Patterns of DNA damage response in intracranial germ cell tumors versus glioblastomas reflect cell of origin rather than brain environment: Implications for the anti-tumor barrier concept and treatment

Molecular Oncology

Volumn 8, Issue 8, 2014, Pages 1667-1678

  Bartkova, Jirina ^a   Hoei Hansen, Christina E ^b   Krizova, Katerina ^a,c   Hamerlik, Petra ^a   Skakkebæk, Niels E ^b   Rajpert De Meyts, Ewa ^b   Bartek, Jiri ^a,c  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b Rigshospitalet   (Denmark)

^c PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

ATM Chk2 p53 pathway; DNA damage signaling; Gliomas; Intracranial germ cell tumors; Testicular germ cell neoplasms

Indexed keywords

ATM PROTEIN; BIOLOGICAL MARKER; CELL DNA; CHECKPOINT KINASE 2; GAMMA HISTONE H2AX; HISTONE H2AX; INTRINSIC FACTOR; KI 67 ANTIGEN; PHOSPHOPROTEIN; PROTEIN P53; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANTITUMOR BARRIER; APOPTOSIS; ARTICLE; BRAIN BIOPSY; BRAIN TISSUE; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER MORPHOLOGY; CARCINOGENESIS; CELL ACTIVATION; CELL AGING; CELL DEATH; CELL DIFFERENTIATION; CELL ORIGIN; CELLULAR DISTRIBUTION; CHILD; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DNA DAMAGE; DNA DAMAGE CHECKPOINT; DNA DAMAGE RESPONSE; EMBRYONAL CARCINOMA; FEMALE; GERM CELL TUMOR; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRACRANIAL TUMOR; IONIZING RADIATION; MALE; NEUROPATHOLOGY; NORMAL HUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PERMEABILITY BARRIER; PRIMARY INTRACRANIAL GERM CELL TUMOR; PRIMARY TUMOR; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84911962519     PISSN: 15747891     EISSN: 18780261     Source Type: Journal    
DOI: 10.1016/j.molonc.2014.07.001     Document Type: Article

References (40)

1. Bartek J., Bartkova J., Lukas J., Staskova Z., Vojtesek B., L.D. Immunohistochemical analysis of the p53 oncoprotein on paraffin sections using a series of novel monoclonal antibodies. J.Pathol. 1993, 169:27-34.
2. Bartek J., Bartkova J., Lukas J. DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 2007, 26:7773-7779.
3. Bartek J., Hodny Z., Lukas J. Cytokine loops driving senescence. Nat. Cell Biol. 2008, 10:887-889.
4. Bartek J., Lukas C., Lukas J. Checking on DNA damage in S phase. Nat. Rev. Mol. Cell Biol. 2004, 5:792-804.
5. Bartkova J., Bakkenist C.J., Meyts E.R., Skakkebæk N.E., Sehested M., Lukas J., Kastan M.B., Bartek J. ATM activation in normal human tissues and testicular cancer. Cell Cycle 2005, 838-845.
6. Bartkova J., Falck J., Rajpert-De Meyts E., Skakkebaek N.E., Lukas J., Bartek J. Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours. Oncogene 2001, 20:5897-5902.
7. Bartkova J., Hamerlik P., Stockhausen M.-T., Ehrmann J., Hlobilkova a, Laursen H., Kalita O., Kolar Z., Poulsen H.S., Broholm H., Lukas J., Bartek J. Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas. Oncogene 2010, 29:5095-5102.
8. Bartkova J., Horejsí Z., Koed K., Krämer A., Tort F., Zieger K., Guldberg P., Sehested M., Nesland J.M., Lukas C., Ørntoft T., Lukas J., Bartek J. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005, 434:864-870.
9. Bartkova J., Horejsí Z., Sehested M., Nesland J.M., Rajpert-De Meyts E., Skakkebaek N.E., Stucki M., Jackson S., Lukas J., Bartek J. DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours. Oncogene 2007, 26:7414-7422.
10. Bartkova J., Lukas C., Sørensen C.S., Rajpert-De Meyts E., Skakkebaek N.E., Lukas J., Bartek J. Deregulation of the RB pathway in human testicular germ cell tumours. J.Pathol. 2003, 200:149-156.
11. Bartkova J., Rajpert-De Meyts E., Skakkebaek N.E., Lukas J., Bartek J. Deregulation of the G1/S-phase control in human testicular germ cell tumours. APMIS 2003, 111:252-265. discussion 265-6.
12. Bartkova J., Rajpert-De Meyts E., Skakkebaek N.E., Lukas J., Bartek J. DNA damage response in human testes and testicular germ cell tumours: biology and implications for therapy. Int. J. Androl. 2007, 30:282-291. discussion 291.
13. Bartkova J., Rezaei N., Liontos M., Karakaidos P., Kletsas D., Issaeva N., Vassiliou L.-V.F., Kolettas E., Niforou K., Zoumpourlis V.C., Takaoka M., Nakagawa H., Tort F., Fugger K., Johansson F., Sehested M., Andersen C.L., Dyrskjot L., Ørntoft T., Lukas J., Kittas C., Helleday T., Halazonetis T.D., Bartek J., Gorgoulis V.G. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006, 444:633-637.
14. Burrell R., McGranahan N., Bartek J., Swanton C. The causes and consequences of genetic heterogeneity in cancer evolution. Nature 2013, 501:338-345.
15. Campisi J., d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 2007, 8:729-740.
16. Di Micco R., Fumagalli M., Cicalese A., Piccinin S., Gasparini P., Luise C., Schurra C., Garre' M., Nuciforo P.G., Bensimon A., Maestro R., Pelicci P.G., d'Adda di Fagagna F. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 2006, 444:638-642.
17. Evangelou K., Bartkova J., Kotsinas a, Pateras I.S., Liontos M., Velimezi G., Kosar M., Liloglou T., Trougakos I.P., Dyrskjot L., Andersen C.L., Papaioannou M., Drosos Y., Papafotiou G., Hodny Z., Sosa-Pineda B., Wu X.-R., Klinakis a, Ørntoft T., Lukas J., Bartek J., Gorgoulis V.G. The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis. Cell Death Differ. 2013, 20:1485-1497.
18. Gobel U., Schneider D.T., Calaminus G., Haas R.J., Schmidt P., Harms D. Review germ-cell tumors in childhood and adolescence. Ann. Oncol. 2000, 11(3):263-271.
19. Gorgoulis V.G., Vassiliou L.F., Karakaidos P., Zacharatos P., Kotsinas A., Liloglou T., Venere M., D R.A., Kastrinakis N.G., Levy B., Kletsas D., Yoneta A., Herlyn M., Kittas C., Halazonetis T.D. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005, 434:907-913.
20. Halazonetis T.D., Gorgoulis V.G., Bartek J. An oncogene-induced DNA damage model for cancer development. Science 2008, 319:1352-1355.
21. Hodny Z., Hubackova S., Bartek J. Cytokine-induced "bystander" senescence in DDR and immuno-surveillance. Oncotarget 2013, 4:1552-1553.
22. Hoei-Hansen C.E., Sehested a, Juhler M., Lau Y.-F.C., Skakkebaek N.E., Laursen H., Rajpert-de Meyts E. New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers. J.Pathol. 2006, 209:25-33.
23. Hubackova S., Krejcikova K., Bartek J., Hodny Z. IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine "bystander senescence". Aging (Albany. NY) 2012, 4:932-951.
24. Jackson S.P., Bartek J. Europe PMC Funders Group the DNA-damage response in human biology and disease. Nature 2009, 461:1071-1078.
25. Jørgensen A., Nielsen J.E., Almstrup K., Toft B.G., Petersen B.L., Rajpert-De Meyts E. Dysregulation of the mitosis-meiosis switch in testicular carcinoma in situ. J.Pathol. 2013, 229:588-598.
26. Kastan M.B., Bartek J. Cell-cycle checkpoints and cancer. Nature 2004, 432:316-323.
27. Koster R., van Vugt M.A., Timmer-Bosscha H., Gietema J.A., de J.S. Unravelling mechanisms of cisplatin sensitivity and resistance in testicular cancer. Expert Rev. Mol. Med. 2013, 15:12.
28. Lukas C., Bartkova J., Latella L., Falck J., Mailand N., Schroeder T., Sehested M., Lukas J., Bartek J. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation, yet correlates with tissue biology. Cancer Res. 2001, 61:4990-4993.
29. Mosbech C.H., Rechnitzer C., Brok J.S., Rajpert-De Meyts E., Hoei-Hansen C.E. Recent advances in understanding the etiology and pathogenesis of pediatric germ cell tumors. J.Pediatr. Hematol. Oncol. 2014, 36:263-270.
30. Oosterhuis J.W., Stoop H., Honecker F., Looijenga L.H.J. Why human extragonadal germ cell tumours occur in the midline of the body: old concepts, new perspectives. Int. J. Androl. 2007, 30:256-263. discussion 263-4.
31. Rajpert-De Meyts E., Bartkova J., Samson M., Hoei-Hansen C.E., Frydelund-Larsen L., Bartek J., Skakkebaek N.E. The emerging phenotype of the testicular carcinoma in situ germ cell. APMIS 2003, 111:267-278.
32. Rosenblum M.K., Matsutani M., VanMeir E.G., K.P., C.W. Pathology and Genetics of Tumours of the Nervous System, Chapter: CNS Germ Cell Tumours 2000, 208-214. IARC Press (International Agency for Research on Cancer).
33. Schneider D.T., Schuster A.E., Fritsch M.K., Pediatric N., Cell G., Hu J., Olson T., Lauer S., Go U. Multipoint imprinting analysis indicates a common precursor cell for gonadal and nongonadal pediatric germ cell tumors. Cancer Res. 2001, 7268-7276.
34. Scotting P.J. Are cranial germ cell tumours really tumours of germ cells?. Neuropathol. Appl. Neurobiol. 2006, 32:569-574.
35. Sherr C.J. Ink4-Arf locus in cancer and aging. Wiley Interdiscip. Rev. Dev. Biol. 2012, 1:731-741.
36. Teilum G. Classification of endodermal sinus tumour (mesoblatoma vitellinum) and so-called "embryonal carcinoma" of the ovary. Acta Pathol. Microbiol. Scand. 1965, 64:407-429.
37. Terashima K., Yu A., Chow W.T., Hsu W.J., Chen P., Wong S., Hung Y.S., Suzuki T., Nishikawa R., Matsutani M., Nakamura H., Ng H., Allen J.C., Aldape K.D., Su J.M., Adesina A.M., Leung H.E., Man T., Lau C.C. Genome-wide analysis of DNA copy number alterations and loss of heterozygosity in intracranial germ cell tumors. Pediatr. Blood Cancer 2014, 593-600.
38. Tort F., Bartkova J., Sehested M., Orntoft T., Lukas J., Bartek J. Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis. Cancer Res. 2006, 66:10258-10263.
39. Velimezi G., Liontos M., Vougas K., Roumeliotis T., Bartkova J., Sideridou M., Dereli-Oz A., Kocylowski M., Pateras I.S., Evangelou K., Kotsinas A., Orsolic I., Bursac S., Cokaric-Brdovcak M., Zoumpourlis V., Kletsas D., Papafotiou G., Klinakis A., Volarevic S., Gu W., Bartek J., Halazonetis T.D., Gorgoulis V.G. Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat. Cell Biol. 2013, 15:967-977.
40. Yamada Y., Coffman C.R. DNA damage-induced programmed cell death: potential roles in germ cell development. Ann. N. Y. Acad. Sci. 2005, 1049:9-16.