Hypoxic induction of endoglin via mitogen-activated protein kinases in mouse brain microvascular endothelial cells

Stroke

Volumn 34, Issue 10, 2003, Pages 2483-2488

  Zhu, Yonghua ^a   Sun, Yunjuan ^a   Xie, Lin ^a   Jin, Kunlin ^a   Sheibani, Nader ^b   Greenberg, David A ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Angiogenesis; Brain; Endoglin; Endothelium; Hypoxia; Mitogen activated protein kinases; Protein kinases

Indexed keywords

ENDOGLIN; MEMBRANE PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL HYPOXIA; CELL LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MICROVASCULATURE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REGULATORY MECHANISM; RENDU OSLER WEBER DISEASE; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD; BRAIN; BRAIN ISCHEMIA; CELL HYPOXIA; CELL LINE; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GENES, DOMINANT; HUMANS; MALE; MAP KINASE KINASE 3; MICE; MICROCIRCULATION; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-TYROSINE KINASES; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFECTION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0141865586     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000088644.60368.ED     Document Type: Article

References (36)

1. Zhang ZG, Zhang L, Jiang Q, Zhang R, Davies K, Powers C, Bruggen N, Chopp M. VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest. 2000;106:829-838.
2. Liu HM. Neovasculature and blood-brain barrier in ischemic brain infarct. Acta Neuropathol. (Berl). 1988;75:422-426.
3. Krupinski J, Kaluza J, Kumar P, Kumar S, Wang JM. Role of angiogenesis in patients with cerebral ischemic stroke. Stroke. 1994;25:1794-1798.
4. Toyoda K, Minematsu K, Yamaguchi T. Long-term changes in cerebral blood flow according to different types of ischemic stroke. J Neurol Sci. 1994;121:222-228.
5. Barbara NP, Wrana JL, Letarte M. Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. J Biol Chem. 1999;274:584-594.
6. Osler W. On a family form of recurring epistaxis, associated with multiple telangiectases of the skin and mucous membranes. Bull Johns Hopkins Hosp. 1901;7:333-337.
7. Li DY, Sorensen LK, Brooke BS, Urness LD, Davis EC, Taylor DG, Boak BB, Wendel DP. Defective angiogenesis in mice lacking endoglin. Science. 1999;284:1534-1537.
8. Kumar S, Ghellal A, Li C, Byrne G, Haboubi N, Wang JM, Bundred N. Breast carcinoma: vascular density determined using CD105 antibody correlates with tumor prognosis. Cancer Res. 1999;59:856-861.
9. Wikstrom P, Lissbrant IF, Stattin P, Egevad L, Bergh A. Endoglin (CD105) is expressed on immature blood vessels and is a market for survival in prostate cancer. Prostate. 2002;51:268-275.
10. Li C, Hampson IN, Hampson L, Kumar P, Bernabeu C, Kumar S. CD105 antagonizes the inhibitory signaling of transforming growth factor beta1 on human vascular endothelial cells. Faseb J. 2000;14:55-64.
11. Rulo HF, Westphal JR, van de Kerkhof PC, de Waal RM, van Vlijmen IM, Ruiter DJ. Expression of endoglin in psoriatic involved and uninvolved skin. J Dermatol Sci. 1995;10:103-109.
12. Szekanecz Z, Haines GK, Harlow LA, Shah MR, Fong TW, Fu R, Lin SJ, Rayan G, Koch AE. Increased synovial expression of transforming growth factor (TGF)-beta receptor endoglin and TGF-beta 1 in rheumatoid arthritis: possible interactions in the pathogenesis of the disease. Clin Immunol Immunopathol. 1995;76:187-194.
13. Zhu Y, Mao XO, Sun Y, Xia Z, Greenberg DA. p38 mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons. J Biol Chem. 2002;277:22909-22914.
14. Jin K, Mao XO, Zhu Y, Greenberg DA, MEK and ERK protect hypoxic cortical neurons via phosphorylation of Bad. J Neurochem. 2002;80:119-125.
15. Pepper MS, Tacchini-Cottier F, Sabapathy TK, Montesano R, Wagner EF. Endothelial cells transformed by polyomavirus middle T oncogene: a model for haemangiomas and other vascular tumours. In: Bicknell R, Lewis CE, Ferrara N, eds. Tumour Angiogenesis. Oxford, UK: Oxford University Press; 1997:309-331.
16. Boggemeyer E, Stehle T, Schaible UE, Hahne M, Vestweber D, Simon MM. Borrelia burgdorferi upregulates the adhesion molecules E-selectin, P-selectin, ICAM-1 and VCAM-1 on mouse endothelioma cells in vitro. Cell Adhes Commun. 1994;2:145-157.
17. Sheibani N, Newman PJ, Frazier WA. Thrombospondin-1, a natural inhibitor of angiogenesis, regulates platelet-endothelial cell adhesion molecule-1 expression and endothelial cell morphogenesis. Mol Biol Cell. 1997;8:1329-1341.
18. Sikorski EE, Hallmann R, Berg EL, Butcher EC. The Peyer's patch high endothelial receptor for lymphocytes, the mucosal vascular addressin, is induced on a murine endothelial cell line by tumor necrosis factor-alpha and IL-1. J Immunol. 1993;151:5239-5250.
19. Govers R, Bevers L, de Bree P, Rabelink TJ. Endothelial nitric oxide synthase activity is linked to its presence at cell-cell contacts. Biochem J. 2002;361:193-201.
20. Morgan SM, Samulowitz U, Darley L, Simmons DL, Vestweber D. Biochemical characterization and molecular cloning of a novel endothelial-specific sialomucin. Blood. 1999;93:165-175.
21. Kwak BR, Pepper MS, Gros DB, Meda P. Inhibition of endothelial wound repair by dominant negative connexin inhibitors. Mol Biol Cell. 2001;12:831-845.
22. Sheibani N, Frazier WA. Thrombospondin 1 expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis. Proc Natl Acad Sci USA. 1995;92:6788-6792.
23. Zhu Y, Sun Y, Jin K, Greenberg DA. Hemin induces neuroglobin expression in neural cells. Blood. 2002;100:2494-2498.
24. Dhar AK, Roux MM, Klimpel KR. Detection and quantification of infectious hypodermal and hematopoietic necrosis virus and white spot virus in shrimp using real-time quantitative PCR and SYBR Green chemistry. J Clin Microbiol. 2001;39:2835-2845.
25. Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol Cell Biol. 1996;16:1247-1255.
26. Pandey A, Dan I, Kristiansen TZ, Watanabe NM, Voldby J, Kajikawa E, Khosravi-Far R, Blagoev B, Mann M. Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain. Oncogene. 2002;21:3939-3948.
27. Zhu Y, Sun Y, Mao XO, Jin K, Greenberg DA. Expression of poly (C) binding proteins is differentially regulated by hypoxia and ischemia in cortical neurons. Neuroscience. 2001;110:191-198.
28. Parmentier-Batteur S, Jin K, Mao XO, Xie L, Greenberg DA. Increased severity of stroke in CB1 cannabinoid receptor knock-out mice. J Neurosci. 2002;22:9771-9775.
29. Williams RL, Risau W, Zerwes HG, Drexler H, Aguzzi A, Wagner EF. Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment. Cell. 1989;57:1053-1063.
30. Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature. 2001;410:37-40.
31. Laderoute KR, Mendonca HL, Calaoagan JM, Knapp AM, Giaccia AJ, Stork PJ. Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments: a candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity. J Biol Chem. 1999;274:12890-12897.
32. Jin N, Hatton N, Swartz DR, Xia X, Harrington MA, Larsen SH, Rhoades RA. Hypoxia activates jun-N-terminal kinase, extracellular signal-regulated protein kinase, and p38 kinase in pulmonary arteries. Am J Respir Cell Mol Biol. 2000;23:593-601.
33. Kumar S, McDonnell PC, Gum RJ, Hand AT, Lee JC, Young PR. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun. 1997;235:533-538.
34. Enslen H, Raingeaud J, Davis RJ. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J Biol Chem. 1998;273:1741-1748.
35. Park SY, Lee H, Hur J, Kim SY, Kim H, Park JH, Cha S, Kang SS, Cho GJ, Choi WS, Suk K. Hypoxia induces nitric oxide production in mouse microglia via p38 mitogen-activated protein kinase pathway. Brain Res Mol Brain Res. 2002;107:9-16.
36. Shemirani B, Crowe DL. Hypoxic induction of HIF-1alpha and VEGF expression in head and neck squamous cell carcinoma lines is mediated by stress activated protein kinases. Oral Oncol. 2002;38:251-257.