Histological analysis of neurodegeneration in the mouse brain

Methods in Molecular Biology

Volumn 1004, Issue , 2013, Pages 91-113

  Yamaguchi, Hiroo ^a   Shen, Jie ^a  

^a Brigham and Women's Hospital Center for Neurologic Diseases   (United States)

Author keywords

Alzheimer's disease; Immunohistochemistry; Mouse brain; Neurodegeneration; Parkinson's disease; Stereological neuron counting

Indexed keywords

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; DEGENERATIVE DISEASE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LABORATORY TEST; MOUSE; NERVE CELL; NERVE DEGENERATION; NICK END LABELING; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STAINING; ADULT; ANIMAL TISSUE; ANTIGEN RETRIEVAL; BRAIN HISTOLOGY; BRAIN PERFUSION; CELL DEATH; COMPLEMENT ACTIVATION; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; NISSL STAINING; STEREOLOGY;

BIOLOGICAL MARKER;

EID: 84926018535     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-383-1_8     Document Type: Article

References (20)

1. Schmitz C, Hof PR (2005) Design-based stereology in neuroscience. Neuroscience 130:813-831
2. Sterio DC (1984) The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc 134:127-136
3. Schweichel JU, Merker HJ (1973) The morphology of various types of cell death in prenatal tissues. Teratology 7:253-266
4. Schmued LC, Hopkins KJ (2000) Fluoro-Jade B: A high af fi nity fl uorescent marker for the localization of neuronal degeneration. Brain Res 874:123-130
5. Negoescu A, Lorimier P, Labat-Moleur F, Drouet C, Robert C, Guillermet C, Brambilla C, Brambilla E (1996) In situ apoptotic cell labeling by the TUNEL method: Improvement and evaluation on cell preparations. J Histochem Cytochem 44:959-968
6. McGeer PL, Itagaki S, Boyes BE, McGeer EG (1988) Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38:1285-1291
7. Hirsch EC, Hunot S (2009) Neuroin flammation in Parkinson's disease: A target for neuroprotection? Lancet Neurol 8:382-397
8. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL et al (2000) In flammation and Alzheimer's disease. Neurobiol Aging 21:383-421
9. O'Callaghan JP, Jensen KF (1992) Enhanced expression of glial fi brillary acidic protein and the cupric silver degeneration reaction can be used as sensitive and early indicators of neurotoxicity. Neurotoxicology 13:113-122
10. Tenner AJ (2001) Complement in Alzheimer's disease: Opportunities for modulating protective and pathogenic events. Neurobiol Aging 22:849-861
11. Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ (1995) The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. Am J Pathol 146:848-860
12. Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher RJ 3rd, Kandel ER, Duff K et al (2004) Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42:23-36
13. Beglopoulos V, Sun X, Saura CA, Lemere CA, Kim RD, Shen J (2004) Reduced beta-amyloid production and increased in flammatory responses in presenilin conditional knock-out mice. J Biol Chem 279:46907-46914
14. Wines-Samuelson M, Schulte EC, Smith MJ, Aoki C, Liu X, Kelleher RJ 3rd, Shen J (2010) Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice. PLoS One 5:e10195
15. Gundersen HJ (1986) Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J Microsc 143:3-45
16. Gundersen HJ, Bagger P, Bendtsen TF, Evans SM, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B et al (1988) The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 96:857-881
17. West MJ, Slomianka L, Gundersen HJ (1991) Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 231:482-497
18. Ward TS, Rosen GD, von Bartheld CS (2008) Optical disector counting in cryosections and vibratome sections underestimates particle numbers: Effects of tissue quality. Microsc Res Tech 71:60-68
19. Evans SM, Nyengaard JR (2004) Number: Section introduction. In: Evans SM, Janson AM, Nyengaard JR (eds) Quantitative methods in neuroscience. Oxford University Press, Oxford, pp 61-89
20. Romijn HJ, van Uum JF, Breedijk I, Emmering J, Radu I, Pool CW (1999) Double immunolabeling of neuropeptides in the human hypothalamus as analyzed by confocal laser scanning fl uorescence microscopy. J Histochem Cytochem 47:229-236