Preferential involvement of mitochondria in Toll-like receptor 3 agonist-induced neuroblastoma cell apoptosis, but not in inhibition of cell growth

Apoptosis

Volumn 17, Issue 4, 2012, Pages 335-348

  Chuang, Jiin Haur ^a   Lin, Tsu Kung ^b   Tai, Ming Hong ^c   Liou, Chia Wei ^b   Huang, Sheng Teng ^b   Wu, Chia Ling ^a   Lin, Hung Yi ^b   Wang, Pei Wen ^b  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Caspase; Endoplasmic reticulum; Mitochondria; Poly(I:C); Rho zero cells; Toll like receptor

Indexed keywords

BAFILOMYCIN A1; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; DOUBLE STRANDED RNA; GLUCOSE REGULATED PROTEIN 78; GLUTATHIONE PEROXIDASE 1; HEAT SHOCK PROTEIN; INOSITOL; POLYINOSINIC POLYCYTIDYLIC ACID; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 3;

APOPTOSIS; ARTICLE; CELL GROWTH; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRION; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; HUMANS; MITOCHONDRIA; NEUROBLASTOMA; POLY I-C; REACTIVE OXYGEN SPECIES; TOLL-LIKE RECEPTOR 3;

EID: 84862501419     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-011-0686-x     Document Type: Article

References (38)

1. Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM (1984) Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 224:1121-1124 (Pubitemid 14106392)
2. Seeger RC, Brodeur GM, Sather H, Dalton A, Siegel SE, Wong KY, Hammond D (1985) Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med 313:1111-1116 (Pubitemid 16216827)
3. Cameron JS, Alexopoulou L, Sloane JA, DiBernardo AB, Ma Y, Kosaras B, Flavell R, Strittmatter SM, Volpe J, Sidman R, Vartanian T (2007) Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals. J Neurosci 27:13033-13041 (Pubitemid 350159595)
4. Hoffmann O, Braun JS, Becker D, Halle A, Freyer D, Dagand E, Lehnardt S, Weber JR (2007) TLR2 mediates neuroinflammation and neuronal damage. J Immunol 178:6476-6481 (Pubitemid 46717431)
5. Ma Y, Li J, Chiu I, Wang Y, Sloane JA, Lü J, Kosaras B, Sidman RL, Volpe JJ, Vartanian T (2006) Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J Cell Biol 175:209-215 (Pubitemid 44631415)
6. Salaun B, Coste I, Rissoan MC, Lebecque SJ, Renno T (2006) TLR3 can directly trigger apoptosis in human cancer cells. J Immunol 176:4894-4901
7. Khvalevsky E, Rivkin L, Rachmilewitz J, Galun E, Giladi H (2007) TLR3 signaling in a hepatoma cell line is skewed towards apoptosis. J Cell Biochem 100:1301-1312 (Pubitemid 46480411)
8. Salaun B, Lebecque S, Matikainen S, Rimoldi D, Romero P (2007) Toll-like receptor 3 expressed by melanoma cells as a target for therapy? Clin Cancer Res 13:4565-4574 (Pubitemid 47219727)
9. Morikawa T, Sugiyama A, Kume H, Ota S, Kashima T, Tomita K, Kitamura T, Kodama T, Fukayama M, Aburatani H (2007) Identification of Toll-like receptor 3 as a potential therapeutic target in clear cell renal cell carcinoma. Clin Cancer Res 13:5703-5709 (Pubitemid 47583894)
10. Salaun B, Zitvogel L, Asselin-Paturel C, Morel Y, Chemin K, Dubois C, Massacrier C, Conforti R, Chenard MP, Sabourin JC, Goubar A, Lebecque S, Pierres M, Rimoldi D, Romero P, Andre F (2011) TLR3 as a biomarker for the therapeutic efficacy of double-stranded RNA in breast cancer. Cancer Res 71:1607-1614
11. Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124:783-801 (Pubitemid 43261452)
12. Hsu WM, Hsieh FJ, Jeng YM, Kuo ML, Tsao PN, Lee H, Lin MT, Lai HS, Chen CN, Lai DM, Chen WJ (2005) GRP78 expression correlates with histologic differentiation and favorable prognosis in neuroblastic tumors. Int J Cancer 113:920-927 (Pubitemid 40096871)
13. Martinon F, Glimcher LH (2011) Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum. Curr Opin Immunol 23:35-40
14. Hacki J, Egger L, Monney L, Conus S, Rosse T, Fellay I, Borner C (2000) Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2. Oncogene 19:2286-2295 (Pubitemid 30307204)
15. Szegezdi E, Macdonald DC, Ni Chonghaile T, Gupta S, Samali A (2009) Bcl-2 family on guard at the ER. Am J Physiol Cell Physiol 296:C941-C953
16. Weber A, Kirejczyk Z, Besch R, Potthoff S, Leverkus M, Häcker G (2010) Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells. Cell Death Differ 17:942-951
17. Sun R, Zhang Y, Lv Q, Liu B, Jin M, Zhang W, He Q, Deng M, Liu X, Li G, Li Y, Zhou G, Xie P, Xie X, Hu J, Duan Z (2011) Toll-like receptor 3 (TLR3) induces apoptosis via death receptors and mitochondria by up-regulating the transactivating p63 isoform alpha (TAP63alpha). J Biol Chem 286:15918-15928
18. Zhong W, Yan T, Lim R, Oberley LW (1999) Expression of superoxide dismutases, catalase, and glutathione peroxidase in glioma cells. Free Radic Biol Med 27:1334-1345 (Pubitemid 30001496)
19. Epperly MW, Gretton JE, Sikora CA, Jefferson M, Bernarding M, Nie S, Greenberger JS (2003) Mitochondrial localization of superoxide dismutase is required for decreasing radiation-induced cellular damage. Radiat Res 160:568-578 (Pubitemid 38055205)
20. Chuang JH, Chuang HC, Huang CC, Wu CL, Du YY, Kung ML, Chen CH, Chen SC, Tai MH (2011) Differential Toll-like Receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells. J Biomed Sci 18:65
21. Mukhopadhyay P, Rajesh M, Yoshihiro K, Hasko G, Pacher P (2007) Simple quantitative detection of mitochondrial superoxide production in live cells. Biochem Biophys Res Commun 358:203-208 (Pubitemid 46719103)
22. Maris JM, Hogarty MD, Bagatell R, Cohn SL (2007) Neuroblastoma. Lancet 369:2106-2120 (Pubitemid 46935947)
23. Garaventa A, Parodi S, De Bernardi B, Dau D, Manzitti C, Conte M, Casale F, Viscardi E, Bianchi M, D'Angelo P, Zanazzo GA, Luksch R, Favre C, Tamburini A, Haupt R (2009) Outcome of children with neuroblastoma after progression or relapse. A retrospective study of the Italian neuroblastoma registry. Eur J Cancer 45:2835-2842
24. Yang W, Tiffany-Castiglioni E, Koh HC, Son IH (2009) Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cells. Toxicol Lett 191: 203-210
25. Brinkmann MM, Spooner E, Hoebe K, Beutler B, Ploegh HL, Kim YM (2007) The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol 177:265-275 (Pubitemid 46658638)
26. Shacka JJ, Klocke BJ, Shibata M, Uchiyama Y, Datta G, Schmidt RE, Roth KA (2006) Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons. Mol Pharmacol 69:1125-1136
27. Zhu J, Lai K, Brownile R, Babiuk LA, Mutwiri GK (2008) Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod. Mol Immunol 45:3238-3243
28. Obexer P, Geiger K, Ambros PF, Meister B, Ausserlechner MJ (2007) FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. Cell Death Differ 14:534-547
29. Lallemand C, Blanchard B, Palmieri M, Lebon P, May E, Tovey MG (2007) Single-stranded RNA viruses inactivate the transcriptional activity of p53 but induce NOXA-dependent apoptosis via post-translational modifications of IRF-1, IRF-3 and CREB. Oncogene 26:328-338 (Pubitemid 46122823)
30. Shen P, Jiang T, Lu H, Han H, Luo R (2011) Combination of poly I:C and arsenic trioxide triggers apoptosis synergistically via activation of TLR3 and mitochondrial pathways in hepatocellular carcinoma cells. Cell Biol Int 35:803-810
31. Djafarzadeh S, Vuda M, Takala J, Ochs M, Jakob SM (2011) Toll-like receptor-3-induced mitochondrial dysfunction in cultured human hepatocytes. Mitochondrion 11:83-88
32. Heeren G, Jarolim S, Laun P, Rinnerthaler M, Stolze K, Perrone GG, Kohlwein SD, Nohl H, Dawes IW, Breitenbach M (2004) The role of respiration, reactive oxygen species and oxidative stress in mother cell-specific ageing of yeast strains defective in the RAS signalling pathway. FEMS Yeast Res 5:157-167 (Pubitemid 39365996)
33. Danielson SR, Carelli V, Tan G, Martinuzzi A, Schapira AH, Savontaus ML, Cortopassi GA (2005) Isolation of transcriptomal changes attributable to LHON mutations and the cybridization process. Brain 128:1026-1037 (Pubitemid 40675458)
34. Cuperus R, Leen R, Tytgat GA, Caron HN, van Kuilenburg AB (2010) Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma. Cell Mol Life Sci 67:807-816
35. Park MA, Mitchell C, Zhang G, Yacoub A, Allegood J, Häussinger D, Reinehr R, Larner A, Spiegel S, Fisher PB, Voelkel- Johnson C, Ogretmen B, Grant S, Dent P (2010) Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species- dependent signaling pathway. Cancer Res 70:6313-6324
36. Khvalevsky E, Rivkin L, Rachmilewitz J, Galun E, Giladi H (2007) TLR3 signaling in a hepatoma cell line is skewed towards apoptosis. J Cell Biochem 100:1301-1312 (Pubitemid 46480411)
37. Saitoh T, Akira S (2010) Regulation of innate immune responses by autophagy-related proteins. J Cell Biol 189:925-935
38. Kroemer G, Mariño G, Levine B (2010) Autophagy and the integrated stress response. Mol Cell 40:280-293