Suppression of PI3K/Akt signaling by synthetic bichalcone analog TSWU-CD4 induces ER stress- and Bax/Bak-mediated apoptosis of cancer cells

Apoptosis

Volumn 19, Issue 11, 2014, Pages 1637-1653

  Lin, Meng Liang ^a   Chen, Shih Shun ^b   Huang, Ren Yu ^a   Lu, Yao Cheng ^b   Liao, Yu Ren ^c   Reddy, Mopuru Vijaya Bhaskar ^c   Lee, Chuan Chun ^a   Wu, Tian Shung ^c  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Bax Bak; Bcl 2; Phosphatidylinositol 3 kinase (PI3K); TSWU CD4 ((2E,2 E) 1,1 (5,5 (piperazine 1,4 diylbis(methylene))bis(4 hydroxy 3 methoxy 5,1 phenylene))bis(3 phenylprop 2 en 1 one))

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 12; CASPASE 3; GLUCOSE REGULATED PROTEIN 78; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; [ 1,1' [5'5' [PIPERAZINE 1,4 DIYLBIS(METHYLENE)]BIS(4 HYDROXY 3 METHOXY 5,1 PHENYLENE)]BIS(3 PHENYLPROP 2 EN 1 ONE)]; BAK1 PROTEIN, HUMAN; BAX PROTEIN, HUMAN; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CHALCONE DERIVATIVE; DANTROLENE; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; PERK KINASE; PIPERAZINE DERIVATIVE; PROTEIN KINASE R; TSWU-CD4 COMPOUND;

APOPTOSIS; ARTICLE; CELL FRACTIONATION; CELL SURVIVAL; CELL VIABILITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REPRESSION; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; LIPID RAFT; MOUSE; MTT ASSAY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; METABOLISM; MITOCHONDRION; PROTEIN MULTIMERIZATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CALCIUM; CALCIUM CHANNEL BLOCKERS; CASPASE 12; CELL LINE; CHALCONES; DANTROLENE; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; HEAT-SHOCK PROTEINS; HUMANS; MITOCHONDRIA; PHOSPHATIDYLINOSITOL 3-KINASES; PIPERAZINES; PROTEIN MULTIMERIZATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84910130405     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-014-1031-y     Document Type: Article

References (51)

1. Rowland AA, Voeltz GK (2012) Endoplasmic reticulum-mitochondria contacts: function of the junction. Nat Rev Mol Cell Biol 13(10):607-625
2. Pizzo P, Pozzan T (2007) Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics. Trends Cell Biol 17(10):511-517
3. Cory S, Huang DC, Adams JM (2003) The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22(53):8590-8607
4. Lai E, Teodoro T, Volchuk A (2007) Endoplasmic reticulum stress: signaling the unfolded protein response. Physiology (Bethesda) 22:193-201
5. Youle RJ, Strasser A (2008) The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 9(1):47-59
6. Zhai D, Jin C, Satterthwait AC, Reed JC (2006) Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins. Cell Death Differ 13(8):1419-1421
7. 2+ homeostasis in the endoplasmic reticulum. Cell Death Differ 13(8):1409-1418
8. 2+ pool depletion. Oncogene 12(10):2051-2055
9. Wang NS, Unkila MT, Reineks EZ, Distelhorst CW (2001) Transient expression of wild-type or mitochondrially targeted Bcl-2 induces apoptosis, whereas transient expression of endoplasmic reticulum-targeted Bcl-2 is protective against Bax-induced cell death. J Biol Chem 276(47):44117-44128
10. Nita ME, Nagawa H, Tominaga O et al (1998) 5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteins. Br J Cancer 78(8):986-992
11. Mahyar-Roemer M, Kohler H, Roemer K (2002) Role of Bax in resveratrol-induced apoptosis of colorectal carcinoma cells. BMC Cancer 2:27
12. Tudor G, Aguilera A, Halverson DO, Laing ND, Sausville EA (2000) Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels. Cell Death Differ 7(6):574-586
13. Gibson LF, Fortney J, Magro G, Ericson SG, Lynch JP, Landreth KS (1999) Regulation of BAX and BCL-2 expression in breast cancer cells by chemotherapy. Breast Cancer Res Treat 55(2):107-117
14. Cartron PF, Juin P, Oliver L, Meflah K, Vallette FM (2003) Impact of proapoptotic proteins Bax and Bak in tumor progression and response to treatment. Expert Rev Anticancer Ther 3(4):563-570
15. Kondo S, Shinomura Y, Miyazaki Y et al (2000) Mutations of the bak gene in human gastric and colorectal cancers. Cancer Res 60(16):4328-4330
16. Wang GQ, Gastman BR, Wieckowski E et al (2001) A role for mitochondrial Bak in apoptotic response to anticancer drugs. J Biol Chem 276(36):34307-34317
17. Brimmell M, Mendiola R, Mangion J, Packham G (1998) BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability. Oncogene 16(14):1803-1812
18. Gutierrez MI, Cherney B, Hussain A et al (1999) Bax is frequently compromised in Burkitt's lymphomas with irreversible resistance to Fas-induced apoptosis. Cancer Res 59(3):696-703
19. Friess H, Lu Z, Graber HU et al (1998) Bax, but not bcl-2, influences the prognosis of human pancreatic cancer. Gut 43(3):414-421
20. Ionov Y, Yamamoto H, Krajewski S, Reed JC, Perucho M (2000) Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution. Proc Natl Acad Sci USA 97(20):10872-10877
21. LeBlanc H, Lawrence D, Varfolomeev E et al (2002) Tumor-cell resistance to death receptor-induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax. Nat Med 8(3):274-281
22. Zong WX, Li C, Hatzivassiliou G et al (2003) Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol 162(1):59-69
23. Krajewski S, Tanaka S, Takayama S, Schibler MJ, Fenton W, Reed JC (1993) Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res 53(19):4701-4714
24. 2+: a control point for apoptosis. Science 300(5616):135-139
25. 2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosis. J Cell Sci 122(Pt 24):4481-4491
26. Reddy MV, Chen SS, Lin ML, Chan HH, Kuo PC, Wu TS (2011) Preparation of a series of novel bichalcones linked with a 1,4-dimethylenepiperazine moiety and examination of their cytotoxicity. Chem Pharm Bull (Tokyo) 59(12):1549-1554
27. Mdee LK, Yeboah SO, Abegaz BM (2003) Rhuschalcones II-VI, five new bichalcones from the root bark of Rhus pyroides. J Nat Prod 66(5):599-604
28. Lin ML, Lu YC, Chung JG et al (2010) Down-regulation of MMP-2 through the p38 MAPK-NF-kappaB-dependent pathway by aloe-emodin leads to inhibition of nasopharyngeal carcinoma cell invasion. Mol Carcinog 49(9):783-797
29. Lin ML, Lu YC, Chen HY, Lee CC, Chung JG, Chen SS (2014) Suppressing the formation of lipid raft-associated Rac1/PI3K/Akt signaling complexes by curcumin inhibits SDF-1alpha-induced invasion of human esophageal carcinoma cells. Mol Carcinog 53(5):360-379
30. Lin ML, Lu YC, Chung JG et al (2010) Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway. Cancer Lett 291(1):46-58
31. Lin ML, Lu YC, Chen HY, Lee CC, Chung JG, Chen SS (2014) Suppressing the formation of lipid raft-associated Rac1/PI3K/Akt signaling complexes by curcumin inhibits SDF-1alpha-induced invasion of human esophageal carcinoma cells. Mol Carcinog 53(5):360-379
32. Thomenius MJ, Distelhorst CW (2003) Bcl-2 on the endoplasmic reticulum: protecting the mitochondria from a distance. J Cell Sci 116(Pt 22):4493-4499
33. 2+ dynamics by proapoptotic BCL-2 family members. Biochem Pharmacol 66(8):1335-1340
34. Eskes R, Desagher S, Antonsson B, Martinou JC (2000) Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane. Mol Cell Biol 20(3):929-935
35. Ruffolo SC, Breckenridge DG, Nguyen M et al (2000) BID-dependent and BID-independent pathways for BAX insertion into mitochondria. Cell Death Differ 7(11):1101-1108
36. Wei MC, Lindsten T, Mootha VK et al (2000) tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev 14(16):2060-2071
37. Nakagawa T, Zhu H, Morishima N et al (2000) Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403(6765):98-103
38. Adams KW, Cooper GM (2007) Rapid turnover of mcl-1 couples translation to cell survival and apoptosis. J Biol Chem 282(9):6192-6200
39. Yung HW, Charnock-Jones DS, Burton GJ (2011) Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner. PLoS ONE 6(3):e17894
40. Mounir Z, Krishnamoorthy JL, Wang S et al (2011) Akt determines cell fate through inhibition of the PERK-eIF2alpha phosphorylation pathway. Sci Signal 4(192):ra62
41. Winnay JN, Boucher J, Mori MA, Ueki K, Kahn CR (2010) A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat Med 16(4):438-445
42. Dufour C, Guenou H, Kaabeche K, Bouvard D, Sanjay A, Marie PJ (2008) FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival. Bone 42(6):1032-1039
43. Drevot P, Langlet C, Guo XJ et al (2002) TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts. EMBO J 21(8):1899-1908
44. Hu P, Han Z, Couvillon AD, Exton JH (2004) Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death. J Biol Chem 279(47):49420-49429
45. Hyoda K, Hosoi T, Horie N, Okuma Y, Ozawa K, Nomura Y (2006) PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells. Biochem Biophys Res Commun 340(1):286-290
46. Han C, Jin L, Mei Y, Wu M (2013) Endoplasmic reticulum stress inhibits cell cycle progression via induction of p27 in melanoma cells. Cell Signal 25(1):144-149
47. Chen M, Gutierrez GJ, Ronai ZA (2011) Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control. Proc Natl Acad Sci USA 108(22):9119-9124
48. Marsden VS, O'Connor L, O'Reilly LA et al (2002) Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature 419(6907):634-637
49. 2+ stores. J Biol Chem 277(11):9219-9225
50. 2+ homeostasis. Mol Biol Cell 23(13):2605-2618
51. Billen LP, Kokoski CL, Lovell JF, Leber B, Andrews DW (2008) Bcl-XL inhibits membrane permeabilization by competing with Bax. PLoS Biol 6(6):e147