New evidence for the origin of intracranial germ cell tumours from primordial germ cells: Expression of pluripotency and cell differentiation markers

Journal of Pathology

Volumn 209, Issue 1, 2006, Pages 25-33

  Hoei Hansen, C E ^a   Sehested, A ^a   Juhler, M ^a   Lau, Y F C ^b   Skakkebaek, N E ^a   Laursen, H ^a   Rajpert De Meyts, E ^a  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AP 2 ; C KIT; Central nervous system; Germ cell tumours; Germinoma; Intracranial; NANOG; Non germinoma; OCT 4; TSPY

Indexed keywords

CELL MARKER; MELANOMA ANTIGEN; NY ESO 1 ANTIGEN; OCTAMER TRANSCRIPTION FACTOR 4; STEM CELL FACTOR; TRANSCRIPTION FACTOR AP 2;

ADULT; ARTICLE; BRAIN TUMOR; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM TUMOR; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; EMBRYONIC STEM CELL; FEMALE; GENDER; GERM CELL TUMOR; GONAD TUMOR; GONADOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MALIGNANT TRANSFORMATION; PATHOGENESIS; PHENOTYPE; PLURIPOTENT STEM CELL; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; ANTIGENS, DIFFERENTIATION; BRAIN NEOPLASMS; CELL DIFFERENTIATION; CHILD; CHILD, PRESCHOOL; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; INFANT, NEWBORN; MALE; NEOPLASM PROTEINS; NEOPLASMS, GERM CELL AND EMBRYONAL; PLURIPOTENT STEM CELLS; STROMAL CELLS; TRANSCRIPTION FACTORS; TUMOR STEM CELLS;

EID: 33645976805     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.1948     Document Type: Article

References (51)

1. Gobel U, Schneider DT, Calaminus G, Haas RJ, Schmidt P, Harms D. Germ cell tumours in childhood and adolescence. GPOH MAKEI and the MAHO study groups. Ann Oncol 2000;11:263-271.
2. Felix I, Becker LE. Intracranial germ cell tumours in children: an immunohistochemical and electron microscopic study. Pediatr Neurosurg 1990;16:156-162.
3. Dreifaldt AC, Carlberg M, Hardell L. Increasing incidence rates of childhood malignant diseases in Sweden during the period 1960-1998. Eur J Cancer 2004;40:1351-1360.
4. Rosenblum MK, Matsutani M, VanMeir EG. CNS germ cell tumours. In Pathology and Genetics of Tumours of the Nervous System, Kleihues P, Cavanee WK (eds). IARC Press: Lyon, France, 2000; 208-214.
5. Friedman NB. The comparative morphogenesis of extragenital and gonadal teratoid tumours. Cancer 1951;4:265-276.
6. Teilum G. Classification of endodermal sinus turnout (mesoblatoma vitellinum) and so-called "embryonal carcinoma" of the ovary. Acta Pathol Microbiol Scand 1965;64:407-429.
7. Schneider DT, Schuster AE, Fritsch MK, Hu J, Olson T, Lauer S, et al. Multipoint imprinting analysis indicates a common precursor cell for gonadal and nongonadal pediatric germ cell tumours. Cancer Res 2001;61:7268-7276.
8. Skakkebaek NE. Possible carcinoma-in-situ of the testis. Lancet 1972;2:516-517.
9. Hawkins E, Heifetz SA, Giller R, Cushing B. The prepubertal testis (prenatal and postnatal): its relationship to intratubular germ cell neoplasia: a combined Pediatric Oncology Group and Children's Cancer Study Group. Hum Pathol 1997;28:404-410.
10. Bohle A, Studer UE, Sonntag RW, Scheidegger JR. Primary or secondary extragonadal germ cell tumours? J Urol 1986;135: 939-943.
11. Daugaard G, Rorth M, von der Maase H, Skakkebaek NE. Management of extragonadal germ cell tumours and the significance of bilateral testicular biopsies. Ann Oncol 1992;3:283-289.
12. Bussey KJ, Lawce HJ, Olson SB, Arthur DC, Kalousek DK, Krailo M, et al. Chromosome abnormalities of eighty-one pediatric germ cell tumours: sex-, age-, site-, and histopathology-related differences - a Children's Cancer Group study. Genes Chromosomes Cancer 1999;25:134-146.
13. Page DC. Hypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads. Development 1987;101:151-155.
14. Lau Y, Chou P, Iezzoni J, Alonzo J, Komuves L. Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma. Cytogenet Cell Genet 2000;91:160-164.
15. Rajpert-De Meyts E, Skakkebaek NE. Expression of the c-kit protein product in carcinoma-in-situ and invasive testicular germ cell tumours. Int J Androl 1994;17:85-92.
16. Kang JL, Rajpert-De Meyts E, Skakkebaek NE. Immunoreactive neuron-specific enolase (NSE) is expressed in testicular carcinoma-in-situ. J Pathol 1996;178:161-165.
17. Rajpert-De Meyts E, Jorgensen N, Graem N, Muller J, Cate RL, Skakkebaek NE. Expression of anti-Mullerian hormone during normal and pathological gonadal development: association with differentiation of Sertoli and granulosa cells. J Clin Endocrinol Metab 1999;84:3836-3844.
18. Aubry F, Satie AP, Rioux-Leclercq N, Rajpert-De Meyts E, Spagnoli GC, Chomez P, et al. MAGE-A4, a germ cell specific marker, is expressed differentially in testicular tumours. Cancer 2001;92:2778-2785.
19. Satie AP, Rajpert-De Meyts E, Spagnoli GC, Henno S, Olivo L, Jacobsen GK, et al. The cancer-testis gene, NY-ESO-1, is expressed in normal foetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ. Lab Invest 2002;82:775-780.
20. Rajpert-De Meyts E, Hanstein R, Jorgensen N, Graem N, Vogt PH, Skakkebaek NE. Developmental expression of POU5F1 (OCT-3/4) in normal and dysgenetic human gonads. Hum Reprod 2004;19:1338-1344.
21. Hoei-Hansen C, Nielsen JE, Almstrup, K, Graem N, Skakkebaek NE, Leffers H, et al. Transcription factor AP-2gamma is a developmentally regulated marker of testicular carcinoma in situ and germ cell tumours. Clin Cancer Res 2004;10:8521-8530.
22. Hoei-Hansen CE, Almstrup K, Nielsen JE, Brask SS, Graem N, Skakkebaek NE, et al. Stem cell pluripotency factor NANOG is expressed in human foetal gonocytes, testicular carcinoma in situ and germ cell tumours. Histopathology 2005;47:48-56.
23. Kaiser E, Kuzmits R, Pregant P, Burghuber O, Worofka W. Clinical biochemistry of neuron specific enolase. Clin Chim Acta 1989;183:13-31.
24. Niehans GA, Manivel JC, Copland GT, Scheithauer BW, Wick MR. Immunohistochemistry of germ cell and trophoblastic neoplasms. Cancer 1988;62:1113-1123.
25. Kawata M, Sekiya S, Hatakeyama R, Takamizawa H. Neuron-specific enolase as a serum marker for immature teratoma and dysgerminoma. Gynecol Oncol 1989;32:191-197.
26. Honecker F, Kersemaekers AM, Molier M, Van Weeren PC, Stoop H, De Krijger RR, et al. Involvement of E-cadherin and beta-catenin in germ cell tumours and in normal male foetal germ cell development. J Pathol 2004;204:167-174.
27. Skakkebaek NE, Berthelsen JG, Giwercman A, Muller J. Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. Int J Androl 1987;10:19-28.
28. Almstrup K, Hoei-Hansen C, Wirkner U, Blake J, Schwager C, Ansorge W, et al. Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling. Cancer Res 2004;64:4736-4743.
29. Scholer HR, Hatzopoulos AK, Balling R, Suzuki N, Gruss P. A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. EMBO J 1989;8:2543-2550.
30. Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S, et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003;113:643-655.
31. Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 2003;113:631-642.
32. Looijenga LH, Stoop H, de Leeuw HP, Gouveia Brazao CA, Gillis AJ, van Roozendaal KE, et al. POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumours. Cancer Res 2003;63:2244-2250.
33. Hattab EM, Tu PH, Wilson JD, Cheng L. OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. Am J Surg Pathol 2005;29:368-371.
34. Boon T, Coulie PG, Van den EB. Tumour antigens recognized by T cells. Immunol Today 1997;18:267-268.
35. Takahashi K, Shichijo S, Noguchi M, Hirohata M, Itoh K. Identification of MAGE-1 and MAGE-4 proteins in spermatogonia and primary spermatocytes of testis. Cancer Res 1995;55:3478-3482.
36. Lau YF. Gonadoblastoma, testicular and prostate cancers, and the TSPY gene. Am J Hum Genet 1999;64:921-927.
37. Kersemaekers AM, Honecker F, Stoop H, Cools M, Molier M, Wolffenbuttel K, et al. Identification of germ cells at risk for neoplastic transformation in gonadoblastoma. Hum Pathol 2005;36: 512-521.
38. Schnieders F, Dork T, Arnemann J, Vogel T, Werner M, Schmidtke J. Testis-specific protein, Y-encoded (TSPY) expression in testicular tissues. Hum Mol Genet 1996;5:1801-1807.
39. Yin YH, Li YY, Qiao H, Wang HC, Yang XA, Zhang HG, et al. TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma. Br J Cancer 2005;93:458-463.
40. Jorgensen N, Rajpert-De Meyts E, Graem N, Muller J, Giwercman A, Skakkebaek NE. Expression of immunohistochemical markers for testicular carcinoma in situ by normal human foetal germ cells. Lab Invest 1995;72:223-231.
41. Strohmeyer T, Reese D, Press M, Ackermann R, Hartmann M, Slamon D. Expression of the c-kit proto-oncogene and its ligand stem cell factor (SCF) in normal and malignant human testicular tissue. J Urol 1995;153:511-515.
42. Pauls K, Jager R, Weber S, Wardelmann E, Koch A, Buttner R, et al. Transcription factor AP-2gamma, a novel marker of gonocytes and seminomatous germ cell tumours. Int J Cancer 2005;115:470-477.
43. Molyneaux K, Wylie C. Primordial germ cell migration. Int J Dev Biol 2004;48:537-544.
44. Takeshima H, Kaji M, Uchida H, Hirano H, Kuratsu J. Expression and distribution of c-kit receptor and its ligand in human CNS germ cell tumours: a useful histological marker for the diagnosis of germinoma. Brain Tumour Pathol 2004;21:13-16.
45. Looijenga. LH, de Leeuw H, van Oorschot M, van Gurp RJ, Stoop H, Gillis AJ, et al. Stem cell factor receptor (c-KIT) codon 816 mutations predict development of bilateral testicular germ cell tumours. Cancer Res 2003;63:7674-7678.
46. Visfeldt J, Cortes D, Thorup JM, Byskov AG. Anti-MIC2 as a tool in examination of testicular biopsies. APMIS 1999;107:631-635.
47. Kommoss F, Oliva E, Bittinger F, Kirkpatrick CJ, Amin MB, Bhan AK, et al. Inhibin-alpha CD99, HEA125, PLAP, and chromogranin immunoreactivity in testicular neoplasms and the androgen insensitivity syndrome. Hum Pathol 2000;31:1055-1061.
48. Al Bozom IA, El Faqih SR, Hassan SH, El Tiraifi AE, Talic RF. Granulosa cell tumour of the adult type: a case report and review of the literature of a very rare testicular tumour. Arch Pathol Lab Med 2000;124:1525-1528.
49. Comperat E, Tissier F, Boye K, De Pinieux G, Vieillefond A. Non-Leydig sex-cord tumours of the testis. The place of immunohistochemistry in diagnosis and prognosis. A study of twenty cases. Virchows Arch 2004;444:567-571.
50. Matias-Guiu X, Pons C, Prat J. Mullerian inhibiting substance, alpha-inhibin, and CD99 expression in sex cord-stromal tumours and endometrioid ovarian carcinomas resembling sex cord-stromal tumours. Hum Pathol 1998;29:840-845.
51. Skakkebaek NE, Rajpert-De Meyts E, Main KM. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 2001;16:972-978.