Ibuprofen inhibits the metabolism of the endogenous cannabimimetic agent anandamide

Pharmacology and Toxicology

Volumn 80, Issue 2, 1997, Pages 103-107

  Fowler, Christopher J ^a   Stenström, Anders ^a   Tiger, Gunnar ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; ACETYLSALICYLIC ACID; AMIDASE; ANANDAMIDE; CANNABINOID RECEPTOR; IBUPROFEN; KETOPROFEN; NABUMETONE; NAPROXEN; PARACETAMOL; SULINDAC;

ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; DRUG EFFECT; DRUG METABOLISM; DRUG RECEPTOR BINDING; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0031047815     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1997.tb00291.x     Document Type: Article

References (20)

1. Adams, I. B., W. Ryan, M. Singer, B. F. Thomas, D. R. Compton, R. K. Razdan & B. R. Martin: Evaluation of cannabinoid receptor binding and in vivo activites for anandamide analogs. J.Pharmacol. Exp. Therap. 1995, 273, 1172-1181.
2. Blower, P. R.: The unique pharmacologic profile of nabumetone. J. Rheumatol. 1992,19, Suppl. 36, 13-19.
3. Childers, S. R., T. Sexton & M. B. Roy: Effects of anandamide on cannabinoid receptors in rat brain membranes. Biochem. Pharmacol. 1994, 47, 711-715.
4. D'Ambra, T. E., K. G. Estep, M. R. Bell, M. A. Eissenstat, K. A. Josef, S. J. Ward, D. A. Haycock, E. R. Baizman, F. M. Casiano, N. C. Beglin, S. M. Chippari, J. D. Grego, R. K. Kullnig & G. T. Daley: Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor. J. Med. Chem. 1992, 35, 124-135.
5. Deutsch, D. G. & S. A. Chin: Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist. Biochem. Pharmacol. 1993, 46, 791-796.
6. Devane, W. A., L. Hanus, A. Breuer, R. G. Pertwee, L. A. Stevenson, G. Griffin, D. Gibson, A. Mandelbaum, A. Etinger & R. Mechoulam: Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 1992, 258, 1946-1949.
7. Dewey, W. L.: Cannabinoid pharmacology. Pharmacol. Rev. 1986, 38, 151-178.
8. Hanus, L., A. Gopher, S. Almog & R. Mechoulam: Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor. J. Med. Chem. 1993, 36, 3032-3034.
9. Haubrich, D. R., S. J. Ward, E. Baizman, M. R. Bell, J. Bradford, R. Ferrari, M. Miller, M. Perrone, A. K. Pierson, J. K. Saelens & D. Luttinger: Pharmacology of pravadoline: a new analgesic agent. J. Pharmacol. Exp. Therap. 1990, 255, 511-522.
10. Hillard, C. J., D. M. Wilkison, W. S. Edgemond & W. B. Campbell: Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain. Biochim. Biophys. Acta 1995, 1257, 249-256.
11. Karttunen, P., V. Saano, P. Paronen, P. Peura & M. Vidgren: Pharmacokinetics of ibuprofen in man: a single-dose comparison of two over-the-counter, 200 mg preparations. Int. J. Clin. Pharmacol. Ther. Toxicol. 1990, 28, 251-255.
12. Mackie, K., W. A. Devane & B. Hille: Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells. Mol. Pharmacol. 1993, 44, 498-503.
13. Mitchell, J. A., P. Akarasereenont, C. Thiemermann, R. J. Flower & J. R. Vane: Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. USA 1994, 90, 11693-11697.
14. 14C] as a substrate for anandamide amidase. Life Sci. 1995, 56, 1999-2005.
15. Pertwee, R.: The evidence for the existence of cannabinoid receptors. Gen. Pharmacol. 1993, 24, 811-824.
16. Pinto, J. C., F. Potié, K. C. Rice, D. Boring, M. R. Johnson, D. M. Evans, G. H. Wilken, C. H. Cantrell & A. C. Howlett: Cannabinoid receptor binding and agonist activity of amides and esters of arachidonic acid. Mol. Pharmacol. 1994, 46, 516-522.
17. Smith, P. B., D. R. Compton, S. P. Welch, R. K. Razdan, R. Mechoulam & B. R. Martin: The pharmacological activity of anandamide, a putatuve endogenous cannabinoid, in mice. J. Pharmacol. Exp. Therap. 1994, 270, 219-227.
18. Sugiura, T., S. Kondo, A. Sukagawa, S. Nakane, A. Shinoda, K. Itoh, A. Yamashita & K. Waku: 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem. Biophys. Res.Commun. 1995, 215, 89-97.
19. Ueda, N., Y. Kurahashi, S. Yamamoto & T. Tokunaga: Partial purification and characterization of the porcine brain enzyme hydrolyzing and synthesizing anandamide. J. Biol. Chem. 1995, 270, 23823-23827.
20. Vogel, Z., J. Barg, R. Levy, D. Saya, E. Heldman & R. Mechoulam: Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase. J. Neurochem. 1993, 61, 352-355.