Intraperitoneal administration of poly(I:C) with polyethylenimine leads to significant antitumor immunity against murine ovarian tumors

Cancer Immunology, Immunotherapy

Volumn 60, Issue 8, 2011, Pages 1085-1096

  Wu, Chao Yi ^a   Yang, Huang Yu ^a,b,c   Monie, Archana ^a   Ma, Barbara ^a   Tsai, Hsiao Hsuan ^d   Wu, T C ^a   Hung, Chien Fu ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^d CATHAY GENERAL HOSPITAL   (Taiwan)

Author keywords

MOSEC tumors; Poly(I:C); Polyethylenimine; Toll like receptor

Indexed keywords

CD11B ANTIGEN; INTERLEUKIN 12; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NUCLEIC ACID; POLYETHYLENEIMINE; POLYINOSINIC POLYCYTIDYLIC ACID;

ADJUVANT THERAPY; ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CANCER CONTROL; CELL SURFACE; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; DRUG UPTAKE; EPITHELIUM CELL; FEMALE; GENETIC TRANSFECTION; LOW DRUG DOSE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MACROPHAGE; MOUSE; NATURAL KILLER T CELL; NONHUMAN; OVARY CELL; OVARY TUMOR; PHENOTYPE; PRIORITY JOURNAL; TREATMENT RESPONSE; TUMOR IMMUNITY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS, CD11B; CARCINOMA; CELL LINE, TUMOR; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; IMMUNITY, INNATE; IMMUNOTHERAPY; INJECTIONS, INTRAPERITONEAL; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED C57BL; OVARIAN NEOPLASMS; POLY I-C; POLYETHYLENEIMINE;

EID: 79960928379     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-011-1013-7     Document Type: Article

References (28)

1. A Aderem RJ Ulevitch 2000 Toll-like receptors in the induction of the innate immune response Nature 406 782 787 10963608 10.1038/35021228 1:STN:280:DC%2BD3cvjtVOhuw%3D%3D
2. S Akira 2001 Toll-like receptors and innate immunity Adv Immunol 78 1 56 11432202 10.1016/S0065-2776(01)78001-7 1:CAS:528:DC%2BD3MXlsV2kt7Y%3D (Pubitemid 32566017)
3. S Akira K Takeda 2004 Toll-like receptor signalling Nat Rev Immunol 4 499 511 15229469 10.1038/nri1391 1:CAS:528:DC%2BD2cXlt1Cqur0%3D (Pubitemid 38931765)
4. K Anwer MN Barnes J Fewell DH Lewis RD Alvarez 2010 Phase-I clinical trial of IL-12 plasmid/lipopolymer complexes for the treatment of recurrent ovarian cancer Gene Ther 17 360 369 20033066 10.1038/gt.2009.159 1:CAS:528:DC%2BD1MXhs1SktbvP
5. SH Chan B Perussia JW Gupta M Kobayashi M Pospisil HA Young, et al. 1991 Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers J Exp Med 173 869 879 1672545 10.1084/jem.173.4.869 1:CAS:528:DyaK3MXhvVemu7Y%3D
6. CM Chuang A Monie A Wu CP Mao CF Hung 2009 Treatment with LL-37 peptide enhances antitumor effects induced by CpG oligodeoxynucleotides against ovarian cancer Hum Gene Ther 20 303 313 19272013 10.1089/hum.2008.124 1:CAS:528:DC%2BD1MXjvFejsbo%3D
7. JR Cubillos-Ruiz X Engle UK Scarlett D Martinez A Barber R Elgueta, et al. 2009 Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity J Clin Invest 119 2231 2244 19620771 1:CAS:528:DC%2BD1MXpsFClurc%3D
8. A D'Andrea M Rengaraju NM Valiante J Chehimi M Kubin M Aste, et al. 1992 Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells J Exp Med 176 1387 1398 1357073 10.1084/jem.176.5.1387
9. CH Fong M Bebien A Didierlaurent R Nebauer T Hussell D Broide, et al. 2008 An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation J Exp Med 205 1269 1276 18490491 10.1084/jem.20080124 1:CAS:528:DC%2BD1cXntFansbY%3D (Pubitemid 351831484)
10. S Gordon 2003 Alternative activation of macrophages Nat Rev Immunol 3 23 35 12511873 10.1038/nri978 1:CAS:528:DC%2BD3sXovVw%3D (Pubitemid 37328697)
11. S Gordon PR Taylor 2005 Monocyte and macrophage heterogeneity Nat Rev Immunol 5 953 964 16322748 10.1038/nri1733 1:CAS:528:DC%2BD2MXht1Kntr3N (Pubitemid 41746764)
12. P Guermonprez J Valladeau L Zitvogel C Thery S Amigorena 2002 Antigen presentation and T cell stimulation by dendritic cells Annu Rev Immunol 20 621 667 11861614 10.1146/annurev.immunol.20.100301.064828 1:CAS:528: DC%2BD38XjtlWgtb4%3D (Pubitemid 34293436)
13. T Hagemann T Lawrence I McNeish KA Charles H Kulbe RG Thompson, et al. 2008 "Re-educating" tumor-associated macrophages by targeting NF-kappaB J Exp Med 205 1261 1268 18490490 10.1084/jem.20080108 1:CAS:528:DC%2BD1cXntFansbk%3D (Pubitemid 351831483)
14. CF Hung YC Tsai L He TC Wu 2007 Control of mesothelin-expressing ovarian cancer using adoptive transfer of mesothelin peptide-specific CD8+ T cells Gene Ther 14 921 929 17377599 10.1038/sj.gt.3302913 1:CAS:528:DC%2BD2sXmtVyjtrg%3D (Pubitemid 46865503)
15. A Iwasaki R Medzhitov 2004 Toll-like receptor control of the adaptive immune responses Nat Immunol 5 987 995 15454922 10.1038/ni1112 1:CAS:528:DC%2BD2cXnvFCgsrg%3D (Pubitemid 41057715)
16. A Jemal R Siegel E Ward T Murray J Xu MJ Thun 2007 Cancer statistics, 2007 CA Cancer J Clin 57 43 66 17237035 10.3322/canjclin.57.1.43 (Pubitemid 46148091)
17. Q Jiang H Wei Z Tian 2008 IFN-producing killer dendritic cells contribute to the inhibitory effect of poly I:C on the progression of murine melanoma J Immunother 31 555 562 18528299 10.1097/CJI.0b013e31817d8e75 1:CAS:528: DC%2BD1cXnslKjtrs%3D
18. S Kakimoto T Hamada Y Komatsu M Takagi T Tanabe H Azuma, et al. 2009 The conjugation of diphtheria toxin T domain to poly(ethylenimine) based vectors for enhanced endosomal escape during gene transfection Biomaterials 30 402 408 18930314 10.1016/j.biomaterials.2008.09.042 1:CAS:528:DC%2BD1cXhtlCkt7bK
19. M Kobayashi L Fitz M Ryan RM Hewick SC Clark S Chan, et al. 1989 Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes J Exp Med 170 827 845 2504877 10.1084/jem.170.3.827 1:CAS:528:DyaL1MXlvFarsr8%3D (Pubitemid 19226667)
20. K-Y Lin FG Guarnieri KF Staveley-O'Carroll HI Levitsky T August DM Pardoll, et al. 1996 Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen Cancer Res 56 21 26 8548765 1:CAS:528:DyaK28Xit1CjtA%3D%3D (Pubitemid 26010379)
21. FO Martinez A Sica A Mantovani M Locati 2008 Macrophage activation and polarization Front Biosci 13 453 461 17981560 10.2741/2692 1:CAS:528: DC%2BD1cXhs1ChsbY%3D (Pubitemid 351599757)
22. M Matsumoto T Seya 2008 TLR3: interferon induction by double-stranded RNA including poly(I:C) Adv Drug Deliv Rev 60 805 812 18262679 10.1016/j.addr.2007. 11.005 1:CAS:528:DC%2BD1cXksVagsL8%3D
23. W Noel G Raes G Hassanzadeh Ghassabeh P De Baetselier A Beschin 2004 Alternatively activated macrophages during parasite infections Trends Parasitol 20 126 133 15036034 10.1016/j.pt.2004.01.004 1:CAS:528:DC%2BD2cXhslSktbo%3D (Pubitemid 38264445)
24. RA Robinson VT DeVita HB Levy S Baron SP Hubbard AS Levine 1976 A phase I-II trial of multiple-dose polyriboinosic-polyribocytidylic acid in patients with leukemia or solid tumors J Natl Cancer Inst 57 599 602 978771 1:STN:280:DyaE2s%2FjtFOmuw%3D%3D
25. KF Roby CC Taylor JP Sweetwood Y Cheng JL Pace O Tawfik, et al. 2000 Development of a syngeneic mouse model for events related to ovarian cancer Carcinogenesis 21 585 591 10753190 10.1093/carcin/21.4.585 1:CAS:528: DC%2BD3cXivFKktL8%3D (Pubitemid 30214011)
26. Salazar AM, Levy HB, Ondra S, Kende M, Scherokman B, Brown D et al. (1996) Long-term treatment of malignant gliomas with intramuscularly administered polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose: an open pilot study. Neurosurgery 38:1096-1104; discussion 1103-1104 (Pubitemid 26162753)
27. CS Tripp SF Wolf ER Unanue 1993 Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist Proc Natl Acad Sci USA 90 3725 3729 8097322 10.1073/pnas.90.8.3725 1:CAS:528:DyaK3sXisFeit7w%3D (Pubitemid 23111440)
28. C Yoshihara T Ito CY Shew Y Koyama 2008 Improvement of transcription- and transfection-efficiency by synthetic polyampholytes Nucleic Acids Symp Ser (Oxf) 52 713 714 10.1093/nass/nrn360 1:CAS:528:DC%2BD1cXhtFGnsr3N