Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: Facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 2, 2000, Pages 925-930

  Kalgutkar, Amit S ^a   Crews, Brenda C ^a   Rowlinson, Scott W ^a   Marnett, Alan B ^a   Kozak, Kevin R ^a   Remmel, Rory P ^a,b   Marnett, Lawrence J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; MECLOFENAMIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; DERIVATIZATION; DRUG EFFECT; DRUG POTENCY; ENZYME INHIBITION; IMMEDIATE EARLY GENE; INFLAMMATORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; TISSUE DISTRIBUTION;

5,8,11,14-EICOSATETRAYNOIC ACID; AMIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DRUG DESIGN; EDEMA; ESTERS; GASTROINTESTINAL DISEASES; HINDLIMB; HUMANS; INDOMETHACIN; ISOENZYMES; KINETICS; MACROPHAGES; MALE; MECLOFENAMIC ACID; MEMBRANE PROTEINS; MICE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; SHEEP;

ANIMALIA; MURINAE;

EID: 0034681109     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.2.925     Document Type: Article

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