Comparison of duplex stabilizing properties of 2'-fluorinated nucleic acid analogues with furanose and non-furanose sugar rings

Journal of Organic Chemistry

Volumn 79, Issue 18, 2014, Pages 8877-8881

  Østergaard, Michael E ^a   Dwight, Timothy ^b   Berdeja, Andres ^a   Swayze, Eric E ^a   Jung, Michael E ^b   Seth, Punit P ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; FLUORINE;

ANTISENSE; FLUORINE SUBSTITUTION; FURANOSE; FURANOSE RING; NUCLEIC ACID ANALOGUES; RELATIVE CONTRIBUTION; STABILIZING PROPERTIES; SUGAR RINGS;

NUCLEIC ACIDS;

2' FLUORINATED RIBONUCLEIC ACID DERIVATIVE; CARBOHYDRATE DERIVATIVE; DOUBLE STRANDED DNA; FLUORINE; FURANOSE; NUCLEIC ACID BASE; RNA DERIVATIVE; THYMINE; UNCLASSIFIED DRUG; CARBOHYDRATE; NUCLEIC ACID; RIBOSE; RNA;

ARTICLE; COMPARATIVE STUDY; HYDRATION; NUCLEOTIDE SEQUENCE; RNA CONFORMATION; RNA STABILITY; STATIC ELECTRICITY; THERMOSTABILITY; X RAY CRYSTALLOGRAPHY; BASE PAIRING; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION;

BASE PAIRING; CARBOHYDRATE CONFORMATION; CARBOHYDRATES; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; NUCLEIC ACIDS; RIBOSE; RNA;

EID: 84911874131     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo501381q     Document Type: Article

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