Synthesis and duplex-stabilizing properties of fluorinated N-methanocarbathymidine analogues locked in the C3'-endo conformation

Angewandte Chemie - International Edition

Volumn 53, Issue 37, 2014, Pages 9893-9897

  Jung, Michael E ^a   Dwight, Timothy A ^a   Vigant, Frederic ^b   Østergaard, Michael E ^c   Swayze, Eric E ^c   Seth, Punit P ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ISIS PHARMACEUTICALS   (United States)

Author keywords

asymmetric synthesis; diastereoselectivity; duplex thermal stability; fluorination; modified nucleosides

Indexed keywords

FLUORINATION; SCAFFOLDS; THERMODYNAMIC STABILITY; ISOMERS;

ANTIVIRAL ACTIVITIES; ASYMMETRIC SYNTHESIS; DIASTEREO-SELECTIVITY; EFFICIENT SYNTHESIS; MODIFIED NUCLEOSIDES; STABILIZING EFFECTS; STABILIZING PROPERTIES;

ISOMERS; THERMODYNAMIC STABILITY;

EID: 84906946276     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201405283     Document Type: Article

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