Acceleration of crossbridge kinetics by protein kinase a phosphorylation of cardiac myosin binding protein c modulates cardiac function

Circulation Research

Volumn 103, Issue 9, 2008, Pages 974-982

  Tong, Carl W ^a   Stelzer, Julian E ^a   Greaser, Marion L ^a   Powers, Patricia A ^a   Moss, Richard L ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

CMyBP C; Contraction kinetics; Phosphorylation

Indexed keywords

ALANINE; BINDING PROTEIN; CARDIAC MYOSIN BINDING PROTEIN C; CYCLIC AMP DEPENDENT PROTEIN KINASE; DOBUTAMINE; SERINE; UNCLASSIFIED DRUG; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CARRIER PROTEIN; MYOSIN BINDING PROTEIN C; MYOSIN-BINDING PROTEIN C; TROPONIN I;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; ECHOCARDIOGRAPHY; ENZYME KINETICS; ENZYME PHOSPHORYLATION; GENE MUTATION; HEART MUSCLE; HEART VENTRICLE HYPERTROPHY; IMMUNOFLUORESCENCE; IN VITRO STUDY; MOUSE; MUSCLE FORCE; MUSCLE RELAXATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOMERE; SYSTOLIC DYSFUNCTION; TRANSGENE; WESTERN BLOTTING; ANIMAL; CARDIOMEGALY; DOPPLER ECHOCARDIOGRAPHY; DRUG EFFECT; ECHOGRAPHY; ENZYMOLOGY; GENETICS; HEART CONTRACTION; HUMAN; KINETICS; MECHANOTRANSDUCTION; METABOLISM; MUSCLE FIBRIL; MUSCLE STRENGTH; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; TRANSGENIC MOUSE;

ADRENERGIC BETA-AGONISTS; ANIMALS; CARDIOMEGALY; CARRIER PROTEINS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOBUTAMINE; ECHOCARDIOGRAPHY, DOPPLER; HUMANS; KINETICS; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, TRANSGENIC; MUSCLE STRENGTH; MUTATION; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOFIBRILS; PHOSPHORYLATION; SARCOMERES; TROPONIN I;

EID: 55449118232     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.177683     Document Type: Article

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