메뉴 건너뛰기




Volumn 200, Issue 2, 2003, Pages 149-156

Deregulation of the RB pathway in human testicular germ cell tumours

Author keywords

Carcinoma in situ; CDK4; Cell cycle; p151NK4b; p161NK4a; Phosphorylation specific antibody; Retinoblastoma tumour suppressor; Spermatogenesis; Testicular germ cell tumours

Indexed keywords

CYCLIN D; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR; RETINOBLASTOMA PROTEIN; SERINE;

EID: 0038604803     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1353     Document Type: Article
Times cited : (56)

References (31)
  • 1
    • 0031586604 scopus 로고    scopus 로고
    • The retinoblastoma protein pathway in cell cycle control and cancer
    • Bartek J, Bartkova J, Lukas J. The retinoblastoma protein pathway in cell cycle control and cancer. Exp Cell Res 1997; 237: 1-6.
    • (1997) Exp. Cell Res. , vol.237 , pp. 1-6
    • Bartek, J.1    Bartkova, J.2    Lukas, J.3
  • 2
    • 0034660892 scopus 로고    scopus 로고
    • The Pezcoller lecture: Cancer cell cycles revisited
    • Sherr CJ. The Pezcoller lecture: cancer cell cycles revisited. Cancer Res 2000; 60: 3689-3695.
    • (2000) Cancer Res. , vol.60 , pp. 3689-3695
    • Sherr, C.J.1
  • 3
    • 0032517341 scopus 로고    scopus 로고
    • The p16INK4a/CDKN2A tumor suppressor and its relatives
    • 1378
    • Ruas M, Peters G. The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim Biophys Acta 1998; 1378: F115-F177.
    • (1998) Biochim. Biophys. Acta
    • Ruas, M.1    Peters, G.2
  • 4
    • 0032960739 scopus 로고    scopus 로고
    • Defects in cell cycle control and cancer
    • Bartek J, Lukas J, Bartkova J. Defects in cell cycle control and cancer. J Pathol 1999; 187: 95-99.
    • (1999) J. Pathol. , vol.187 , pp. 95-99
    • Bartek, J.1    Lukas, J.2    Bartkova, J.3
  • 5
    • 0030905785 scopus 로고    scopus 로고
    • Aberrant expression of cyclin D2 is an early event in human male germ cell tumorigenesis
    • Houldsworth J, Reuter C, Bosl GJ, Chaganti RSK. Aberrant expression of cyclin D2 is an early event in human male germ cell tumorigenesis. Cell Growth Differ 1997; 8: 293-299.
    • (1997) Cell Growth Differ. , vol.8 , pp. 293-299
    • Houldsworth, J.1    Reuter, C.2    Bosl, G.J.3    Chaganti, R.S.K.4
  • 6
    • 10544256183 scopus 로고    scopus 로고
    • Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
    • Sicinski P, Donaher JL, Geng Y, et al. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature 1996; 384: 470-474.
    • (1996) Nature , vol.384 , pp. 470-474
    • Sicinski, P.1    Donaher, J.L.2    Geng, Y.3
  • 7
    • 0032997009 scopus 로고    scopus 로고
    • D-type cyclins in adult human testis and testicular cancer: Relation to cell type, proliferation, differentiation, and malignancy
    • Bartkova J, Rajpert-de Meyts E, Skakkebæk NE, Bartek J. D-type cyclins in adult human testis and testicular cancer: relation to cell type, proliferation, differentiation, and malignancy. J Pathol 1999; 187: 573-581.
    • (1999) J. Pathol. , vol.187 , pp. 573-581
    • Bartkova, J.1    Rajpert-de Meyts, E.2    Skakkebæk, N.E.3    Bartek, J.4
  • 9
    • 0033989105 scopus 로고    scopus 로고
    • Cell cycle regulation in testicular cancer: Loss of p18INK4C marks progression from carcinoma in situ to invasive germ cell tumours
    • Bartkova J, Thullberg M, Rajpert-de Meyts E, Skakkebæk. NE, Bartek J. Cell cycle regulation in testicular cancer: loss of p18INK4C marks progression from carcinoma in situ to invasive germ cell tumours. Int J Cancer 2000; 85: 370-375.
    • (2000) Int. J. Cancer , vol.85 , pp. 370-375
    • Bartkova, J.1    Thullberg, M.2    Rajpert-de Meyts, E.3    Skakkebæk, N.E.4    Bartek, J.5
  • 10
    • 0031913752 scopus 로고    scopus 로고
    • The origin and biology of CIS cells: General discussion
    • Grigor KM, Wylie CC. The origin and biology of CIS cells: general discussion. APMIS 1998; 106: 221-224.
    • (1998) APMIS , vol.106 , pp. 221-224
    • Grigor, K.M.1    Wylie, C.C.2
  • 11
    • 0032989692 scopus 로고    scopus 로고
    • Pathogenesis of testicular germ cell tumors
    • Looijenga LHJ, Oosterhuis JW. Pathogenesis of testicular germ cell tumors. Rev Reprod 1999; 4: 90-100.
    • (1999) Rev. Reprod. , vol.4 , pp. 90-100
    • Looijenga, L.H.J.1    Oosterhuis, J.W.2
  • 12
    • 0033760969 scopus 로고    scopus 로고
    • Origin of germ cell cancer: Biological and clinical significance of testicular carcinoma in situ
    • Rajpert-De Meyts E, Skakkebæk NE. Origin of germ cell cancer: biological and clinical significance of testicular carcinoma in situ. Endocrinologist 2000; 10: 335-340.
    • (2000) Endocrinologist , vol.10 , pp. 335-340
    • Rajpert-De Meyts, E.1    Skakkebæk, N.E.2
  • 13
    • 0028170508 scopus 로고
    • Testicular cancer in nine northern European countries
    • Adami HO, Bergström R, Möhner M, et al. Testicular cancer in nine northern European countries. Int J Cancer 1994; 59: 33-38.
    • (1994) Int. J. Cancer , vol.59 , pp. 33-38
    • Adami, H.O.1    Bergström, R.2    Möhner, M.3
  • 14
    • 0032879043 scopus 로고    scopus 로고
    • Rising risk of testicular cancer by birth cohort in the United States from 1973 to 1995
    • McKiernan JM, Goluboff ET, Liberson GL, Golden R, Fisch H, Rising risk of testicular cancer by birth cohort in the United States from 1973 to 1995. J Urol 1999; 162: 361-363.
    • (1999) J. Urol. , vol.162 , pp. 361-363
    • McKiernan, J.M.1    Goluboff, E.T.2    Liberson, G.L.3    Golden, R.4    Fisch, H.5
  • 15
    • 0015499388 scopus 로고
    • Possible carcinoma in situ of the testis
    • Skakkebæk NE. Possible carcinoma in situ of the testis. Lancet 1972; ii: 516-517.
    • (1972) Lancet , vol.2 , pp. 516-517
    • Skakkebæk, N.E.1
  • 16
    • 0002639979 scopus 로고
    • Histological classification of germ-cell tumours of the testis
    • Jones WG, Ward AM, Anderson CK (eds). Pergamon: Oxford
    • Mostofi FK, Sesterhenn IA, Davis CJ. Histological classification of germ-cell tumours of the testis. In Germ-Cell Tumours, Vol II, Jones WG, Ward AM, Anderson CK (eds). Pergamon: Oxford, 1986; 1-23.
    • (1986) Germ-Cell Tumours , vol.2 , pp. 1-23
    • Mostofi, F.K.1    Sesterhenn, I.A.2    Davis, C.J.3
  • 17
    • 0034710395 scopus 로고    scopus 로고
    • Lack of p19INK4d in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesis
    • Bartkova J, Thullberg M, Rajpert-De Meyts E, Skakkebæk NE, Bartek J. Lack of p19INK4d in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesis. Oncogene 2000; 19: 4146-4150.
    • (2000) Oncogene , vol.19 , pp. 4146-4150
    • Bartkova, J.1    Thullberg, M.2    Rajpert-De Meyts, E.3    Skakkebæk, N.E.4    Bartek, J.5
  • 18
    • 0032586934 scopus 로고    scopus 로고
    • Immunochemical analysis of the D-type cyclin-dependent kinases Cdk4 and Cdk6, using a series of monoclonal antibodies
    • Lukas C, Skjöde Jensen S, Bartkova J, Lukas J, Bartek J. Immunochemical analysis of the D-type cyclin-dependent kinases Cdk4 and Cdk6, using a series of monoclonal antibodies. Hybridoma 1999; 18: 225-234.
    • (1999) Hybridoma , vol.18 , pp. 225-234
    • Lukas, C.1    Skjöde Jensen, S.2    Bartkova, J.3    Lukas, J.4    Bartek, J.5
  • 19
    • 0026593194 scopus 로고
    • Cellular localisation and T antigen binding of the retinoblastoma protein
    • Bartek J, Vojtesek B, Grand RJA, Gallimore PH, Lane DP. Cellular localisation and T antigen binding of the retinoblastoma protein. Oncogene 1992; 7: 101-108.
    • (1992) Oncogene , vol.7 , pp. 101-108
    • Bartek, J.1    Vojtesek, B.2    Grand, R.J.A.3    Gallimore, P.H.4    Lane, D.P.5
  • 20
    • 0028925360 scopus 로고
    • Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity
    • Lukas J, Bartkova J, Rohde M, Strauss M, Bartek J. Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Mol Cell Biol 1995; 15: 2600-2611.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 2600-2611
    • Lukas, J.1    Bartkova, J.2    Rohde, M.3    Strauss, M.4    Bartek, J.5
  • 21
    • 0033536076 scopus 로고    scopus 로고
    • p16INK4a, but not constitutively active pRb, is able to impose a sustained G1 arrest: Molecular mechanisms and implications for oncogenesis
    • Lukas J, Sørensen CS, Lukas C, Santoni-Rugiu E, Bartek J. p16INK4a, but not constitutively active pRb, is able to impose a sustained G1 arrest: molecular mechanisms and implications for oncogenesis. Oncogene 1999; 18: 3930-3935.
    • (1999) Oncogene , vol.18 , pp. 3930-3935
    • Lukas, J.1    Sørensen, C.S.2    Lukas, C.3    Santoni-Rugiu, E.4    Bartek, J.5
  • 22
    • 12644284504 scopus 로고    scopus 로고
    • The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2
    • Kitagawa M, Higashi H, Jung HK, et al. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J 1996; 15: 7060-7069.
    • (1996) EMBO J. , vol.15 , pp. 7060-7069
    • Kitagawa, M.1    Higashi, H.2    Jung, H.K.3
  • 23
    • 0032929930 scopus 로고    scopus 로고
    • Defining the substrate specificity of cdk4 kinase-cyclin D1 complex
    • Grafstrom RH, Pan W, Hoess RH. Defining the substrate specificity of cdk4 kinase-cyclin D1 complex. Carcinogenesis 1999; 20: 193-198.
    • (1999) Carcinogenesis , vol.20 , pp. 193-198
    • Grafstrom, R.H.1    Pan, W.2    Hoess, R.H.3
  • 24
    • 0028276571 scopus 로고
    • Expression of the retinoblastoma protein is regulated in normal human tissues
    • Cordon-Cardo C, Richon VM. Expression of the retinoblastoma protein is regulated in normal human tissues. Am J Pathol 1994; 144: 500-510.
    • (1994) Am. J. Pathol. , vol.144 , pp. 500-510
    • Cordon-Cardo, C.1    Richon, V.M.2
  • 26
    • 0031019197 scopus 로고    scopus 로고
    • Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation
    • Connell-Crowley L, Harper JW, Goodrich DW. Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol Biol Cell 1997; 8: 287-301.
    • (1997) Mol. Biol. Cell , vol.8 , pp. 287-301
    • Connell-Crowley, L.1    Harper, J.W.2    Goodrich, D.W.3
  • 28
    • 0030611614 scopus 로고    scopus 로고
    • INK4 (MTS1) gene inactivation in testicular germ cell tumors
    • INK4 (MTS1) gene inactivation in testicular germ cell tumors. Am J Pathol 1997; 151: 859-865.
    • (1997) Am. J. Pathol. , vol.151 , pp. 859-865
    • Chaubert, P.1    Buillou, L.2    Kurt, A.-M.3
  • 29
    • 0035872457 scopus 로고    scopus 로고
    • Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors
    • Schmidt BA, Rose A, Steinhoff C, Strohmeyer, Hartmann M, Ackermann R. Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors. Cancer Res 2001; 61: 4214-4221.
    • (2001) Cancer Res. , vol.61 , pp. 4214-4221
    • Schmidt, B.A.1    Rose, A.2    Steinhoff, C.3    Strohmeyer, A.4    Hartmann, M.5    Ackermann, R.6
  • 30
    • 0035868338 scopus 로고    scopus 로고
    • Differential expression and regulation of the retinoblastoma family of proteins during testicular development and spermatogenesis
    • Yan W, Kero J, Suominen J, Toppari J. Differential expression and regulation of the retinoblastoma family of proteins during testicular development and spermatogenesis. Oncogene 2001; 20: 1343-1356.
    • (2001) Oncogene , vol.20 , pp. 1343-1356
    • Yan, W.1    Kero, J.2    Suominen, J.3    Toppari, J.4
  • 31
    • 0029944241 scopus 로고    scopus 로고
    • A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation
    • Lutzker S, Levine AJ. A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation. Nature Med 1996; 2: 804-810.
    • (1996) Nature Med. , vol.2 , pp. 804-810
    • Lutzker, S.1    Levine, A.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.