Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol

Hepatology

Volumn 23, Issue 1, 1996, Pages 155-163

  Albano, Emanuele ^a   Clot, Paolo ^a   Morimoto, Michio ^b   Tomasi, Aldo ^c   Ingelman Sundberg, Magnus ^d   French, Samuel W ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b HARBOR UCLA MEDICAL CENTER   (United States)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYL SULFIDE; CYTOCHROME P450; FREE RADICAL;

ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY TITER; ANTIGEN ANTIBODY REACTION; ARTICLE; CONTROLLED STUDY; LIPID BLOOD LEVEL; LIPID PEROXIDATION; LIVER INJURY; LIVER MICROSOME; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

EID: 0030045690     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.1996.v23.pm0008550035     Document Type: Article

References (26)

1. Nordmann R, Ribière C, Rouach H. Implication of free radical mechanisms in ethanol induced cellular injury. Free Rad Biol Med 1992;12:219-240.
2. Lettèron P, Duchatelle V, Berson A, Fromenty B, Degott C, Ben-haumou JP, Pessayre D. Increased ethane exhalation, an in vivo index of lipid peroxidation, in alcohol-abusers. Gut 1993;34:409-414.
3. Lecomte E, Herberth B, Pirrolet P, Chancerelle Y, Arnaud J, Musse N, Paille F, et al. Effect of alcohol consumption on blood antioxidant nutrients and oxidative stress indicators. Am J Clin Nutr 1994;60:255-261.
4. Clot P, Tabone M, Aricò S, Albano E. Monitoring oxidative damage in patients with liver cirrhosis and different daily alcohol intake. Gut 1994;35:1637-1643.
5. Kamimura S, Gaal K, Britton RS, Bacon BR, Triadafilopoulos G, Tsukamoto H. Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: association of lipid peroxidation with liver fibrogenesis. HEPATOLOGY 1992;16:448-453.
6. French SW, Wong K, Jui L, Albano E, Hagbjörk A-L, Ingelman-Sundberg M. Effect of ethanol on cytochrome P4502E1 (CYP2E1), lipid peroxidation and serum protein adduct formation in relation to liver pathology pathogenesis. Exp Mol Pathol 1993;58:61-75.
7. Morimoto M, Hagbjörk A-L, Nanji AA, Ingelman-Sundberg M, Lindros K, Fu PC, Albano E, et al. Role of cytochrome P4502E1 in alcoholic liver disease pathogenesis. Alcohol 1993;10:459-464.
8. Sadrzadeh HSM, Nanji AA, Price PL. The oral iron chelator, 1,2-dimethyl-3-hydroxypyrid-4-one reduces hepatic-free iron, lipid peroxidation and fat accumulation in chronically ethanol-fed rats. J Pharmacol Exp Ther 1994;269:632-636.
9. Nanji AA, Khwaja S, Tahan SR, Sadrzadeh HSM. Plasma levels of a novel noncyclooxygenase-derived prostanoid (8-isoprostane) correlate with severity of liver injury in experimental alcoholic liver disease. J Pharmacol Exp Ther 1994;269:1280-1285.
10. Morimoto M, Hagbjörk A-L, Wan YJY, Fu PC, Ingelman-Sundberg M, Albano E, Clot P, et al. Modulation of alcoholic liver disease by cytochrome P4502E1 inhibitors. HEPATOLOGY 1995;21:1610-1617.
11. Albano E, Tomasi A, Goria-Gatti L, Dianzani MU. Spin trapping of free radical species produced during the microsomal metabolism of ethanol. Chem Biol Interact 1988;65:223-234.
12. Albano E, Tomasi A, Goria-Gatti L, Persson JO, Terelius Y, Ingelman-Sundberg M, Dianzani MU. Role of ethanol-inducible cytochrome P-450 (P450IIE1) in catalysing the free radical activation of aliphatic alcohols. Biochem Pharmacol 1991;41:1895-1902.
13. Albano E, Parola M, Comoglio A, Dianzani MU. Evidence for the covalent binding of hydroxyethyl radicals to rat liver microsomal proteins. Alcohol Alcohol 1993;28:453-459.
14. Moncada C, Torres V, Vargese E, Albano E, Israel Y. Ethanolderived immunoreactive species formed by free radical mechanisms. Mol Pharmacol 1994;46:786-791.
15. Clot P, Bellomo G, Tabone M, Arico S, Albano E. Detection of antibodies against proteins modified by hydroxyethyl free radicals in patients with alcoholic cirrhosis. Gastroentrology 1995;108:201-207.
16. Tsukamoto H, Heidelberger RD, French SW, Largman C. Longterm cannulation model for blood sampling and intragastric infusion in the rat. Am J Physiol 1984;247:R595-R599.
17. Ekström G, Von Bahr C, Ingelman-Sundberg M. Human liver cytochrome P-450IIE1. Immunological evaluation of its contribution to microsomal ethanol oxidation, carbon tetrachloride reduction and NADPH oxidase activity. Biochem Pharmacol 1989;38:689-693.
18. Albano E, Tomasi A, Ingelman-Sundberg M. Spin trapping of alcohol-derived radicals in microsomes and reconstituted systems by electron spin resonance. Methods Enzymol 1994; 233:117-127.
19. Esterbauer H, Lang J, Zadravec S, Slater TF. Detection of malonaldehyde by high-performance liquid chromatography. Methods Enzymol 1984; 105:319-325.
20. Comiacini M, Garbin U, Davoli A, Micciolo R, Bosello O, Gaviraghi G, Scuro LA, et al. A simple test for predisposition to LDL oxidation based on the fluorescence development during coppercatalyzed oxidative modification. J Lipid Res 1991;32:349-358.
21. Knecht KT, Thurman RG, Mason RP. Role of superoxide and trace transition metals in the production of α-hydroxyethyl radi-cal from ethanol by microsomes from alcohol dehydrogenasedeficient deermice. Arch Biochem Biophys 1993;303:339-348.
22. Knecht KT, Bradfort BU, Mason RP, Thurman RG. In vivo formation of free radical metabolite of ethanol. Mol Pharmacol 1990;38:26-30.
23. Moore DR, Reinke LA, McCay PB. Metabolism of ethanol to 1-hydroxyethyl radicals in vivo: detection with intravenous administration of α-(4-pyridyl-1-oxide)N-t-butylnitrone. Mol Pharmacol 1995;47:1224-1230.
24. Knecht KT, Adachi Y, Bradfort BU, Iimuro Y, Kadiiska M, QunHui X, Thurman RG. Free radical adducts in the bile of ras treated chronically with intragastric alcohol: inhibition by destruction of Kupffer cells. Mol Pharmacol 1995;47:1028-1034.
25. Clot P, Ingelman-Sundberg M, Bellomo G, Tabone M, Aricò S, Israel Y, Moncada C, et al. Detection of antibodies against CYP2E1 modified by hydroxyethyl free radicals in patients with alcoholic cirrhosis [Abstract]. HEPATOLOGY 1994;20:317A.
26. Persson JO, Terelius Y, Ingelman-Sundberg M. Cytochrome P450-dependent formation of oxygen radicals. Isoenzyme-specific inhibition of P450-mediated reduction of oxygen radicals and carbon tetrachloride. Xenobiotica 1990;20:887-900.