On the complexities of ceramide changes in cells undergoing apoptosis: Lack of evidence for a second messenger function in apoptotic induction

Cell Death and Differentiation

Volumn 6, Issue 2, 1999, Pages 105-114

  Watts, Julian D ^a   Ming, Gu ^a,b   Patterson, Scott D ^c   Aebersold, Ruedi ^a   Polverino, Anthony J ^c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b PFIZER INC   (United States)

^c AMGEN INC   (United States)

Author keywords

Anisomycin; Electrospray ionization; Geranylgeraniol; Mass spectrometry; Precursor ion scanning; Tumor necrosis factor

Indexed keywords

ANISOMYCIN; CERAMIDE; CYCLOHEXIMIDE; GERANYLGERANIOL; TUMOR NECROSIS FACTOR;

APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIPID ANALYSIS; MASS SPECTROMETRY; PRIORITY JOURNAL; SECOND MESSENGER;

EID: 0345130100     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400472     Document Type: Article

References (38)

1. Ameisen JC (1996) The origin of programmed cell death. Science 272: 1278-1279
2. Hale AJ, Smith CA, Sutherland LC, Stoneman VE, Longthorne VL, Culhane AC and Williams GT (1996) Apoptosis: molecular regulation of cell death. Eur. J. Biochem. 236: 1-26.
3. Merrill Jr, AH, Schmelz EM, Dillehay DL, Spiegel S, Shayman JA, Schroeder JJ, Riley RT, Voss KA and Wang E (1997) Sphingolipids - the enigmatic lipid class: biochemistry, physiology, and pathophysiology. Toxicol. Appl. Pharmacol. 142: 208-225
4. Hannum YA (1996) Functions of ceramide in coordinating cellular responses to stress. Science 274: 1855-1859
5. Kolesnick RN and Krönke M (1998) Regulation of ceramide production and apoptosis. Ann. Rev. Physiol. 60: 643-665
6. Dbaibo GS, Obeid LM and Hannun YA (1993) Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B. J. Biol. Chem. 268: 17762-17766
7. Yang Z, Costanzo M, Golde DW and Kolesnick RN (1993) Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells. J. Biol. Chem. 268: 20520-20523
8. Gulbins E, Bissonnette R, Mahboubi A, Martin S, Nishioka W, Brunner T, Baier G, Baier-Bitterlich G, Byrd C, Lang F, Kolesnick R, Altman A and Green D (1995) FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. Immunity 2: 341-351
9. Gulbins E, Szabo I and Lang F (1996) Physiology of Fas-induced programmed cell death. Cell. Physiol. Biochem. 6: 361-375
10. Tepper CG, Jayadev S, Liu B, Bielawska A, Wolff R, Yonehara S, Hannun YA and Seldin MF (1995) Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc. Natl. Acad. Sci. USA 92: 8443-8447
11. Kuno K and Matsushima K (1994) The IL-1 receptor signaling pathway. J. Leuk. Biol. 56: 542-547
12. Krönke M, Schütze S, Wiegmann K and Machleidt T (1996) Sphingomyelinases and TNF-induced apoptosis. Cell. Physiol. Biochem. 6: 337-344
13. Wiegmann K, Schütze S, Machleidt T, Witte D and Krönke M (1994) Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell 78: 1005-1015
14. Haimovitz-Friedman A, Kan C-C, Ehleiter D, Persaud RS, McLoughlin M, Fuks Z and Kolesnick RN (1994) Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J. Exp. Med. 180: 525-535
15. Martin SJ, Newmeyer DD, Mathias S, Farschon DM, Wang HG, Reed JC, Kolesnick RN and Green DR (1995) Cell-free reconstitution of Fas-, UV radiation-and ceramide-induced apoptosis. EMBO J. 14: 5191-5200
16. Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grants, Birrer MJ, Szabo E, Zon LI, Kyriakis JM, Haimovitz-Friedman A, Fuks Z and Kolesnick RN (1996) Requirement for ceramide-initiated SAPK/JNK signalling ir stress-induced apoptosis. Nature 390: 75-79
17. Bose R, Verheij M, Haimovitz-Friedman A, Scotto K, Fuks Z and Kolesnick R (1995) Ceramide synthase mediates daunorubicin-inducec apoptosis: An alternative mechanism for generating death signals. Cell 82: 405-414
18. Jaffrézou JP, Levade T, Bettaïeb A, Andrieu N, Bezombes C, Maestre N, Vermeersch S, Rousse A and Laurent G (1996) Daunorubicin-induced apoptosis: Triggering of ceramide generation through sphingomyelin hydrolysis. EMBOJ. 15: 2417-2424
19. Faris M, Kokot N, Latinis K, Kasibhatla S, Green DR, Koretzky GA and Nel A (1998) The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand express on. J. Immunol. 160: 134-144
20. Polverino AJ and Patterson SD (1997) Selective activation of caspases during apoptotic induction in HL-60 cells. J. Biol. Chem. 272: 7013-7021
21. Masuda Y, Nakaya M, Nakajo S and Nakaya K (1997) Geranylgeraniol potently induces caspase-3-like activity during apoptosis in human leukemia U937 cells. Biochem. Biophys. Res. Commun. 234: 641-645
22. Ohizumi H, Masuda Y, Nakajo S, Sakai I, Ohsawa S and Nakaya K (1995) Geranylgeraniol is a potent inducer of apoptosis in tumor cells. J. Biochem. 117: 11-13
23. Voziyan PA, Haug JS and Melnykovych G (1995) Mechanism of farnesol cytotoxicity: further evidence for the role of PKC-dependent signal transduction in farnesol-induced apoptotic cell death. Biochem. Biophys. Res. Comm. 212: 479-486
24. Gu M, Kerwin JL, Watts JD and Aebersold R (1997) Ceramide profiling of complex lipid mixtures by electrospray ionization mass spectrometry. Anal. Biochem. 244: 347-356
25. Watts JD, Gu M, Polverino AJ, Patterson SD and Aebersold R (1997) Fas-induced apoptosis of T cells occurs independently of ceramide generation. Proc. Natl. Acad. Sci. USA 94: 7292-7296
26. Baichwal VR and Baeuerle PA (1997) Apoptosis: Activate NF-kappaB or die? Curr. Biol. 7:R94-R96
27. Cohen GM (1997) Caspases: the executioners of apoptosis. Biochem. J. 326: 1-16
28. Kidd VJ (1998) Proteolytic activities that mediate apoptosis. Ann. Rev. Physiol. 60: 533-573
29. Gamen S, Anel A, Piñeiro A and Naval J (1998) Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway. Cell Death Differ. 5: 241-249
30. Hsu S-C, Wu C-C, Luh T-Y, Chou C-K, Han S-H and Lai M-Z (1998) Apoptotic signal of Fas is not mediated by ceramide. Blood 91: 2658-2663
31. Sillence DJ and Allan D (1997) Evidence against an early signalling role for ceramide in Fas-mediated apoptosis. Biochem. J. 324: 29-32
32. Bruno AP, Laurent G, Averbeck D, Demur C, Bonnet J, Bettaïeb A, Levade T and Jaffrézou JP (1998) Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation. Cell Death Differ. 5: 172-182
33. Adam D, Ruff A, Strelow A, Wiegmann K and Krönke M (1998) Induction of stress-activated protein kinases/c-jun N-terminal kinases by the p55 tumour necrosis factor does not require sphingomyelinases. Biochem. J. 333: 343-350
34. Tomiuk S, Hofmann K, Nix M, Zumbansen M and Stoffel W (1998) Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling? Proc. Natl. Acad. Sci. USA 95: 3638-3643
35. Zumbansen M and Stoffel W (1997) Tumor necrosis factor α activates NF-κB in acid sphingomyelinase-deficient mouse embryonic fibroblasts. J. Biol. Chem. 272: 10904-10909
36. Schulze-Osthoff K, Ferrari D, Los M, Wesselborg S and Peter ME (1998) Apoptosis signaling by death receptors. Eur. J. Biochem. 254: 439-459
37. Huang H-W, Goldberg EM and Zidovetzki R (1998) Ceramides perturb the structure of phosphatidylcholine bilayers and modulate the activity of phospholipase A2. Eur. Biophys. J. 27: 361-366
38. Mano N, Oda Y, Yamada K, Asakawa N and Katayama K (1997) Simultaneous quantitative determination method for sphingolipid metabolites by liquid chromatography/ionspray ionization tandem mass spectrometry. Anal. Biochem. 244: 291-300