Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase

Circulation

Volumn 124, Issue 24, 2011, Pages 2735-2745

  Von Leitner, Eike Christin ^a,b   Klinke, Anna ^a   Atzler, Dorothee ^b   Slocum, Jessica L ^c   Lund, Natalie ^a   Kielstein, Jan T ^e   Maas, Renke ^b,g   Schmidt Haupt, Robin ^b   Pekarova, Michaela ^f   Hellwinkel, Olaf ^b   Tsikas, Dimitrios ^e   D'Alecy, Louis G ^d   Lau, Denise ^a   Willems, Stephan ^a   Kubala, Lukas ^f   Ehmke, Heimo ^b   Meinertz, Thomas ^a   Blankenberg, Stefan ^a   Schwedhelm, Edzard ^b   Gadegbeku, Crystal A ^c   Böger, Rainer H ^b   Baldus, Stephan ^a   Sydow, Karsten ^a,b   more..

^a UNIVERSITY HEART CENTER HAMBURG   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c Division of Nephrology   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e HANNOVER MEDICAL SCHOOL   (Germany)

^f INSTITUTE OF BIOPHYSICS   (Czech Republic)

^g UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

arteriosclerosis; endothelium; inflammation; leukocytes; nitric oxide synthase

Indexed keywords

AMINO ACID TRANSPORTER; DIMETHYLARGININASE; HYPOCHLOROUS ACID; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; N(G),N(G) DIMETHYLARGININE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; BLOOD LEVEL; CELL ACTIVATION; CONTROLLED STUDY; DEGRANULATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; ENZYME RELEASE; EX VIVO STUDY; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LEUKOCYTE; LEUKOCYTE ADHERENCE; MALE; MASS SPECTROMETRY; MOUSE; NEUTROPHIL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; UMBILICAL VEIN ENDOTHELIAL CELL;

AMIDOHYDROLASES; ANIMALS; ARGININE; CARDIOVASCULAR DISEASES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HL-60 CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, ANIMAL; NEUTROPHILS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PEROXIDASE; SIGNAL TRANSDUCTION; SUPEROXIDES;

EID: 83455230998     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.060541     Document Type: Article

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