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Volumn 6, Issue 11, 2014, Pages 1423-1435

Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease

Author keywords

Autoimmunity; Diabetes; IGF 1; Multiple sclerosis; T regulatory cells

Indexed keywords

RECOMBINANT SOMATOMEDIN C; STREPTOZOCIN; RECOMBINANT PROTEIN; SOMATOMEDIN C;

EID: 84910651421     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201303376     Document Type: Article
Times cited : (96)

References (72)
  • 2
    • 17644361955 scopus 로고    scopus 로고
    • The NOD mouse: a model of immune dysregulation
    • Anderson MS, Bluestone JA (2005) The NOD mouse: a model of immune dysregulation. Annu Rev Immunol 23: 447-485
    • (2005) Annu Rev Immunol , vol.23 , pp. 447-485
    • Anderson, M.S.1    Bluestone, J.A.2
  • 4
    • 0033001488 scopus 로고    scopus 로고
    • The NOD mouse model of type 1 diabetes: as good as it gets?
    • Atkinson MA, Leiter EH (1999) The NOD mouse model of type 1 diabetes: as good as it gets? Nat Med 5: 601-604
    • (1999) Nat Med , vol.5 , pp. 601-604
    • Atkinson, M.A.1    Leiter, E.H.2
  • 5
    • 0028879735 scopus 로고
    • Insulin-like growth factor-1 (IGF-1) protects NOD mice from insulitis and diabetes
    • Bergerot I, Fabien N, Maguer V, Thivolet C (1995) Insulin-like growth factor-1 (IGF-1) protects NOD mice from insulitis and diabetes. Clin Exp Immunol 102: 335-340
    • (1995) Clin Exp Immunol , vol.102 , pp. 335-340
    • Bergerot, I.1    Fabien, N.2    Maguer, V.3    Thivolet, C.4
  • 6
    • 77951776390 scopus 로고    scopus 로고
    • Genetics, pathogenesis and clinical interventions in type 1 diabetes
    • Bluestone JA, Herold K, Eisenbarth G (2010) Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 464: 1293-1300
    • (2010) Nature , vol.464 , pp. 1293-1300
    • Bluestone, J.A.1    Herold, K.2    Eisenbarth, G.3
  • 7
    • 50049105173 scopus 로고    scopus 로고
    • Orchestrating the orchestrators: chemokines in control of T cell traffic
    • Bromley SK, Mempel TR, Luster AD (2008) Orchestrating the orchestrators: chemokines in control of T cell traffic. Nat Immunol 9: 970-980
    • (2008) Nat Immunol , vol.9 , pp. 970-980
    • Bromley, S.K.1    Mempel, T.R.2    Luster, A.D.3
  • 9
    • 0031751086 scopus 로고    scopus 로고
    • The role of growth hormone and insulin-like growth factors in the immune system
    • van Buul-Offers SC, Kooijman R (1998) The role of growth hormone and insulin-like growth factors in the immune system. Cell Mol Life Sci 54: 1083-1094
    • (1998) Cell Mol Life Sci , vol.54 , pp. 1083-1094
    • van Buul-Offers, S.C.1    Kooijman, R.2
  • 10
    • 79961153751 scopus 로고    scopus 로고
    • Treg cells: patrolling a dangerous neighborhood
    • Campbell DJ, Koch MA (2011) Treg cells: patrolling a dangerous neighborhood. Nat Med 17: 929-930
    • (2011) Nat Med , vol.17 , pp. 929-930
    • Campbell, D.J.1    Koch, M.A.2
  • 11
    • 0034495084 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 fails to enhance central nervous system myelin repair during autoimmune demyelination
    • Cannella B, Pitt D, Capello E, Raine CS (2000) Insulin-like growth factor-1 fails to enhance central nervous system myelin repair during autoimmune demyelination. Am J Pathol 157: 933-943
    • (2000) Am J Pathol , vol.157 , pp. 933-943
    • Cannella, B.1    Pitt, D.2    Capello, E.3    Raine, C.S.4
  • 12
    • 0032417035 scopus 로고    scopus 로고
    • Recombinant human insulin-like growth factor-I (rhIGF-I) therapy in adults with type 1 diabetes mellitus: effects on IGFs, IGF-binding proteins, glucose levels and insulin treatment
    • Carroll PV, Umpleby M, Alexander EL, Egel VA, Callison KV, Sönksen PH, Russell-Jones DL (1998) Recombinant human insulin-like growth factor-I (rhIGF-I) therapy in adults with type 1 diabetes mellitus: effects on IGFs, IGF-binding proteins, glucose levels and insulin treatment. Clin Endocrinol 49: 739-746
    • (1998) Clin Endocrinol , vol.49 , pp. 739-746
    • Carroll, P.V.1    Umpleby, M.2    Alexander, E.L.3    Egel, V.A.4    Callison, K.V.5    Sönksen, P.H.6    Russell-Jones, D.L.7
  • 14
    • 0842291575 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I/IGF-binding protein-3 complex: therapeutic efficacy and mechanism of protection against type 1 diabetes
    • Chen W, Salojin KV, Mi QS, Grattan M, Meagher TC, Zucker P, Delovitch TL (2004) Insulin-like growth factor (IGF)-I/IGF-binding protein-3 complex: therapeutic efficacy and mechanism of protection against type 1 diabetes. Endocrinology 145: 627-638
    • (2004) Endocrinology , vol.145 , pp. 627-638
    • Chen, W.1    Salojin, K.V.2    Mi, Q.S.3    Grattan, M.4    Meagher, T.C.5    Zucker, P.6    Delovitch, T.L.7
  • 15
    • 0024578766 scopus 로고
    • Multiple low dose streptozotocin induces systemic MHC expression in mice by triggering T cells to release IFN-gamma
    • Cockfield SM, Ramassar V, Urmson J, Halloran PF (1989) Multiple low dose streptozotocin induces systemic MHC expression in mice by triggering T cells to release IFN-gamma. J Immunol 142: 1120-1128
    • (1989) J Immunol , vol.142 , pp. 1120-1128
    • Cockfield, S.M.1    Ramassar, V.2    Urmson, J.3    Halloran, P.F.4
  • 16
    • 79959271429 scopus 로고    scopus 로고
    • WebGestalt2: an updated and expanded version of the Web-based Gene Set Analysis Toolkit
    • Duncan DT, Prodduturi N, Zhang B (2010) WebGestalt2: an updated and expanded version of the Web-based Gene Set Analysis Toolkit. BMC Bioinformatics 11(Suppl. 4): 10
    • (2010) BMC Bioinformatics , vol.11 , pp. 10
    • Duncan, D.T.1    Prodduturi, N.2    Zhang, B.3
  • 18
    • 70349755645 scopus 로고    scopus 로고
    • How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets
    • Feuerer M, Shen Y, Littman DR, Benoist C, Mathis D (2009) How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets. Immunity 31: 654-664
    • (2009) Immunity , vol.31 , pp. 654-664
    • Feuerer, M.1    Shen, Y.2    Littman, D.R.3    Benoist, C.4    Mathis, D.5
  • 20
    • 25844487856 scopus 로고    scopus 로고
    • Target expression of IGF-1 in the central nervous system fails to protect mice from experimental autoimmune encephalomyelitis
    • Genoud S, Maricic I, Kumar V, Gage FH (2005) Target expression of IGF-1 in the central nervous system fails to protect mice from experimental autoimmune encephalomyelitis. J Neuroimmunol 168: 40-45
    • (2005) J Neuroimmunol , vol.168 , pp. 40-45
    • Genoud, S.1    Maricic, I.2    Kumar, V.3    Gage, F.H.4
  • 23
    • 2942692037 scopus 로고    scopus 로고
    • + T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion
    • + T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med 199: 1479-1489
    • (2004) J Exp Med , vol.199 , pp. 1479-1489
    • Herman, A.E.1    Freeman, G.J.2    Mathis, D.3    Benoist, C.4
  • 24
    • 36048978911 scopus 로고    scopus 로고
    • Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
    • Hill JA, Feuerer M, Tash K, Haxhinasto S, Perez J, Melamed R, Mathis D, Benoist C (2007) Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity 27: 786-800
    • (2007) Immunity , vol.27 , pp. 786-800
    • Hill, J.A.1    Feuerer, M.2    Tash, K.3    Haxhinasto, S.4    Perez, J.5    Melamed, R.6    Mathis, D.7    Benoist, C.8
  • 26
    • 0027491775 scopus 로고
    • Expression of transcription factor E2F1 induces quiescent cells to enter S phase
    • Johnson DG, Schwartz JK, Cress WD, Nevins JR (1993) Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365: 349-352
    • (1993) Nature , vol.365 , pp. 349-352
    • Johnson, D.G.1    Schwartz, J.K.2    Cress, W.D.3    Nevins, J.R.4
  • 27
    • 0030248933 scopus 로고    scopus 로고
    • Insulin-like growth factor I (IGF-I) delays the onset of diabetes in non-obese diabetic (NOD) mice
    • Kaino Y, Hirai H, Ito T, Kida K (1996) Insulin-like growth factor I (IGF-I) delays the onset of diabetes in non-obese diabetic (NOD) mice. Diabetes Res Clin Pract 34: 7-11
    • (1996) Diabetes Res Clin Pract , vol.34 , pp. 7-11
    • Kaino, Y.1    Hirai, H.2    Ito, T.3    Kida, K.4
  • 28
    • 72049094542 scopus 로고    scopus 로고
    • Contrasting roles of the IL-1 and IL-18 receptors in MyD88-dependent contact hypersensitivity
    • Klekotka PA, Yang L, Yokoyama WM (2010) Contrasting roles of the IL-1 and IL-18 receptors in MyD88-dependent contact hypersensitivity. J Invest Dermatol 130: 184-191
    • (2010) J Invest Dermatol , vol.130 , pp. 184-191
    • Klekotka, P.A.1    Yang, L.2    Yokoyama, W.M.3
  • 30
    • 0031587697 scopus 로고    scopus 로고
    • Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors
    • Le Roith D (1997) Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors. N Engl J Med 336: 633-640
    • (1997) N Engl J Med , vol.336 , pp. 633-640
    • Le Roith, D.1
  • 31
    • 37549029242 scopus 로고    scopus 로고
    • The mechanisms of alloxan- and streptozotocin-induced diabetes
    • Lenzen S (2008) The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 51: 216-226
    • (2008) Diabetologia , vol.51 , pp. 216-226
    • Lenzen, S.1
  • 32
    • 33847221165 scopus 로고    scopus 로고
    • Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1
    • LeRoith D, Yakar S (2007) Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1. Nat Clin Pract Endocrinol Metab 3: 302-310
    • (2007) Nat Clin Pract Endocrinol Metab , vol.3 , pp. 302-310
    • LeRoith, D.1    Yakar, S.2
  • 33
    • 0017179001 scopus 로고
    • Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus
    • Like AA, Rosini AA (1976) Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 193: 415-417
    • (1976) Science , vol.193 , pp. 415-417
    • Like, A.A.1    Rosini, A.A.2
  • 35
    • 77950349016 scopus 로고    scopus 로고
    • Th17 and regulatory T cells in mediating and restraining inflammation
    • Littman DR, Rudensky AY (2010) Th17 and regulatory T cells in mediating and restraining inflammation. Cell 140: 845-858
    • (2010) Cell , vol.140 , pp. 845-858
    • Littman, D.R.1    Rudensky, A.Y.2
  • 36
    • 0031044489 scopus 로고    scopus 로고
    • Insulin-like growth factor-I treatment reduces immune cell responses in acute non-demyelinative experimental autoimmune encephalomyelitis
    • Liu X, Linnington C, Webster HD, Lassmann S, Yao DL, Hudson LD, Wekerle H, Kreutzberg GW (1997) Insulin-like growth factor-I treatment reduces immune cell responses in acute non-demyelinative experimental autoimmune encephalomyelitis. J Neurosci Res 47: 531-538
    • (1997) J Neurosci Res , vol.47 , pp. 531-538
    • Liu, X.1    Linnington, C.2    Webster, H.D.3    Lassmann, S.4    Yao, D.L.5    Hudson, L.D.6    Wekerle, H.7    Kreutzberg, G.W.8
  • 37
    • 84887024554 scopus 로고    scopus 로고
    • IL-2 therapy in type 1 diabetes: "Trials" and tribulations
    • Long SA, Buckner JH, Greenbaum CJ (2013) IL-2 therapy in type 1 diabetes: "Trials" and tribulations. Clin Immunol 149: 324-331
    • (2013) Clin Immunol , vol.149 , pp. 324-331
    • Long, S.A.1    Buckner, J.H.2    Greenbaum, C.J.3
  • 38
    • 0032523210 scopus 로고    scopus 로고
    • Regulation of experimental autoimmune encephalomyelitis with insulin-like growth factor (IGF-1) and IGF-1/IGF-binding protein-3 complex (IGF-1/IGFBP3)
    • Lovett-Racke AE, Bittner P, Cross AH, Carlino JA, Racke MK (1998) Regulation of experimental autoimmune encephalomyelitis with insulin-like growth factor (IGF-1) and IGF-1/IGF-binding protein-3 complex (IGF-1/IGFBP3). J Clin Invest 101: 1797-1804
    • (1998) J Clin Invest , vol.101 , pp. 1797-1804
    • Lovett-Racke, A.E.1    Bittner, P.2    Cross, A.H.3    Carlino, J.A.4    Racke, M.K.5
  • 39
    • 0031686176 scopus 로고    scopus 로고
    • Effector mechanisms in low-dose streptozotocin-induced diabetes
    • Lukić ML, Stosić-Grujicić S, Shahin A (1998) Effector mechanisms in low-dose streptozotocin-induced diabetes. Dev Immunol 6: 119-128
    • (1998) Dev Immunol , vol.6 , pp. 119-128
    • Lukić, M.L.1    Stosić-Grujicić, S.2    Shahin, A.3
  • 40
    • 0035554676 scopus 로고    scopus 로고
    • Regulatory T cells in the control of immune pathology
    • Maloy KJ, Powrie F (2001) Regulatory T cells in the control of immune pathology. Nat Immunol 2: 816-822
    • (2001) Nat Immunol , vol.2 , pp. 816-822
    • Maloy, K.J.1    Powrie, F.2
  • 41
    • 34447580869 scopus 로고    scopus 로고
    • Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis
    • Min B, Thornton A, Caucheteux SM, Younes SA, Oh K, Hu-Li J, Paul WE (2007) Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis. Eur J Immunol 37: 1916-1923
    • (2007) Eur J Immunol , vol.37 , pp. 1916-1923
    • Min, B.1    Thornton, A.2    Caucheteux, S.M.3    Younes, S.A.4    Oh, K.5    Hu-Li, J.6    Paul, W.E.7
  • 42
    • 0028300538 scopus 로고
    • Recombinant human insulin-like growth factor-I therapy improves glycemic control and insulin action in the type A syndrome of severe insulin resistance
    • Morrow LA, O'Brien MB, Moller DE, Flier JS, Moses AC (1994) Recombinant human insulin-like growth factor-I therapy improves glycemic control and insulin action in the type A syndrome of severe insulin resistance. J Clin Endocrinol Metab 79: 205-210
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 205-210
    • Morrow, L.A.1    O'Brien, M.B.2    Moller, D.E.3    Flier, J.S.4    Moses, A.C.5
  • 44
    • 0021216149 scopus 로고
    • The role of thymic immunity and insulitis in the development of streptozocin-induced diabetes in mice
    • Nakamura M, Nagafuchi S, Yamaguchi K, Takaki R (1984) The role of thymic immunity and insulitis in the development of streptozocin-induced diabetes in mice. Diabetes 33: 894-900
    • (1984) Diabetes , vol.33 , pp. 894-900
    • Nakamura, M.1    Nagafuchi, S.2    Yamaguchi, K.3    Takaki, R.4
  • 45
    • 4043052238 scopus 로고    scopus 로고
    • Regulatory T cells and mechanisms of immune system control
    • O'Garra A, Vieira P (2004) Regulatory T cells and mechanisms of immune system control. Nat Med 10: 801-805
    • (2004) Nat Med , vol.10 , pp. 801-805
    • O'Garra, A.1    Vieira, P.2
  • 46
    • 0036154986 scopus 로고    scopus 로고
    • Increasing local levels of IGF-I mRNA expression using adenoviral vectors does not alter oligodendrocyte remyelination in the CNS of aged rats
    • O'Leary MT, Hinks GL, Charlton HM, Franklin RJ (2002) Increasing local levels of IGF-I mRNA expression using adenoviral vectors does not alter oligodendrocyte remyelination in the CNS of aged rats. Mol Cell Neurosci 19: 32-42
    • (2002) Mol Cell Neurosci , vol.19 , pp. 32-42
    • O'Leary, M.T.1    Hinks, G.L.2    Charlton, H.M.3    Franklin, R.J.4
  • 47
    • 0019135171 scopus 로고
    • Insulin-dependent diabetes mellitus induced by subdiabetogenic doses of streptozotocin: obligatory role of cell-mediated autoimmune processes
    • Paik S, Fleischer N, Shin S (1980) Insulin-dependent diabetes mellitus induced by subdiabetogenic doses of streptozotocin: obligatory role of cell-mediated autoimmune processes. Proc Natl Acad Sci USA 77: 6129-6133
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 6129-6133
    • Paik, S.1    Fleischer, N.2    Shin, S.3
  • 48
    • 0028071193 scopus 로고
    • The immunosuppressant FK506 inhibits the damage to mouse pancreatic islets induced by low dose streptozocin
    • Papaccio G, Latronico M, Chieffi Baccari G (1994) The immunosuppressant FK506 inhibits the damage to mouse pancreatic islets induced by low dose streptozocin. Cell Tissue Res 277: 573-578
    • (1994) Cell Tissue Res , vol.277 , pp. 573-578
    • Papaccio, G.1    Latronico, M.2    Chieffi Baccari, G.3
  • 50
    • 73349103151 scopus 로고    scopus 로고
    • Recombinant human insulin-like growth factor-I therapy for children with growth disorders
    • Richmond EJ, Rogol AD (2008) Recombinant human insulin-like growth factor-I therapy for children with growth disorders. Adv Ther 25: 1276-1287
    • (2008) Adv Ther , vol.25 , pp. 1276-1287
    • Richmond, E.J.1    Rogol, A.D.2
  • 51
    • 0018074911 scopus 로고
    • Complete protection from low-dose streptozotocin-induced diabetes in mice
    • Rossini AA, Williams RM, Appel MC, Like AA (1978) Complete protection from low-dose streptozotocin-induced diabetes in mice. Nature 276: 182-184
    • (1978) Nature , vol.276 , pp. 182-184
    • Rossini, A.A.1    Williams, R.M.2    Appel, M.C.3    Like, A.A.4
  • 53
    • 36249024247 scopus 로고    scopus 로고
    • Regulatory T cells - a brief history and perspective
    • Sakaguchi S, Wing K, Miyara M (2007) Regulatory T cells - a brief history and perspective. Eur J Immunol 37(Suppl. 1): S116-S123
    • (2007) Eur J Immunol , vol.37 , pp. S116-S123
    • Sakaguchi, S.1    Wing, K.2    Miyara, M.3
  • 55
    • 77952349493 scopus 로고    scopus 로고
    • Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?
    • Smith TJ (2010) Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases? Pharmacol Rev 62: 199-236
    • (2010) Pharmacol Rev , vol.62 , pp. 199-236
    • Smith, T.J.1
  • 56
    • 70350787008 scopus 로고    scopus 로고
    • Retinoids differentially regulate the progression of autoimmune diabetes in three preclinical models in mice
    • Stosić-Grujicić S, Cvjetićanin T, Stojanović I (2009) Retinoids differentially regulate the progression of autoimmune diabetes in three preclinical models in mice. Mol Immunol 47: 79-86
    • (2009) Mol Immunol , vol.47 , pp. 79-86
    • Stosić-Grujicić, S.1    Cvjetićanin, T.2    Stojanović, I.3
  • 57
    • 34248647881 scopus 로고    scopus 로고
    • Active induction of experimental allergic encephalomyelitis
    • Stromnes IM, Goverman JM (2006) Active induction of experimental allergic encephalomyelitis. Nat Protoc 1: 1810-1819
    • (2006) Nat Protoc , vol.1 , pp. 1810-1819
    • Stromnes, I.M.1    Goverman, J.M.2
  • 58
    • 77953082101 scopus 로고    scopus 로고
    • Class 2 IGF-1 isoforms are dispensable for viability, growth and maintenance of IGF-1 serum levels
    • Temmerman L, Slonimsky E, Rosenthal N (2010) Class 2 IGF-1 isoforms are dispensable for viability, growth and maintenance of IGF-1 serum levels. Growth Hormon IGF Res 20: 255-263
    • (2010) Growth Hormon IGF Res , vol.20 , pp. 255-263
    • Temmerman, L.1    Slonimsky, E.2    Rosenthal, N.3
  • 60
    • 33847125247 scopus 로고    scopus 로고
    • Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
    • Wan YY, Flavell RA (2007) Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 445: 766-770
    • (2007) Nature , vol.445 , pp. 766-770
    • Wan, Y.Y.1    Flavell, R.A.2
  • 62
    • 65549091509 scopus 로고    scopus 로고
    • In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islografts without immunosuppression
    • Webster KE, Walters S, Kohler RE, Mrkvan T, Boyman O, Surh CD, Grey ST, Sprent J (2009) In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med 206: 751-760
    • (2009) J Exp Med , vol.206 , pp. 751-760
    • Webster, K.E.1    Walters, S.2    Kohler, R.E.3    Mrkvan, T.4    Boyman, O.5    Surh, C.D.6    Grey, S.T.7    Sprent, J.8
  • 63
    • 67249159743 scopus 로고    scopus 로고
    • Time point is important for effects of syngeneic bone marrow transplantation for type 1 diabetes in mice
    • Wen Y, Ouyang J, Li W, Chen J, Liu Y, Meng L, Zhang H, Zhou X (2009) Time point is important for effects of syngeneic bone marrow transplantation for type 1 diabetes in mice. Transplant Proc 41: 1801-1807
    • (2009) Transplant Proc , vol.41 , pp. 1801-1807
    • Wen, Y.1    Ouyang, J.2    Li, W.3    Chen, J.4    Liu, Y.5    Meng, L.6    Zhang, H.7    Zhou, X.8
  • 64
    • 34247271308 scopus 로고    scopus 로고
    • Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
    • Williams LM, Rudensky AY (2007) Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol 8: 277-284
    • (2007) Nat Immunol , vol.8 , pp. 277-284
    • Williams, L.M.1    Rudensky, A.Y.2
  • 65
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • Wing K, Sakaguchi S (2010) Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 11: 7-13
    • (2010) Nat Immunol , vol.11 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 67
    • 0029042367 scopus 로고
    • Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis
    • Yao DL, Liu X, Hudson LD, Webster HD (1995) Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 92: 6190-6194
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 6190-6194
    • Yao, D.L.1    Liu, X.2    Hudson, L.D.3    Webster, H.D.4
  • 68
    • 84888348626 scopus 로고    scopus 로고
    • Insulin therapies: current and future trends at dawn
    • Yaturu S (2013) Insulin therapies: current and future trends at dawn. World J Diabetes 4: 1-7
    • (2013) World J Diabetes , vol.4 , pp. 1-7
    • Yaturu, S.1
  • 69
    • 70350749391 scopus 로고    scopus 로고
    • Regulatory T cells and ST2 signaling control diabetes induction with multiple low doses of streptozotocin
    • Zdravkovic N, Shahin A, Arsenijevic N, Lukic ML, Mensah-Brown EP (2009) Regulatory T cells and ST2 signaling control diabetes induction with multiple low doses of streptozotocin. Mol Immunol 47: 28-36
    • (2009) Mol Immunol , vol.47 , pp. 28-36
    • Zdravkovic, N.1    Shahin, A.2    Arsenijevic, N.3    Lukic, M.L.4    Mensah-Brown, E.P.5
  • 70
    • 0026740350 scopus 로고
    • Effects of insulin-like growth factor-I on glucose tolerance, insulin levels, and insulin secretion
    • Zenobi PD, Graf S, Ursprung H, Froesch ER (1992) Effects of insulin-like growth factor-I on glucose tolerance, insulin levels, and insulin secretion. J Clin Invest 89: 1908-1913
    • (1992) J Clin Invest , vol.89 , pp. 1908-1913
    • Zenobi, P.D.1    Graf, S.2    Ursprung, H.3    Froesch, E.R.4
  • 71
    • 23144464901 scopus 로고    scopus 로고
    • WebGestalt: an integrated system for exploring gene sets in various biological contexts
    • Zhang B, Kirov SA, Snoddy JR (2005) WebGestalt: an integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res 33: W741-W748
    • (2005) Nucleic Acids Res , vol.33 , pp. W741-W748
    • Zhang, B.1    Kirov, S.A.2    Snoddy, J.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.