1    Srivatanakul, P.2    Haas, C.3
  • 35
    • 0034031990 scopus 로고    scopus 로고
    • Etheno-adduct-forming chemicals: from mutagenicity testing to tumor mutation spectra
    • Barbin A. Etheno-adduct-forming chemicals: from mutagenicity testing to tumor mutation spectra. Mutation Research 2000, 462:55-69. http://www.ncbi.nlm.nih.gov/pubmed/10767618, 10.1016/S1383-5742(00)00014-4.
    • (2000) Mutation Research , vol.462 , pp. 55-69
    • Barbin, A.1
  • 36
    • 0028216653 scopus 로고
    • Formation, detection, and role in carcinogenesis of ethenobases in DNA
    • Bartsch H., Barbin A., Marion M.J., Nair J., Guichard Y. Formation, detection, and role in carcinogenesis of ethenobases in DNA. Drug Metabolism Reviews 1994, 26:349-371. http://www.ncbi.nlm.nih.gov/pubmed/8082574, 10.3109/03602539409029802.
    • (1994) Drug Metabolism Reviews , vol.26 , pp. 349-371
    • Bartsch, H.1    Barbin, A.2    Marion, M.J.3    Nair, J.4    Guichard, Y.5
  • 37
    • 0027146414 scopus 로고
    • Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole
    • Basu A.K., Wood M.L., Niedernhofer L.J., Ramos L.A., Essigmann J.M. Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole. Biochemistry 1993, 32:12793-12801. http://www.ncbi.nlm.nih.gov/pubmed/8251500, 10.1021/bi00210a031.
    • (1993) Biochemistry , vol.32 , pp. 12793-12801
    • Basu, A.K.1    Wood, M.L.2    Niedernhofer, L.J.3    Ramos, L.A.4    Essigmann, J.M.5
  • 38
    • 0029665327 scopus 로고    scopus 로고
    • N6-ethenodeoxyadenosine, a DNA adduct highly mutagenic in mammalian cells
    • Pandya G.A., Moriya M. N6-ethenodeoxyadenosine, a DNA adduct highly mutagenic in mammalian cells. Biochemistry 1996, 35:11487-11492. http://www.ncbi.nlm.nih.gov/pubmed/8784204, 10.1021/bi960170h.
    • (1996) Biochemistry , vol.35 , pp. 11487-11492
    • Pandya, G.A.1    Moriya, M.2
  • 39
    • 0027215020 scopus 로고
    • Quantitative multiplex sequence analysis of mutational hot spots. Frequency and specificity of mutations induced by a site-specific ethenocytosine in M13 viral DNA
    • Palejwala V.A., Rzepka R.W., Simha D., Humayun M.Z. Quantitative multiplex sequence analysis of mutational hot spots. Frequency and specificity of mutations induced by a site-specific ethenocytosine in M13 viral DNA. Biochemistry 1993, 32:4105-4111. http://www.ncbi.nlm.nih.gov/pubmed/8471617, 10.1021/bi00066a036.
    • (1993) Biochemistry , vol.32 , pp. 4105-4111
    • Palejwala, V.A.1    Rzepka, R.W.2    Simha, D.3    Humayun, M.Z.4
  • 40
  • 41
    • 0033883772 scopus 로고    scopus 로고
    • Mutagenesis induced by a single 1,N6-ethenodeoxyadenosine adduct in human cells
    • Levine R.L., Yang I.Y., Hossain M., Pandya G.A., Grollman A.P., Moriya M. Mutagenesis induced by a single 1,N6-ethenodeoxyadenosine adduct in human cells. Cancer Research 2000, 60:4098-4104. http://www.ncbi.nlm.nih.gov/pubmed/10945616.
    • (2000) Cancer Research , vol.60 , pp. 4098-4104
    • Levine, R.L.1    Yang, I.Y.2    Hossain, M.3    Pandya, G.A.4    Grollman, A.P.5    Moriya, M.6
  • 42
    • 0026572753 scopus 로고
    • Etheno adducts formed in DNA of vinyl chloride-exposed rats are highly persistent in liver
    • Swenberg J.A., Fedtke N., Ciroussel F., Barbin A., Bartsch H. Etheno adducts formed in DNA of vinyl chloride-exposed rats are highly persistent in liver. Carcinogenesis 1992, 13:727-729. http://www.ncbi.nlm.nih.gov/pubmed/1576725, 10.1093/carcin/13.4.727.
    • (1992) Carcinogenesis , vol.13 , pp. 727-729
    • Swenberg, J.A.1    Fedtke, N.2    Ciroussel, F.3    Barbin, A.4    Bartsch, H.5
  • 44
    • 0020595109 scopus 로고
    • The metabolic activation and nucleic acid adducts of naturally-occurring carcinogens: recent results with ethyl carbamate and the spice flavors safrole and estragole
    • Miller J.A., Miller E.C. The metabolic activation and nucleic acid adducts of naturally-occurring carcinogens: recent results with ethyl carbamate and the spice flavors safrole and estragole. British Journal of Cancer 1983, 48:1-15. http://www.ncbi.nlm.nih.gov/pubmed/6191767, 10.1038/bjc.1983.151.
    • (1983) British Journal of Cancer , vol.48 , pp. 1-15
    • Miller, J.A.1    Miller, E.C.2
  • 45
    • 0036850924 scopus 로고    scopus 로고
    • The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma
    • Hu W., Feng Z., Eveleigh J., Iyer G., Pan J., Amin S., Chung F.L., et al. The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma. Carcinogenesis 2002, 23:1781-1789. http://www.ncbi.nlm.nih.gov/pubmed/12419825, 10.1093/carcin/23.11.1781.
    • (2002) Carcinogenesis , vol.23 , pp. 1781-1789
    • Hu, W.1    Feng, Z.2    Eveleigh, J.3    Iyer, G.4    Pan, J.5    Amin, S.6    Chung, F.L.7
  • 46
    • 79952202355 scopus 로고    scopus 로고
    • Quantifying etheno-DNA adducts in human tissues, white blood cells, and urine by ultrasensitive (32)P-postlabeling and immunohistochemistry
    • Nair J., Nair U.J., Sun X., Wang Y., Arab K., Bartsch H. Quantifying etheno-DNA adducts in human tissues, white blood cells, and urine by ultrasensitive (32)P-postlabeling and immunohistochemistry. Methods in Molecular Biology (Clifton, N.J.) 2011, 682:189-205. http://www.ncbi.nlm.nih.gov/pubmed/21057929, 10.1007/978-1-60327-409-8_14.
    • (2011) Methods in Molecular Biology (Clifton, N.J.) , vol.682 , pp. 189-205
    • Nair, J.1    Nair, U.J.2    Sun, X.3    Wang, Y.4    Arab, K.5    Bartsch, H.6
  • 47
    • 84912136297 scopus 로고    scopus 로고
    • Lipid peroxidation-derived DNA adduts and the role in inflammation-related carcinogenesis
    • John Wiley & Sons, Hoboken, NJ, Y. Hiraku, S. Kawanishi, H. Ohshima (Eds.)
    • Bartsch H., Nair J. Lipid peroxidation-derived DNA adduts and the role in inflammation-related carcinogenesis. Cancer and Inflammation Mechanisms: Chemical, Biological and Clinical Aspects 2014, 61-74. John Wiley & Sons, Hoboken, NJ. Y. Hiraku, S. Kawanishi, H. Ohshima (Eds.).
    • (2014) Cancer and Inflammation Mechanisms: Chemical, Biological and Clinical Aspects , pp. 61-74
    • Bartsch, H.1    Nair, J.2
  • 48
    • 33745499905 scopus 로고    scopus 로고
    • Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress
    • Seitz H.K., Stickel F. Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress. Biological Chemistry 2006, 387:349-360. http://www.ncbi.nlm.nih.gov/pubmed/16606331, 10.1515/BC.2006.047.
    • (2006) Biological Chemistry , vol.387 , pp. 349-360
    • Seitz, H.K.1    Stickel, F.2
  • 49
    • 0036017173 scopus 로고    scopus 로고
    • Neutrophilic infiltration in alcoholic hepatitis
    • Bautista A.P. Neutrophilic infiltration in alcoholic hepatitis. Alcohol (Fayetteville, N.Y.) 2002, 27:17-21. http://www.ncbi.nlm.nih.gov/pubmed/12062632, 10.1016/S0741-8329(02)00206-9.
    • (2002) Alcohol (Fayetteville, N.Y.) , vol.27 , pp. 17-21
    • Bautista, A.P.1
  • 52
    • 0029813873 scopus 로고    scopus 로고
    • Nitric oxide and liver injury in alcohol-fed rats after lipopolysaccharide administration
    • Chamulitrat W., Spitzer J.J. Nitric oxide and liver injury in alcohol-fed rats after lipopolysaccharide administration. Alcoholism, Clinical and Experimental Research 1996, 20:1065-1070. http://www.ncbi.nlm.nih.gov/pubmed/8892528, 10.1111/j.1530-0277.1996.tb01947.x.
    • (1996) Alcoholism, Clinical and Experimental Research , vol.20 , pp. 1065-1070
    • Chamulitrat, W.1    Spitzer, J.J.2
  • 53
    • 0014962167 scopus 로고
    • Hepatic microsomal ethanol-oxidizing system. In vitro characteristics and adaptive properties in vivo
    • Lieber C.S., DeCarli L.M. Hepatic microsomal ethanol-oxidizing system. In vitro characteristics and adaptive properties in vivo. Journal of Biological Chemistry 1970, 245(10):2505-2512. http://www.ncbi.nlm.nih.gov/pubmed/4315645.
    • (1970) Journal of Biological Chemistry , vol.245 , Issue.10 , pp. 2505-2512
    • Lieber, C.S.1    DeCarli, L.M.2
  • 55
    • 0036128317 scopus 로고    scopus 로고
    • Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase
    • Oneta C.M., Lieber C.S., Li J.J., Rüttimann S., Schmid B., Lattmann J., Rosman A.S., Seitz H.K. Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase. Journal of Hepatology 2002, 36(1):47-52. http://www.ncbi.nlm.nih.gov/pubmed/11804663, 10.1016/S0168-8278(01)00223-9.
    • (2002) Journal of Hepatology , vol.36 , Issue.1 , pp. 47-52
    • Oneta, C.M.1    Lieber, C.S.2    Li, J.J.3    Rüttimann, S.4    Schmid, B.5    Lattmann, J.6    Rosman, A.S.7    Seitz, H.K.8
  • 56
    • 34548588533 scopus 로고    scopus 로고
    • Role of medium-chain triglycerides in the alcohol-mediated cytochrome P450 2E1 induction of mitochondria
    • Lieber C.S., Cao Q., DeCarli L.M., Leo M.A., Mak K.M., Ponomarenko A., Ren C., et al. Role of medium-chain triglycerides in the alcohol-mediated cytochrome P450 2E1 induction of mitochondria. Alcoholism, Clinical and Experimental Research 2007, 31:1660-1668. http://www.ncbi.nlm.nih.gov/pubmed/17681033, 10.1111/j.1530-0277.2007.00475.x.
    • (2007) Alcoholism, Clinical and Experimental Research , vol.31 , pp. 1660-1668
    • Lieber, C.S.1    Cao, Q.2    DeCarli, L.M.3    Leo, M.A.4    Mak, K.M.5    Ponomarenko, A.6    Ren, C.7
  • 57
    • 0030045690 scopus 로고    scopus 로고
    • Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol
    • Albano E., Clot P., Morimoto M., Tomasi A., Ingelman-Sundberg M., French S.W. Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol. Hepatology (Baltimore, Md.) 1996, 23:155-163. http://www.ncbi.nlm.nih.gov/pubmed/8550035, 10.1002/hep.510230121.
    • (1996) Hepatology (Baltimore, Md.) , vol.23 , pp. 155-163
    • Albano, E.1    Clot, P.2    Morimoto, M.3    Tomasi, A.4    Ingelman-Sundberg, M.5    French, S.W.6
  • 58
    • 84872406355 scopus 로고    scopus 로고
    • CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease
    • Leung T.M., Nieto N. CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease. Journal of Hepatology 2013, 58:395-398. http://www.ncbi.nlm.nih.gov/pubmed/22940046, 10.1016/j.jhep.2012.08.018.
    • (2013) Journal of Hepatology , vol.58 , pp. 395-398
    • Leung, T.M.1    Nieto, N.2
  • 59
    • 34250375240 scopus 로고    scopus 로고
    • Induction of cytochrome P450 2E1 promotes liver injury in ob/ob mice
    • Dey A., Cederbaum A.I. Induction of cytochrome P450 2E1 promotes liver injury in ob/ob mice. Hepatology (Baltimore, Md.) 2007, 45:1355-1365. http://www.ncbi.nlm.nih.gov/pubmed/17538970, 10.1002/hep.21603.
    • (2007) Hepatology (Baltimore, Md.) , vol.45 , pp. 1355-1365
    • Dey, A.1    Cederbaum, A.I.2
  • 60
    • 23044516645 scopus 로고    scopus 로고
    • Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice
    • Wang X., Lu Y., Cederbaum A.I. Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice. Hepatology (Baltimore, Md.) 2005, 42:400-410. http://www.ncbi.nlm.nih.gov/pubmed/16025513, 10.1002/hep.20792.
    • (2005) Hepatology (Baltimore, Md.) , vol.42 , pp. 400-410
    • Wang, X.1    Lu, Y.2    Cederbaum, A.I.3
  • 61
    • 0038580392 scopus 로고    scopus 로고
    • Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells
    • Pérez M.J., Cederbaum A.I. Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells. Hepatology (Baltimore, Md.) 2003, 37(6):1395-1404. http://www.ncbi.nlm.nih.gov/pubmed/12774019, 10.1053/jhep.2003.50228.
    • (2003) Hepatology (Baltimore, Md.) , vol.37 , Issue.6 , pp. 1395-1404
    • Pérez, M.J.1    Cederbaum, A.I.2
  • 62
    • 43949086592 scopus 로고    scopus 로고
    • Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice
    • Lu Y., Zhuge J., Wang X., Bai J., Cederbaum A.I. Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology (Baltimore, Md.) 2008, 47(5):1483-1494. http://www.ncbi.nlm.nih.gov/pubmed/18393316, 10.1002/hep.22222.
    • (2008) Hepatology (Baltimore, Md.) , vol.47 , Issue.5 , pp. 1483-1494
    • Lu, Y.1    Zhuge, J.2    Wang, X.3    Bai, J.4    Cederbaum, A.I.5
  • 63
    • 0036298103 scopus 로고    scopus 로고
    • Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage
    • Morgan K., French S.W., Morgan T.R. Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage. Hepatology (Baltimore, Md.) 2002, 36:122-134. http://www.ncbi.nlm.nih.gov/pubmed/12085356, 10.1053/jhep.2002.33720.
    • (2002) Hepatology (Baltimore, Md.) , vol.36 , pp. 122-134
    • Morgan, K.1    French, S.W.2    Morgan, T.R.3
  • 65
    • 19944432987 scopus 로고    scopus 로고
    • Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver
    • Bradford B.U., Kono H., Isayama F., Kosyk O., Wheeler M.D., Akiyama T.E., Bleye L., et al. Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver. Hepatology (Baltimore, Md.) 2005, 41:336-344. http://www.ncbi.nlm.nih.gov/pubmed/15660387, 10.1002/hep.20532.
    • (2005) Hepatology (Baltimore, Md.) , vol.41 , pp. 336-344
    • Bradford, B.U.1    Kono, H.2    Isayama, F.3    Kosyk, O.4    Wheeler, M.D.5    Akiyama, T.E.6    Bleye, L.7
  • 66
    • 68949165996 scopus 로고    scopus 로고
    • Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease
    • Wang Y., Millonig G., Nair J., Patsenker E., Stickel F., Mueller S., Bartsch H., Seitz H.K. Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease. Hepatology (Baltimore, Md.) 2009, 50(2):453-461. http://www.ncbi.nlm.nih.gov/pubmed/19489076, 10.1002/hep.22978.
    • (2009) Hepatology (Baltimore, Md.) , vol.50 , Issue.2 , pp. 453-461
    • Wang, Y.1    Millonig, G.2    Nair, J.3    Patsenker, E.4    Stickel, F.5    Mueller, S.6    Bartsch, H.7    Seitz, H.K.8
  • 67
    • 0031962151 scopus 로고    scopus 로고
    • Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis
    • Weltman M.D., Farrell G.C., Hall P., Ingelman-Sundberg M., Liddle C. Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology (Baltimore, Md.) 1998, 27:128-133. http://www.ncbi.nlm.nih.gov/pubmed/9425928, 10.1002/hep.510270121.
    • (1998) Hepatology (Baltimore, Md.) , vol.27 , pp. 128-133
    • Weltman, M.D.1    Farrell, G.C.2    Hall, P.3    Ingelman-Sundberg, M.4    Liddle, C.5
  • 68
    • 84866421262 scopus 로고    scopus 로고
    • Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis
    • Abdelmegeed M.A., Banerjee A., Yoo S.H., et al. Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis. Journal of Hepatology 2012, 57:860-866. http://www.ncbi.nlm.nih.gov/pubmed/22668639, 10.1016/j.jhep.2012.05.019.
    • (2012) Journal of Hepatology , vol.57 , pp. 860-866
    • Abdelmegeed, M.A.1    Banerjee, A.2    Yoo, S.H.3
  • 69
    • 0037369729 scopus 로고    scopus 로고
    • Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis
    • Chalasani N., Gorski J.C., Asghar M.S., et al. Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis. Hepatology (Baltimore, Md.) 2003, 37:544-550. http://www.ncbi.nlm.nih.gov/pubmed/12601351, 10.1053/jhep.2003.50095.
    • (2003) Hepatology (Baltimore, Md.) , vol.37 , pp. 544-550
    • Chalasani, N.1    Gorski, J.C.2    Asghar, M.S.3
  • 70
    • 84863098121 scopus 로고    scopus 로고
    • Inflammation and fibrogenesis in steatohepatitis
    • Fujii H., Kawada N. Inflammation and fibrogenesis in steatohepatitis. Journal of Gastroenterology 2012, 47:215-225. http://www.ncbi.nlm.nih.gov/pubmed/22310735, 10.1007/s00535-012-0527-x.
    • (2012) Journal of Gastroenterology , vol.47 , pp. 215-225
    • Fujii, H.1    Kawada, N.2
  • 71
    • 34247643846 scopus 로고    scopus 로고
    • Pediatric nonalcoholic fatty liver disease (NAFLD): a "growing" problem?
    • Roberts E.A. Pediatric nonalcoholic fatty liver disease (NAFLD): a "growing" problem?. Journal of Hepatology 2007, 46:1133-1142. http://www.ncbi.nlm.nih.gov/pubmed/17445934, 10.1016/j.jhep.2007.03.003.
    • (2007) Journal of Hepatology , vol.46 , pp. 1133-1142
    • Roberts, E.A.1
  • 72
    • 79961186344 scopus 로고    scopus 로고
    • Factors associated with hepatic steatosis in obese children and adolescents
    • Ruiz-Extremera Á, Carazo Á, Salmerón Á, et al. Factors associated with hepatic steatosis in obese children and adolescents. Journal of Pediatric Gastroenterology and Nutrition 2011, 53:196-201. http://www.ncbi.nlm.nih.gov/pubmed/21788762, 10.1097/MPG.0b013e3182185ac4.
    • (2011) Journal of Pediatric Gastroenterology and Nutrition , vol.53 , pp. 196-201
    • Ruiz-Extremera, Á1    Carazo, Á2    Salmerón, Á3
  • 75
    • 85015523540 scopus 로고    scopus 로고
    • Detection of hepatic highly carcinogenic, exocyclic etheno-DNA-adducts in patients with alcoholic and non-alcoholic fatty liver disease and in children with non-alcoholic steatoheopatitis
    • Qin H., Teufel U., Engelmann G., et al. Detection of hepatic highly carcinogenic, exocyclic etheno-DNA-adducts in patients with alcoholic and non-alcoholic fatty liver disease and in children with non-alcoholic steatoheopatitis. Journal of Hepatology 2012, 56(Suppl. 2):S520. 10.1016/S0168-8278(12)61331-2.
    • (2012) Journal of Hepatology , vol.56 , pp. S520
    • Qin, H.1    Teufel, U.2    Engelmann, G.3
  • 76
    • 84860389258 scopus 로고    scopus 로고
    • Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK
    • Xu J., Lai K.K., Verlinsky A., Lugea A., French S.W., Cooper M.P., Ji C., et al. Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. Journal of Hepatology 2011, 55:673-682. http://www.ncbi.nlm.nih.gov/pubmed/21256905, 10.1016/j.jhep.2010.12.034.
    • (2011) Journal of Hepatology , vol.55 , pp. 673-682
    • Xu, J.1    Lai, K.K.2    Verlinsky, A.3    Lugea, A.4    French, S.W.5    Cooper, M.P.6    Ji, C.7
  • 77
    • 77749295136 scopus 로고    scopus 로고
    • Moderate alcohol consumption aggravates high-fat diet induced steatohepatitis in rats
    • Wang Y., Seitz H.K., Wang X.D. Moderate alcohol consumption aggravates high-fat diet induced steatohepatitis in rats. Alcoholism, Clinical and Experimental Research 2010, 34(3):567-573. http://www.ncbi.nlm.nih.gov/pubmed/20028348, 10.1111/j.1530-0277.2009.01122.x.
    • (2010) Alcoholism, Clinical and Experimental Research , vol.34 , Issue.3 , pp. 567-573
    • Wang, Y.1    Seitz, H.K.2    Wang, X.D.3
  • 78
    • 77952730428 scopus 로고    scopus 로고
    • The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
    • Ascha M.S., Hanouneh I.A., Lopez R., et al. The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology (Baltimore, Md.) 2010, 51:1972-1978. http://www.ncbi.nlm.nih.gov/pubmed/20209604, 10.1002/hep.23527.
    • (2010) Hepatology (Baltimore, Md.) , vol.51 , pp. 1972-1978
    • Ascha, M.S.1    Hanouneh, I.A.2    Lopez, R.3
  • 80
    • 2342457210 scopus 로고    scopus 로고
    • Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C*1 allele, possibly due to salivary acetaldehyde
    • Visapää J.P., Götte K., Benesova M., Li J., Homann N., Conradt C., Inoue H., et al. Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C*1 allele, possibly due to salivary acetaldehyde. Gut 2004, 53:871-876. http://www.ncbi.nlm.nih.gov/pubmed/15138216, 10.1136/gut.2003.018994.
    • (2004) Gut , vol.53 , pp. 871-876
    • Visapää, J.P.1    Götte, K.2    Benesova, M.3    Li, J.4    Homann, N.5    Conradt, C.6    Inoue, H.7
  • 82
    • 78649867714 scopus 로고    scopus 로고
    • Ethanol-mediated carcinogenesis in the human esophagus implicates CYP2E1 induction and the generation of carcinogenic DNA-lesions
    • Millonig G., Wang Y., Homann N., Bernhardt F., Qin H., Mueller S., Bartsch H. Ethanol-mediated carcinogenesis in the human esophagus implicates CYP2E1 induction and the generation of carcinogenic DNA-lesions. International Journal of Cancer: Journal International du Cancer 2011, 128(3):533-540. http://www.ncbi.nlm.nih.gov/pubmed/20715111, 10.1002/ijc.25604.
    • (2011) International Journal of Cancer: Journal International du Cancer , vol.128 , Issue.3 , pp. 533-540
    • Millonig, G.1    Wang, Y.2    Homann, N.3    Bernhardt, F.4    Qin, H.5    Mueller, S.6    Bartsch, H.7
  • 83
    • 0027968127 scopus 로고
    • Enhancement of ethanol induced rectal mucosal hyper regeneration with age in F344 rats
    • Simanowski U.A., Suter P., Russell R.M., Heller M., Waldherr R., Ward R., Peters T.J., et al. Enhancement of ethanol induced rectal mucosal hyper regeneration with age in F344 rats. Gut 1994, 35:1102-1106. http://www.ncbi.nlm.nih.gov/pubmed/7926914, 10.1136/gut.35.8.1102.
    • (1994) Gut , vol.35 , pp. 1102-1106
    • Simanowski, U.A.1    Suter, P.2    Russell, R.M.3    Heller, M.4    Waldherr, R.5    Ward, R.6    Peters, T.J.7
  • 84
    • 0034864153 scopus 로고    scopus 로고
    • Increased rectal cell proliferation following alcohol abuse
    • Simanowski U.A., Homann N., Knühl M., Arce L., Waldherr R., Conradt C., Bosch F.X., et al. Increased rectal cell proliferation following alcohol abuse. Gut 2001, 49:418-422. http://www.ncbi.nlm.nih.gov/pubmed/11511565, 10.1136/gut.49.3.418.
    • (2001) Gut , vol.49 , pp. 418-422
    • Simanowski, U.A.1    Homann, N.2    Knühl, M.3    Arce, L.4    Waldherr, R.5    Conradt, C.6    Bosch, F.X.7
  • 90
    • 79958189574 scopus 로고    scopus 로고
    • Long-term ethanol consumption promotes hepatic tumorigenesis but impairs normal hepatocyte proliferation in rats
    • Chavez P.R., Lian F., Chung J., et al. Long-term ethanol consumption promotes hepatic tumorigenesis but impairs normal hepatocyte proliferation in rats. Journal of Nutrition 2011, 141:1049-1055. http://www.ncbi.nlm.nih.gov/pubmed/21490289, 10.3945/jn.110.136531.
    • (2011) Journal of Nutrition , vol.141 , pp. 1049-1055
    • Chavez, P.R.1    Lian, F.2    Chung, J.3
  • 91
    • 84883824648 scopus 로고    scopus 로고
    • Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats.
    • Ye Q., Lian F., Chavez P.R., et al. Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats. Hepatobiliary Surgery and Nutrition 2012, 1:5-18.
    • (2012) Hepatobiliary Surgery and Nutrition , vol.1 , pp. 5-18
    • Ye, Q.1    Lian, F.2    Chavez, P.R.3
  • 92
    • 84879842564 scopus 로고    scopus 로고
    • Chronic ingestion of ethanol induces hepatocellular carcinoma in mice without additional hepatic insult
    • Tsuchishima M., George J., Shiroeda H., et al. Chronic ingestion of ethanol induces hepatocellular carcinoma in mice without additional hepatic insult. Digestive Diseases and Sciences 2013, 58:1923-1933. http://www.ncbi.nlm.nih.gov/pubmed/23371017, 10.1007/s10620-013-2574-4.
    • (2013) Digestive Diseases and Sciences , vol.58 , pp. 1923-1933
    • Tsuchishima, M.1    George, J.2    Shiroeda, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.