CGP-48506 increases contractility of ventricular myocytes and myofilaments by effects on actin-myosin reaction

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 270, Issue 1 39-1, 1996, Pages

  Wolska, Beata M ^a   Kitada, Yoshimi ^a   Palmiter, Kimberly A ^a   Westfall, Margaret V ^a   Johnson, Mary D ^a   Solaro, R John ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

calcium sensitivity; cardiotonic; myocytes; myofilaments

Indexed keywords

1,3,5,6 TETRAHYDRO 5 METHYL 6 PHENYL 3,6 METHANO 1,5 BENZODIAZOCINE 2,4 DIONE; 5 [1 (3,4 DIMETHOXYBENZOYL) 1,2,3,4 TETRAHYDRO 6 QUINOLYL] 3,6 DIHYDRO 6 METHYL 2H 1,3,4 THIADIAZIN 2 ONE; AZOCINE DERIVATIVE; UNCLASSIFIED DRUG;

ACTIN MYOSIN INTERACTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CALCIUM BINDING; CALCIUM CELL LEVEL; CARDIOVASCULAR RESPONSE; CELL MEMBRANE PERMEABILITY; DRUG EFFECT; HEART MUSCLE CELL; LIGAND BINDING; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SMOOTH MUSCLE CONTRACTILITY;

EID: 0030066896     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.270.1.h24     Document Type: Article

References (27)

1. Brenner, B. Changes in calcium sensitivity at the cross-bridge level. In: Modulation of Cardiac Calcium Sensitivity. A New Approach to Increasing the Strength of the Heart, edited by J A. Lee and D. G. Allen. Oxford: Oxford University Press, 1993, p. 197-214.
2. Chiu, Y. L., J. Asayama, and L. E. Ford. A sensitive photoelectric force transducer with a resonant frequency of 6 kHz. Am. J. Physiol. 243 (Cell Physiol. 12): C299-C302, 1982.
3. El-Saleh, S. C., and R. J. Solaro. Calmidazolium, a calmodulin antagonist, stimulates calcium-troponin C and calcium-calmodulin-dependent activation of striated muscle myofilaments. J. Biol. Chem. 262: 17240-17246, 1987.
4. Endo, M., and T. Kitazawa. E-C coupling studies on skinned cardiac fibers. In: Biophysical Aspects of Cardiac Muscle, edited by M. Morad. New York: Academic, 1978, p. 307-327.
5. 2+ activation and the inotropic effect of pimobendan: comparison with milrinone. Circ. Res. 63: 911-922, 1988.
6. Gambassi, G., M. C. Capogrossi, M. Klockow, and E. G. Lakatta. Enantiomeric dissection of the effects of the inotropic agent, EMD-53998, in single cardiac myocytes. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H728-H738, 1993.
7. Gwathmey, J. K., R. J. Hajjar, and R. J. Solaro. Contractile deactivation and uncoupling of crossbridges. Effects of 2,3-butanedione monoxime on mammalian myocardium. Circ. Res. 69: 1280-1292, 1991.
8. Herold, P., J. W. Herzig, P. Wenk, T. Leutert, P. Zbinden, W. Fuhrer, S. Stutz, K. Schenker, M. Meier, and G. Rihs. 5-Methyl-6-phenyl-1,3,5,6-tetrahydro-3,6-methano-1,5-benzodiazocine-2,4-dione (BA 41899): representative of a novel class of purely calcium-sensitizing agents. J. Med. Chem. 38: 2946-2954, 1995.
9. Herrmann, C., J. Wray, F. Travers, and T. Barman. Effect of 2,3-butanedione monoxime on myosin and myofibrillar ATPases. An example of an uncompetitive inhibitor. Biochemistry 31: 12227-12232, 1992.
10. Hibberd, M. G., and B. R. Jewell. Calcium-and length-dependent force production in rat ventricular muscle. J. Physiol. Lond. 329: 527-540, 1982.
11. 2+ binding by MCI-154, a novel cardiotonic agent. J. Pharmacol. Exp. Ther. 250: 272-277, 1989.
12. Kraft, T., I. Lues, and B. Brenner. Increase in force per cross-bridge by EMD-57033, a calcium-sensitizing agent (Abstract). Biophys. J. 66: A188, 1994.
13. 2+-sensitizing agent. Pfluegers Arch. 421: 388-390, 1992.
14. Li, T., N. Sperelakis, R. E. TenEick, and R. J. Solaro. Effects of diacetyl monoxime on cardiac excitation-contraction coupling. J. Pharmacol. Exp. Ther. 232: 688-695, 1985.
15. Pan, B. S., and R. J. Solaro. Calcium-binding properties of troponin C in detergent-skinned heart muscle fibers. J. Biol. Chem. 262: 7839-7849, 1987.
16. Rapundalo, S. T., R. J. Solaro, and E. G. Kranias. Inotropic responses to isoproterenol and phosphodiesterase inhibitors in intact guinea pig hearts: comparison of cAMP levels and phosphorylation of sarcoplasmic reticulum and myofibrillar proteins. Circ. Res. 64: 104-111, 1989.
17. Solaro, R. J., K. Fujino, and N. Sperelakis. The positive inotropic effect of pimobendan involves stereospecific increases in the calcium sensitivity of cardiac myofilaments. J. Cardiovasc. Pharmacol. 14, Suppl. 2: S7-S12, 1989.
18. Solaro, R. J., G. Gambassi, D. M. Warshaw, M. R. Keller, H. A. Spurgeon, N. Beier, and E. G. Lakatta. Stereoselective actions of thiadiazinones on canine cardiac myocytes and myofilaments. Circ. Res 73: 981-990, 1993.
19. Spurgeon, H. A., W. H. DuBell, M. D. Stern, S. J. Sollott, B. D. Ziman, H. S. Silverman, M. C. Capogrossi, A. Talo, and E. G. Lakatta. Cytosolic calcium and myofilaments in single rat cardiac myocytes achieve a dynamic equilibrium during twitch relaxation. J. Physiol. Lond. 447: 83-102, 1992.
20. Steadman, B. W., K. B. Moore, K. W. Spitzer, and J. H. B. Bridge. A video system for measuring motion in contracting heart cells. IEEE Trans. Biomed. Eng. 35: 264-272, 1988.
21. Strauss, J. D., C. Bletz, and J. C. Rüegg. The calcium sensitizer EMD-53998 antagonizes phosphate-induced increases in energy cost of isometric tension in cardiac skinned fibres. Eur. J. Pharmacol. 252: 219-224, 1994.
22. Strauss, J. D., C. Zeugner, and J. C. Rüegg. The positive inotropic calcium sensitizer EMD-53998 antagonizes phosphate action on cross-bridges in cardiac skinned fibers. Eur. J. Pharmacol 227: 437-441, 1992.
23. Westfall, M. V., G. M. Wahler, and R. J. Solaro. A highly specific benzimidazole pyridazinone reverses phosphate-induced changes in cardiac myofilament activation. Biochemistry 32: 10464-10470, 1993.
24. 2+ extrusion from the resting myocytes of guinea-pig heart: comparison with rat. J. Mol. Cell Cardiol. 25: 75-91, 1993.
25. 2+ current in cardiac myocytes isolated from normal mouse (Abstract). Biophys. J. 64: A205, 1993.
26. Yagi, N., S. Takemori, M. Watanabe, K. Horiuti, and Y. Amemiya. Effects of 2,3-butanedione monoxime on contraction of frog skeletal muscles: an X-ray diffraction study. J. Muscle Res. Cell Motil. 13: 153-160, 1992.
27. Zhao, Y., and M. Kawai. BDM affects nucleotide binding and force generation steps of the cross-bridge cycle in rabbit psoas muscle fibers. Am. J. Physiol. 266 (Cell Physiol. 35): C437-C447, 1994.