Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylation

Basic Research in Cardiology

Volumn 109, Issue 6, 2014, Pages

  Simon, Jillian N ^a,b   Chowdhury, Shamim A K ^a   Warren, Chad M ^a   Sadayappan, Sakthivel ^d   Wieczorek, David F ^e   Solaro, R John ^a   Wolska, Beata M ^a,c  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d LOYOLA UNIVERSITY CHICAGO   (United States)

^e UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Diabetes; Lipotoxicity; Myosin binding protein C; Troponin

Indexed keywords

C6 DIHYDROCERAMIDE; CALCIUM; CELL PROTEIN; CERAMIDE; CERAMIDE DERIVATIVE; MYOFILAMENT PROTEIN; MYOSIN BINDING PROTEIN C; PROTEIN KINASE C; PROTEIN KINASE C EPSILON; SERINE; SERINE 273; SERINE 302; TROPONIN I; UNCLASSIFIED DRUG; N-CAPROYLSPHINGOSINE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME REGULATION; GROWTH INHIBITION; HEART MUSCLE CELL; INOTROPISM; MALE; MOLECULAR DYNAMICS; MUSCLE FIBER CONTRACTION; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; ANIMAL; METABOLISM; MUSCLE FIBRIL; PHOSPHORYLATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CERAMIDES; MALE; MYOCYTES, CARDIAC; MYOFIBRILS; PHOSPHORYLATION; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84911892265     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-014-0445-6     Document Type: Article

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