Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Flierl, Adrian ^a   Oliveira, Luís M A ^b   Falomir Lockhart, Lisro J ^b   Mak, Sally K ^a   Hesley, Jayne ^c   Soldner, Frank ^d   Arndt Jovin, Donna J ^b   Jaenisch, Rudolf ^d   Langston, J William ^a   Jovin, Thomas M ^b   Le, Birgitt Schu ^a  

^a PARKINSON S INSTITUTE   (United States)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^c MOLECULAR DEVICES CORPORATION   (United States)

^d WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA SYNUCLEIN; CASPASE; CYTOCHROME C; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; CULTURE MEDIUM; GLUCOSE; HYDROGEN PEROXIDE; SMALL INTERFERING RNA; SNCA PROTEIN, HUMAN; STAUROSPORINE;

AGING; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL GROWTH; CELL LOSS; CELL METABOLISM; CELL STRESS; CELL STRUCTURE; CELL VIABILITY; CELLULAR DISTRIBUTION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; ENERGY METABOLISM; ENVIRONMENTAL STRESS; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENE MUTATION; GENE SILENCING; GENE TRIPLICATION; GENETIC PREDISPOSITION; GENOTYPE ENVIRONMENT INTERACTION; HETEROZYGOSITY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NERVE DEGENERATION; NEURAL STEM CELL; NEUROPATHOLOGY; OXIDATIVE STRESS; PARKINSON DISEASE; PHYSICAL RESISTANCE; PLURIPOTENT STEM CELL; PROTEIN AGGREGATION; SNCA GENE; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL AGING; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; CULTURE MEDIUM; DEFICIENCY; DRUG EFFECTS; FEMALE; GENE DUPLICATION; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; PATHOLOGY; SUBSTANTIA NIGRA;

ALPHA-SYNUCLEIN; APOPTOSIS; CELL AGING; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA; ENERGY METABOLISM; FEMALE; GENE DUPLICATION; GENE EXPRESSION REGULATION; GLUCOSE; HUMANS; HYDROGEN PEROXIDE; INDUCED PLURIPOTENT STEM CELLS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NEURAL STEM CELLS; PARKINSON DISEASE; RNA, SMALL INTERFERING; STAUROSPORINE; SUBSTANTIA NIGRA;

EID: 84911469217     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0112413     Document Type: Article

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