Probiotics against neoplastic transformation of gastric mucosa: Effects on cell proliferation and polyamine metabolism

World Journal of Gastroenterology

Volumn 20, Issue 37, 2014, Pages 13258-13272

  Russo, Francesco ^a   Linsalata, Michele ^a   Orlando, Antonella ^a  

^a NATIONAL INSTITUTE FOR DIGESTIVE DISEASES   (Italy)

Author keywords

Cell proliferation; Gastric cancer; Microbiota; Polyamines; Probiotics

Indexed keywords

CARCINOGEN; POLYAMINE; PROBIOTIC AGENT; PUTRESCINE; SPERMIDINE; SPERMINE;

ACTINOBACTERIA; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ATOPOBIUM; BACTERIAL STRAIN; BACTEROIDES; BACTEROIDETES; BIFIDOBACTERIUM; BIFIDOBACTERIUM BIFIDUM; CANCER PREVENTION; CANCER RISK; CELL GROWTH; CELL PROLIFERATION; CLOSTRIDIA; ENTEROBACTERIACEAE; ENTEROCOCCUS; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; EUBACTERIUM; FIRMICUTES; FUSOBACTERIUM; HELICOBACTER HEILMANNII; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; IN VITRO STUDY; INTESTINE FLORA; LACTOBACILLUS; LACTOBACILLUS ACIDOPHILUS; LACTOBACILLUS FERMENTUM; LACTOBACILLUS RHAMNOSUS; MALIGNANT TRANSFORMATION; NONHUMAN; PEPTOCOCCUS; PEPTOSTREPTOCOCCUS; POLYAMINE METABOLISM; PROPIONIBACTERIUM; PROTEOBACTERIA; REVIEW; RUMINOCOCCUS; STOMACH CANCER; STOMACH MUCOSA; STOMACH PROTECTION; STOMACH ULCER; STREPTOCOCCUS; ANIMAL; BACTERIUM; CELL TRANSFORMATION; GASTRIC MUCOSA; GROWTH, DEVELOPMENT AND AGING; HOST PATHOGEN INTERACTION; METABOLISM; MICROBIOLOGY; MICROFLORA; PATHOLOGY; STOMACH NEOPLASMS;

ANIMALS; BACTERIA; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; GASTRIC MUCOSA; HOST-PATHOGEN INTERACTIONS; HUMANS; MICROBIOTA; POLYAMINES; PROBIOTICS; STOMACH NEOPLASMS;

EID: 84910011271     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i37.13258     Document Type: Review

References (131)

1. Coleman MP, Estève J, Damiecki P, Arslan A, Renard H. Trends in cancer incidence and mortality. IARC Sci Publ 1993; (121): 1-806 [PMID: 8258476]
2. Bornschein J, Rokkas T, Selgrad M, Malfertheiner P. Gastric cancer: clinical aspects, epidemiology and molecular background. Helicobacter 2011; 16 Suppl 1: 45-52 [PMID: 21896085 DOI: 10.1111/j.1523-5378.2011.00880.x]
3. Tlaskalová-Hogenová H, Stěpánková R, Kozáková H, Hudcovic T, Vannucci L, Tučková L, Rossmann P, Hrnčíř T, Kverka M, Zákostelská Z, Klimešová K, Přibylová J, Bártová J, Sanchez D, Fundová P, Borovská D, Sru˚tková D, Zídek Z, Schwarzer M, Drastich P, Funda DP. The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases. Cell Mol Immunol 2011; 8: 110-120 [PMID: 21278760 DOI: 10.1038/cmi.2010.67]
4. Guarner F. Enteric flora in health and disease. Digestion 2006; 73 Suppl 1: 5-12 [PMID: 16498248 DOI: 10.1159/000089775]
5. Uccello M, Malaguarnera G, Basile F, D'agata V, Malaguarnera M, Bertino G, Vacante M, Drago F, Biondi A. Potential role of probiotics on colorectal cancer prevention. BMC Surg 2012; 12 Suppl 1: S35 [PMID: 23173670]
6. Reid G, Sanders ME, Gaskins HR, Gibson GR, Mercenier A, Rastall R, Roberfroid M, Rowland I, Cherbut C, Klaenhammer TR. New scientific paradigms for probiotics and prebiotics. J Clin Gastroenterol 2003; 37: 105-118 [PMID: 12869879]
7. Food and Agriculture Organization of the United Nations, World Health Organization. Probiotics in food: health and nutritional properties and guidelines for evaluation. Rome: Food and Agriculture Organization of the United Nations, World Health Organization, 2006
8. Goossens DA, Jonkers DM, Russel MG, Stobberingh EE, Stockbrügger RW. The effect of a probiotic drink with Lactobacillus plantarum 299v on the bacterial composition in faeces and mucosal biopsies of rectum and ascending colon. Aliment Pharmacol Ther 2006; 23: 255-263 [PMID: 16393305 DOI: 10.1111/j.1365-2036.2006.02749.x]
9. Ciorba MA. A gastroenterologist's guide to probiotics. Clin Gastroenterol Hepatol 2012; 10: 960-968 [PMID: 22504002 DOI: 10.1016/j.cgh.2012.03.024]
10. Sanders ME, Guarner F, Guerrant R, Holt PR, Quigley EM, Sartor RB, Sherman PM, Mayer EA. An update on the use and investigation of probiotics in health and disease. Gut 2013; 62: 787-796 [PMID: 23474420 DOI: 10.1136/gutjnl-2012-302504]
11. Bhandari A, Crowe SE. Helicobacter pylori in gastric malignancies. Curr Gastroenterol Rep 2012; 14: 489-496 [PMID: 23054813 DOI: 10.1007/s11894-012-0296-y]
12. Pegg AE, McCann PP. Polyamine metabolism and function. Am J Physiol 1982; 243: C212-C221 [PMID: 6814260]
13. Linsalata M, Russo F, Cavallini A, Berloco P, Di Leo A. Polyamines, diamine oxidase, and ornithine decarboxylase activity in colorectal cancer and in normal surrounding mucosa. Dis Colon Rectum 1993; 36: 662-667 [PMID: 8348850]
14. Jeffery IB, Claesson MJ, O'Toole PW, Shanahan F. Categorization of the gut microbiota: enterotypes or gradients? Nat Rev Microbiol 2012; 10: 591-592 [PMID: 23066529]
15. Lagier JC, Armougom F, Million M, Hugon P, Pagnier I, Robert C, Bittar F, Fournous G, Gimenez G, Maraninchi M, Trape JF, Koonin EV, La Scola B, Raoult D. Microbial culturomics: paradigm shift in the human gut microbiome study. Clin Microbiol Infect 2012; 18: 1185-1193 [PMID: 23033984 DOI: 10.1111/1469-0691.12023]
16. Shen D, Liu C, Xu R, Zhang F. Human gut microbiota: dysbiosis and manipulation. Front Cell Infect Microbiol 2012; 2: 123 [PMID: 23061053 DOI: 10.3389/fcimb.2012.00123]
17. Ley RE, Peterson DA, Gordon JI. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 2006; 124: 837-848 [PMID: 16497592 DOI: 10.1016/j.cell.2006.02.017]
18. Yang I, Nell S, Suerbaum S. Survival in hostile territory: the microbiota of the stomach. FEMS Microbiol Rev 2013; 37: 736-761 [PMID: 23790154]
19. McColl KE, el-Omar E, Gillen D, Banerjee S. The role of Helicobacter pylori in the pathophysiology of duodenal ulcer disease and gastric cancer. Semin Gastrointest Dis 1997; 8: 142-155 [PMID: 9232727]
20. Andersson AF, Lindberg M, Jakobsson H, Bäckhed F, Nyrén P, Engstrand L. Comparative analysis of human gut microbiota by barcoded pyrosequencing. PLoS One 2008; 3: e2836 [PMID: 18665274]
21. Bik EM, Eckburg PB, Gill SR, Nelson KE, Purdom EA, Francois F, Perez-Perez G, Blaser MJ, Relman DA. Molecular analysis of the bacterial microbiota in the human stomach. Proc Natl Acad Sci USA 2006; 103: 732-737 [PMID: 16407106]
22. Baele M, Pasmans F, Flahou B, Chiers K, Ducatelle R, Haesebrouck F. Non-Helicobacter pylori helicobacters detected in the stomach of humans comprise several naturally occurring Helicobacter species in animals. FEMS Immunol Med Microbiol 2009; 55: 306-313 [PMID: 19243435]
23. Rossi M, Hänninen ML. Helicobacter spp. other than H. pylori. Helicobacter 2012; 17 Suppl 1: 56-61 [PMID: 22958157 DOI: 10.1111/j.1523-5378.2012.00984.x]
24. Sanduleanu S, Jonkers D, De Bruïne A, Hameeteman W, Stockbrügger RW. Double gastric infection with Helicobacter pylori and non-Helicobacter pylori bacteria during acidsuppressive therapy: increase of pro-inflammatory cytokines and development of atrophic gastritis. Aliment Pharmacol Ther 2001; 15: 1163-1175 [PMID: 11472319]
25. Hu Y, He LH, Xiao D, Liu GD, Gu YX, Tao XX, Zhang JZ. Bacterial flora concurrent with Helicobacter pylori in the stomach of patients with upper gastrointestinal diseases. World J Gastroenterol 2012; 18: 1257-1261 [PMID: 22468090 DOI: 10.3748/wjg.v18.i11.1257]
26. Crew KD, Neugut AI. Epidemiology of gastric cancer. World J Gastroenterol 2006; 12: 354-362 [PMID: 16489633]
27. AIRTUM Working Group. Italian cancer figures, report 2009: Cancer trend (1998-2005). Epidemiol Prev 2009; 33: 1-168 [PMID: 20124636]
28. Wroblewski LE, Peek RM, Wilson KT. Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev 2010; 23: 713-739 [PMID: 20930071 DOI: 10.1128/CMR.00011-10]
29. De Vries AC, Van Driel HF, Richardus JH, Ouwendijk M, Van Vuuren AJ, De Man RA, Kuipers EJ. Migrant communities constitute a possible target population for primary prevention of Helicobacter pylori-related complications in low incidence countries. Scand J Gastroenterol 2008; 43: 403-409 [PMID: 18365904 DOI: 10.1080/00365520701814077]
30. Eslick GD. Helicobacter pylori infection causes gastric cancer? A review of the epidemiological, meta-analytic, and experimental evidence. World J Gastroenterol 2006; 12: 2991-2999 [PMID: 16718777]
31. Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Freeman C, Galichet L, Cogliano V. A review of human carcinogens - Part B: biological agents. Lancet Oncol 2009; 10: 321-322 [PMID: 19350698]
32. Kokkola A, Valle J, Haapiainen R, Sipponen P, Kivilaakso E, Puolakkainen P. Helicobacter pylori infection in young patients with gastric carcinoma. Scand J Gastroenterol 1996; 31: 643-647 [PMID: 8819211]
33. Gisbert JP, Calvet X. Review article: common misconceptions in the management of Helicobacter pyloriassociated gastric MALT-lymphoma. Aliment Pharmacol Ther 2011; 34: 1047-1062 [PMID: 21919927 DOI: 10.1111/j.1365-2036.2011.04839.x]
34. Sihvo EI, Salminen JT, Rämö OJ, Salo JA. The epidemiology of oesophageal adenocarcinoma: has the cancer of gastric cardia an influence on the rising incidence of oesophageal adenocarcinoma? Scand J Gastroenterol 2000; 35: 1082-1086 [PMID: 11099062]
35. Romano M, Ricci V, Zarrilli R. Mechanisms of disease: Helicobacter pylori-related gastric carcinogenesis - implications for chemoprevention. Nat Clin Pract Gastroenterol Hepatol 2006; 3: 622-632 [PMID: 17068500 DOI: 10.1038/ncpgasthep0634]
36. Ngoan LT, Mizoue T, Fujino Y, Tokui N, Yoshimura T. Dietary factors and stomach cancer mortality. Br J Cancer 2002; 87: 37-42 [PMID: 12085253 DOI: 10.1038/sj.bjc.6600415]
37. Joossens JV, Hill MJ, Elliott P, Stamler R, Lesaffre E, Dyer A, Nichols R, Kesteloot H. Dietary salt, nitrate and stomach cancer mortality in 24 countries. European Cancer Prevention (ECP) and the INTERSALT Cooperative Research Group. Int J Epidemiol 1996; 25: 494-504 [PMID: 8671549]
38. La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997; 27: 65-68 [PMID: 8970184]
39. Fox JG, Dangler CA, Taylor NS, King A, Koh TJ, Wang TC. High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL/6 mice. Cancer Res 1999; 59: 4823-4828 [PMID: 10519391]
40. Sinha R, Rothman N, Brown ED, Mark SD, Hoover RN, Caporaso NE, Levander OA, Knize MG, Lang NP, Kadlubar FF. Pan-fried meat containing high levels of heterocyclic aromatic amines but low levels of polycyclic aromatic hydrocarbons induces cytochrome P4501A2 activity in humans. Cancer Res 1994; 54: 6154-6159 [PMID: 7954461]
41. You WC, Zhao L, Chang YS, Blot WJ, Fraumeni JF. Progression of precancerous gastric lesions. Lancet 1995; 345: 866-867 [PMID: 7898258]
42. Zhang ZW, Abdullahi M, Farthing MJ. Effect of physiological concentrations of vitamin C on gastric cancer cells and Helicobacter pylori. Gut 2002; 50: 165-169 [PMID: 11788554]
43. Hou IC, Amarnani S, Chong MT, Bishayee A. Green tea and the risk of gastric cancer: epidemiological evidence. World J Gastroenterol 2013; 19: 3713-3722 [PMID: 23840110 DOI: 10.3748/wjg.v19.i24.3713]
44. Ma JL, Zhang L, Brown LM, Li JY, Shen L, Pan KF, Liu WD, Hu Y, Han ZX, Crystal-Mansour S, Pee D, Blot WJ, Fraumeni JF, You WC, Gail MH. Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality. J Natl Cancer Inst 2012; 104: 488-492 [PMID: 22271764 DOI: 10.1093/jnci/djs003]
45. Temple NJ, Gladwin KK. Fruit, vegetables, and the prevention of cancer: research challenges. Nutrition 2003; 19: 467-470 [PMID: 12714102]
46. Compare D, Nardone G. Contribution of gut microbiota to colonic and extracolonic cancer development. Dig Dis 2011; 29: 554-561 [PMID: 22179211 DOI: 10.1159/000332967]
47. Kalliomäki M, Salminen S, Isolauri E. Positive interactions with the microbiota: probiotics. Adv Exp Med Biol 2008; 635: 57-66 [PMID: 18841703 DOI: 10.1007/978-0-387-09550-9-5]
48. Malaguarnera G, Leggio F, Vacante M, Motta M, Giordano M, Bondi A, Basile F, Mastrojeni S, Mistretta A, Malaguarnera M, Toscano MA, Salmeri M. Probiotics in the gastrointestinal diseases of the elderly. J Nutr Health Aging 2012; 16: 402-410 [PMID: 22499466]
49. De Preter V, Hamer HM, Windey K, Verbeke K. The impact of pre- and/or probiotics on human colonic metabolism: does it affect human health? Mol Nutr Food Res 2011; 55: 46-57 [PMID: 21207512 DOI: 10.1002/mnfr.201000451]
50. Marteau P, Minekus M, Havenaar R, Huis in't Veld JH. Survival of lactic acid bacteria in a dynamic model of the stomach and small intestine: validation and the effects of bile. J Dairy Sci 1997; 80: 1031-1037 [PMID: 9201571 DOI: 10.3168/jds.S0022-0302(97)76027-2]
51. Rosania R, Minenna MF, Giorgio F, Facciorusso A, De Francesco V, Hassan C, Panella C, Ierardi E. Probiotic multistrain treatment may eradicate Helicobacter pylori from the stomach of dyspeptics: a placebo-controlled pilot study. Inflamm Allergy Drug Targets 2012; 11: 244-249 [PMID: 22452604]
52. Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M, Taniyama K, Sasaki N, Schlemper RJ. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 2001; 345: 784-789 [PMID: 11556297 DOI: 10.1056/NEJMoa001999]
53. Hansson LE, Nyrén O, Hsing AW, Bergström R, Josefsson S, Chow WH, Fraumeni JF, Adami HO. The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N Engl J Med 1996; 335: 242-249 [PMID: 8657240 DOI: 10.1056/NEJM199607253350404]
54. Ziebarth D, Spiegelhalder B, Bartsch H. N-nitrosation of medicinal drugs catalysed by bacteria from human saliva and gastro-intestinal tract, including Helicobacter pylori. Carcinogenesis 1997; 18: 383-389 [PMID: 9054633]
55. Nagaoka M, Hashimoto S, Watanabe T, Yokokura T, Mori Y. Anti-ulcer effects of lactic acid bacteria and their cell wall polysaccharides. Biol Pharm Bull 1994; 17: 1012-1017 [PMID: 7820099]
56. Lam EK, Tai EK, Koo MW, Wong HP, Wu WK, Yu L, So WH, Woo PC, Cho CH. Enhancement of gastric mucosal integrity by Lactobacillus rhamnosus GG. Life Sci 2007; 80: 2128-2136 [PMID: 17499310 DOI: 10.1016/j.lfs.2007.03.018]
57. Uchida M, Shimizu K, Kurakazu K. Yogurt containing Lactobacillus gasseri OLL 2716 (LG21 yogurt) accelerated the healing of acetic acid-induced gastric ulcer in rats. Biosci Biotechnol Biochem 2010; 74: 1891-1894 [PMID: 20834166]
58. Lam EK, Yu L, Wong HP, Wu WK, Shin VY, Tai EK, So WH, Woo PC, Cho CH. Probiotic Lactobacillus rhamnosus GG enhances gastric ulcer healing in rats. Eur J Pharmacol 2007; 565: 171-179 [PMID: 17395175 DOI: 10.1016/j.ejphar.2007.02.050]
59. Dharmani P, De Simone C, Chadee K. The probiotic mixture VSL#3 accelerates gastric ulcer healing by stimulating vascular endothelial growth factor. PLoS One 2013; 8: e58671 [PMID: 23484048 DOI: 10.1371/journal.pone.0058671]
60. Senol A, Işler M, Karahan AG, Kilic¸ GB, Kuleaşan H, Gören I, Saritaş U, Kaya S, Ciriş M, Aktürk O, Aridoʇan BC, Demirin H, Cakmakc¸i LM. Effect of probiotics on aspirin-induced gastric mucosal lesions. Turk J Gastroenterol 2011; 22: 18-26 [PMID: 21480106]
61. Gomi A, Harima-Mizusawa N, Shibahara-Sone H, Kano M, Miyazaki K, Ishikawa F. Effect of Bifidobacterium bifidum BF-1 on gastric protection and mucin production in an acute gastric injury rat model. J Dairy Sci 2013; 96: 832-837 [PMID: 23200466 DOI: 10.3168/jds.2012-5950]
62. Elliott SN, Buret A, McKnight W, Miller MJ, Wallace JL. Bacteria rapidly colonize and modulate healing of gastric ulcers in rats. Am J Physiol 1998; 275: G425-G432 [PMID: 9724253]
63. Vesper BJ, Jawdi A, Altman KW, Haines GK, Tao L, Radosevich JA. The effect of proton pump inhibitors on the human microbiota. Curr Drug Metab 2009; 10: 84-89 [PMID: 19149516]
64. Del Piano M, Anderloni A, Balzarini M, Ballarè M, Carmagnola S, Montino F, Orsello M, Pagliarulo M, Tari R, Soattini L, Sforza F, Mogna L, Mogna G. The innovative potential of Lactobacillus rhamnosus LR06, Lactobacillus pentosus LPS01, Lactobacillus plantarum LP01, and Lactobacillus delbrueckii Subsp. delbrueckii LDD01 to restore the "gastric barrier effect" in patients chronically treated with PPI: a pilot study. J Clin Gastroenterol 2012; 46 Suppl: S18-S26 [PMID: 22955351 DOI: 10.1097/MCG.0b013e318267b55d]
65. Gotteland M, Cruchet S, Verbeke S. Effect of Lactobacillus ingestion on the gastrointestinal mucosal barrier alterations induced by indometacin in humans. Aliment Pharmacol Ther 2001; 15: 11-17 [PMID: 11136273]
66. Akama F, Nishino R, Makino S, Kobayashi K, Kamikaseda K, Nagano J, Koga Y. The effect of probiotics on gastric mucosal permeability in humans administered with aspirin. Scand J Gastroenterol 2011; 46: 831-836 [PMID: 21492054 DOI: 10.3109/00365521.2011.574730]
67. Azcarate-Peril MA, Tallon R, Klaenhammer TR. Temporal gene expression and probiotic attributes of Lactobacillus acidophilus during growth in milk. J Dairy Sci 2009; 92: 870-886 [PMID: 19233780 DOI: 10.3168/jds.2008-1457]
68. Khalil R . Evidence for probiotic potential of a capsularproducing Streptococcus thermophilus CHCC 3534 strain. Pol J Microbiol 2009; 58: 49-55 [PMID: 19469286]
69. Tallon R, Arias S, Bressollier P, Urdaci MC. Strain- and matrix-dependent adhesion of Lactobacillus plantarum is mediated by proteinaceous bacterial compounds. J Appl Microbiol 2007; 102: 442-451 [PMID: 17241350 DOI: 10.1111/j.1365-2672.2006.03086.x]
70. Servin AL, Coconnier MH. Adhesion of probiotic strains to the intestinal mucosa and interaction with pathogens. Best Pract Res Clin Gastroenterol 2003; 17: 741-754 [PMID: 14507585]
71. Chen X, Liu XM, Tian F, Zhang Q, Zhang HP, Zhang H, Chen W. Antagonistic activities of lactobacilli against Helicobacter pylori growth and infection in human gastric epithelial cells. J Food Sci 2012; 77: M9-14 [PMID: 22181017 DOI: 10.1111/j.1750-3841.2011.02498.x]
72. Hsieh PS, Tsai YC, Chen YC, Teh SF, Ou CM, King VA. Eradication of Helicobacter pylori infection by the probiotic strains Lactobacillus johnsonii MH-68 and L. salivarius ssp. salicinius AP-32. Helicobacter 2012; 17: 466-477 [PMID: 23067294 DOI: 10.1111/j.1523-5378.2012.00992.x]
73. Cui Y, Wang CL, Liu XW, Wang XH, Chen LL, Zhao X, Fu N, Lu FG. Two stomach-originated Lactobacillus strains improve Helicobacter pylori infected murine gastritis. World J Gastroenterol 2010; 16: 445-452 [PMID: 20101769]
74. Burns AJ, Rowland IR. Antigenotoxicity of probiotics and prebiotics on faecal water-induced DNA damage in human colon adenocarcinoma cells. Mutat Res 2004; 551: 233-243 [PMID: 15225596 DOI: 10.1016/j.mrfmmm.2004.03.010]
75. Hirayama K, Rafter J. The role of probiotic bacteria in cancer prevention. Microbes Infect 2000; 2: 681-686 [PMID: 10884619]
76. Chang JH, Shim YY, Cha SK, Reaney MJ, Chee KM. Effect of Lactobacillus acidophilus KFRI342 on the development of chemically induced precancerous growths in the rat colon. J Med Microbiol 2012; 61: 361-368 [PMID: 22034161 DOI: 10.1099/jmm.0.035154-0]
77. Foo NP, Ou Yang H, Chiu HH, Chan HY, Liao CC, Yu CK, Wang YJ. Probiotics prevent the development of 1,2-dimethylhydrazine (DMH)-induced colonic tumorigenesis through suppressed colonic mucosa cellular proliferation and increased stimulation of macrophages. J Agric Food Chem 2011; 59: 13337-13345 [PMID: 22049926 DOI: 10.1021/jf203444d]
78. van Zanten GC, Knudsen A, Röytiö H, Forssten S, Lawther M, Blennow A, Lahtinen SJ, Jakobsen M, Svensson B, Jespersen L. The effect of selected synbiotics on microbial composition and short-chain fatty acid production in a model system of the human colon. PLoS One 2012; 7: e47212 [PMID: 23082149 DOI: 10.1371/journal.pone.0047212]
79. Nowak A, Libudzisz Z. Ability of probiotic Lactobacillus casei DN 114001 to bind or/and metabolise heterocyclic aromatic amines in vitro. Eur J Nutr 2009; 48: 419-427 [PMID: 19448966 DOI: 10.1007/s00394-009-0030-1]
80. Knasmüller S, Steinkellner H, Hirschl AM, Rabot S, Nobis EC, Kassie F. Impact of bacteria in dairy products and of the intestinal microflora on the genotoxic and carcinogenic effects of heterocyclic aromatic amines. Mutat Res 2001; 480-481: 129-138 [PMID: 11506806]
81. Stidl R, Sontag G, Koller V, Knasmüller S. Binding of heterocyclic aromatic amines by lactic acid bacteria: results of a comprehensive screening trial. Mol Nutr Food Res 2008; 52: 322-329 [PMID: 18320573 DOI: 10.1002/mnfr.200700034]
82. Orrhage K, Sillerström E, Gustafsson JA, Nord CE, Rafter J. Binding of mutagenic heterocyclic amines by intestinal and lactic acid bacteria. Mutat Res 1994; 311: 239-248 [PMID: 7526189]
83. Oelschlaeger TA. Mechanisms of probiotic actions - A review. Int J Med Microbiol 2010; 300: 57-62 [PMID: 19783474]
84. Yoshimura A, Mori H, Ohishi M, Aki D, Hanada T. Negative regulation of cytokine signaling influences inflammation. Curr Opin Immunol 2003; 15: 704-708 [PMID: 14630206]
85. Lee JS, Paek NS, Kwon OS, Hahm KB. Anti-inflammatory actions of probiotics through activating suppressor of cytokine signaling (SOCS) expression and signaling in Helicobacter pylori infection: a novel mechanism. J Gastroenterol Hepatol 2010; 25: 194-202 [PMID: 20136974 DOI: 10.1111/j.1440-1746.2009.06127.x]
86. Hanada T, Kinjyo I, Inagaki-Ohara K, Yoshimura A. Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases. Rev Physiol Biochem Pharmacol 2003; 149: 72-86 [PMID: 12687406 DOI: 10.1007/s10254-003-0015-z]
87. O'Shea JJ, Gadina M, Schreiber RD. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 2002; 109 Suppl: S121-S131 [PMID: 11983158]
88. Yang YJ, Chuang CC, Yang HB, Lu CC, Sheu BS. Lactobacillus acidophilus ameliorates H. pylori-induced gastric inflammation by inactivating the Smad7 and NFκB pathways. BMC Microbiol 2012; 12: 38 [PMID: 22429929 DOI: 10.1186/1471-2180-12-38]
89. Doger FK, Meteoglu I, Ozkara E, Erkul ZK, Okyay P, Yükselen V. Expression of NF-kappaB in Helicobacter pylori infection. Dig Dis Sci 2006; 51: 2306-2309 [PMID: 17103034 DOI: 10.1007/s10620-006-9352-5]
90. D'Elios MM, Manghetti M, De Carli M, Costa F, Baldari CT, Burroni D, Telford JL, Romagnani S, Del Prete G. T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease. J Immunol 1997; 158: 962-967 [PMID: 8993017]
91. Johnson-Henry KC, Mitchell DJ, Avitzur Y, Galindo-Mata E, Jones NL, Sherman PM. Probiotics reduce bacterial colonization and gastric inflammation in H. pylori-infected mice. Dig Dis Sci 2004; 49: 1095-1102 [PMID: 15387328]
92. Ushiyama A, Tanaka K, Aiba Y, Shiba T, Takagi A, Mine T, Koga Y. Lactobacillus gasseri OLL2716 as a probiotic in clarithromycin-resistant Helicobacter pylori infection. J Gastroenterol Hepatol 2003; 18: 986-991 [PMID: 12859730]
93. Jansen MS, Nagel SC, Miranda PJ, Lobenhofer EK, Afshari CA, McDonnell DP. Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. Proc Natl Acad Sci USA 2004; 101: 7199-7204 [PMID: 15103026 DOI: 10.1073/pnas.0402014101]
94. Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol 2007; 35: 495-516 [PMID: 17562483 DOI: 10.1080/01926230701320337]
95. McBain JA, Eastman A, Nobel CS, Mueller GC. Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors. Biochem Pharmacol 1997; 53: 1357-1368 [PMID: 9214697]
96. Jan G, Belzacq AS, Haouzi D, Rouault A, Métivier D, Kroemer G, Brenner C. Propionibacteria induce apoptosis of colorectal carcinoma cells via short-chain fatty acids acting on mitochondria. Cell Death Differ 2002; 9: 179-188 [PMID: 11840168 DOI: 10.1038/sj.cdd.4400935]
97. Bhatia SJ, Kochar N, Abraham P, Nair NG, Mehta AP. Lactobacillus acidophilus inhibits growth of Campylobacter pylori in vitro. J Clin Microbiol 1989; 27: 2328-2330 [PMID: 2511224]
98. Aiba Y, Suzuki N, Kabir AM, Takagi A, Koga Y. Lactic acid-mediated suppression of Helicobacter pylori by the oral administration of Lactobacillus salivarius as a probiotic in a gnotobiotic murine model. Am J Gastroenterol 1998; 93: 2097-2101 [PMID: 9820379 DOI: 10.1111/j.1572-0241.1998.00600.x]
99. Sgouras D, Maragkoudakis P, Petraki K, Martinez-Gonzalez B, Eriotou E, Michopoulos S, Kalantzopoulos G, Tsakalidou E, Mentis A. In vitro and in vivo inhibition of Helicobacter pylori by Lactobacillus casei strain Shirota. Appl Environ Microbiol 2004; 70: 518-526 [PMID: 14711683]
100. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebocontrolled study. Dig Dis Sci 2007; 52: 3259-3265 [PMID: 17393330]
101. Le Leu RK, Hu Y, Brown IL, Woodman RJ, Young GP. Synbiotic intervention of Bifidobacterium lactis and resistant starch protects against colorectal cancer development in rats. Carcinogenesis 2010; 31: 246-251 [PMID: 19696163]
102. De Vuyst L, Leroy F. Bacteriocins from lactic acid bacteria: production, purification, and food applications. J Mol Microbiol Biotechnol 2007; 13: 194-199 [PMID: 17827969 DOI: 10.1159/000104752]
103. Flynn S, van Sinderen D, Thornton GM, Holo H, Nes IF, Collins JK. Characterization of the genetic locus responsible for the production of ABP-118, a novel bacteriocin produced by the probiotic bacterium Lactobacillus salivarius subsp. salivarius UCC118. Microbiology 2002; 148: 973-984 [PMID: 11932444]
104. Rea MC, Clayton E, O'Connor PM, Shanahan F, Kiely B, Ross RP, Hill C. Antimicrobial activity of lacticin 3,147 against clinical Clostridium difficile strains. J Med Microbiol 2007; 56: 940-946 [PMID: 17577060 DOI: 10.1099/jmm.0.47085-0]
105. Tsai CC, Huang LF, Lin CC, Tsen HY. Antagonistic activity against Helicobacter pylori infection in vitro by a strain of Enterococcus faecium TM39. Int J Food Microbiol 2004; 96: 1-12 [PMID: 15358500 DOI: 10.1016/j.ijfoodmicro.2003.10.019]
106. Pinchuk IV, Bressollier P, Verneuil B, Fenet B, Sorokulova IB, Mégraud F, Urdaci MC. In vitro anti-Helicobacter pylori activity of the probiotic strain Bacillus subtilis 3 is due to secretion of antibiotics. Antimicrob Agents Chemother 2001; 45: 3156-3161 [PMID: 11600371 DOI: 10.1128/AAC.45.11.3156-31 61.2001]
107. Collado MC, González A, González R, Hernández M, Ferrús MA, Sanz Y. Antimicrobial peptides are among the antagonistic metabolites produced by Bifidobacterium against Helicobacter pylori. Int J Antimicrob Agents 2005; 25: 385-391 [PMID: 15848292 DOI: 10.1016/j.ijantimicag.2005.01.017]
108. Kanmani P, Satish Kumar R, Yuvaraj N, Paari KA, Pattukumar V, Arul V. Probiotics and its functionally valuable products-a review. Crit Rev Food Sci Nutr 2013; 53: 641-658 [PMID: 23627505 DOI: 10.1080/10408398.2011.553752]
109. Singh PK, Kaur IP. Synbiotic (probiotic and ginger extract) loaded floating beads: a novel therapeutic option in an experimental paradigm of gastric ulcer. J Pharm Pharmacol 2012; 64: 207-217 [PMID: 22221096]
110. Liong MT. Roles of probiotics and prebiotics in colon cancer prevention: Postulated mechanisms and in-vivo evidence. Int J Mol Sci 2008; 9: 854-863 [PMID: 19325789 DOI: 10.3390/ ijms9050854]
111. Guengerich FP . Cytochromes P450, drugs, and diseases. Mol Interv 2003; 3: 194-204 [PMID: 14993447 DOI: 10.1124/mi.3.4.194]
112. Igarashi K, Kashiwagi K. Modulation of cellular function by polyamines. Int J Biochem Cell Biol 2010; 42: 39-51 [PMID: 19643201 DOI: 10.1016/j.biocel.2009.07.009]
113. Casero RA, Marton LJ. Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat Rev Drug Discov 2007; 6: 373-390 [PMID: 17464296]
114. Iacomino G, Picariello G, D'Agostino L. DNA and nuclear aggregates of polyamines. Biochim Biophys Acta 2012; 1823: 1745-1755 [PMID: 22705882 DOI: 10.1016/j.bbamcr.2012.05.033]
115. Thomas T, Thomas TJ. Polyamine metabolism and cancer. J Cell Mol Med 2003; 7: 113-126 [PMID: 12927050]
116. Linsalata M, Messa C, Russo F, Cavallini A, Di Leo A. Estrogen receptors and polyamine levels in human gastric carcinoma. Scand J Gastroenterol 1994; 29: 67-70 [PMID: 8128178]
117. Linsalata M, Russo F, Notarnicola M, Berloco P, Di Leo A. Polyamine profile in human gastric mucosa infected by Helicobacter pylori. Ital J Gastroenterol Hepatol 1998; 30: 484-489 [PMID: 9836101]
118. Orlando A, Messa C, Linsalata M, Cavallini A, Russo F. Effects of Lactobacillus rhamnosus GG on proliferation and polyamine metabolism in HGC-27 human gastric and DLD-1 colonic cancer cell lines. Immunopharmacol Immunotoxicol 2009; 31: 108-116 [PMID: 19234959]
119. Linsalata M, Cavallini A, Messa C, Orlando A, Refolo MG, Russo F. Lactobacillus rhamnosus GG influences polyamine metabolism in HGC-27 gastric cancer cell line: a strategy toward nutritional approach to chemoprevention of gastric cance. Curr Pharm Des 2010; 16: 847-853 [PMID: 20388096]
120. Linsalata M, Russo F, Berloco P, Valentini AM, Caruso ML, De Simone C, Barone M, Polimeno L, Di Leo A. Effects of probiotic bacteria (VSL#3) on the polyamine biosynthesis and cell proliferation of normal colonic mucosa of rats. In Vivo 2005; 19: 989-995 [PMID: 16277012]
121. Linsalata M, Russo F, Berloco P, Caruso ML, Matteo GD, Cifone MG, Simone CD, Ierardi E, Di Leo A. The influence of Lactobacillus brevis on ornithine decarboxylase activity and polyamine profiles in Helicobacter pylori-infected gastric mucosa. Helicobacter 2004; 9: 165-172 [PMID: 15068419]
122. Famularo G, Perluigi M, Coccia R, Mastroiacovo P, De Simone C. Microecology, bacterial vaginosis and probiotics: perspectives for bacteriotherapy. Med Hypotheses 2001; 56: 421-430 [PMID: 11339841]
123. Di Marzio L, Russo FP, D'Alò S, Biordi L, Ulisse S, Amicosante G, De Simone C, Cifone MG. Apoptotic effects of selected strains of lactic acid bacteria on a human T leukemia cell line are associated with bacterial arginine deiminase and/or sphingomyelinase activities. Nutr Cancer 2001; 40: 185-196 [PMID: 11962255]
124. Ouyang L, Shi Z, Zhao S, Wang FT, Zhou TT, Liu B, Bao JK. Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif 2012; 45: 487-498 [PMID: 23030059 DOI: 10.1111/j.1365-2184.2012.00845.x]
125. Call JA, Eckhardt SG, Camidge DR. Targeted manipulation of apoptosis in cancer treatment. Lancet Oncol 2008; 9: 1002-1011 [PMID: 18760670 DOI: 10.1016/S1470-2045(08)70209-2]
126. Pagnini C, Corleto VD, Hoang SB, Saeed R, Cominelli F, Delle Fave G. Commensal bacteria and "oncologic surveillance": suggestions from an experimental model. J Clin Gas-troenterol 2008; 42 Suppl 3 Pt 2: S193-S196 [PMID: 18685507 DOI: 10.1097/MCG.0b013e31817f1284]
127. Cousin FJ, Jouan-Lanhouet S, Dimanche-Boitrel MT, Corcos L, Jan G. Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells. PLoS One 2012; 7: e31892 [PMID: 22442660 DOI: 10.1371/journal.pone.0031892]
128. Hwang JW, Baek YM, Yang KE, Yoo HS, Cho CK, Lee YW, Park J, Eom CY, Lee ZW, Choi JS, Jang IS. Lactobacillus casei extract induces apoptosis in gastric cancer by inhibiting NF-κB and mTOR-mediated signaling. Integr Cancer Ther 2013; 12: 165-173 [PMID: 22505595 DOI: 10.1177/1534735412442380]
129. Lee NK, Park JS, Park E, Paik HD. Adherence and anticarcinogenic effects of Bacillus polyfermenticus SCD in the large intestine. Lett Appl Microbiol 2007; 44: 274-278 [PMID: 17309504 DOI: 10.1111/j.1472-765X.2006.02078.x]
130. Kim Y, Lee D, Kim D, Cho J, Yang J, Chung M, Kim K, Ha N. Inhibition of proliferation in colon cancer cell lines and harmful enzyme activity of colon bacteria by Bifidobacterium adolescentis SPM0212. Arch Pharm Res 2008; 31: 468-473 [PMID: 18449504 DOI: 10.1007/s12272-001-1180-y]
131. Du YQ, Su T, Fan JG, Lu YX, Zheng P, Li XH, Guo CY, Xu P, Gong YF, Li ZS. Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection. World J Gastroenterol 2012; 18: 6302-6307 [PMID: 23180952 DOI: 10.3748/wjg.v18.i43.6302]