메뉴 건너뛰기




Volumn 20, Issue 42, 2014, Pages 6555-6564

The exploitation of toll-like receptor 3 signaling in cancer therapy

Author keywords

Cancer; Poly (I: C); Signaling; Therapy; Toll like receptor 3

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOXYMETHYLCELLULOSE POLYCYTIDYLIC POLYINOSINIC ACID POLYLYSINE; MDA5 PROTEIN; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN; RETINOIC ACID INDUCIBLE PROTEIN I; RINTATOLIMOD; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG;

EID: 84911468481     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612820666140826153347     Document Type: Article
Times cited : (39)

References (73)
  • 2
    • 0036076593 scopus 로고    scopus 로고
    • Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling
    • Matsumoto M, Kikkawa S, Kohase M, Miyake K, Seya T. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem Biophys Res Commun 2002; 293: 1364-9.
    • (2002) Biochem Biophys Res Commun , vol.293 , pp. 1364-1369
    • Matsumoto, M.1    Kikkawa, S.2    Kohase, M.3    Miyake, K.4    Seya, T.5
  • 3
    • 42349090335 scopus 로고    scopus 로고
    • Structural basis of toll-like receptor 3 signaling with double-stranded RNA
    • Liu L, Botos I, Wang Y, et al. Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science 2008; 320: 379-81.
    • (2008) Science , vol.320 , pp. 379-381
    • Liu, L.1    Botos, I.2    Wang, Y.3
  • 4
    • 38349115933 scopus 로고    scopus 로고
    • The TLR3 signaling complex forms by cooperative receptor dimerization
    • Leonard JN, Ghirlando R, Askins J, et al. The TLR3 signaling complex forms by cooperative receptor dimerization. Proc Natl Acad Sci USA 2008; 105: 258-63.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 258-263
    • Leonard, J.N.1    Ghirlando, R.2    Askins, J.3
  • 5
    • 84896708687 scopus 로고    scopus 로고
    • Toll-IL-1-receptor-containing adaptor molecule-1: A signaling adaptor linking innate immunity to adaptive immunity
    • Matsumoto M, Funami K, Oshiumi H, Seya T. Toll-IL-1-receptor-containing adaptor molecule-1: a signaling adaptor linking innate immunity to adaptive immunity. Prog Mol Biol Transl Sci 2013; 117: 487-510.
    • (2013) Prog Mol Biol Transl Sci , vol.117 , pp. 487-510
    • Matsumoto, M.1    Funami, K.2    Oshiumi, H.3    Seya, T.4
  • 6
    • 33947520687 scopus 로고    scopus 로고
    • Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation
    • Sarkar SN, Elco CP, Peters KL, Chattopadhyay S, Sen GC. Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation. J Biol Chem 2007; 282: 3423-7.
    • (2007) J Biol Chem , vol.282 , pp. 3423-3427
    • Sarkar, S.N.1    Elco, C.P.2    Peters, K.L.3    Chattopadhyay, S.4    Sen, G.C.5
  • 7
    • 7544225495 scopus 로고    scopus 로고
    • Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in doublestranded RNA signaling
    • Sarkar SN, Peters KL, Elco CP, Sakamoto S, Pal S, Sen GC. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in doublestranded RNA signaling. Nat Struct Mol Biol 2004; 11: 1060-7.
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 1060-1067
    • Sarkar, S.N.1    Peters, K.L.2    Elco, C.P.3    Sakamoto, S.4    Pal, S.5    Sen, G.C.6
  • 8
    • 17144413785 scopus 로고    scopus 로고
    • Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif
    • Kaiser WJ, Offermann MK. Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. J Immunol 2005; 174: 4942-52.
    • (2005) J Immunol , vol.174 , pp. 4942-4952
    • Kaiser, W.J.1    Offermann, M.K.2
  • 9
    • 33750976374 scopus 로고    scopus 로고
    • 5'-Triphosphate RNA is the ligand for RIG-I
    • Hornung V, Ellegast J, Kim S, et al. 5'-Triphosphate RNA is the ligand for RIG-I. Science 2006; 314: 994-7.
    • (2006) Science , vol.314 , pp. 994-997
    • Hornung, V.1    Ellegast, J.2    Kim, S.3
  • 10
    • 46949097299 scopus 로고    scopus 로고
    • Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5
    • Kato H, Takeuchi O, Mikamo-Satoh E, et al. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med 2008; 205: 1601-10.
    • (2008) J Exp Med , vol.205 , pp. 1601-1610
    • Kato, H.1    Takeuchi, O.2    Mikamo-Satoh, E.3
  • 11
    • 77955357662 scopus 로고    scopus 로고
    • Immunomodulatory effects of dsRNA and its potential as vaccine adjuvant
    • Jin B, Sun T, Yu XH, et al. Immunomodulatory effects of dsRNA and its potential as vaccine adjuvant. J Biomed Biotechnol 2010; 2010: 690438.
    • (2010) J Biomed Biotechnol , vol.2010
    • Jin, B.1    Sun, T.2    Yu, X.H.3
  • 12
    • 22744453319 scopus 로고    scopus 로고
    • Toll-like receptors-2,-3 and-4 expression patterns on human colon and their regulation by mucosal-associated bacteria
    • Furrie E, Macfarlane S, Thomson G, Macfarlane GT. Toll-like receptors-2,-3 and-4 expression patterns on human colon and their regulation by mucosal-associated bacteria. Immunology 2005; 115: 565-74.
    • (2005) Immunology , vol.115 , pp. 565-574
    • Furrie, E.1    Macfarlane, S.2    Thomson, G.3    Macfarlane, G.T.4
  • 15
    • 84860290510 scopus 로고    scopus 로고
    • Expression profiles of Toll-like receptors in non-small cell lung cancer and idiopathic pulmonary fibrosis
    • Samara KD, Antoniou KM, Karagiannis K, et al. Expression profiles of Toll-like receptors in non-small cell lung cancer and idiopathic pulmonary fibrosis. Int J Oncol 2012; 40: 1397-404.
    • (2012) Int J Oncol , vol.40 , pp. 1397-1404
    • Samara, K.D.1    Antoniou, K.M.2    Karagiannis, K.3
  • 16
    • 34547665101 scopus 로고    scopus 로고
    • Tolllike receptor 3 expressed by melanoma cells as a target for therapy?
    • Salaun B, Lebecque S, Matikainen S, Rimoldi D, Romero P. Tolllike receptor 3 expressed by melanoma cells as a target for therapy? Clin Cancer Res 2007; 13(15 Pt 1): 4565-74.
    • (2007) Clin Cancer Res , vol.13 , Issue.15 , pp. 4565-4574
    • Salaun, B.1    Lebecque, S.2    Matikainen, S.3    Rimoldi, D.4    Romero, P.5
  • 17
    • 78649552269 scopus 로고    scopus 로고
    • Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis
    • Gonzalez-Reyes S, Marin L, Gonzalez L, et al. Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis. BMC Cancer 2010; 10: 665.
    • (2010) BMC Cancer , vol.10 , pp. 665
    • Gonzalez-Reyes, S.1    Marin, L.2    Gonzalez, L.3
  • 18
    • 38949130755 scopus 로고    scopus 로고
    • Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer
    • Pries R, Hogrefe L, Xie L, et al. Induction of c-Myc-dependent cell proliferation through toll-like receptor 3 in head and neck cancer. Int J Mol Med 2008; 21: 209-15.
    • (2008) Int J Mol Med , vol.21 , pp. 209-215
    • Pries, R.1    Hogrefe, L.2    Xie, L.3
  • 19
    • 84870915632 scopus 로고    scopus 로고
    • Toll-like receptor 3 expressing tumor parenchyma and infiltrating natural killer cells in hepatocellular carcinoma patients
    • Chew V, Tow C, Huang C, et al. Toll-like receptor 3 expressing tumor parenchyma and infiltrating natural killer cells in hepatocellular carcinoma patients. J Natl Cancer Inst 2012; 104: 1796-807.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 1796-1807
    • Chew, V.1    Tow, C.2    Huang, C.3
  • 20
    • 67649818408 scopus 로고    scopus 로고
    • Functionally active toll-like receptor 3 on human primary and metastatic cancer cells
    • Matijevic T, Marjanovic M, Pavelic J. Functionally active toll-like receptor 3 on human primary and metastatic cancer cells. Scand J Immunol 2009; 70: 18-24.
    • (2009) Scand J Immunol , vol.70 , pp. 18-24
    • Matijevic, T.1    Marjanovic, M.2    Pavelic, J.3
  • 21
    • 82355173421 scopus 로고    scopus 로고
    • The dual role of TLR3 in metastatic cell line
    • Matijevic T, Pavelic J. The dual role of TLR3 in metastatic cell line. Clin Exp Metastasis 2011; 28: 701-12.
    • (2011) Clin Exp Metastasis , vol.28 , pp. 701-712
    • Matijevic, T.1    Pavelic, J.2
  • 22
    • 84862501419 scopus 로고    scopus 로고
    • Preferential involvement of mitochondria in Toll-like receptor 3 agonist-induced neuroblastoma cell apoptosis, but not in inhibition of cell growth
    • Chuang JH, Lin TK, Tai MH, et al. Preferential involvement of mitochondria in Toll-like receptor 3 agonist-induced neuroblastoma cell apoptosis, but not in inhibition of cell growth. Apoptosis 2012; 17: 335-48.
    • (2012) Apoptosis , vol.17 , pp. 335-348
    • Chuang, J.H.1    Lin, T.K.2    Tai, M.H.3
  • 23
    • 49349103910 scopus 로고    scopus 로고
    • Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC-alpha-dependent mechanism
    • Paone A, Starace D, Galli R, et al. Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC-alpha-dependent mechanism. Carcinogenesis 2008; 29: 1334-42.
    • (2008) Carcinogenesis , vol.29 , pp. 1334-1342
    • Paone, A.1    Starace, D.2    Galli, R.3
  • 25
    • 84865192787 scopus 로고    scopus 로고
    • dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8
    • Estornes Y, Toscano F, Virard F, et al. dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8. Cell Death Differ 2012; 19: 1482-94.
    • (2012) Cell Death Differ , vol.19 , pp. 1482-1494
    • Estornes, Y.1    Toscano, F.2    Virard, F.3
  • 26
    • 79955542144 scopus 로고    scopus 로고
    • Toll-like receptor 3 (TLR3) induces apoptosis via death receptors and mitochondria by up-regulating the transactivating p63 isoform alpha (TAP63alpha)
    • Sun R, Zhang Y, Lv Q, et al. Toll-like receptor 3 (TLR3) induces apoptosis via death receptors and mitochondria by up-regulating the transactivating p63 isoform alpha (TAP63alpha). J Biol Chem 2011; 286: 15918-28.
    • (2011) J Biol Chem , vol.286 , pp. 15918-15928
    • Sun, R.1    Zhang, Y.2    Lv, Q.3
  • 27
    • 84878996981 scopus 로고    scopus 로고
    • Toll-like receptor 3 (TLR3) activation induces microRNA-dependent reexpression of functional RARbeta and tumor regression
    • Galli R, Paone A, Fabbri M, et al. Toll-like receptor 3 (TLR3) activation induces microRNA-dependent reexpression of functional RARbeta and tumor regression. Proc Natl Acad Sci USA 2013; 110: 9812-7.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 9812-9817
    • Galli, R.1    Paone, A.2    Fabbri, M.3
  • 28
    • 58149195681 scopus 로고    scopus 로고
    • Dual topology of functional Toll-like receptor 3 expression in human hepatocellular carcinoma: Differential signaling mechanisms of TLR3-induced NF-kappaB activation and apoptosis
    • Yoneda K, Sugimoto K, Shiraki K, et al. Dual topology of functional Toll-like receptor 3 expression in human hepatocellular carcinoma: differential signaling mechanisms of TLR3-induced NF-kappaB activation and apoptosis. Int J Oncol 2008; 33: 929-36.
    • (2008) Int J Oncol , vol.33 , pp. 929-936
    • Yoneda, K.1    Sugimoto, K.2    Shiraki, K.3
  • 29
    • 34548064011 scopus 로고    scopus 로고
    • High basal levels of functional toll-like receptor 3 (TLR3) and noncanonical Wnt5a are expressed in papillary thyroid cancer and are coordinately decreased by phenylmethimazole together with cell proliferation and migration
    • McCall KD, Harii N, Lewis CJ, et al. High basal levels of functional toll-like receptor 3 (TLR3) and noncanonical Wnt5a are expressed in papillary thyroid cancer and are coordinately decreased by phenylmethimazole together with cell proliferation and migration. Endocrinology 2007; 148: 4226-37.
    • (2007) Endocrinology , vol.148 , pp. 4226-4237
    • McCall, K.D.1    Harii, N.2    Lewis, C.J.3
  • 30
    • 67449156114 scopus 로고    scopus 로고
    • Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration
    • Schwartz AL, Malgor R, Dickerson E, et al. Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration. Clin Cancer Res 2009; 15: 4114-22.
    • (2009) Clin Cancer Res , vol.15 , pp. 4114-4122
    • Schwartz, A.L.1    Malgor, R.2    Dickerson, E.3
  • 31
    • 77954995650 scopus 로고    scopus 로고
    • Toll-like receptor 3 regulates angiogenesis and apoptosis in prostate cancer cell lines through hy-poxia-inducible factor 1 alpha
    • Paone A, Galli R, Gabellini C, et al. Toll-like receptor 3 regulates angiogenesis and apoptosis in prostate cancer cell lines through hy-poxia-inducible factor 1 alpha. Neoplasia 2010; 12: 539-49.
    • (2010) Neoplasia , vol.12 , pp. 539-549
    • Paone, A.1    Galli, R.2    Gabellini, C.3
  • 32
    • 84885135776 scopus 로고    scopus 로고
    • Extracellular HSP27 mediates angiogenesis through Toll-like receptor 3
    • Jun 26. [Epub ahead of print]
    • Thuringer D, Jego G, Wettstein G, et al. Extracellular HSP27 mediates angiogenesis through Toll-like receptor 3. Faseb J 2013; Jun 26. [Epub ahead of print].
    • (2013) Faseb J
    • Thuringer, D.1    Jego, G.2    Wettstein, G.3
  • 33
    • 79151485605 scopus 로고    scopus 로고
    • Study of TLR3, TLR4, and TLR9 in prostate carcinomas and their association with biochemical recurrence
    • Gonzalez-Reyes S, Fernandez JM, Gonzalez LO, et al. Study of TLR3, TLR4, and TLR9 in prostate carcinomas and their association with biochemical recurrence. Cancer Immunol Immunother 2011; 60: 217-26.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 217-226
    • Gonzalez-Reyes, S.1    Fernandez, J.M.2    Gonzalez, L.O.3
  • 34
    • 77954856721 scopus 로고    scopus 로고
    • Poly(I: C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells
    • Friboulet L, Gourzones C, Tsao SW, et al. Poly(I: C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells. BMC Cancer 2010; 10: 327.
    • (2010) BMC Cancer , vol.10 , pp. 327
    • Friboulet, L.1    Gourzones, C.2    Tsao, S.W.3
  • 35
    • 55849099271 scopus 로고    scopus 로고
    • Recurrent overexpression of c-IAP2 in EBV-associated nasopharyngeal carcinomas: Critical role in resistance to Toll-like receptor 3-mediated apoptosis
    • Friboulet L, Pioche-Durieu C, Rodriguez S, et al. Recurrent overexpression of c-IAP2 in EBV-associated nasopharyngeal carcinomas: critical role in resistance to Toll-like receptor 3-mediated apoptosis. Neoplasia 2008; 10: 1183-94.
    • (2008) Neoplasia , vol.10 , pp. 1183-1194
    • Friboulet, L.1    Pioche-Durieu, C.2    Rodriguez, S.3
  • 36
    • 77952241062 scopus 로고    scopus 로고
    • Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells
    • Weber A, Kirejczyk Z, Besch R, Potthoff S, Leverkus M, Hacker G. Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells. Cell Death Differ 2010; 17: 942-51.
    • (2010) Cell Death Differ , vol.17 , pp. 942-951
    • Weber, A.1    Kirejczyk, Z.2    Besch, R.3    Potthoff, S.4    Leverkus, M.5    Hacker, G.6
  • 37
    • 84877872421 scopus 로고    scopus 로고
    • The polymorphisms in Toll-like receptor genes and cancer risk
    • Gomaz A, Pavelic J, Matijevic Glavan T. The polymorphisms in Toll-like receptor genes and cancer risk. Period Biol 2012; 114: 461-9.
    • (2012) Period Biol , vol.114 , pp. 461-469
    • Gomaz, A.1    Pavelic, J.2    Matijevic Glavan, T.3
  • 38
    • 37049010741 scopus 로고    scopus 로고
    • Genetic polymorphisms of TLR3 are associated with nasopharyngeal carcinoma risk in Cantonese population
    • He JF, Jia WH, Fan Q, et al. Genetic polymorphisms of TLR3 are associated with nasopharyngeal carcinoma risk in Cantonese population. BMC Cancer 2007; 7: 194.
    • (2007) BMC Cancer , vol.7 , pp. 194
    • He, J.F.1    Jia, W.H.2    Fan, Q.3
  • 39
    • 79955531832 scopus 로고    scopus 로고
    • TLR-3 polymorphism is an independent prognostic marker for stage II colorectal cancer
    • Castro FA, Forsti A, Buch S, et al. TLR-3 polymorphism is an independent prognostic marker for stage II colorectal cancer. Eur J Cancer 2011; 47: 1203-10.
    • (2011) Eur J Cancer , vol.47 , pp. 1203-1210
    • Castro, F.A.1    Forsti, A.2    Buch, S.3
  • 40
    • 0017108014 scopus 로고
    • A phase I-II trial of multiple-dose polyriboinosic-polyribocytidylic acid in patients with leukemia or solid tumors
    • Robinson RA, DeVita VT, Levy HB, Baron S, Hubbard SP, Levine AS. A phase I-II trial of multiple-dose polyriboinosic-polyribocytidylic acid in patients with leukemia or solid tumors. J Natl Cancer Inst 1976; 57: 599-602.
    • (1976) J Natl Cancer Inst , vol.57 , pp. 599-602
    • Robinson, R.A.1    DeVita, V.T.2    Levy, H.B.3    Baron, S.4    Hubbard, S.P.5    Levine, A.S.6
  • 41
    • 0028009931 scopus 로고
    • A controlled clinical trial with a specifically configured RNA drug, poly(I). Poly(C12U), in chronic fatigue syndrome
    • Strayer DR, Carter WA, Brodsky I, et al. A controlled clinical trial with a specifically configured RNA drug, poly(I). poly(C12U), in chronic fatigue syndrome. Clin Infect Dis 1994; 18 Suppl 1: S88-95.
    • (1994) Clin Infect Dis , vol.18 , pp. S88-S95
    • Strayer, D.R.1    Carter, W.A.2    Brodsky, I.3
  • 42
    • 34247143394 scopus 로고    scopus 로고
    • TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I: C12U), but not Poly(I: C): Differential recognition of synthetic dsRNA molecules
    • Gowen BB, Wong MH, Jung KH, et al. TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I: C12U), but not Poly(I: C): differential recognition of synthetic dsRNA molecules. J Immunol 2007; 178: 5200-8.
    • (2007) J Immunol , vol.178 , pp. 5200-5208
    • Gowen, B.B.1    Wong, M.H.2    Jung, K.H.3
  • 43
    • 0037472447 scopus 로고    scopus 로고
    • Dendritic cell (DC) based therapy for cervical cancer: Use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]: Poly [C(12)U] (Ampligen R)
    • Adams M, Navabi H, Jasani B, et al. Dendritic cell (DC) based therapy for cervical cancer: use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]: poly [C(12)U] (Ampligen R). Vaccine 2003; 21: 787-90.
    • (2003) Vaccine , vol.21 , pp. 787-790
    • Adams, M.1    Navabi, H.2    Jasani, B.3
  • 44
    • 56949108633 scopus 로고    scopus 로고
    • A clinical grade poly I: C-analogue (Ampligen) promotes optimal DC maturation and Th1-type T cell responses of healthy donors and cancer patients in vitro
    • Navabi H, Jasani B, Reece A, et al. A clinical grade poly I: C-analogue (Ampligen) promotes optimal DC maturation and Th1-type T cell responses of healthy donors and cancer patients in vitro. Vaccine 2009; 27: 107-15.
    • (2009) Vaccine , vol.27 , pp. 107-115
    • Navabi, H.1    Jasani, B.2    Reece, A.3
  • 45
    • 78650188526 scopus 로고    scopus 로고
    • Small interfering RNAs induce target-independent inhibition of tumor growth and vasculature remodeling in a mouse model of hepatocellular carcinoma
    • Berge M, Bonnin P, Sulpice E, et al. Small interfering RNAs induce target-independent inhibition of tumor growth and vasculature remodeling in a mouse model of hepatocellular carcinoma. Am J Pathol 2010; 177: 3192-201.
    • (2010) Am J Pathol , vol.177 , pp. 3192-3201
    • Berge, M.1    Bonnin, P.2    Sulpice, E.3
  • 46
    • 84862059630 scopus 로고    scopus 로고
    • Polyinosinic-polycytidylic acid limits tumor outgrowth in a mouse model of metastatic lung cancer
    • Forte G, Rega A, Morello S, et al. Polyinosinic-polycytidylic acid limits tumor outgrowth in a mouse model of metastatic lung cancer. J Immunol 2012; 188: 5357-64.
    • (2012) J Immunol , vol.188 , pp. 5357-5364
    • Forte, G.1    Rega, A.2    Morello, S.3
  • 47
    • 77950787070 scopus 로고    scopus 로고
    • Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance
    • Chin AI, Miyahira AK, Covarrubias A, et al. Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance. Cancer Res 2010; 70: 2595-603.
    • (2010) Cancer Res , vol.70 , pp. 2595-2603
    • Chin, A.I.1    Miyahira, A.K.2    Covarrubias, A.3
  • 48
    • 84857136783 scopus 로고    scopus 로고
    • Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors
    • Shime H, Matsumoto M, Oshiumi H, et al. Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors. Proc Natl Acad Sci USA 2012; 109: 2066-71.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 2066-2071
    • Shime, H.1    Matsumoto, M.2    Oshiumi, H.3
  • 49
    • 0022526911 scopus 로고
    • Preliminary trial of poly ICLC in chronic progressive multiple sclerosis
    • Bever CT, Jr., Salazar AM, Neely E, et al. Preliminary trial of poly ICLC in chronic progressive multiple sclerosis. Neurology 1986; 36: 494-8.
    • (1986) Neurology , vol.36 , pp. 494-498
    • Bever, C.T.1    Salazar, A.M.2    Neely, E.3
  • 50
    • 0016777909 scopus 로고
    • A modified polyriboinosinic-polyribocytidylic acid complex that induces interferon in primates
    • Levy HB, Baer G, Baron S, et al. A modified polyriboinosinic-polyribocytidylic acid complex that induces interferon in primates. J Infect Dis 1975; 132: 434-9.
    • (1975) J Infect Dis , vol.132 , pp. 434-439
    • Levy, H.B.1    Baer, G.2    Baron, S.3
  • 51
    • 33847674371 scopus 로고    scopus 로고
    • Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models
    • Zhu X, Nishimura F, Sasaki K, et al. Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models. J Transl Med 2007; 5: 10.
    • (2007) J Transl Med , vol.5 , pp. 10
    • Zhu, X.1    Nishimura, F.2    Sasaki, K.3
  • 52
    • 84870359509 scopus 로고    scopus 로고
    • Phase I trial of overlapping long peptides from a tumor self-antigen and poly-ICLC shows rapid induction of integrated immune response in ovarian cancer patients
    • Sabbatini P, Tsuji T, Ferran L, et al. Phase I trial of overlapping long peptides from a tumor self-antigen and poly-ICLC shows rapid induction of integrated immune response in ovarian cancer patients. Clin Cancer Res 2012; 18: 6497-508.
    • (2012) Clin Cancer Res , vol.18 , pp. 6497-6508
    • Sabbatini, P.1    Tsuji, T.2    Ferran, L.3
  • 53
    • 77956928890 scopus 로고    scopus 로고
    • TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA
    • Perrot I, Deauvieau F, Massacrier C, et al. TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA. J Immunol 2010; 185: 2080-8.
    • (2010) J Immunol , vol.185 , pp. 2080-2088
    • Perrot, I.1    Deauvieau, F.2    Massacrier, C.3
  • 54
    • 40149085707 scopus 로고    scopus 로고
    • Phase III trial of adjuvant 5-fluorouracil and adriamycin versus 5-fluorouracil, adriamycin, and polyadenylic-polyuridylic acid (poly A: U) for locally advanced gastric cancer after curative surgery: Final results of 15-year follow-up
    • Jeung HC, Moon YW, Rha SY, et al. Phase III trial of adjuvant 5-fluorouracil and adriamycin versus 5-fluorouracil, adriamycin, and polyadenylic-polyuridylic acid (poly A: U) for locally advanced gastric cancer after curative surgery: final results of 15-year follow-up. Ann Oncol 2008; 19: 520-6.
    • (2008) Ann Oncol , vol.19 , pp. 520-526
    • Jeung, H.C.1    Moon, Y.W.2    Rha, S.Y.3
  • 55
    • 0034541497 scopus 로고    scopus 로고
    • Polyadenylic-polyuridylic acid plus locoregional radiotherapy versus chemotherapy with CMF in operable breast cancer: A 14 year follow-up analysis of a randomized trial of the Federation Nationale des Centres de Lutte contre le Cancer (FNCLCC)
    • Laplanche A, Alzieu L, Delozier T, et al. Polyadenylic-polyuridylic acid plus locoregional radiotherapy versus chemotherapy with CMF in operable breast cancer: a 14 year follow-up analysis of a randomized trial of the Federation Nationale des Centres de Lutte contre le Cancer (FNCLCC). Breast Cancer Res Treat 2000; 64: 189-91.
    • (2000) Breast Cancer Res Treat , vol.64 , pp. 189-191
    • Laplanche, A.1    Alzieu, L.2    Delozier, T.3
  • 56
    • 0027102293 scopus 로고
    • Polyadenylic-polyuridylic acid as an adjuvant in resectable colorectal carcinoma: A 6 1/2 year follow-up analysis of a multicentric double blind randomized trial
    • Lacour J, Laplanche A, Malafosse M, et al. Polyadenylic-polyuridylic acid as an adjuvant in resectable colorectal carcinoma: a 6 1/2 year follow-up analysis of a multicentric double blind randomized trial. Eur J Surg Oncol 1992; 18: 599-604.
    • (1992) Eur J Surg Oncol , vol.18 , pp. 599-604
    • Lacour, J.1    Laplanche, A.2    Malafosse, M.3
  • 57
    • 83755206819 scopus 로고    scopus 로고
    • Antitumor activity from the combined application of poly(I: C) and chemotherapeutics in human metastatic pharyngeal cell lines
    • Matijevic T, Kirinec G, Pavelic J. Antitumor activity from the combined application of poly(I: C) and chemotherapeutics in human metastatic pharyngeal cell lines. Chemotherapy 2011; 57: 460-7.
    • (2011) Chemotherapy , vol.57 , pp. 460-467
    • Matijevic, T.1    Kirinec, G.2    Pavelic, J.3
  • 58
    • 39449118809 scopus 로고    scopus 로고
    • Poly I: C enhances cycloheximide-induced apoptosis of tumor cells through TLR3 pathway
    • Jiang Q, Wei H, Tian Z. Poly I: C enhances cycloheximide-induced apoptosis of tumor cells through TLR3 pathway. BMC Cancer 2008; 8: 12.
    • (2008) BMC Cancer , vol.8 , pp. 12
    • Jiang, Q.1    Wei, H.2    Tian, Z.3
  • 59
    • 84859887762 scopus 로고    scopus 로고
    • Poly I: C inhibits cell proliferation and enhances the growth inhibitory effect of paclitaxel in oral sqaumous cell carcinoma
    • Park JH, Jeon DI, Yoon HE, et al. Poly I: C inhibits cell proliferation and enhances the growth inhibitory effect of paclitaxel in oral sqaumous cell carcinoma. Acta Odontol Scand 2012; 70: 241-5.
    • (2012) Acta Odontol Scand , vol.70 , pp. 241-245
    • Park, J.H.1    Jeon, D.I.2    Yoon, H.E.3
  • 60
    • 84864771282 scopus 로고    scopus 로고
    • Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics
    • Van DN, Roberts CF, Marion JD, et al. Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics. Faseb J 2012; 26: 3188-98.
    • (2012) Faseb J , vol.26 , pp. 3188-3198
    • Van, D.N.1    Roberts, C.F.2    Marion, J.D.3
  • 61
    • 55449105737 scopus 로고    scopus 로고
    • p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines
    • Taura M, Eguma A, Suico MA, et al. p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines. Mol Cell Biol 2008; 28: 6557-67.
    • (2008) Mol Cell Biol , vol.28 , pp. 6557-6567
    • Taura, M.1    Eguma, A.2    Suico, M.A.3
  • 62
    • 77954640888 scopus 로고    scopus 로고
    • TLR3 induction by anticancer drugs potentiates poly I: C-induced tumor cell apoptosis
    • Taura M, Fukuda R, Suico MA, et al. TLR3 induction by anticancer drugs potentiates poly I: C-induced tumor cell apoptosis. Cancer Sci 2010; 10: 1610-7.
    • (2010) Cancer Sci , vol.10 , pp. 1610-1617
    • Taura, M.1    Fukuda, R.2    Suico, M.A.3
  • 63
    • 85040956394 scopus 로고    scopus 로고
    • Toll-like receptor 3 in Epstein-Barr virus-associated nasopharyngeal carcinomas: Consistent expression and cytotoxic effects of its synthetic ligand poly(A: U) combined to a Smac-mimetic
    • Verillaud B, Gressette M, Morel Y, et al. Toll-like receptor 3 in Epstein-Barr virus-associated nasopharyngeal carcinomas: consistent expression and cytotoxic effects of its synthetic ligand poly(A: U) combined to a Smac-mimetic. Infect Agent Cancer 2012; 7: 36.
    • (2012) Infect Agent Cancer , vol.7 , pp. 36
    • Verillaud, B.1    Gressette, M.2    Morel, Y.3
  • 64
    • 84878958382 scopus 로고    scopus 로고
    • Synergy between RA and TLR3 promotes type I IFN-dependent apoptosis through upregulation of TRAIL pathway in breast cancer cells
    • Bernardo AR, Cosgaya JM, Aranda A, Jimenez-Lara AM. Synergy between RA and TLR3 promotes type I IFN-dependent apoptosis through upregulation of TRAIL pathway in breast cancer cells. Cell Death Dis 2013; 4: e479.
    • (2013) Cell Death Dis , vol.4
    • Bernardo, A.R.1    Cosgaya, J.M.2    Aranda, A.3    Jimenez-Lara, A.M.4
  • 65
    • 84868216252 scopus 로고    scopus 로고
    • Combined TLR stimulation with Pam3Cys and Poly I: C enhances Flt3-ligand dendritic cell activation for tumor immunotherapy
    • Lim SN, Kuhn S, Hyde E, Ronchese F. Combined TLR stimulation with Pam3Cys and Poly I: C enhances Flt3-ligand dendritic cell activation for tumor immunotherapy. J Immunother 2012; 35: 670-9.
    • (2012) J Immunother , vol.35 , pp. 670-679
    • Lim, S.N.1    Kuhn, S.2    Hyde, E.3    Ronchese, F.4
  • 66
    • 79955533553 scopus 로고    scopus 로고
    • Adoptive immunotherapy combined with intratumoral TLR agonist delivery eradicates es tablished melanoma in mice
    • Amos SM, Pegram HJ, Westwood JA, et al. Adoptive immunotherapy combined with intratumoral TLR agonist delivery eradicates es tablished melanoma in mice. Cancer Immunol Immunother 2011; 60: 671-83.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 671-683
    • Amos, S.M.1    Pegram, H.J.2    Westwood, J.A.3
  • 67
    • 84877825063 scopus 로고    scopus 로고
    • BiVax: A pep-tide/poly-IC subunit vaccine that mimics an acute infection elicits vast and effective anti-tumor CD8 T-cell responses
    • Cho HI, Barrios K, Lee YR, Linowski AK, Celis E. BiVax: a pep-tide/poly-IC subunit vaccine that mimics an acute infection elicits vast and effective anti-tumor CD8 T-cell responses. Cancer Immunol Immunother 2013; 62: 787-99.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 787-799
    • Cho, H.I.1    Barrios, K.2    Lee, Y.R.3    Linowski, A.K.4    Celis, E.5
  • 68
    • 71549172516 scopus 로고    scopus 로고
    • Optimized peptide vaccines eliciting extensive CD8 T-cell responses with therapeutic antitumor effects
    • Cho HI, Celis E. Optimized peptide vaccines eliciting extensive CD8 T-cell responses with therapeutic antitumor effects. Cancer Res 2009; 69: 9012-9.
    • (2009) Cancer Res , vol.69 , pp. 9012-9019
    • Cho, H.I.1    Celis, E.2
  • 69
    • 79960928379 scopus 로고    scopus 로고
    • Intraperitoneal administration of poly(I: C) with polyethylenimine leads to significant antitumor immunity against murine ovarian tumors
    • Wu CY, Yang HY, Monie A, et al. Intraperitoneal administration of poly(I: C) with polyethylenimine leads to significant antitumor immunity against murine ovarian tumors. Cancer Immunol Immuno-ther 2011; 60: 1085-96.
    • (2011) Cancer Immunol Immuno-ther , vol.60 , pp. 1085-1096
    • Wu, C.Y.1    Yang, H.Y.2    Monie, A.3
  • 70
    • 32044465218 scopus 로고    scopus 로고
    • EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice
    • Shir A, Ogris M, Wagner E, Levitzki A. EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice. PLoS Med 2006; 3: e6.
    • (2006) PLoS Med , vol.3
    • Shir, A.1    Ogris, M.2    Wagner, E.3    Levitzki, A.4
  • 71
    • 79952261244 scopus 로고    scopus 로고
    • EGFR-homing dsRNA activates cancer-targeted immune response and eliminates disseminated EGFR-overexpressing tumors in mice
    • Shir A, Ogris M, Roedl W, Wagner E, Levitzki A. EGFR-homing dsRNA activates cancer-targeted immune response and eliminates disseminated EGFR-overexpressing tumors in mice. Clin Cancer Res 2011; 17: 1033-43.
    • (2011) Clin Cancer Res , vol.17 , pp. 1033-1043
    • Shir, A.1    Ogris, M.2    Roedl, W.3    Wagner, E.4    Levitzki, A.5
  • 72
    • 84859075506 scopus 로고    scopus 로고
    • PolyIC GE11 polyplex inhibits EGFR-overexpressing tumors
    • Abourbeh G, Shir A, Mishani E, et al. PolyIC GE11 polyplex inhibits EGFR-overexpressing tumors. IUBMB Life 2012; 64: 324-30.
    • (2012) IUBMB Life , vol.64 , pp. 324-330
    • Abourbeh, G.1    Shir, A.2    Mishani, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.