Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics

FASEB Journal

Volumn 26, Issue 8, 2012, Pages 3188-3198

  Van, Danielle N ^a   Roberts, Charlotte F ^a   Marion, James D ^a   Lépine, Sandrine ^a   Harikumar, Kuzhuvelil B ^a   Schreiter, Jessica ^b   Dumur, Catherine I ^a   Fang, Xianjun ^a   Spiegel, Sarah ^a   Bell, Jessica K ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b CENTOCOR INC   (United States)

Author keywords

Biomarker; Caspase; Pattern recognition receptors; Targeted therapy; Type I interferon

Indexed keywords

CARBOPLATIN; CASPASE 8; CASPASE 9; DOUBLE STRANDED RNA; INTERFERON; PACLITAXEL; PATTERN RECOGNITION RECEPTOR; RETINOIC ACID INDUCIBLE PROTEIN I; SHORT HAIRPIN RNA; TOLL LIKE RECEPTOR 3; TUMOR MARKER;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INNATE IMMUNITY; OVARY CANCER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

APOPTOSIS; CASPASES; CELL LINE, TUMOR; CISPLATIN; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; ENZYME ACTIVATION; FEMALE; HUMANS; INTERFERON-BETA; NF-KAPPA B; OVARIAN NEOPLASMS; PACLITAXEL; RNA, DOUBLE-STRANDED; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL;

EID: 84864771282     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-202333     Document Type: Article

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