Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells

Hepatology

Volumn 37, Issue 6, 2003, Pages 1395-1404

  Pérez, María José ^b   Cederbaum, Arthur I ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; ARACHIDONIC ACID; CYTOCHROME P450 2E1; GLUTATHIONE; IRON; PROTEASOME INHIBITOR; PROTEIN;

ALCOHOL LIVER CIRRHOSIS; ALCOHOLISM; ANIMAL CELL; ARTICLE; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME REGULATION; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER CELL CARCINOMA; LIVER INJURY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

EID: 0038580392     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2003.50228     Document Type: Article

References (46)

1. Baraona E, Leo MA, Borowsky SA, Lieber CS. Alcoholic hepatomegaly: accumulation of protein in the liver. Science 1975;90:794-795.
2. Donohue TM Jr, Zetterman RK, Tuma DJ. Effect of chronic ethanol administration on protein catabolism in rat liver. Alcohol Clin Exp Res 1989;13:49-57.
3. Poso AR, Hirsimaki P. Inhibition of proteolysis in the liver by chronic ethanol feeding. Biochem J 1991;273:149-152.
4. Henell F, Berkenstam A, Ahlberg J, Glaumann H. Degradation of short-and long-lived proteins in perfused liver and in isolated autophagic vacuoles-lysosomes. Exp Mol Pathol 1987;46:1-14.
5. Goldberg AL. Functions of the proteasome: the lysis at the end of the tunnel. Science 1995;268:522-523.
6. Ciechanover A. The ubiquitin-proteasome proteolytic pathway. Cell 1994;79:13-21.
7. Kharbanda KK, McVicker DL, Zetterman RK, Donohue TM Jr. Ethanol consumption reduces the proteolytic capacity and protease activities of hepatic lysosomes. Biochim Biophys Acta 1995;1245:421-429.
8. Takagi M, Yamauchi M, Toda G, Takada K, Hirakawa T, Ohkawa K. Serum ubiquitin levels in patients with alcoholic liver disease. Alcohol Clin Exp Res 1999;23:76S-80S.
9. Lowe J, Blanchard A, Morrell K, Lennox G, Reynolds L, Billett M, Landon M, et al. Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease. J Pathol 1988;155:9-15.
10. Born LJ, Kharbanda KK, McVicker DL, Zetterman RK, Donohue TM Jr. Effects of ethanol administration on components of the ubiquitin proteolytic pathway in rat liver. HEPATOLOGY 1996;23:1556-1563.
11. Fataccioli V, Andraud E, Gentil M, French SW, Rouach H. Effects of chronic ethanol administration on rat liver proteasome activities: relationship with oxidative stress. HEPATOLOGY 1999;29:14-20.
12. Rouach H, Fataccioli V, Gentil M, French SW, Morimoto M, Nordmann R. Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology. HEPATOLOGY 1997;25:351-355.
13. Gouillon Z, Lucas D, Li J, Hagbjork AL, French BA, Fu P, Fang C, et al. Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole. Proc Soc Exp Biol Med 2000;224:302-308.
14. Roberts BJ. Evidence of proteasome-mediated cytochrome P-450 degradation. J Biol Chem 1997;272:9771-9778.
15. Goasduff T, Cederbaum AI. NADPH-dependent microsomal electron transfer increases degradation of CYP2E1 by the proteasome complex: role of reactive oxygen species. Arch Biochem Biophys 1999;370:258-270.
16. Banerjee A, Kocarek TA, Novak RF. Identification of a ubiquitinationtarget/substrate-interaction domain of cytochrome P-450 (CYP) 2E1. Drug Metab Dispos 2000;28:118-124.
17. Davies KJA. Intracellular proteolytic systems may function as secondary antioxidant defenses: an hypothesis. J Free Radic Biol Med 1986;2:155-173.
18. Grune T, Reinheckel T, Joshi M, Davies KJ. Proteolysis in cultured liver epithelial cells during oxidative stress. Role of the multicatalytic proteinase complex, proteasome. J Biol Chem 1995;270:2344-2351.
19. Grune T, Reinheckel T, Davies KJ. Degradation of oxidized proteins in mammalian cells. FASEB J 1997;11:526-534.
20. Chen Q, Galleano M, Cederbaum AI. Cytotoxicity and apoptosis produced by arachidonic acid in HepG2 cells overexpressing human cytochrome P4502E1. J Biol Chem 1997;272:14532-14541.
21. Pérez MJ, Cederbaum AI. Spin trapping agents (Tempol and POBN) protect HepG2 cells overexpressing CYP2E1 against arachidonic acid toxicity. Free Radic Biol Med 2001;30:734-746.
22. Pérez MJ, Cederbaum AI. Antioxidant and pro-oxidant effects of a manganese porphyrin complex against CYP2E1-dependent toxicity. Free Radic Biol Med 2002;33:111-127.
23. Caro AA, Cederbaum AI. Synergistic toxicity of iron and arachidonic acid in HepG2 cells overexpressing CYP2E1. Mol Pharmacol 2001;60:742-752.
24. Takahashi H, Johansson H, French SW. Effect of dietary fat composition on activities of the microsomal ethanol oxidizing system and ethanol-inducible cytochrome P450 (CYP2E1) in the liver of rats chronically fed ethanol. Pharmacol Toxicol 1992;70:347-351.
25. Tsukamoto H, Horne W, Kamimura S, Niemela O, Parkkila S, Yla-Herttuala S, Brittenham GM. Experimental liver cirrhosis induced by alcohol and iron. J Clin Invest 1995;96:620-630.
26. Nanji A, Zhao S, Lamb RG, Sadrzadeh SMH, Dannenberg AJ, Waxman DJ. Changes in microsomal phospholipases and arachidonic acid in experimental alcoholic liver injury: relationship to cytochrome P-450 2E1 induction and conjugated diene formation. Alcohol Clin Exp Res 1993;17:598-603.
27. Morimoto M, Hagbjork AL, Nanji AA, Ingelman-Sundberg M, Lindros KO, Fu PC, Albano E, et al. Role of cytochrome P4502E1 in alcoholic liver disease pathogenesis. Alcohol 1993;10:459-464.
28. Fernandez-Checa JC, Hirano T, Tsukamoto H, Kaplowitz N. Mitochondrial glutathione depletion in alcoholic liver disease. Alcohol 1993;10:469-475.
29. Chen Q, Cederbaum AI. Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells. Mol Pharmacol 1998;53:638-648.
30. Bai J, Cederbaum AI. Adenovirus-mediated overexpression in the cytosolic or mitochondrial compartment protects against cytochrome P4502E1-dependent toxicity in HepG2 cells. J Biol Chem 2001;276:4315-4321.
31. Wu D, Cederbaum AI. Ethanol and arachidonic acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of CYP2E1. Mol Cell Biochem 2000;204:157-167.
32. Niehaus WG, Samuelsson B. Formation of malonaldehyde from phospholipid arachidonate during microsomal lipid peroxidation. Eur J Biochem 1968;6:126-130.
33. Reznick AZ, Packer L. Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods Enzymol 1994;233:357-363.
34. Wu D, Cederbaum AI. Cyclosporine A protects against arachidonic acid toxicity in rat hepatocytes: role of CYP2E1 and mitochondria. HEPATOLOGY 2002;35:1420-1430.
35. Donohue TM Jr, Zetterman RK, Zhang-Gouillon ZQ, French SW. Peptidase activities of the multicatalytic protease in rat liver after voluntary and intragastric ethanol administration. HEPATOLOGY 1998;28:486-491.
36. Rock KL, Gramm C, Rothstein L, Clark K, Stein R, Dick L, Hwang D, et al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 1994;78:761-771.
37. Yang MX, Cederbaum AI. Characterization of cytochrome P4502E1 turn-over in transfected HepG2 cells expressing human CYP2E1. Arch Biochem Biophys 1997;341:25-33.
38. Bardag-Gorce F, Yuan QX, Li J, French BA, Fang C, Ingelman-Sundberg M, French SW. The effect of ethanol-induced cytochrome p4502E1 on the inhibition of proteasome activity by alcohol. Biochem Biophys Res Commun 2000;279:23-29.
39. Dunlop RA, Rodgers KJ, Dean RT. Recent developments in the intracellular degradation of oxidized proteins. Free Radic Biol Med 2002;33:894-906.
40. Pirlich M, Muller C, Sandig G, Jakstadt M, Sitte N, Lochs H, Grune T. Increased proteolysis after single-dose exposure with hepatotoxins in HepG2 cells. Free Radic Biol Med 2002;33:283-291.
41. Bailey SM, Patel VB, Young TA, Asayama K, Cunningham CC. Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver. Alcohol Clin Exp Res 2001;25:726-733.
42. Stadtman ER, Berlett BS. Reactive oxygen-mediated protein oxidation in aging and disease. Drug Metab Rev 1998;30:225-243.
43. Nanji AA, Jokelainen K, Lau GK, Rahemtulla A, Tipoe GL, Polavarapu R, Lalani EN. Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration. J Pharmacol Exp Ther 2001;299:832-839.
44. Baraona E, Zeballos GA, Shoichet L, Mak KM, Lieber CS. Ethanol consumption increases nitric oxide production in rats, and its peroxynitrite mediated toxicity is attenuated by polyenylphosphatidylcholine. Alcohol Clin Exp Res 2002;26:883-889.
45. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 1996;271:C1424-C1437.
46. Lee MH, Hyun DH, Jenner P, Halliwell B. Effect of proreasome inhibition on cellular oxidative damage, antioxidant defences and nitric oxide production. J Neurochem 2001;78:32-41.