Production of free methylarginines via the proteasome and autophagy pathways in cultured cells

Molecular Medicine Reports

Volumn 4, Issue 4, 2011, Pages 615-620

  Shirakawa, Takuma ^a   Kako, Koichiro ^a   Shimada, Takashi ^a   Nagashima, Yusuke ^a   Nakamura, Ayumi ^a   Ishida, Junji ^a   Fukamizu, Akiyoshi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Autophagy; Matrix assisted laser desorption ionization quadrupole ion trap time of flight tandem mass spectrometry; Methylarginine; Proteasome; Protein arginine methyltransferase (PRMT); Ultra high performance liquid chromatography

Indexed keywords

6 N,N' DIMETHYLARGININE; N(G) METHYLARGININE; N(G),N(G) DIMETHYLARGININE; PROTEASOME;

AMINO ACID ANALYSIS; AMINO ACID SYNTHESIS; ARTICLE; AUTOPHAGY; BIOSYNTHESIS; CONTROLLED STUDY; ENZYME INACTIVATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INTRACELLULAR SPACE; ION TRAP MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METHYLATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ARGININE; AUTOPHAGY; CELL LINE; CHLOROQUINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; LEUPEPTINS; METHYLATION; OLIGOPEPTIDES; OMEGA-N-METHYLARGININE; PROTEASOME ENDOPEPTIDASE COMPLEX; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 79957643315     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.488     Document Type: Article

References (24)

1. Bedford MT and Clarke SG: Protein arginine methylation in mammals: who, what, and why. Mol Cell 33: 1-13, 2010.
2. Wolf S: The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans. Cell Mol Life Sci 66: 2109-2121, 2009.
3. Lin WJ, Gary JD, Yang MC, Clarke S and Herschman HR: The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase. J Biol Chem 271: 15034-15044, 1996. (Pubitemid 26197578)
4. Lakowski TM and Frankel A: Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. Biochem J 421: 253-261, 2009.
5. Tang J, Gary JD, Clarke S and Herschman HR: PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation. J Biol Chem 273: 16935-16945, 1998. (Pubitemid 28311725)
6. Chen D, Ma H, Hong H, et al: Regulation of transcription by a protein methyltransferase. Science 284: 2174-2177, 1999. (Pubitemid 29297477)
7. Frankel A, Yadav N, Lee J, Branscombe TL, Clarke S and Bedford MT: The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. J Biol Chem 277: 3537-3543, 2002. (Pubitemid 34953224)
8. Lee J, Sayegh J, Daniel J, Clarke S and Bedford MT: PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. J Biol Chem 280: 32890-32896, 2005. (Pubitemid 41368338)
9. Kim J-D, Kako K, Kakiuchi M, Park GG and Fukamizu A: EWS is a substrate of type I protein arginine methyltransferase, PRMT8. Int J Mol Med 22: 309-315, 2008.
10. Pollack BP, Kotenko SV, He W, Izotova LS, Barnoski BL and Pestka S: The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity. J Biol Chem 274: 31531-31542, 1999.
11. Miranda TB, Miranda M, Frankel A and Clarke S: PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity. J Biol Chem 279: 22902-22907, 2004. (Pubitemid 38685591)
12. Cook JR, Lee J-H, Yang Z-H, Krause CD, Herth N, Hoffmann R, and Pestka S: FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues. Biochem Biophys Res Commun 342: 472-481, 2006. (Pubitemid 43289016)
13. Miyake M and Kakimoto Y: Synthesis and degradation of methylated proteins of mouse organs: correlation with protein synthesis and degradation. Metab Clin Exp 25: 885-896, 1976.
14. Drapier JC and Hibbs JB: Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible. J Clin Invest 78: 790-797, 1986.
15. Vallance P, Leone A, Calver A, Collier J and Moncada S: Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339: 572-575, 1992.
16. Calver A, Collier J, Leone A, Moncada S and Vallance P: Effect of local intra-arterial asymmetric dimethylarginine (ADMA) on the forearm arteriolar bed of healthy volunteers. J Hum Hypertens 7: 193-194, 1993. (Pubitemid 23138200)
17. G-dimethyl-L- arginine in plasma by liquid chromatography as AccQ-Fluor fluorescent derivatives. J Chromatogr B Analyt Technol Biomed Life Sci 805: 325-329, 2004.
18. Yamagata K, Daitoku H, Takahashi Y, et al: Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. Mol Cell 32: 221-231, 2008.
19. Kasai H, Tsubuki M, Shimada K, Nambara T and Honda T: Analyses of biologically active steroids: antitumor active OSW-1 and cardiotonic marinobufotoxin, by matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight tandem mass spectrometry. Chem Pharm Bull 57: 948-956, 2009.
20. Kabeya Y, Mizushima N, Ueno T, et al: LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19: 5720-5728, 2000.
21. Teerlink T: HPLC analysis of ADMA and other methylated L-arginine analogs in biological fluids. J Chromatogr B Analyt Technol Biomed Life Sci 851: 21-29, 2007.
22. Bulau P, Zakrzewicz D, Kitowska K, Wardega B, Kreuder J and Eickelberg O: Quantitative assessment of arginine methylation in free versus protein-incorporated amino acids in vitro and in vivo using protein hydrolysis and high-performance liquid chromatography. Biotechniques 40: 305-310, 2006. (Pubitemid 46542622)
23. Wibo M and Poole B: Protein degradation in cultured cells. II. The uptake of chloroquine by rat fibroblasts and the inhibition of cellular protein degradation and cathepsin B1. J Cell Biol 63: 430-440, 1974.
24. Gray RH, Sokol M, Brabec RK and Brabec MJ: Characterization of chloroquine-induced autophagic vacuoles isolated from rat liver. Exp Mol Pathol 34: 72-86, 1981. (Pubitemid 11134211)