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Volumn 20, Issue 22, 2014, Pages 3530-3547

Pharmacology and clinical pharmacology of methylarginines used as inhibitors of nitric oxide synthases

Author keywords

Alanine glyoxylate aminotransferase 2 (AGXT2); Asymmetric dimethylarginine (ADMA); Dimethylarginine dimethylaminohydrolase (DDAH); Monomethylarginine (L NMMA); Nitric oxide synthase (NOS); Symmetric dimethylarginine (SDMA)

Indexed keywords

ALANINE GLYOXYLATE AMINOTRANSFERASE; CARRIER PROTEIN; DIMETHYLARGININASE; N(G) METHYLARGININE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; ARGININE; DIMETHYLARGININE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENZYME INHIBITOR; NITRIC OXIDE;

EID: 84911861771     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/13816128113196660750     Document Type: Article
Times cited : (19)

References (114)
  • 1
    • 0023092102 scopus 로고
    • Macrophage cytotoxicity: Role for L-arginine deiminase and imino nitrogen oxidation to nitrite
    • Hibbs JBJ, Taintor RR, Vavrin Z. Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. Science 1987; 235: 473-6.
    • (1987) Science , vol.235 , pp. 473-476
    • Hibbs, J.1    Taintor, R.R.2    Vavrin, Z.3
  • 2
    • 0023198721 scopus 로고
    • Nitric oxide release accounts for biological activity of endotehlium-derived relaxing factor
    • Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for biological activity of endotehlium-derived relaxing factor. Nature 1987; 327: 524-6.
    • (1987) Nature , vol.327 , pp. 524-526
    • Palmer, R.1    Ferrige, A.G.2    Moncada, S.3
  • 3
    • 0023912670 scopus 로고
    • Vascular endothelial cells synthesize nitric oxide from L-arginine
    • Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1987; 333: 664-6.
    • (1987) Nature , vol.333 , pp. 664-666
    • Palmer, R.1    Ashton, D.S.2    Moncada, S.3
  • 4
    • 0001599370 scopus 로고
    • Role of endothelium-derived nitric oxide in the regulation of blood pressure
    • Rees DD, Palmer RMJ, Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci USA 1989; 86: 3375-8.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 3375-3378
    • Rees, D.D.1    Palmer, R.2    Moncada, S.3
  • 5
    • 0024475102 scopus 로고
    • NG-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: Does nitric oxide regulate blood pressure in vivo?
    • Aisaka K, Gross SS, Griffith OW, Levi R. NG-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo? Biochem Biophys Res Commun 1989; 160: 881-6.
    • (1989) Biochem Biophys Res Commun , vol.160 , pp. 881-886
    • Aisaka, K.1    Gross, S.S.2    Griffith, O.W.3    Levi, R.4
  • 6
    • 0026548912 scopus 로고
    • Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
    • Vallance P, Leone A, Calver A, Collier J, Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 1992; 339: 572-5.
    • (1992) Lancet , vol.339 , pp. 572-575
    • Vallance, P.1    Leone, A.2    Calver, A.3    Collier, J.4    Moncada, S.5
  • 7
    • 0034716974 scopus 로고    scopus 로고
    • Assessment of nitric oxide synthase activity in vitro and in vivo by gas chromatography-mass spectrometry
    • Tsikas D, Sandmann J, Savva A, et al. Assessment of nitric oxide synthase activity in vitro and in vivo by gas chromatography-mass spectrometry. J Chromatogr B 2000; 742: 143-53.
    • (2000) J Chromatogr B , vol.742 , pp. 143-153
    • Tsikas, D.1    Sandmann, J.2    Savva, A.3
  • 8
    • 0342757751 scopus 로고    scopus 로고
    • Endogenous nitric oxide synthase inhibitors are responsible for the L-arginine paradox
    • Tsikas D, Böger RH, Sandmann J, Bode-Böger SM, Frölich JC. Endogenous nitric oxide synthase inhibitors are responsible for the L-arginine paradox. FEBS Lett 2000; 478: 1-3.
    • (2000) FEBS Lett , vol.478 , pp. 1-3
    • Tsikas, D.1    Böger, R.H.2    Sandmann, J.3    Bode-Böger, S.M.4    Frölich, J.C.5
  • 9
    • 0014940650 scopus 로고
    • Isolation and identification of N-G,N-G-and N-G,N'-G-dimethyl-arginine, N-epsilon-mono-, di-, and trimethyllysine, and glucosylgalactosyl-and galactosyl-delta-hydroxylysine from human urine
    • Kakimoto Y, Akazawa S. Isolation and identification of N-G,N-G-and N-G,N'-G-dimethyl-arginine, N-epsilon-mono-, di-, and trimethyllysine, and glucosylgalactosyl-and galactosyl-delta-hydroxylysine from human urine. J Biol Chem 1970; 245: 5751-8.
    • (1970) J Biol Chem , vol.245 , pp. 5751-5758
    • Kakimoto, Y.1    Akazawa, S.2
  • 10
    • 0014200317 scopus 로고
    • Enzymatic methylation of protein fractions from calf thymus nuclei
    • Paik WK, Kim S. Enzymatic methylation of protein fractions from calf thymus nuclei. Biochem Biophys Res Commun 1967; 29: 14-20.
    • (1967) Biochem Biophys Res Commun , vol.29 , pp. 14-20
    • Paik, W.K.1    Kim, S.2
  • 11
    • 0031603283 scopus 로고    scopus 로고
    • RNA and protein interactions modulated by protein arginine methylation
    • Gary JD, Clarke S. RNA and protein interactions modulated by protein arginine methylation. Prog Nucleic Acid Res Mol Biol 1998; 61: 65-131.
    • (1998) Prog Nucleic Acid Res Mol Biol , vol.61 , pp. 65-131
    • Gary, J.D.1    Clarke, S.2
  • 12
    • 33645960698 scopus 로고    scopus 로고
    • Quantitative assessment of arginine methylation in free versus protein-incorporated amino acids in vitro and in vivo using protein hydrolysis and high-performance liquid chromatography
    • Bulau P, Zakrzewicz D, Kitowska K, Wardega B, Kreuder J, Eickelberg O. Quantitative assessment of arginine methylation in free versus protein-incorporated amino acids in vitro and in vivo using protein hydrolysis and high-performance liquid chromatography. Biotechniques 2006; 40: 305-10.
    • (2006) Biotechniques , vol.40 , pp. 305-310
    • Bulau, P.1    Zakrzewicz, D.2    Kitowska, K.3    Wardega, B.4    Kreuder, J.5    Eickelberg, O.6
  • 13
    • 0016809905 scopus 로고
    • Methylated amino acid residues of proteins of brain and other organs
    • Kakimoto Y, Matsuoka Y, Miyake M, Konishi H. Methylated amino acid residues of proteins of brain and other organs. J Neurochem 1975; 24: 893-902.
    • (1975) J Neurochem , vol.24 , pp. 893-902
    • Kakimoto, Y.1    Matsuoka, Y.2    Miyake, M.3    Konishi, H.4
  • 14
    • 0037072804 scopus 로고    scopus 로고
    • Endogenous methylarginines regulate neuronal nitric-oxide synthase and prevent excitotoxic injury
    • Cardounel AJ, Zweier JL. Endogenous methylarginines regulate neuronal nitric-oxide synthase and prevent excitotoxic injury. J Biol Chem 2002; 277: 33995-4002.
    • (2002) J Biol Chem , vol.277 , pp. 33995-34002
    • Cardounel, A.J.1    Zweier, J.L.2
  • 15
    • 0029360750 scopus 로고
    • Induction of NG-monomethyl-L-arginine uptake: A mechanism for differential inhibition of NO synthases?
    • Bogle RG, MacAllister RJ, Whitley GS, Vallance P. Induction of NG-monomethyl-L-arginine uptake: a mechanism for differential inhibition of NO synthases? Am J Physiol 1995; 269: C750-6.
    • (1995) Am J Physiol , vol.269
    • Bogle, R.G.1    Macallister, R.J.2    Whitley, G.S.3    Vallance, P.4
  • 17
    • 0033667562 scopus 로고    scopus 로고
    • An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes
    • Böger R, Bode-Böger SM, Tsao PS, Lin PS, Chan JR, Cooke JP. An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes. J Am Coll Cardiol 2000; 36: 2287-95.
    • (2000) J am Coll Cardiol , vol.36 , pp. 2287-2295
    • Böger, R.1    Bode-Böger, S.M.2    Tsao, P.S.3    Lin, P.S.4    Chan, J.R.5    Cooke, J.P.6
  • 18
    • 33847757915 scopus 로고    scopus 로고
    • Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function
    • Cardounel AJ, Cui H, Samouilov A, et al. Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function. J Biol Chem 2007; 282: 879-87.
    • (2007) J Biol Chem , vol.282 , pp. 879-887
    • Cardounel, A.J.1    Cui, H.2    Samouilov, A.3
  • 19
    • 79957643315 scopus 로고    scopus 로고
    • Production of free methylarginines via the proteasome and autophagy pathways in cultured cells
    • Shirakawa T, Kako K, Shimada T, et al. Production of free methylarginines via the proteasome and autophagy pathways in cultured cells. Mol Med Rep 2011; 4: 615-20.
    • (2011) Mol Med Rep , vol.4 , pp. 615-620
    • Shirakawa, T.1    Kako, K.2    Shimada, T.3
  • 20
    • 34248224898 scopus 로고    scopus 로고
    • A stable-isotope based technique for the determination of dimethylarginine dimethylaminohydrolase (DDAH) activity in mouse tissue
    • Maas R, Tan-Andreesen J, Schwedhelm E, Schulze F, Böger RH. A stable-isotope based technique for the determination of dimethylarginine dimethylaminohydrolase (DDAH) activity in mouse tissue. J Chromatogr B Analyt Technol Biomed Life Sci 2007; 851: 220-8.
    • (2007) J Chromatogr B Analyt Technol Biomed Life Sci , vol.851 , pp. 220-228
    • Maas, R.1    Tan-Andreesen, J.2    Schwedhelm, E.3    Schulze, F.4    Böger, R.H.5
  • 21
    • 33847005404 scopus 로고    scopus 로고
    • Disruption of methylarginine metabolism impairs vascular homeostasis
    • Leiper J, Nandi M, Torondel B, et al. Disruption of methylarginine metabolism impairs vascular homeostasis. Nat Med 2007; 13: 198-203.  
    • (2007) Nat Med , vol.13 , pp. 198-203
    • Leiper, J.1    Nandi, M.2    Torondel, B.3
  • 22
    • 0041733065 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase
    • Achan V, Broadhead M, Malaki M, et al. Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase. Arterioscler Thromb Vasc Biol 2003; 23: 1455-9.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1455-1459
    • Achan, V.1    Broadhead, M.2    Malaki, M.3
  • 23
    • 84874940308 scopus 로고    scopus 로고
    • The methylarginines NMMA, ADMA, and SDMA are ubiquitous constituents of the main vegetables of human nutrition
    • Servillo L, Giovane A, Cautela D, Castaldo D, Balestrieri ML. The methylarginines NMMA, ADMA, and SDMA are ubiquitous constituents of the main vegetables of human nutrition. Nitric Oxide 2013; 30: 43-8.
    • (2013) Nitric Oxide , vol.30 , pp. 43-48
    • Servillo, L.1    Giovane, A.2    Cautela, D.3    Castaldo, D.4    Balestrieri, M.L.5
  • 24
    • 27744463745 scopus 로고    scopus 로고
    • ADMA metabolism and clearance
    • Teerlink T. ADMA metabolism and clearance. Vasc Med 2005; 10(Suppl 1): S73-81.
    • (2005) Vasc Med , vol.10
    • Teerlink, T.1
  • 25
    • 0033812927 scopus 로고    scopus 로고
    • Acute elevations of plasma asymmetric dimethylarginine and impaired endothelial function in response to a high-fat meal in patients with type 2 diabetes
    • Fard A, Tuck CH, Donis JA, et al. Acute elevations of plasma asymmetric dimethylarginine and impaired endothelial function in response to a high-fat meal in patients with type 2 diabetes. Arterioscler Thromb Vasc Biol 2000; 20: 2039-44.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 2039-2044
    • Fard, A.1    Tuck, C.H.2    Donis, J.A.3
  • 26
    • 34547924521 scopus 로고    scopus 로고
    • Acute effects of various fast-food meals on vascular function and cardiovascular disease risk markers: The Hamburg Burger Trial
    • Rudolph TK, Ruempler K, Schwedhelm E, et al. Acute effects of various fast-food meals on vascular function and cardiovascular disease risk markers: the Hamburg Burger Trial. Am J Clin Nutr 2007; 86: 334-40.
    • (2007) Am J Clin Nutr , vol.86 , pp. 334-340
    • Rudolph, T.K.1    Ruempler, K.2    Schwedhelm, E.3
  • 27
    • 34247245816 scopus 로고    scopus 로고
    • Structure and function of cationic amino acid transporters (CATs)
    • Closs EI, Boissel JP, Habermeier A, Rotmann A. Structure and function of cationic amino acid transporters (CATs). J Membr Biol 2006; 213: 67-77.
    • (2006) J Membr Biol , vol.213 , pp. 67-77
    • Closs, E.I.1    Boissel, J.P.2    Habermeier, A.3    Rotmann, A.4
  • 28
    • 84864820728 scopus 로고    scopus 로고
    • Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (CAT1)
    • Strobel J, Mieth M, Endreß B, et al. Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (CAT1). J Mol Cell Cardiol 2012.
    • (2012) J Mol Cell Cardiol
    • Strobel, J.1    Mieth, M.2    Endreß, B.3
  • 29
    • 85039882559 scopus 로고    scopus 로고
    • Transport kinetics of asymmetric dimethylarginine (ADMA) by human cationic amino acid transporters (CAT1 and CAT2A)
    • Strobel J, König J, Maas R. Transport kinetics of asymmetric dimethylarginine (ADMA) by human cationic amino acid transporters (CAT1 and CAT2A). Naunyn Schmiedebergs Arch Pharmakol 2011; 383: 82-2.
    • (2011) Naunyn Schmiedebergs Arch Pharmakol , vol.383 , pp. 82
    • Strobel, J.1    König, J.2    Maas, R.3
  • 30
    • 0031424947 scopus 로고    scopus 로고
    • Interference of L-arginine analogues with L-arginine transport mediated by the y+ carrier hCAT-2B
    • Closs EI, Basha FZ, Habermeier A, Förstermann U. Interference of L-arginine analogues with L-arginine transport mediated by the y+ carrier hCAT-2B. Nitric oxide 1997; 1: 65-73.
    • (1997) Nitric Oxide , vol.1 , pp. 65-73
    • Closs, E.I.1    Basha, F.Z.2    Habermeier, A.3    Förstermann, U.4
  • 31
    • 84862902598 scopus 로고    scopus 로고
    • Impairment of the extrusion transporter for asymmetric dimethyl-L-arginine: A novel mechanism underlying vasospastic angina
    • Closs EI, Ostad MA, Simon A, et al. Impairment of the extrusion transporter for asymmetric dimethyl-L-arginine: a novel mechanism underlying vasospastic angina. Biochem Biophys Res Commun 2012; 423: 218-23.
    • (2012) Biochem Biophys Res Commun , vol.423 , pp. 218-223
    • Closs, E.I.1    Ostad, M.A.2    Simon, A.3
  • 32
    • 0017111104 scopus 로고
    • Studies on the catabolism of Ng-methylarginine, Ng, Ng-dimethylarginine and Ng, Ng-dimethylarginine in the rabbit
    • McDermott JR. Studies on the catabolism of Ng-methylarginine, Ng, Ng-dimethylarginine and Ng, Ng-dimethylarginine in the rabbit. Biochem J 1976; 154: 179-84.
    • (1976) Biochem J , vol.154 , pp. 179-184
    • McDermott, J.R.1
  • 34
    • 0025607080 scopus 로고
    • Dimethylarginine:Pyruvate aminotransferase in rats. Purification, properties, and identity with alanine:Glyoxylate aminotransferase 2
    • Ogawa T, Kimoto M, Sasaoka K. Dimethylarginine:pyruvate aminotransferase in rats. Purification, properties, and identity with alanine:glyoxylate aminotransferase 2. J Biol Chem 1990; 265: 20938-45.
    • (1990) J Biol Chem , vol.265 , pp. 20938-20945
    • Ogawa, T.1    Kimoto, M.2    Sasaoka, K.3
  • 35
    • 84870063190 scopus 로고    scopus 로고
    • Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure
    • Caplin B, Wang Z, Slaviero A, et al. Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure. Arterioscler Thromb Vasc Biol 2012; 32: 2892-900.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 2892-2900
    • Caplin, B.1    Wang, Z.2    Slaviero, A.3
  • 36
    • 77949313676 scopus 로고    scopus 로고
    • Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production
    • Rodionov RN, Murry DJ, Vaulman SF, Stevens JW, Lentz SR. Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production. J Biol Chem 2010; 285: 5385-91.
    • (2010) J Biol Chem , vol.285 , pp. 5385-5391
    • Rodionov, R.N.1    Murry, D.J.2    Vaulman, S.F.3    Stevens, J.W.4    Lentz, S.R.5
  • 37
    • 0024340138 scopus 로고
    • Purification and properties of a new enzyme, NG,NG-dimethylarginine dimethylaminohydrolase, from rat kidney
    • Ogawa T, Kimoto M, Sasaoka K. Purification and properties of a new enzyme, NG,NG-dimethylarginine dimethylaminohydrolase, from rat kidney. J Biol Chem 1989; 264: 10206-9.
    • (1989) J Biol Chem , vol.264 , pp. 10206-10209
    • Ogawa, T.1    Kimoto, M.2    Sasaoka, K.3
  • 38
    • 0023667668 scopus 로고
    • Occurrence of a new enzyme catalyzing the direct conversion of NG,NG-dimethyl-L-arginine to L-citrulline in rats
    • Ogawa T, Kimoto M, Sasaoka K. Occurrence of a new enzyme catalyzing the direct conversion of NG,NG-dimethyl-L-arginine to L-citrulline in rats. Biochem Biophys Res Commun 1987; 148: 671-7.
    • (1987) Biochem Biophys Res Commun , vol.148 , pp. 671-677
    • Ogawa, T.1    Kimoto, M.2    Sasaoka, K.3
  • 39
    • 79952715746 scopus 로고    scopus 로고
    • The biology and therapeutic potential of the DDAH/ADMA pathway
    • Arrigoni F, Ahmetaj B, Leiper J. The biology and therapeutic potential of the DDAH/ADMA pathway. Curr Pharm Des 2010; 16: 4089-102.
    • (2010) Curr Pharm Des , vol.16 , pp. 4089-4102
    • Arrigoni, F.1    Ahmetaj, B.2    Leiper, J.3
  • 41
    • 0033214074 scopus 로고    scopus 로고
    • Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases
    • Leiper JM, Santa Maria J, Chubb A, et al. Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases. Biochem J 1999; 343 Pt 1: 209-14.
    • (1999) Biochem J , vol.343 , pp. 209-214
    • Leiper, J.M.1    Santa Maria, J.2    Chubb, A.3
  • 42
    • 34748915802 scopus 로고    scopus 로고
    • Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO
    • Wang D, Gill PS, Chabrashvili T, et al. Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO. Circ Res 2007; 101: 627-35.
    • (2007) Circ Res , vol.101 , pp. 627-635
    • Wang, D.1    Gill, P.S.2    Chabrashvili, T.3
  • 43
    • 79959707563 scopus 로고    scopus 로고
    • Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine
    • Hu X, Atzler D, Xu X, et al. Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. Arterioscler Thromb Vasc Biol 2011; 31: 1540-6.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 1540-1546
    • Hu, X.1    Atzler, D.2    Xu, X.3
  • 44
    • 85039875253 scopus 로고    scopus 로고
    • A global knock out of the dimethylarginine dimethylaminohydrolase 2 (DDAH2) gene in mice has no impact on aortic endothelial function and viability
    • Geldmacher F, Lüneburg N, Bernges I, et al. A global knock out of the dimethylarginine dimethylaminohydrolase 2 (DDAH2) gene in mice has no impact on aortic endothelial function and viability. Naunyn Schmiedebergs Arch Pharmakol 2011; 383: 63-63.
    • (2011) Naunyn Schmiedebergs Arch Pharmakol , vol.383 , pp. 63
    • Geldmacher, F.1    Lüneburg, N.2    Bernges, I.3
  • 45
    • 73449121413 scopus 로고    scopus 로고
    • Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine
    • Hu X, Xu X, Zhu G, et al. Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine. Circulation 2009; 120: 2222-9.
    • (2009) Circulation , vol.120 , pp. 2222-2229
    • Hu, X.1    Xu, X.2    Zhu, G.3
  • 46
    • 0346365087 scopus 로고    scopus 로고
    • Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: Genetic and physiological evidence
    • Dayoub H, Achan V, Adimoolam S, et al. Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence. Circulation 2003; 108: 3042-7.
    • (2003) Circulation , vol.108 , pp. 3042-3047
    • Dayoub, H.1    Achan, V.2    Adimoolam, S.3
  • 47
    • 20144362691 scopus 로고    scopus 로고
    • Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis
    • Jacobi J, Sydow K, von Degenfeld G, et al. Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis. Circulation 2005; 111: 1431-8.
    • (2005) Circulation , vol.111 , pp. 1431-1438
    • Jacobi, J.1    Sydow, K.2    Von Degenfeld, G.3
  • 48
    • 24944522337 scopus 로고    scopus 로고
    • Dimethylarginine dimethylaminohydrolase overexpression suppresses graft coronary artery disease
    • Tanaka M, Sydow K, Gunawan F, et al. Dimethylarginine dimethylaminohydrolase overexpression suppresses graft coronary artery disease. Circulation 2005; 112: 1549-56.
    • (2005) Circulation , vol.112 , pp. 1549-1556
    • Tanaka, M.1    Sydow, K.2    Gunawan, F.3
  • 49
    • 33847422194 scopus 로고    scopus 로고
    • Dimethylarginine dimethylaminohydrolase promotes endothelial repair after vascular injury
    • Konishi H, Sydow K, Cooke JP. Dimethylarginine dimethylaminohydrolase promotes endothelial repair after vascular injury. J Am Coll Cardiol 2007; 49: 1099-105.
    • (2007) J am Coll Cardiol , vol.49 , pp. 1099-1105
    • Konishi, H.1    Sydow, K.2    Cooke, J.P.3
  • 50
    • 38149020150 scopus 로고    scopus 로고
    • Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation
    • Dayoub H, Rodionov RN, Lynch C, et al. Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation. Stroke 2008; 39: 180-4.
    • (2008) Stroke , vol.39 , pp. 180-184
    • Dayoub, H.1    Rodionov, R.N.2    Lynch, C.3
  • 51
    • 77649099537 scopus 로고    scopus 로고
    • Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia
    • Rodionov RN, Dayoub H, Lynch CM, et al. Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia. Circ Res 2010; 106: 551-8.
    • (2010) Circ Res , vol.106 , pp. 551-558
    • Rodionov, R.N.1    Dayoub, H.2    Lynch, C.M.3
  • 52
    • 77952067397 scopus 로고    scopus 로고
    • Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine
    • Jacobi J, Maas R, Cardounel AJ, et al. Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine. Am J Pathol 2010; 176: 2559-70.
    • (2010) Am J Pathol , vol.176 , pp. 2559-2570
    • Jacobi, J.1    Maas, R.2    Cardounel, A.J.3
  • 54
    • 39149138131 scopus 로고    scopus 로고
    • Role of asymmetric dimethylarginine for angiotensin II-induced target organ damage in mice
    • Jacobi J, Maas R, Cordasic N, et al. Role of asymmetric dimethylarginine for angiotensin II-induced target organ damage in mice. Am J Physiol Heart Circ Physiol 2008; 294: H1058-H1066.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Jacobi, J.1    Maas, R.2    Cordasic, N.3
  • 55
    • 34547590325 scopus 로고    scopus 로고
    • Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2
    • Hasegawa K, Wakino S, Tatematsu S, et al. Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2. Circ Res 2007; 101: e2-10.
    • (2007) Circ Res , vol.101
    • Hasegawa, K.1    Wakino, S.2    Tatematsu, S.3
  • 59
    • 1642453719 scopus 로고    scopus 로고
    • Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans
    • Kielstein JT, Impraim B, Simmel S, et al. Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans. Circulation 2004; 109: 172-7.
    • (2004) Circulation , vol.109 , pp. 172-177
    • Kielstein, J.T.1    Impraim, B.2    Simmel, S.3
  • 60
    • 0024428094 scopus 로고
    • Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man
    • Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 1989; 8670: 997-1000.
    • (1989) Lancet , vol.8670 , pp. 997-1000
    • Vallance, P.1    Collier, J.2    Moncada, S.3
  • 62
    • 0031967493 scopus 로고    scopus 로고
    • Haemodynamic effects of inhibition of nitric oxide synthase and of L-arginine at rest and during exercise
    • Brett SE, Cockcroft JR, Mant TGK, Ritter JM, Chowienczyk PJ. Haemodynamic effects of inhibition of nitric oxide synthase and of L-arginine at rest and during exercise. J Hypertens 1998; 16: 429-35.
    • (1998) J Hypertens , vol.16 , pp. 429-435
    • Brett, S.E.1    Cockcroft, J.R.2    Mant, T.3    Ritter, J.M.4    Chowienczyk, P.J.5
  • 63
    • 0033502966 scopus 로고    scopus 로고
    • The effect of the nitric oxide synthase inhibitor L-NMMA on basal CBF and vasoneuronal coupling in man: A PET study
    • White RP, Hindley C, Bloomfield PM, et al. The effect of the nitric oxide synthase inhibitor L-NMMA on basal CBF and vasoneuronal coupling in man: a PET study. J Cereb Blood Flow Metab 1999; 19: 673-8.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 673-678
    • White, R.P.1    Hindley, C.2    Bloomfield, P.M.3
  • 64
    • 0032923525 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic profile of systemic nitric oxide-synthase inhibition with L-NMMA in humans
    • Mayer BX, Mensik C, Krishnaswami S, et al. Pharmacokinetic-pharmacodynamic profile of systemic nitric oxide-synthase inhibition with L-NMMA in humans. Br J Clin Pharmacol 1999; 47: 539-44.
    • (1999) Br J Clin Pharmacol , vol.47 , pp. 539-544
    • Mayer, B.X.1    Mensik, C.2    Krishnaswami, S.3
  • 65
    • 0034724294 scopus 로고    scopus 로고
    • L-NMMA (A nitric oxide synthase inhibitor) is effective in the treatment of cardiogenic shock
    • Cotter G, Kaluski E, Blatt A, et al. L-NMMA (a nitric oxide synthase inhibitor) is effective in the treatment of cardiogenic shock. Circulation 2000; 101: 1358-61.
    • (2000) Circulation , vol.101 , pp. 1358-1361
    • Cotter, G.1    Kaluski, E.2    Blatt, A.3
  • 66
    • 0242266405 scopus 로고    scopus 로고
    • A dose-response study of nitric oxide synthase inhibition in different vascular beds in man
    • Hjorth LL, Klingenberg IH, Olesen J. A dose-response study of nitric oxide synthase inhibition in different vascular beds in man. Eur J Clin Pharmacol 2003; 59: 499-505.
    • (2003) Eur J Clin Pharmacol , vol.59 , pp. 499-505
    • Hjorth, L.L.1    Klingenberg, I.H.2    Olesen, J.3
  • 67
    • 34548301578 scopus 로고    scopus 로고
    • Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: A phase II dose-ranging study
    • Dzavík V, Cotter G, Reynolds HR, et al. Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study. Eur Heart J 2007; 28: 1109-16.
    • (2007) Eur Heart J , vol.28 , pp. 1109-1116
    • Dzavík, V.1    Cotter, G.2    Reynolds, H.R.3
  • 68
    • 34247392754 scopus 로고    scopus 로고
    • Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: The TRIUMPH randomized controlled trial
    • TRIUMPH Investigators, Alexander JH, Reynolds HR, et al. Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial. JAMA 2007; 297: 1657-66.
    • (2007) JAMA , vol.297 , pp. 1657-1666
    • Investigators, T.1    Alexander, J.H.2    Reynolds, H.R.3
  • 69
    • 4344682099 scopus 로고    scopus 로고
    • Subpressor dose asymmetric dimethylarginine modulates renal function in humans through nitric oxide synthase inhibition
    • Kielstein JT, Simmel S, Bode-Böger SM, et al. Subpressor dose asymmetric dimethylarginine modulates renal function in humans through nitric oxide synthase inhibition. Kidney Blood Press Res 2004; 27: 143-7.
    • (2004) Kidney Blood Press Res , vol.27 , pp. 143-147
    • Kielstein, J.T.1    Simmel, S.2    Bode-Böger, S.M.3
  • 70
    • 33747186695 scopus 로고    scopus 로고
    • ADMA increases arterial stiffness and decreases cerebral blood flow in humans
    • Kielstein JT, Donnerstag F, Gasper S, et al. ADMA increases arterial stiffness and decreases cerebral blood flow in humans. Stroke 2006; 37: 2024-9.
    • (2006) Stroke , vol.37 , pp. 2024-2029
    • Kielstein, J.T.1    Donnerstag, F.2    Gasper, S.3
  • 71
    • 83455230998 scopus 로고    scopus 로고
    • Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase
    • von Leitner EC, Klinke A, Atzler D, et al. Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase. Circulation 2011; 124: 2735-45.
    • (2011) Circulation , vol.124 , pp. 2735-2745
    • Von Leitner, E.C.1    Klinke, A.2    Atzler, D.3
  • 73
    • 0025750850 scopus 로고
    • Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells
    • Pollock JS, Förstermann U, Mitchell JA, et al. Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc Natl Acad Sci USA 1991; 88: 10480-4.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10480-10484
    • Pollock, J.S.1    Förstermann, U.2    Mitchell, J.A.3
  • 74
    • 0842347848 scopus 로고    scopus 로고
    • The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor
    • Böger RH. The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor. Cardiovasc Res 2003; 59: 824-33.
    • (2003) Cardiovasc Res , vol.59 , pp. 824-833
    • Böger, R.H.1
  • 75
    • 77949813688 scopus 로고    scopus 로고
    • Inhibition of L-arginine metabolizing enzymes by L-arginine-derived advanced glycation end products
    • Lai YL, Aoyama S, Nagai R, Miyoshi N, Ohshima H. Inhibition of L-arginine metabolizing enzymes by L-arginine-derived advanced glycation end products. J Clin Biochem Nutr 2010; 46: 177-85.
    • (2010) J Clin Biochem Nutr , vol.46 , pp. 177-185
    • Lai, Y.L.1    Aoyama, S.2    Nagai, R.3    Miyoshi, N.4    Ohshima, H.5
  • 76
    • 0028978149 scopus 로고
    • N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthases
    • Reif DW, McCreedy SS. N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthases. Arch Biochem Biophys 1995; 320: 170-6.
    • (1995) Arch Biochem Biophys , vol.320 , pp. 170-176
    • Reif, D.W.1    McCreedy, S.S.2
  • 77
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: Structure, function and inhibition
    • Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J 2001; 357: 593-615.
    • (2001) Biochem J , vol.357 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 78
    • 0029903915 scopus 로고    scopus 로고
    • 2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo
    • Faraci WS, Nagel AA, Verdries KA, et al. 2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo. Br J Pharmacol 1996; 119: 1101-8.
    • (1996) Br J Pharmacol , vol.119 , pp. 1101-1108
    • Faraci, W.S.1    Nagel, A.A.2    Verdries, K.A.3
  • 79
    • 34247472124 scopus 로고    scopus 로고
    • Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase
    • Li W, Xue J, Niu C, et al. Synergistic neuroprotection by bis(7)-tacrine via concurrent blockade of N-methyl-D-aspartate receptors and neuronal nitric-oxide synthase. Mol Pharmacol 2007; 71: 1258-67.
    • (2007) Mol Pharmacol , vol.71 , pp. 1258-1267
    • Li, W.1    Xue, J.2    Niu, C.3
  • 80
    • 0025191219 scopus 로고
    • Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme
    • Bredt DS, Snyder SH. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA 1990; 87: 682-5.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 682-685
    • Bredt, D.S.1    Snyder, S.H.2
  • 83
    • 0028818990 scopus 로고
    • Response of cerebral blood vessels to an endogenous inhibitor of nitric oxide synthase
    • Faraci FM, Brian JE, Heistad DD. Response of cerebral blood vessels to an endogenous inhibitor of nitric oxide synthase. Am J Physiol Heart Circ Physiol 1995; 269: H1522-H1524.
    • (1995) Am J Physiol Heart Circ Physiol , vol.269
    • Faraci, F.M.1    Brian, J.E.2    Heistad, D.D.3
  • 84
    • 0028073388 scopus 로고
    • Effect of opioid receptor agonists on nitric oxide synthase activity in rat cerebral cortex homogenate
    • Barjavel MJ, Bhargava HN. Effect of opioid receptor agonists on nitric oxide synthase activity in rat cerebral cortex homogenate. Neurosci Lett 1994; 181: 27-30.
    • (1994) Neurosci Lett , vol.181 , pp. 27-30
    • Barjavel, M.J.1    Bhargava, H.N.2
  • 85
    • 0028140141 scopus 로고
    • Inhibitors of brain nitric oxide synthase. Binding kinetics, metabolism, and enzyme inactivation
    • Klatt P, Schmidt K, Brunner F, Mayer B. Inhibitors of brain nitric oxide synthase. Binding kinetics, metabolism, and enzyme inactivation. J Biol Chem 1994; 269: 1674-80.
    • (1994) J Biol Chem , vol.269 , pp. 1674-1680
    • Klatt, P.1    Schmidt, K.2    Brunner, F.3    Mayer, B.4
  • 86
    • 0030755230 scopus 로고    scopus 로고
    • Effect of methylguanidine, guanidine and structurally related compounds on constitutive and inducible nitric oxide synthase activity
    • Sorrentino R, Sautebin L, Pinto A. Effect of methylguanidine, guanidine and structurally related compounds on constitutive and inducible nitric oxide synthase activity. Life Sci 1997; 61: 1283-91.
    • (1997) Life Sci , vol.61 , pp. 1283-1291
    • Sorrentino, R.1    Sautebin, L.2    Pinto, A.3
  • 87
    • 0025787205 scopus 로고
    • Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: An FAD-and FMN-containing flavoprotein
    • Stuehr DJ, Cho HJ, Kwon NS, Weise MF, Nathan CF. Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: An FAD-and FMN-containing flavoprotein. Proc Natl Acad Sci USA 1991; 88: 7773-7.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 7773-7777
    • Stuehr, D.J.1    Cho, H.J.2    Kwon, N.S.3    Weise, M.F.4    Nathan, C.F.5
  • 88
    • 0026323665 scopus 로고
    • Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein
    • Hevel JM, White KA, Marletta MA. Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein. J Biol Chem 1991; 226: 22789-91.
    • (1991) J Biol Chem , vol.226 , pp. 22789-22791
    • Hevel, J.M.1    White, K.A.2    Marletta, M.A.3
  • 89
    • 0035377659 scopus 로고    scopus 로고
    • Induction and kinetic characterization of nitric oxide synthase in hepatocytes
    • Tang X, Zhou D, Kang G. Induction and kinetic characterization of nitric oxide synthase in hepatocytes. Zhonghua Gan Zang Bing Za Zhi 2001; 9: 169-71.
    • (2001) Zhonghua Gan Zang Bing Za Zhi , vol.9 , pp. 169-171
    • Tang, X.1    Zhou, D.2    Kang, G.3
  • 91
    • 0025046968 scopus 로고
    • Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine
    • Gross SS, Stuehr DJ, Aisaka K, Jaffe EA, Levi R, Griffith OW. Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine. Biochem Biophys Res Commun 1990; 170: 96-103.
    • (1990) Biochem Biophys Res Commun , vol.170 , pp. 96-103
    • Gross, S.S.1    Stuehr, D.J.2    Aisaka, K.3    Jaffe, E.A.4    Levi, R.5    Griffith, O.W.6
  • 92
    • 0025194144 scopus 로고
    • LNG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilation in vitro
    • Moore PK, al-Swayeh OA, Chong NWS, Evans RA, Gibson A. LNG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilation in vitro. Br J Pharmacol 1990; 99: 408-12.
    • (1990) Br J Pharmacol , vol.99 , pp. 408-412
    • Moore, P.K.1    Al-Swayeh, O.A.2    Chong, N.3    Evans, R.A.4    Gibson, A.5
  • 93
    • 0025011716 scopus 로고
    • Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo
    • Rees DD, Palmer RM, Schulz R, Hodson HF, Moncada S. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 1990; 101: 746-52.
    • (1990) Br J Pharmacol , vol.101 , pp. 746-752
    • Rees, D.D.1    Palmer, R.M.2    Schulz, R.3    Hodson, H.F.4    Moncada, S.5
  • 94
    • 0028346288 scopus 로고
    • Effects of guanidino and uremic compounds on nitric oxide pathways
    • MacAllister RJ, Whitley G, Vallance P. Effects of guanidino and uremic compounds on nitric oxide pathways. Kidney Int 1994; 45: 737-42.
    • (1994) Kidney Int , vol.45 , pp. 737-742
    • Macallister, R.J.1    Whitley, G.2    Vallance, P.3
  • 95
    • 0034754959 scopus 로고    scopus 로고
    • Inhibition of nitric oxide activity by arginine analogs in human renal arteries
    • Segarra G, Medina P, Vila JM, Chuan P, Domenech C, Torondel B, et al. Inhibition of nitric oxide activity by arginine analogs in human renal arteries. Am J Hypertens 2001; 14: 1142-8.
    • (2001) Am J Hypertens , vol.14 , pp. 1142-1148
    • Segarra, G.1    Medina, P.2    Vila, J.M.3    Chuan, P.4    Domenech, C.5    Torondel, B.6
  • 97
    • 0027373825 scopus 로고
    • Regional and cardiac haemodynamic effects of NG, NG,dimethyl-L-arginine and their reversibility by vasodilators in conscious rats
    • Gardiner SM, Kemp PA, Bennett T, Palmer RM, Moncada S. Regional and cardiac haemodynamic effects of NG, NG,dimethyl-L-arginine and their reversibility by vasodilators in conscious rats. Br J Pharmacol 1993; 110: 1457-64.
    • (1993) Br J Pharmacol , vol.110 , pp. 1457-1464
    • Gardiner, S.M.1    Kemp, P.A.2    Bennett, T.3    Palmer, R.M.4    Moncada, S.5
  • 98
    • 4444248826 scopus 로고    scopus 로고
    • Asymmetric dimethyl-arginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice: involvement of renin-angiotensin system and oxidative stress
    • Suda O, Tsutsui M, Morishita T, et al. Asymmetric dimethyl-arginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice: involvement of renin-angiotensin system and oxidative stress. Arterioscler Thromb Vasc Biol 2004; 24: 1682-8.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1682-1688
    • Suda, O.1    Tsutsui, M.2    Morishita, T.3
  • 99
    • 34250025922 scopus 로고    scopus 로고
    • Effect of asymmetric dimethylarginine on atherogenesis and erythrocyte deformability in apolipoprotein
    • Xiao HB, Yang ZC, Jia SJ, et al. Effect of asymmetric dimethylarginine on atherogenesis and erythrocyte deformability in apolipoprotein E deficient mice. Life sci 2007; 81: 1-7.
    • (2007) E Deficient Mice. Life Sci , vol.81 , pp. 1-7
    • Xiao, H.B.1    Yang, Z.C.2    Jia, S.J.3
  • 100
    • 59149102060 scopus 로고    scopus 로고
    • Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice
    • Wells SM, Buford MC, Migliaccio CT, Holian A. Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice. Am J Respir Cell Mol Biol 2009; 40: 179-88.
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 179-188
    • Wells, S.M.1    Buford, M.C.2    Migliaccio, C.T.3    Holian, A.4
  • 101
    • 68149162181 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine reference intervals determined with liquid chromatography-tandem mass spectrometry: Results from the Framingham offspring cohort
    • Schwedhelm E, Xanthakis V, Maas R, et al. Asymmetric dimethylarginine reference intervals determined with liquid chromatography-tandem mass spectrometry: results from the Framingham offspring cohort. Clin Chem 2009; 55: 1539-45.
    • (2009) Clin Chem , vol.55 , pp. 1539-1545
    • Schwedhelm, E.1    Xanthakis, V.2    Maas, R.3
  • 102
    • 80755171198 scopus 로고    scopus 로고
    • Plasma symmetric dimethylarginine reference limits from the Framingham offspring cohort
    • Schwedhelm E, Xanthakis V, Maas R, et al. Plasma symmetric dimethylarginine reference limits from the Framingham offspring cohort. Clin Chem Lab Med 2011; 49: 1907-10.
    • (2011) Clin Chem Lab Med , vol.49 , pp. 1907-1910
    • Schwedhelm, E.1    Xanthakis, V.2    Maas, R.3
  • 103
    • 69849106418 scopus 로고    scopus 로고
    • Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: Potential mechanisms beyond nitric oxide synthase inhibition
    • Wang Z, Tang WH, Cho L, Brennan DM, Hazen SL. Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: potential mechanisms beyond nitric oxide synthase inhibition. Arterioscler Thromb Vasc Biol 2009; 29: 1383-91.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1383-1391
    • Wang, Z.1    Tang, W.H.2    Cho, L.3    Brennan, D.M.4    Hazen, S.L.5
  • 104
    • 70350057304 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality--an update on patient populations with a wide range of cardiovascular risk
    • Böger RH, Maas R, Schulze F, Schwedhelm E. Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality--an update on patient populations with a wide range of cardiovascular risk. Pharmacol Res 2009; 60: 481-7.
    • (2009) Pharmacol Res , vol.60 , pp. 481-487
    • Böger, R.H.1    Maas, R.2    Schulze, F.3    Schwedhelm, E.4
  • 105
    • 34147194549 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine, smoking, and risk of coronary heart disease in apparently healthy men: Prospective analysis from the population-based Monitoring of Trends and Determinants in Cardiovascular Disease/Kooperative Gesundheitsforschung in der Region Augsburg study and experimental data
    • Maas R, Schulze F, Baumert J, et al. Asymmetric dimethylarginine, smoking, and risk of coronary heart disease in apparently healthy men: prospective analysis from the population-based Monitoring of Trends and Determinants in Cardiovascular Disease/Kooperative Gesundheitsforschung in der Region Augsburg study and experimental data. Clin Chem 2007; 53: 693-701.
    • (2007) Clin Chem , vol.53 , pp. 693-701
    • Maas, R.1    Schulze, F.2    Baumert, J.3
  • 106
    • 0035936390 scopus 로고    scopus 로고
    • Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine
    • Valkonen VP, Paiva H, Salonen JT, et al. Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine. Lancet 2001; 358: 2127-8.
    • (2001) Lancet , vol.358 , pp. 2127-2128
    • Valkonen, V.P.1    Paiva, H.2    Salonen, J.T.3
  • 107
    • 27744511357 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine and the risk of cardiovascular events and death in patients with coronary artery disease: Results from the AtheroGene Study
    • Schnabel R, Blankenberg S, Lubos E, et al. Asymmetric dimethylarginine and the risk of cardiovascular events and death in patients with coronary artery disease: results from the AtheroGene Study. Circ Res 2005; 97: e53-9.
    • (2005) Circ Res , vol.97
    • Schnabel, R.1    Blankenberg, S.2    Lubos, E.3
  • 108
    • 70450245459 scopus 로고    scopus 로고
    • Methylarginines and mortality in patients with end stage renal disease: A prospective cohort study
    • Aucella F, Maas R, Vigilante M, et al. Methylarginines and mortality in patients with end stage renal disease: a prospective cohort study. Atherosclerosis 2009; 207: 541-5.
    • (2009) Atherosclerosis , vol.207 , pp. 541-545
    • Aucella, F.1    Maas, R.2    Vigilante, M.3
  • 109
    • 0035936406 scopus 로고    scopus 로고
    • Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: A prospective study
    • Zoccali C, Bode-Böger S, Mallamaci F, et al. Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: a prospective study. Lancet 2001; 358: 2113-7.
    • (2001) Lancet , vol.358 , pp. 2113-2117
    • Zoccali, C.1    Bode-Böger, S.2    Mallamaci, F.3
  • 110
    • 12244262222 scopus 로고    scopus 로고
    • Asymmetrical dimethylarginine (ADMA) in critically ill patients: High plasma ADMA concentration is an independent risk factor of ICU mortality
    • Nijveldt RJ, Teerlink T, Van Der Hoven B, et al. Asymmetrical dimethylarginine (ADMA) in critically ill patients: high plasma ADMA concentration is an independent risk factor of ICU mortality. Clin Nutr 2003; 22: 23-30.
    • (2003) Clin Nutr , vol.22 , pp. 23-30
    • Nijveldt, R.J.1    Teerlink, T.2    Van Der Hoven, B.3
  • 111
    • 65249119330 scopus 로고    scopus 로고
    • Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community
    • Böger RH, Sullivan LM, Schwedhelm E, et al. Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community. Circulation 2009; 119: 1592-600.
    • (2009) Circulation , vol.119 , pp. 1592-1600
    • Böger, R.H.1    Sullivan, L.M.2    Schwedhelm, E.3
  • 112
    • 84890038945 scopus 로고    scopus 로고
    • Asymmetric dimethyl-arginine predicts survival in the elderly
    • Pizzarelli F, Maas R, Dattolo P, et al. Asymmetric dimethyl-arginine predicts survival in the elderly. Age (Dordr) 2013.
    • (2013) Age (Dordr)
    • Pizzarelli, F.1    Maas, R.2    Dattolo, P.3
  • 113
    • 74749108725 scopus 로고    scopus 로고
    • Symmetric dimethylarginine predicts all-cause mortality following ischemic stroke
    • Schulze F, Carter AM, Schwedhelm E, et al. Symmetric dimethylarginine predicts all-cause mortality following ischemic stroke. Atherosclerosis 2010; 208: 518-23.
    • (2010) Atherosclerosis , vol.208 , pp. 518-523
    • Schulze, F.1    Carter, A.M.2    Schwedhelm, E.3
  • 114
    • 70350044686 scopus 로고    scopus 로고
    • ADMA and the role of the genes: Lessons from genetically modified animals and human gene polymorphisms
    • Maas R, Böger R, Lüneburg N. ADMA and the role of the genes: lessons from genetically modified animals and human gene polymorphisms. Pharmacol Res 2009; 60: 475-80.
    • (2009) Pharmacol Res , vol.60 , pp. 475-480
    • Maas, R.1    Böger, R.2    Lüneburg, N.3


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