Chemistry around imidazopyrazine and ibuprofen: Discovery of novel fatty acid amide hydrolase (FAAH) inhibitors

European Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2010, Pages 3564-3574

  De Wael, Frédéric ^a   Muccioli, Giulio G ^a   Lambert, Didier M ^a   Sergent, Thérse ^a   Schneider, Yves Jacques ^a   Rees, Jean Franois ^b   Marchand Brynaert, Jacqueline ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b U de Biochimie Physiologique   (Belgium)

Author keywords

2 Ketoaldehyde; Aminopyrazine; Anti inflammatory; Antioxidant; FAAH inhibitor; Ibuprofen

Indexed keywords

1 (1,3 DITHIAN 2 YL) 2 (4 ISOBUTYLPHENYL) PROPAN 1 ONE; 1 (1,3 DITHIAN 2 YL) 2 PHENYLETHAN 1 ONE; 1 (1,3 DITHIAN 2 YL) 2 PHENYLPROPAN 1 ONE; 1 (BENZOTRIAZOL 1 YL) 2 (4 ISOBUTYLPHENYL)PROPAN 1 ONE; 1 (N HYDROXYIMINO) 3 (4 ISOBUTYLPHENYL)BUTAN 2 ONE; 1 BROMO 3 PHENYLPROPAN 2 ONE; 2 (4 ISOBUTYL PHENYL) PROPIONYL CHLORIDE; 2 AMINO 1,4 PYRAZINE; 2 HYDROXY 3 PHENYL 2 PROPENAL; 2 KETOALDEHYDE; 2 KETOALDOXIME; 2 PHENYL 6 P HYDROXYPHENYLIMIDAZO[1,2 A]PYRAZIN 3(7H) IMINE; 2 PHENYL 6 P HYDROXYPHENYLIMIDAZO[1,2 A]PYRAZIN 3(7H) ONE; 2 PHENYLIMIDAZO[1,2 A]PYRAZIN 3 (7H) ONE; 2 PHENYLIMIDAZO[1,2 A]PYRAZIN 3(7H) IMINE; 3 (4 ISOBUTYLPHENYL) 1 NITRATE BUTAN 2 ONE; 3 (4 ISOBUTYLPHENYL) 1 NITROBUTAN 2 ONE; FATTY ACID AMIDASE INHIBITOR; IBUPROFEN; IMIDAZOPYRAZINE DERIVATIVE; N METHOXY N METHYL 2 (4 ISOBUTYLPHENYL)PROPANAMIDE; N METHOXY N METHYL 2 PHENYLACETAMIDE; N METHOXY N METHYL 2 PHENYLPROPIONAMIDE; PHENYLGLYOXAL; PHENYLGLYOXAL ALDOXIME; PYRAZINE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; LIPID PEROXIDATION; MICROWAVE RADIATION; OXIDATION;

EID: 77955558082     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.04.040     Document Type: Article

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