Toll-like receptor 3 (TLR3) activation induces microRNA-dependent reexpression of functional RARβ and tumor regression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 24, 2013, Pages 9812-9817

  Galli, Roberta ^a,b   Paone, Alessio ^b   Fabbri, Muller ^c,d   Zanesi, Nicola ^b   Calore, Federica ^b   Cascionee, Luciano ^b,e   Acunzo, Mario ^b   Stoppacciaro, Antonella ^a   Tubaro, Andrea ^a   Lovat, Francesca ^b   Gasparini, Pierluigi ^b   Fadda, Paolo ^b   Alder, Hansjuerg ^b   Volinia, Stefano ^b,f   Filippini, Antonio ^a   Ziparo, Elio ^a   Riccioli, Anna ^a   Croce, Carlo M ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d CHILDREN S HOSPITAL LOS ANGELES   (United States)

^e UNIVERSITY OF CATANIA   (Italy)

^f UNIVERSITY OF FERRARA   (Italy)

Author keywords

Combined chemotherapy; Inflammation

Indexed keywords

DNA METHYLTRANSFERASE; MICRORNA; MICRORNA 148B; MICRORNA 152; MICRORNA 29B; MICRORNA 29C; POLYINOSINIC POLYCYTIDYLIC ACID; RETINOIC ACID; RETINOIC ACID RECEPTOR BETA; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CELL; CANCER CELL CULTURE; CONTROLLED STUDY; DEMETHYLATION; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; PRIORITY JOURNAL; PROSTATE CANCER; TUMOR REGRESSION;

COMBINED CHEMOTHERAPY; INFLAMMATION;

ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOBLOTTING; MALE; MICE; MICE, NUDE; MICRORNAS; NEOPLASMS; POLY I-C; PROSTATIC NEOPLASMS; RECEPTORS, RETINOIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOLL-LIKE RECEPTOR 3; TRETINOIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84878996981     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1304610110     Document Type: Article

References (31)

1. Larsen PH, Holm TH, Owens T (2007) Toll-like receptors in brain development and homeostasis. Sci STKE 2007(402):pe47.
2. Michelsen KS, Arditi M (2007) Toll-like receptors and innate immunity in gut homeostasis and pathology. Curr Opin Hematol 14(1):48-54. (Pubitemid 44885612)
3. Medzhitov R, Horng T (2009) Transcriptional control of the infl ammatory response. Nat Rev Immunol 9(10):692-703.
4. Paone A, et al. (2008) Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC-alpha-dependent mechanism. Carcinogenesis 29(7):1334-1342.
5. Salaun B, Coste I, Rissoan MC, Lebecque SJ, Renno T (2006) TLR3 can directly trigger apoptosis in human cancer cells. J Immunol 176(8):4894-4901.
6. Galli R, et al. (2010) TLR stimulation of prostate tumor cells induces chemokine-mediated recruitment of specific immune cell types. J Immunol 184(12):6658-6669.
7. Conforti R, et al. (2010) Opposing effects of toll-like receptor (TLR3) signaling in tumors can be therapeutically uncoupled to optimize the anticancer efficacy of TLR3 ligands. Cancer Res 70(2):490-500.
8. Chin AI, et al. (2010) Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance. Cancer Res 70(7):2595-2603.
9. Crawford ED (2003) Epidemiology of prostate cancer. Urology 62(6, Suppl 1):3-12.
10. López-Otín C, Diamandis EP (1998) Breast and prostate cancer: An analysis of common epidemiological, genetic, and biochemical features. Endocr Rev 19(4):365-396. (Pubitemid 29116015)
11. Croce CM (2009) Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet 10(10):704-714.
12. Zhou B, Wang S, Mayr C, Bartel DP, Lodish HF (2007) miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci USA 104(17):7080-7085. (Pubitemid 47186012)
13. O'Neill LA, Sheedy FJ, McCoy CE (2011) MicroRNAs: The fine-tuners of Toll-like receptor signalling. Nat Rev Immunol 11(3):163-175.
14. Braconi C, Huang N, Patel T (2010) MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes. Hepatology 51(3):881-890.
15. Fabbri M, et al. (2007) MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci USA 104(40):15805-15810. (Pubitemid 350035380)
16. Garzon R, et al. (2009) MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood 113(25):6411-6418.
17. Maruyama R, et al. (2002) Aberrant promoter methylation profile of prostate cancers and its relationship to clinicopathological features. Clin Cancer Res 8(2):514-519. (Pubitemid 34193971)
18. Nakayama T, et al. (2001) The role of epigenetic modifications in retinoic acid receptor beta2 gene expression in human prostate cancers. Lab Invest 81(7):1049-1057. (Pubitemid 32645980)
19. Sirchia SM, et al. (2000) Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells. Oncogene 19(12):1556-1563. (Pubitemid 30175677)
20. Tili E, et al. (2007) Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol 179(8):5082-5089.
21. Motsch N, Pfuhl T, Mrazek J, Barth S, Grässer FA (2007) Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induces the expression of the cellular microRNA miR-146a. RNA Biol 4(3):131-137. (Pubitemid 351237914)
22. Moschos SA, et al. (2007) Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids. BMC Genomics 8:240.
23. Liu X, et al. (2010) MicroRNA-148/152 impair innate response and antigen presentation of TLR-triggered dendritic cells by targeting CaMKIIα. J Immunol 185(12):7244-7251.
24. Inao T, et al. (2012) Antitumor effects of cytoplasmic delivery of an innate adjuvant receptor ligand, poly(I:C), on human breast cancer. Breast Cancer Res Treat 134(1):89-100.
25. Yamanaka M, et al. (2003) Altered methylation of multiple genes in carcinogenesis of the prostate. Int J Cancer 106(3):382-387. (Pubitemid 36870401)
26. Wang C, Bian Z, Wei D, Zhang JG (2011) miR-29b regulates migration of human breast cancer cells. Mol Cell Biochem 352(1-2):197-207.
27. Allenby G, et al. (1993) Retinoic acid receptors and retinoid X receptors: Interactions with endogenous retinoic acids. Proc Natl Acad Sci USA 90(1):30-34. (Pubitemid 23010243)
28. Berggren SM, Johannesson G, Fex G (1995) Expression of human all-trans-retinoic acid receptor beta and its ligand-binding domain in Escherichia coli. Biochem J 308(Pt 1):353-359.
29. Salaun B, Romero P, Lebecque S (2007) Toll-like receptors' two-edged sword: When immunity meets apoptosis. Eur J Immunol 37(12):3311-3318.
30. Cittelly DM, et al. (2012) Progestin suppression of miR-29 potentiates dedifferentiation of breast cancer cells via KLF4. Oncogene, 10.1038/onc.2012.275.
31. Iorio MV, et al. (2005) MicroRNA gene expression deregulation in human breast cancer. Cancer Res 65(16):7065-7070. (Pubitemid 41161233)