Rhuschalcones II-VI, five new bichalcones from the root bark of Rhus pyroides

Journal of Natural Products

Volumn 66, Issue 5, 2003, Pages 599-604

  Mdee, Ladislaus K ^a   Yeboah, Samuel O ^a   Abegaz, Berhanu M ^a  

^a UNIVERSITY OF BOTSWANA   (Botswana)

Author keywords

[No Author keywords available]

Indexed keywords

2',4',4'',2''' TETRAHYDROXY 4''' METHOXY 4 O 5''' BICHALCONE; 2',4',4'',2''',4''' PENTAHYDROXY 4 O 5''' BICHALCONE; 4,2',4'',2''' TETRAHYDROXY 4''' METHOXY 4' O 5''' BICHALCONE; 4,2',4',4'',2''',4''' HEXAHYDROXY 3,5''' BICHALCONE; 4,2',4',4'',2''',4''' HEXAHYDROXY 3,5''' DIHYDROCHALCONE CHALCONE; BIOFLAVONOID; UNCLASSIFIED DRUG;

ANACARDIACEAE; ARTICLE; CELL STRAIN HT29; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANT ROOT; RHUS PYROIDES;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BOTSWANA; CHALCONE; COLONIC NEOPLASMS; DRUG SCREENING ASSAYS, ANTITUMOR; FLAVONOIDS; MELANOMA; MOLECULAR STRUCTURE; PLANT BARK; PLANT ROOTS; PLANTS, MEDICINAL; RHUS; TUMOR CELLS, CULTURED;

ANACARDIACEAE; RHUS; RHUS PYROIDES;

EID: 0037850981     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np020138q     Document Type: Article

References (16)

1. Hutchings, A. Zulu Medicinal Plants: An Inventory; University of Natal Press: Pietermaritzburg, 1996; p 180.
2. (a) Harborne, J. B., Baxter, H., Eds. The Handbook of Natural Flavonoids; John Wiley & Sons: Chichester, 1999; Vol. 1, pp 645-688.
3. (b) Lin, Y.-M.; Cheng, F.-C.; Liang, C. M. Phytochemistry 1974, 12, 276-277.
4. (c) Cheng, F.-C.; Lin, Y.-M. J. Chem. Soc., Perkin Trans. 1 1976, 98-101.
5. (d) Lin, Y.-M.; Cheng, F.-C. Phytochemistry 1974, 13, 657-658.
6. (e) Lin, Y.-M.; Cheng, F.-C. Phytochemistry 1974, 13, 1617-1619.
7. (a) Lin, Y.-M.; Flavin, M. T.; Schure, R.; Chen, F.-C.; Sidwell, R.; Barnard, D. L.; Huffman, J. H.; Kern, E. R. Planta Med. 1999, 65, 120-125.
8. (b) Lin, Y.-M.; Anderson, H.; Flavin, M. T.; Pai, Y.-H. S.; Mata-Greenwood, E.; Pengsuparp, T.; Pezzuto, J. M.; Schinazi, R. F.; Hughes, S. H.; Chen, F.-C. J. Nat. Prod. 1997, 60, 884-888.
9. Lale, A.; Herbert, J. M.; Augereau, J. M.; Billon, M.; Leconte, M.; Gley, J. J. Nat. Prod. 1996, 59, 273-276.
10. Kuo, Y.-H.; Lin, C.-H.; Hwang, S.-Y.; Shen, Y.-C.; Lee, Y.-L.; Li, S.-Y. Chem. Pharm. Bull. 2000, 48, 440-441.
11. Ahmad, M. S.; Galal, A. M.; Ross, S. A., Ferreira, D.; Elsohly, M. A.; Ibrahim, A. S.; Mossa, J. S.; El-Feraly, F. S. Phytochemistry 2001, 58, 599-602.
12. Masesane, I. B.; Yeboah, S. O.; Liebscher, J.; Mügge, C.; Abegaz, B. M. Phytochemistry 2000, 53, 1005-1008.
13. Boyd, M. R.; Paull, K. D. Drug Dev. Res. 1995, 34, 91-109.
14. Compound 8 (isoliquiritigenin trimethyl ether) is a known compound (The Combined Chemical Dictionary on CD-ROM (Version 4.2); Chapman and Hall/CRC Press: New York, 2001), and it and the bromochalcone 9 were synthesized from readily available materials. Details will be reported elsewhere.
15. Silva, D. H. S.; Yoshida, M.; Kato, M. J. Phytochemistry 1997, 46, 579-582.
16. Drewes, S. E.; Hudson, N. A. J. Chem. Soc., Perkin Trans. 1 1987, 2809-2813.