ATM activation in normal human tissues and testicular cancer

Cell Cycle

Volumn 4, Issue 6, 2005, Pages 838-845

  Bartkova, Jirina ^a   Bakkenist, Christopher J ^b   Rajpert De Meyts, Ewa ^c   Skakkebæk, Niels E ^c   Sehested, Maxwell ^c   Lukas, Jiri ^a   Kastan, Michael B ^b   Bartek, Jiri ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c Mental Health Services CPH   (Denmark)

Author keywords

ATM kinase; DNA damage; Histone H2AX; Human tissues; Testicular tumors

Indexed keywords

ATM PROTEIN; DNA; HISTONE;

ANTIBODY SPECIFICITY; ARTICLE; BONE MARROW; CANCER STAGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TYPE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA DAMAGE; EMBRYONAL CARCINOMA; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENETIC RECOMBINATION; GERM CELL TUMOR; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE; MEIOSIS; PROTEIN PHOSPHORYLATION; SEMINOMA; SPERMATOCYTE; STAINING; TERATOMA; TESTIS; TESTIS CANCER;

EID: 23844520213     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.4.6.1742     Document Type: Article

References (30)

1. Kastan MB, Lim DS. The many substrates and functions of ATM. Nat Rev Mol Cell Biol 2000; 1:179-86.
2. Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 2003; 3:155-68.
3. Kastan MB, Bartek J. Cell cycle checkpoints and cancer. Nature 2004; 432:316-23.
4. Bartek J, Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 2003; 3:421-9.
5. Bartek J, Lukas C, Lukas J. Checking on DNA damage in S phase. Nature Rev Mol Cell Biol 2004; 5:792-804.
6. Bernstein JL, Seminara D, Böressen-Dale AL. Workshop on the epidemiology of the ATM gene: Impact on breast cancer risk and treatment, present status and future focus. Breast Cancer Res 2002; 4:249-52.
7. Bassing CH, Alt FW. The cellular response to general and programmed DNA double strand breaks. DNA Repair 2004; 3:781-96.
8. Shechter D, Costanzo V, Gautier J. ATR and ATM regulate the timing of DNA replication origin firing. Nature Cell Biol 2004; 6:648-55.
9. d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, von Zglinicki T, Saretzki G, Carter NP, Jackson SP. A DNA damage checkpoint response in telomere-initiated senescence Nature 2003; 426:194-8.
10. Takai H, Smogorzewska A, de Lange T. DNA damage foci at dysfunctional telomeres. Curr Biol 2003; 13:1549-1556.
11. Bakkenist CJ, Drissi R, Wu J, Kastan MB, Dome JS. Disappearance of the telomere dysfunction-induced stress response in fully senescent cells. Cancer Res 2004; 64:3748-52.
12. Bakkenist CJ, Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimmer dissociation. Nature 2003; 421:499-506.
13. Bakkenist CJ, Kastan MB. Initiating cellular stress responses. Cell 2004; 118:9-17.
14. Falck J, Coates J, Jackson SP., Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 2005; 434:605-11.
15. Petrini JH, Stracker TH. The cellular response to DNA double-strand breaks: defining the sensors and mediators. Trends Cell Biol 2003; 13:458-62.
16. Lee JH, Paull TT. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 2005, (March 24, Epub ahead of print).
17. DiTullio RA Jr, Mochan TA, Venere M, Bartkova J, Sehested M, Bartek J, Halazonetis TD. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer Nature Cell Biology 2002; 4:998-1002.
18. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 1998; 281:1677-9.
19. Bartkova J, Guldberg P, Gronbaek K, Koed K, Primdahl H, Moller K, Lukas J, Orntoft TF, Bartek J. Aberrations of the Chk2 tumor suppressor in advanced urinary bladder cancer. Oncogene 2004; 23:8545-51.
20. Gorgoulis VG, Vassiliou L-VF, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, DiTullio RA, Kastrinakis NG, Levy B, Kletsas D, Yoneta A, Herlyn M, Kittas C, Halazonetis TD. Activation of the DNA damage checkpoint and genomic instability are early events in the natural history of human cancer. Nature 2005; 434:307-13.
21. Bartkova J, Horejsi Z, Koed K, Krämer A, Tort F, Zieger KL, Guldberg P, Sehested M, Nesland JM, Lukas C, Ørntoft T, Lukas J, Bartek J. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005; 434:864-70.
22. Oosterhuis JW, Looijenga LHJ. Testicular germ-cell tumors in a broader perspective. Nature Rev Cancer 2005; 5:210-22.
23. Rajpert-De Meyts E, Skakkebsek NE. Origin of germ cell cancer: biological and clinical significance of testicular carcinoma in situ. Endocrinologist 2000; 10:335-40.
24. Hamer G, Kal HB, Westphal CH, Ashley T, de Rooij DG. ATM expression and activation in the testis. Biol Reprod 2004; 70:1206-12.
25. Collis SJ, Schwaninger JM, Ntambi AJ, Keller TW, Nelson WG, Dillehay LE, Deweese TL. Evasion of early cellular response mechanisms following low level radiation-induced DNA damage J Biol Chem 2004; 279:49624-32.
26. Bartkova J, Lukas C, Sørensen CS, Rajpert-De Meyts E, Skakkebæk NE, Lukas J, Bartek J. Deregulation of the RB pathway in human testicular germ cell tumors. J Pathol 2003; 200:149-56.
27. Strohmeyer T, Reissmann P, Cordon-Cardo C, Hartmann M, Ackermann R, Slamon D. Correlation between retinoblastoma gene expression and differentiation in human testicular tumors Proc Natl Acad Sci USA 1991; 88:6662-6.
28. Bartkova J, Bartek J, Lukas J, Vojtesek B, Stakova Z, Rejthar A, Kovarik J, Midgley CM, Lane DP. p53 protein alterations in human testicular cancer including preinvasive intratubular germ cell neoplasia. Int J Cancer 1991; 49:196-202.
29. Lutzker S, Levine AJ. A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation. Nature Med 1996; 2:804-10.
30. Lukas C, Bartkova J, Latella L, Falck J, Mailand N, Schroeder T, Sehested M, Lukas J, Bartek J. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. Cancer Res 2001; 61:4990-3.