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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 24, 2014, Pages 5695-5698

Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates

(5) Rose, Tyler M a Reilly, Christopher A b Deering Rice, Cassandra E b Brewster, Clinton a Brewster, Chelsea a

a ROSEMAN UNIVERSITY OF HEALTH SCIENCES (United States)

Author keywords

Arachidonoyl serotonin; Dual inhibition; FAAH; Fatty acid amide hydrolase; Multimodal inhibition; NSAID; Transient receptor potential vanilloid type 1; TRPV1

Indexed keywords

ACETYLSALICYLIC ACID; CARBOXYLIC ACID; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; FATTY ACID AMIDASE; FATTY ACID AMIDASE INHIBITOR; FENOPROFEN; FLUFENAMIC ACID; FLURBIPROFEN; IBUPROFEN; INDOMETACIN; KETOPROFEN; KETOROLAC; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; SALICYLIC ACID; SEROTONIN; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST; AMIDASE; FATTY-ACID AMIDE HYDROLASE; PTGS2 PROTEIN, HUMAN; TRPV1 PROTEIN, HUMAN; VANILLOID RECEPTOR;

AMIDATION; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; IC50; IN VITRO STUDY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HUMAN; METABOLISM;

AMIDOHYDROLASES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 2; FLURBIPROFEN; HUMANS; SEROTONIN; TRPV CATION CHANNELS;

EID: 84911872089 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.10.064 Document Type: Article

Times cited : (16)

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