-
1
-
-
0035487104
-
The INK4a/ARF network in tumour suppression.
-
doi: 10.1038/35096061
-
Sherr CJ. The INK4a/ARF network in tumour suppression. Nat Rev Mol Cell Biol 2001, 2:731-737. doi: 10.1038/35096061
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 731-737
-
-
Sherr, C.J.1
-
2
-
-
50149120366
-
Cellular mechanisms of tumour suppression by the retinoblastoma gene.
-
doi:10.1038/nrc2399.
-
Burkhart DL, Sage J. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer 2008, 8:671-682. doi:10.1038/nrc2399.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 671-682
-
-
Burkhart, D.L.1
Sage, J.2
-
3
-
-
65349103899
-
Blinded by the light: the growing complexity of p53.
-
doi:10.1016/j.cell.2009.04.037.
-
Vousden KH, Prives C. Blinded by the light: the growing complexity of p53. Cell 2009, 137:413-431. doi:10.1016/j.cell.2009.04.037.
-
(2009)
Cell
, vol.137
, pp. 413-431
-
-
Vousden, K.H.1
Prives, C.2
-
4
-
-
70350565471
-
P53-a jack of all trades but master of none.
-
doi:10.1038/nrc2778].
-
Juntilla MR, Evan GI. P53-a jack of all trades but master of none. Nat Rev Cancer 2009, 9:821-829. doi:10.1038/nrc2778].
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 821-829
-
-
Juntilla, M.R.1
Evan, G.I.2
-
5
-
-
59349088766
-
Small DNA tumor viruses: large contributors to biomedical sciences.
-
doi: 10.1016/j.virol.2008. 12.006.
-
Howley PM, Livingston DM. Small DNA tumor viruses: large contributors to biomedical sciences. Virology 2009, 384:256-259. doi: 10.1016/j.virol.2008. 12.006.
-
(2009)
Virology
, vol.384
, pp. 256-259
-
-
Howley, P.M.1
Livingston, D.M.2
-
6
-
-
0033834247
-
Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology.
-
doi:10.1038/78592.
-
Wright WE, Shay JW. Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology. Nat Med 2000, 6:849-851. doi:10.1038/78592.
-
(2000)
Nat Med
, vol.6
, pp. 849-851
-
-
Wright, W.E.1
Shay, J.W.2
-
7
-
-
0030931491
-
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA.
-
doi:10.1016/S0092-8674(01)80006-4.
-
Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp P, DePinho RA, Greider CW. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997, 91:25-34. doi:10.1016/S0092-8674(01)80006-4.
-
(1997)
Cell
, vol.91
, pp. 25-34
-
-
Blasco, M.A.1
Lee, H.W.2
Hande, M.P.3
Samper, E.4
Lansdorp, P.5
DePinho, R.A.6
Greider, C.W.7
-
8
-
-
0034632717
-
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice.
-
doi:10.1038/ 35020592.
-
Artandi SE, Chang S, Lee SL, Alson S, Gottleib GJ, Chin L, DePinho RA. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 2000, 406:641-645. doi:10.1038/ 35020592.
-
(2000)
Nature
, vol.406
, pp. 641-645
-
-
Artandi, S.E.1
Chang, S.2
Lee, S.L.3
Alson, S.4
Gottleib, G.J.5
Chin, L.6
DePinho, R.A.7
-
9
-
-
78650990326
-
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.
-
doi:10.1038/nature09603.
-
Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Cadiñanos J, et al. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 2011, 469:102-106. doi:10.1038/nature09603.
-
(2011)
Nature
, vol.469
, pp. 102-106
-
-
Jaskelioff, M.1
Muller, F.L.2
Paik, J.H.3
Thomas, E.4
Jiang, S.5
Adams, A.C.6
Sahin, E.7
Kost-Alimova, M.8
Protopopov, A.9
Cadiñanos, J.10
-
10
-
-
0033588882
-
The INK4 family of cell cycle inhibitors in cancer.
-
Roussel MF. The INK4 family of cell cycle inhibitors in cancer. Oncogene 1999, 18:5311-5317.
-
(1999)
Oncogene
, vol.18
, pp. 5311-5317
-
-
Roussel, M.F.1
-
11
-
-
33750030758
-
The regulation of INK4/ARF in cancer and aging.
-
doi:10. 1016/j.cell.2006.10.003.
-
Kim WY, Sharpless NE. The regulation of INK4/ARF in cancer and aging. Cell 2006, 127:265-275. doi:10. 1016/j.cell.2006.10.003.
-
(2006)
Cell
, vol.127
, pp. 265-275
-
-
Kim, W.Y.1
Sharpless, N.E.2
-
12
-
-
33747587608
-
Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.
-
doi:10. 1038/nrm1987.
-
Gil J, Peters G. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol 2006, 7:667-677. doi:10. 1038/nrm1987.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 667-677
-
-
Gil, J.1
Peters, G.2
-
13
-
-
0035817688
-
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.
-
doi:10.1038/35092592.
-
Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguiree AJ, Wu EA, Horner JW, DePinho RA. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 413:86-91. doi:10.1038/35092592.
-
Nature
, vol.413
, pp. 86-91
-
-
Sharpless, N.E.1
Bardeesy, N.2
Lee, K.H.3
Carrasco, D.4
Castrillon, D.H.5
Aguiree, A.J.6
Wu, E.A.7
Horner, J.W.8
DePinho, R.A.9
-
14
-
-
0035817687
-
Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice.
-
doi:10.1038/35092584.
-
Krimpenfort P, Quon KC, Mooi WJ, Loonstra A, Berns A. Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. Nature 2001, 413:83-86. doi:10.1038/35092584.
-
(2001)
Nature
, vol.413
, pp. 83-86
-
-
Krimpenfort, P.1
Quon, K.C.2
Mooi, W.J.3
Loonstra, A.4
Berns, A.5
-
15
-
-
0033574614
-
Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors.
-
doi:10.1006/jmbi.1999.2640.
-
Pavletich NP. Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors. J Mol Biol 1999, 287:821-828. doi:10.1006/jmbi.1999.2640.
-
(1999)
J Mol Biol
, vol.287
, pp. 821-828
-
-
Pavletich, N.P.1
-
16
-
-
34548176271
-
p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a.
-
doi:10.1038/nature06084].
-
Krimpenfort P, Ijpenberg A, Song JY, vand der Valk M, Nawjin M, Zevenhoven J, Berns A. p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a. Nature 2007, 448:943-946. doi:10.1038/nature06084].
-
(2007)
Nature
, vol.448
, pp. 943-946
-
-
Krimpenfort, P.1
Ijpenberg, A.2
Song, J.Y.3
vand der Valk, M.4
Nawjin, M.5
Zevenhoven, J.6
Berns, A.7
-
17
-
-
41449108880
-
Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development.
-
doi:10.1016/j.ccr.2008.02.010.
-
Wiedemeyer R, Brennan C, Hefferman TP, Xiao Y, Mahoney J, Protopopov A, Zheng H, Bignell G, Furnari F, Cavenee WK, et al. Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development. Cancer Cell 2008, 13:355-364. doi:10.1016/j.ccr.2008.02.010.
-
(2008)
Cancer Cell
, vol.13
, pp. 355-364
-
-
Wiedemeyer, R.1
Brennan, C.2
Hefferman, T.P.3
Xiao, Y.4
Mahoney, J.5
Protopopov, A.6
Zheng, H.7
Bignell, G.8
Furnari, F.9
Cavenee, W.K.10
-
18
-
-
33747819484
-
Divorcing Arf and p53: an unsettled case.
-
doi:10.1038/nrc1954.
-
Sherr CJ. Divorcing Arf and p53: an unsettled case. Nat Rev Cancer 2006, 6:663-673. doi:10.1038/nrc1954.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 663-673
-
-
Sherr, C.J.1
-
19
-
-
0030728468
-
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame protein p19ARF.
-
doi:10.1016/S0092-8674(00)80452-3.
-
Kamijo T, Zindy F, Roussel MF, Quelle DE, Downing JR, Ashmun RA, Grosveld G, Sherr CJ. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame protein p19ARF. Cell 1997, 649-659. doi:10.1016/S0092-8674(00)80452-3.
-
(1997)
Cell
, pp. 649-659
-
-
Kamijo, T.1
Zindy, F.2
Roussel, M.F.3
Quelle, D.E.4
Downing, J.R.5
Ashmun, R.A.6
Grosveld, G.7
Sherr, C.J.8
-
20
-
-
0029993450
-
Role of the INK4a locus in tumor suppression and cell mortality.
-
doi:10.1016/S0092-8674(00)81079-X.
-
Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA. Role of the INK4a locus in tumor suppression and cell mortality. Cell 1996, 85:27-37. doi:10.1016/S0092-8674(00)81079-X.
-
(1996)
Cell
, vol.85
, pp. 27-37
-
-
Serrano, M.1
Lee, H.2
Chin, L.3
Cordon-Cardo, C.4
Beach, D.5
DePinho, R.A.6
-
21
-
-
0032504783
-
P14ARF links the tumour suppressors RB and p53.
-
doi:10.1038/25867.
-
Bates S, Phillips AC, Clark PA, Stott F, Peters G, Ludwig RL, Vousden KH. P14ARF links the tumour suppressors RB and p53. Nature 1998, 395:124-125. doi:10.1038/25867.
-
(1998)
Nature
, vol.395
, pp. 124-125
-
-
Bates, S.1
Phillips, A.C.2
Clark, P.A.3
Stott, F.4
Peters, G.5
Ludwig, R.L.6
Vousden, K.H.7
-
22
-
-
0032169516
-
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.
-
doi:10.1093/emboj/17.17.5001.
-
Stott FJ, Bates S, James MC, McConnell BB, Starborg M, Brookes S, Palmero I, Ryan K, Hara E, Vousden KH, et al. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J 1998, 17:5001-5014. doi:10.1093/emboj/17.17.5001.
-
(1998)
EMBO J
, vol.17
, pp. 5001-5014
-
-
Stott, F.J.1
Bates, S.2
James, M.C.3
McConnell, B.B.4
Starborg, M.5
Brookes, S.6
Palmero, I.7
Ryan, K.8
Hara, E.9
Vousden, K.H.10
-
23
-
-
0030944985
-
Oncogenic ras promotes premature cell senescence associated with accumulation of p53 and p16INK4a.
-
doi:10.1016/S0092-8674(00)81 902-9.
-
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras promotes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88:593-602. doi:10.1016/S0092-8674(00)81 902-9.
-
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
24
-
-
33745712849
-
The power and promise of oncogene-induced senescence markers.
-
doi:10.1038/nrc1884.
-
Collado M, Serrano M. The power and promise of oncogene-induced senescence markers. Nat Rev Cancer 2006, 6:472-476. doi:10.1038/nrc1884.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 472-476
-
-
Collado, M.1
Serrano, M.2
-
25
-
-
79951912532
-
Four faces of cellular senescence.
-
doi: 10.1083/ jcb.201009094.
-
Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol 2011, 192:547-556. doi: 10.1083/ jcb.201009094.
-
(2011)
J Cell Biol
, vol.192
, pp. 547-556
-
-
Rodier, F.1
Campisi, J.2
-
26
-
-
72949096792
-
Senescence in tumours: evidence from mice and humans.
-
doi:10.1038/nrc2772.
-
Collado M, Serrano M. Senescence in tumours: evidence from mice and humans. Nat Rev Cancer 2010, 10:51-57. doi:10.1038/nrc2772.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 51-57
-
-
Collado, M.1
Serrano, M.2
-
27
-
-
68549099997
-
Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology.
-
doi: 10.1101/sqb.2008.73.048.
-
Krizhanovsky V, Xue W, Zender L, Yon M, Hernando E, Lowe SW. Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology. Cold Spring Harb Symp Quant Biol 2008, 73:513-522. doi: 10.1101/sqb.2008.73.048.
-
(2008)
Cold Spring Harb Symp Quant Biol
, vol.73
, pp. 513-522
-
-
Krizhanovsky, V.1
Xue, W.2
Zender, L.3
Yon, M.4
Hernando, E.5
Lowe, S.W.6
-
28
-
-
40449120350
-
An oncogene-induced DNA damage model for cancer development.
-
doi: 10.1126/science.1140735.
-
Halazonetis TD, Gorgoulis VG, Bartek J. An oncogene-induced DNA damage model for cancer development. Science 2008, 319:1352-1355. doi: 10.1126/science.1140735.
-
(2008)
Science
, vol.319
, pp. 1352-1355
-
-
Halazonetis, T.D.1
Gorgoulis, V.G.2
Bartek, J.3
-
29
-
-
34548186667
-
Cellular senescence: when bad things happen to good cells.
-
doi:10.1038/nrm2233.
-
Campisi J, D'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 2007, 8:729-740. doi:10.1038/nrm2233.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 729-740
-
-
Campisi, J.1
D'Adda di Fagagna, F.2
-
30
-
-
11144268164
-
Significant role for p16INK4a in p53-dependent telomere-directed senescence.
-
doi:10.1016/j.cub.2004.12.025.
-
Jacobs JJ, de Lange T. Significant role for p16INK4a in p53-dependent telomere-directed senescence. Curr Biol 2004, 14:2302-2308. doi:10.1016/j.cub.2004.12.025.
-
(2004)
Curr Biol
, vol.14
, pp. 2302-2308
-
-
Jacobs, J.J.1
de Lange, T.2
-
31
-
-
77950265945
-
Linking functional decline of telomeres, mitochondria, and stem cells during ageing.
-
doi:10.1038/nature08982.
-
Sahin E, DePinho RA. Linking functional decline of telomeres, mitochondria, and stem cells during ageing. Nature 2010, 464:520-528. doi:10.1038/nature08982.
-
(2010)
Nature
, vol.464
, pp. 520-528
-
-
Sahin, E.1
DePinho, R.A.2
-
32
-
-
34447543913
-
Cellular senescence in cancer and aging.
-
doi:10.1016/j.cell.2007.07.003.
-
Collado M, Blasco MA, Serrano M. Cellular senescence in cancer and aging. Cell 2007, 130:223-233. doi:10.1016/j.cell.2007.07.003.
-
(2007)
Cell
, vol.130
, pp. 223-233
-
-
Collado, M.1
Blasco, M.A.2
Serrano, M.3
-
33
-
-
0033553516
-
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis.
-
doi:10.1016/ S0092-8674(00)80762-X.
-
Chin L, Artandi SE, Shen Q, Tam A, Lee SL, Gottlieb GJ, Greider CW, DePinho RA. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 1999, 97:527-538. doi:10.1016/ S0092-8674(00)80762-X.
-
(1999)
Cell
, vol.97
, pp. 527-538
-
-
Chin, L.1
Artandi, S.E.2
Shen, Q.3
Tam, A.4
Lee, S.L.5
Gottlieb, G.J.6
Greider, C.W.7
DePinho, R.A.8
-
34
-
-
34247225987
-
Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse.
-
doi: 10.1073/ pnas.0700093104.
-
Khoo CM, Carrasco DR, Bosenberg MW, Paik JH, DePinho RA. Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse. Proc Natl Acad Sci U S A 2007, 104:3931-3936. doi: 10.1073/ pnas.0700093104.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 3931-3936
-
-
Khoo, C.M.1
Carrasco, D.R.2
Bosenberg, M.W.3
Paik, J.H.4
DePinho, R.A.5
-
35
-
-
70350220586
-
Mechanisms of stem cell self-renewal.
-
doi: 10.1146/annurev.cellbio.042308. 113248.
-
He S, Nakada D, Morrison SJ. Mechanisms of stem cell self-renewal. Annu Rev Cell Dev Biol 2009, 25:377-406. doi: 10.1146/annurev.cellbio.042308. 113248.
-
(2009)
Annu Rev Cell Dev Biol
, vol.25
, pp. 377-406
-
-
He, S.1
Nakada, D.2
Morrison, S.J.3
-
36
-
-
0033564697
-
CDK inhibitors: positive and negative regulators of G1-phase progression.
-
Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999, 13:1501-1512.
-
(1999)
Genes Dev
, vol.13
, pp. 1501-1512
-
-
Sherr, C.J.1
Roberts, J.M.2
-
37
-
-
4444307411
-
Mouse development and cell proliferation in the absence of D-cyclins.
-
doi:10.1016/j.cell.2004.07.025.
-
Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, et al. Mouse development and cell proliferation in the absence of D-cyclins. Cell 2004, 118:477-491. doi:10.1016/j.cell.2004.07.025.
-
(2004)
Cell
, vol.118
, pp. 477-491
-
-
Kozar, K.1
Ciemerych, M.A.2
Rebel, V.I.3
Shigematsu, H.4
Zagozdzon, A.5
Sicinska, E.6
Geng, Y.7
Yu, Q.8
Bhattacharya, S.9
Bronson, R.T.10
-
38
-
-
33750379420
-
Polycomb silencers control cell fate, development and cancer.
-
doi:10.1038/nrc1991.
-
Sparmann A, van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 2006, 6:846-856. doi:10.1038/nrc1991.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 846-856
-
-
Sparmann, A.1
van Lohuizen, M.2
-
39
-
-
66449121507
-
Stem cells use distinct self-renewal programs at different ages.
-
doi: 10.1101/sqb. 2008.73.049.
-
Levi BP, Morrison SJ. Stem cells use distinct self-renewal programs at different ages. Cold Spring Harb Symp Quant Biol 2008, 73:539-553. doi: 10.1101/sqb. 2008.73.049.
-
(2008)
Cold Spring Harb Symp Quant Biol
, vol.73
, pp. 539-553
-
-
Levi, B.P.1
Morrison, S.J.2
-
40
-
-
0033552813
-
The oncogene and polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus.
-
doi:10.1038/16476.
-
Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M. The oncogene and polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 1999, 397:164-168. doi:10.1038/16476.
-
(1999)
Nature
, vol.397
, pp. 164-168
-
-
Jacobs, J.J.1
Kieboom, K.2
Marino, S.3
DePinho, R.A.4
van Lohuizen, M.5
-
41
-
-
22344449361
-
Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.
-
doi: 10.1101/gad.1299505.
-
Molofsky AV, He S, Bydon M, Morrison SJ, Pardal R. Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev 2005, 19:1432-1437. doi: 10.1101/gad.1299505.
-
(2005)
Genes Dev
, vol.19
, pp. 1432-1437
-
-
Molofsky, A.V.1
He, S.2
Bydon, M.3
Morrison, S.J.4
Pardal, R.5
-
42
-
-
43449084346
-
Long-term haematopoietic reconstitution by Trp53-/- p16Ink4a-/- Arf-/- multipotent progenitors.
-
doi:10.1038/nature06869.
-
Akala OO, Park IK, Qian D, Pihalja M, Becker MF, Clarke MF. Long-term haematopoietic reconstitution by Trp53-/- p16Ink4a-/- Arf-/- multipotent progenitors. Nature 2008, 453:228-232. doi:10.1038/nature06869.
-
(2008)
Nature
, vol.453
, pp. 228-232
-
-
Akala, O.O.1
Park, I.K.2
Qian, D.3
Pihalja, M.4
Becker, M.F.5
Clarke, M.F.6
-
43
-
-
44849129491
-
Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL.
-
doi: 10.1101/ gad.1673908.
-
Mullighan CG, Williams RT, Downing JR, Sherr CJ. Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL. Genes Dev 2008, 22:1411-1415. doi: 10.1101/ gad.1673908.
-
(2008)
Genes Dev
, vol.22
, pp. 1411-1415
-
-
Mullighan, C.G.1
Williams, R.T.2
Downing, J.R.3
Sherr, C.J.4
-
44
-
-
34548841964
-
Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemia.
-
doi: 10.1101/gad.1588607.
-
Williams RT, den Besten W, Sherr CJ. Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemia. Genes Dev 2007, 21:2283-2287. doi: 10.1101/gad.1588607.
-
(2007)
Genes Dev
, vol.21
, pp. 2283-2287
-
-
Williams, R.T.1
den Besten, W.2
Sherr, C.J.3
-
45
-
-
78751661556
-
Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells.
-
doi:10.1038/nature09733.
-
Notta F, Mullighan CG, Wang JC, Poeppl A, Doulatov S, Phillips LA, Ma J, Minden MD, Downing JR, Dick JE. Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells. Nature 2011, 469:362-367. doi:10.1038/nature09733.
-
(2011)
Nature
, vol.469
, pp. 362-367
-
-
Notta, F.1
Mullighan, C.G.2
Wang, J.C.3
Poeppl, A.4
Doulatov, S.5
Phillips, L.A.6
Ma, J.7
Minden, M.D.8
Downing, J.R.9
Dick, J.E.10
-
46
-
-
24344506258
-
Cancer stem cells: lessons from leukemia.
-
doi: 10.1016/j.tcb.2005.07.004.
-
Wang JC, Dick JE. Cancer stem cells: lessons from leukemia. Trends Cell Biol 2005, 15:494-501. doi: 10.1016/j.tcb.2005.07.004.
-
(2005)
Trends Cell Biol
, vol.15
, pp. 494-501
-
-
Wang, J.C.1
Dick, J.E.2
-
47
-
-
0030612349
-
Expression of the p16INK4a tumor suppressor versus other INK4A family members during mouse development and aging.
-
Zindy F, Quelle DE, Roussel MF, Sherr CJ. Expression of the p16INK4a tumor suppressor versus other INK4A family members during mouse development and aging. Oncogene 1997, 15:203-211.
-
(1997)
Oncogene
, vol.15
, pp. 203-211
-
-
Zindy, F.1
Quelle, D.E.2
Roussel, M.F.3
Sherr, C.J.4
-
48
-
-
33749172559
-
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.
-
doi:10.1038/nature05159.
-
Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 2006, 443:421-426. doi:10.1038/nature05159.
-
(2006)
Nature
, vol.443
, pp. 421-426
-
-
Janzen, V.1
Forkert, R.2
Fleming, H.E.3
Saito, Y.4
Waring, M.T.5
Dombkowski, D.M.6
Cheng, T.7
DePinho, R.A.8
Sharpless, N.E.9
Scadden, D.T.10
-
49
-
-
33749187810
-
p16INK4a induces an age-dependent decline in islet regenerative potential.
-
doi:10.1038/ nature05092.
-
Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE. p16INK4a induces an age-dependent decline in islet regenerative potential. Nature 2006, 443:453-457. doi:10.1038/ nature05092.
-
(2006)
Nature
, vol.443
, pp. 453-457
-
-
Krishnamurthy, J.1
Ramsey, M.R.2
Ligon, K.L.3
Torrice, C.4
Koh, A.5
Bonner-Weir, S.6
Sharpless, N.E.7
-
50
-
-
33749171885
-
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing.
-
doi:10.1038/nature05091.
-
Molofsky AV, Slutsky SG, Joseph NM, He S, Pardal R, Krishnamurthy J, Sharpless NE, Morrison SJ. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 2006, 443:448-452. doi:10.1038/nature05091.
-
(2006)
Nature
, vol.443
, pp. 448-452
-
-
Molofsky, A.V.1
Slutsky, S.G.2
Joseph, N.M.3
He, S.4
Pardal, R.5
Krishnamurthy, J.6
Sharpless, N.E.7
Morrison, S.J.8
-
51
-
-
84900969225
-
Ink4a/Arf expression is a biomarker of aging.
-
doi:10.1172/JCI22475.
-
Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, Sharpless NE. Ink4a/Arf expression is a biomarker of aging. J Clin Invest 2004, 114:1299-1307. doi:10.1172/JCI22475.
-
(2004)
J Clin Invest
, vol.114
, pp. 1299-1307
-
-
Krishnamurthy, J.1
Torrice, C.2
Ramsey, M.R.3
Kovalev, G.I.4
Al-Regaiey, K.5
Su, L.6
Sharpless, N.E.7
-
52
-
-
56549120340
-
Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf.
-
doi: 10.1101/ gad.1715808.
-
Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf. Genes Dev 2008, 22:3115-3120. doi: 10.1101/ gad.1715808.
-
(2008)
Genes Dev
, vol.22
, pp. 3115-3120
-
-
Signer, R.A.1
Montecino-Rodriguez, E.2
Witte, O.N.3
Dorshkind, K.4
-
53
-
-
79953086335
-
Expression of p16INK4a prevents cancer and promotes aging in lymphocytes.
-
doi: 10.1182/ blood-2010-09-304402.
-
Liu Y, Johnson SM, Fedoriw Y, Rogers AB, Yuan H, Krishnamurthy J, Sharpless NE. Expression of p16INK4a prevents cancer and promotes aging in lymphocytes. Blood 2011, 117:3257-3267. doi: 10.1182/ blood-2010-09-304402.
-
(2011)
Blood
, vol.117
, pp. 3257-3267
-
-
Liu, Y.1
Johnson, S.M.2
Fedoriw, Y.3
Rogers, A.B.4
Yuan, H.5
Krishnamurthy, J.6
Sharpless, N.E.7
-
54
-
-
34447517413
-
Delayed ageing through damage protection by the Arf/p53 pathway.
-
doi:10. 1038/nature05949.
-
Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, Borras C, Flores JM, Viňa J, Blasco MA, Serrano M. Delayed ageing through damage protection by the Arf/p53 pathway. Nature 2007, 448:375-379. doi:10. 1038/nature05949.
-
(2007)
Nature
, vol.448
, pp. 375-379
-
-
Matheu, A.1
Maraver, A.2
Klatt, P.3
Flores, I.4
Garcia-Cao, I.5
Borras, C.6
Flores, J.M.7
Viňa, J.8
Blasco, M.A.9
Serrano, M.10
-
55
-
-
67349156082
-
Bmi1 regulates mitochondrial function and the DNA damage response pathway.
-
doi:10.1038/nature08040.
-
Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, et al. Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature 2009, 459:387-392. doi:10.1038/nature08040.
-
(2009)
Nature
, vol.459
, pp. 387-392
-
-
Liu, J.1
Cao, L.2
Chen, J.3
Song, S.4
Lee, I.H.5
Quijano, C.6
Liu, H.7
Keyvanfar, K.8
Chen, H.9
Cao, L.Y.10
-
56
-
-
34248547495
-
Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF.
-
doi: 10.1158/0008-5472.CAN-06-2004.
-
Pasmant E, Laurendeau I, Héron D, Vidaud M, Vidaud D, Bièche I. Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. Cancer Res 2007, 67:3963-3369. doi: 10.1158/0008-5472.CAN-06-2004.
-
(2007)
Cancer Res
, vol.67
, pp. 3963-3369
-
-
Pasmant, E.1
Laurendeau, I.2
Héron, D.3
Vidaud, M.4
Vidaud, D.5
Bièche, I.6
-
57
-
-
64549083268
-
INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis.
-
doi: 10.1371/journal.pone.0005027.
-
Liu Y, Sanoff HK, Cho H, Burd CE, Torrice C, Mohlke KL, Ibrahim JG, Thomas NE, Sharpless NE. INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis. PLoS One 2009, 4:e5027. doi: 10.1371/journal.pone.0005027.
-
(2009)
PLoS One
, vol.4
-
-
Liu, Y.1
Sanoff, H.K.2
Cho, H.3
Burd, C.E.4
Torrice, C.5
Mohlke, K.L.6
Ibrahim, J.G.7
Thomas, N.E.8
Sharpless, N.E.9
-
58
-
-
77949775636
-
Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice.
-
doi:10.1038/nature08801.
-
Visel A, Zhu Y, May D, Afzal V, Gong E, Attanasio C, Blow MJ, Cohen JC, Rubin EM, Pennacchio LA. Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature 2010, 464:409-412. doi:10.1038/nature08801.
-
(2010)
Nature
, vol.464
, pp. 409-412
-
-
Visel, A.1
Zhu, Y.2
May, D.3
Afzal, V.4
Gong, E.5
Attanasio, C.6
Blow, M.J.7
Cohen, J.C.8
Rubin, E.M.9
Pennacchio, L.A.10
-
59
-
-
79951473520
-
9p21 DNA variants associated with coronary artery disease impair interferon-γ signaling response.
-
doi:10.1038/nature09753.
-
Harismendy O, Notani D, Song X, Rahim NG, Tanasa B, Heintzman N, Ren B, Fu X-D, Topol E, Rosenfeld M, et al. 9p21 DNA variants associated with coronary artery disease impair interferon-γ signaling response. Nature 2011, 470:264-270. doi:10.1038/nature09753.
-
(2011)
Nature
, vol.470
, pp. 264-270
-
-
Harismendy, O.1
Notani, D.2
Song, X.3
Rahim, N.G.4
Tanasa, B.5
Heintzman, N.6
Ren, B.7
Fu, X.-D.8
Topol, E.9
Rosenfeld, M.10
-
60
-
-
77953096072
-
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.
-
doi: 10.1016/j.molcel.2010.03.021.
-
Yap KL, Li S, Muñoz-Cabello AM, Raguz S, Zeng L, Mujtaba S, Gil J, Walsh MJ, Zhou MM. Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell 2010, 38:662-674. doi: 10.1016/j.molcel.2010.03.021.
-
(2010)
Mol Cell
, vol.38
, pp. 662-674
-
-
Yap, K.L.1
Li, S.2
Muñoz-Cabello, A.M.3
Raguz, S.4
Zeng, L.5
Mujtaba, S.6
Gil, J.7
Walsh, M.J.8
Zhou, M.M.9
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