Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF

Pharmacology Biochemistry and Behavior

Volumn 104, Issue 1, 2013, Pages 10-19

  Littrell, Ofelia M ^a   Granholm, Ann Charlotte ^b   Gerhardt, Greg A ^a   Boger, Heather A ^b  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Dopamine; Glial cell line derived neurotrophic factor; Neurodegeneration; Parkinson's disease; Striatum; Substantia nigra

Indexed keywords

DOPAMINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; TYROSINE 3 MONOOXYGENASE;

ARTICLE; BRAIN; DOWN REGULATION; GENE DELETION; LOCOMOTION; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NERVE CELL; NERVOUS SYSTEM INFLAMMATION; NIGRONEOSTRIATAL SYSTEM; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUBSTANTIA NIGRA;

ANIMALS; CORPUS STRIATUM; CYCLOOXYGENASE 2; DOPAMINE; DOPAMINERGIC NEURONS; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; OXIDATIVE STRESS; RECOMBINANT PROTEINS; SUBSTANTIA NIGRA; SUPEROXIDE DISMUTASE; TYROSINE 3-MONOOXYGENASE;

MUS;

EID: 84873468045     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2012.12.022     Document Type: Article

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