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1
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0029014206
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A novel cytokine-inducible gene CIS encodes an SH2 containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
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Yoshimura A., Ichihara M., Kinjyo I., Moriyama M., Copeland N.G., Gilbert D.J., Jenkins N.A., Hara T., Miyajima A. A novel cytokine-inducible gene CIS encodes an SH2 containing protein that binds to tyrosine- phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 14:1995;2816-2826.
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Yoshimura, A.1
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Kinjyo, I.3
Moriyama, M.4
Copeland, N.G.5
Gilbert, D.J.6
Jenkins, N.A.7
Hara, T.8
Miyajima, A.9
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3
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0032772125
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Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice
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Matsumoto A., Seki Y., Kubo M., Ohtsuka S., Suzuki A., Hayashi I., Tsuji K., Nakahata T., Okabe M., Yamada S., Yoshimura A. Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice. Mol. Cell. Biol. 19:1999;6396-6407.
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Mol. Cell. Biol.
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Matsumoto, A.1
Seki, Y.2
Kubo, M.3
Ohtsuka, S.4
Suzuki, A.5
Hayashi, I.6
Tsuji, K.7
Nakahata, T.8
Okabe, M.9
Yamada, S.10
Yoshimura, A.11
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4
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0030839112
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A new protein containing an SH2 domain that inhibits JAK kinases
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Endo T.A., Masuhara M., Yokouchi M., Suzuki R., Sakamoto H., Mitsui K., Matsumoto A., Tanimura S., Ohtsubo M., Misawa H., et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature. 387:1997;921-924.
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Nature
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Endo, T.A.1
Masuhara, M.2
Yokouchi, M.3
Suzuki, R.4
Sakamoto, H.5
Mitsui, K.6
Matsumoto, A.7
Tanimura, S.8
Ohtsubo, M.9
Misawa, H.10
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5
-
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0030755934
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Structure and function of a new STAT-induced STAT inhibitor
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Naka T., Narazaki M., Hirata M., Matsumoto T., Minamoto S., Aono A., Nishimoto N., Kajita T., Taga T., Yoshizaki K., et al. Structure and function of a new STAT-induced STAT inhibitor. Nature. 387:1997;924-929.
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Nature
, vol.387
, pp. 924-929
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Naka, T.1
Narazaki, M.2
Hirata, M.3
Matsumoto, T.4
Minamoto, S.5
Aono, A.6
Nishimoto, N.7
Kajita, T.8
Taga, T.9
Yoshizaki, K.10
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6
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0030792590
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A family of cytokine-inducible inhibitors of signalling
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Starr R., Willson T.A., Viney E.M., Murray L.J., Rayner J.R., Jenkins B.J., Gonda T.J., Alexander W.S., Metcalf D., Nicola N.A., Hilton D.J. A family of cytokine-inducible inhibitors of signalling. Nature. 387:1997;917-921.
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(1997)
Nature
, vol.387
, pp. 917-921
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Starr, R.1
Willson, T.A.2
Viney, E.M.3
Murray, L.J.4
Rayner, J.R.5
Jenkins, B.J.6
Gonda, T.J.7
Alexander, W.S.8
Metcalf, D.9
Nicola, N.A.10
Hilton, D.J.11
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7
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0037317179
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A three-dimensional model of Suppressor of Cytokine Signalling 1 (SOCS-1)
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This is an interesting paper that predicts the three-dimensional structure of a JAK2-SOCS1-elongin complex.
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Giordanetto F., Kroemer R.T. A three-dimensional model of Suppressor Of Cytokine Signalling 1 (SOCS-1). Protein Eng. 16:2003;115-124 This is an interesting paper that predicts the three-dimensional structure of a JAK2-SOCS1-elongin complex.
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(2003)
Protein Eng.
, vol.16
, pp. 115-124
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Giordanetto, F.1
Kroemer, R.T.2
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8
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0032803530
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Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain
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Sasaki A., Yasukawa H., Suzuki A., Kamizono S., Syoda T., Kinjyo I., Sasaki M., Johnston J.A., Yoshimura A. Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells. 4:1999;339-351.
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(1999)
Genes Cells
, vol.4
, pp. 339-351
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Sasaki, A.1
Yasukawa, H.2
Suzuki, A.3
Kamizono, S.4
Syoda, T.5
Kinjyo, I.6
Sasaki, M.7
Johnston, J.A.8
Yoshimura, A.9
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9
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0037414817
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SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130
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Lehmann U., Schmitz J., Weissenbach M., Sobota R.M., Hortner M., Friederichs K., Behrmann I., Tsiaris W., Sasaki A., Schneider-Mergener J., et al. SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. J. Biol. Chem. 278:2003;661-671.
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(2003)
J. Biol. Chem.
, vol.278
, pp. 661-671
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Lehmann, U.1
Schmitz, J.2
Weissenbach, M.3
Sobota, R.M.4
Hortner, M.5
Friederichs, K.6
Behrmann, I.7
Tsiaris, W.8
Sasaki, A.9
Schneider-Mergener, J.10
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10
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0001421697
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SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
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Bjorbak C., Lavery H.J., Bates S.H., Olson R.K., Davis S.M., Flier J.S., Myers M.G. Jr. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J. Biol. Chem. 275:2000;40649-40657.
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(2000)
J. Biol. Chem.
, vol.275
, pp. 40649-40657
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Bjorbak, C.1
Lavery, H.J.2
Bates, S.H.3
Olson, R.K.4
Davis, S.M.5
Flier, J.S.6
Myers Jr., M.G.7
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11
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0036105755
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A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor
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Hortner M., Nielsch U., Mayr L.M., Heinrich P.C., Haan S. A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor. Eur. J. Biochem. 269:2002;2516-2526.
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(2002)
Eur. J. Biochem.
, vol.269
, pp. 2516-2526
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Hortner, M.1
Nielsch, U.2
Mayr, L.M.3
Heinrich, P.C.4
Haan, S.5
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12
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0033520326
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SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine
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Alexander W.S., Starr R., Fenner J.E., Scott C.L., Handman E., Sprigg N.S., Corbin J.E., Cornish A.L., Darwiche R., Owczarek C.M., et al. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell. 98:1999;597-608.
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(1999)
Cell.
, vol.98
, pp. 597-608
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Alexander, W.S.1
Starr, R.2
Fenner, J.E.3
Scott, C.L.4
Handman, E.5
Sprigg, N.S.6
Corbin, J.E.7
Cornish, A.L.8
Darwiche, R.9
Owczarek, C.M.10
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13
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0033520467
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SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
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Marine J.C., Topham D.J., McKay C., Wang D., Parganas E., Stravopodis D., Yoshimura A., Ihle J.N. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell. 98:1999;609-616.
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(1999)
Cell
, vol.98
, pp. 609-616
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Marine, J.C.1
Topham, D.J.2
Mckay, C.3
Wang, D.4
Parganas, E.5
Stravopodis, D.6
Yoshimura, A.7
Ihle, J.N.8
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14
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0037154210
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Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)
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This paper indicates that IFN-γ/SOCS1 double KO mice still suffer from inflammatory diseases. Therefore, this paper suggests that SOCS1 is a negative regulator of inflammatory cytokines in addition to IFN-γ.
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Metcalf D., Mifsud S., Di Rago L., Nicola N.A., Hilton D.J., Alexander W.S. Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). Proc. Natl. Acad. Sci. USA. 99:2002;943-948 This paper indicates that IFN-γ/SOCS1 double KO mice still suffer from inflammatory diseases. Therefore, this paper suggests that SOCS1 is a negative regulator of inflammatory cytokines in addition to IFN-γ.
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(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 943-948
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-
Metcalf, D.1
Mifsud, S.2
Di Rago, L.3
Nicola, N.A.4
Hilton, D.J.5
Alexander, W.S.6
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15
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85047687240
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Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation
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This paper suggests that SOCS1 suppresses antigen-induced autoimmune arthritis.
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Egan P.J., Lawlor K.E., Alexander W.S., Wicks I.P. Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation. J. Clin. Invest. 111:2003;915-924 This paper suggests that SOCS1 suppresses antigen-induced autoimmune arthritis.
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(2003)
J. Clin. Invest.
, vol.111
, pp. 915-924
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Egan, P.J.1
Lawlor, K.E.2
Alexander, W.S.3
Wicks, I.P.4
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16
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0035042611
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SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
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Yoshikawa H., Matsubara K., Qian G.S., Jackson P., Groopman J.D., Manning J.E., Harris C.C., Herman J.G. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat. Genet. 28:2001;29-35.
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(2001)
Nat. Genet.
, vol.28
, pp. 29-35
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Yoshikawa, H.1
Matsubara, K.2
Qian, G.S.3
Jackson, P.4
Groopman, J.D.5
Manning, J.E.6
Harris, C.C.7
Herman, J.G.8
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17
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0036854891
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Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: Regulation by SOCS
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This paper suggests that STAT1 promoters liver injury, whereas STAT3 protects it.
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Hong F., Jaruga B., Kim W.H., Radaeva S., El-Assal O.N., Tian Z., Nguyen V.A., Gao B. Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS. J. Clin. Invest. 110:2002;1503-1513 This paper suggests that STAT1 promoters liver injury, whereas STAT3 protects it.
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(2002)
J. Clin. Invest.
, vol.110
, pp. 1503-1513
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Hong, F.1
Jaruga, B.2
Kim, W.H.3
Radaeva, S.4
El-Assal, O.N.5
Tian, Z.6
Nguyen, V.A.7
Gao, B.8
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18
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0035008978
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SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo
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Naka T., Tsutsui H., Fujimoto M., Kawazoe Y., Kohzaki H., Morita Y., Nakagawa R., Narazaki M., Adachi K., Yoshimoto T., et al. SOCS-1/ SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo. Immunity. 14:2001;535-545.
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(2001)
Immunity
, vol.14
, pp. 535-545
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-
Naka, T.1
Tsutsui, H.2
Fujimoto, M.3
Kawazoe, Y.4
Kohzaki, H.5
Morita, Y.6
Nakagawa, R.7
Narazaki, M.8
Adachi, K.9
Yoshimoto, T.10
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19
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0037396793
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Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation
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-/- mice.
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-/- mice.
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(2003)
Immunity
, vol.18
, pp. 475-487
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Chong, M.M.1
Cornish, A.L.2
Darwiche, R.3
Stanley, E.G.4
Purton, J.F.5
Godfrey, D.I.6
Hilton, D.J.7
Starr, R.8
Alexander, W.S.9
Kay, T.W.10
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20
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0036850946
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SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
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SOCS1 is shown to be required for suppression of LPS signaling in macrophages.
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Kinjyo I., Hanada T., Inagaki-Ohara K., Mori H., Aki D., Ohishi M., Yoshida H., Kubo M., Yoshimura A. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity. 17:2002;583-591 SOCS1 is shown to be required for suppression of LPS signaling in macrophages.
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(2002)
Immunity
, vol.17
, pp. 583-591
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Kinjyo, I.1
Hanada, T.2
Inagaki-Ohara, K.3
Mori, H.4
Aki, D.5
Ohishi, M.6
Yoshida, H.7
Kubo, M.8
Yoshimura, A.9
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21
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18744371050
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SOCS-1 participates in negative regulation of LPS responses
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SOCS1 is shown to be required for suppression of LPS signaling in macrophages.
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Nakagawa R., Naka T., Tsutsui H., Fujimoto M., Kimura A., Abe T., Seki E., Sato S., Takeuchi O., Takeda K., et al. SOCS-1 participates in negative regulation of LPS responses. Immunity. 17:2002;677-687 SOCS1 is shown to be required for suppression of LPS signaling in macrophages.
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(2002)
Immunity
, vol.17
, pp. 677-687
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Nakagawa, R.1
Naka, T.2
Tsutsui, H.3
Fujimoto, M.4
Kimura, A.5
Abe, T.6
Seki, E.7
Sato, S.8
Takeuchi, O.9
Takeda, K.10
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22
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0035877256
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Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs
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Dalpke A.H., Opper S., Zimmermann S., Heeg K. Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs. J. Immunol. 166:2001;7082-7089.
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(2001)
J. Immunol.
, vol.166
, pp. 7082-7089
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Dalpke, A.H.1
Opper, S.2
Zimmermann, S.3
Heeg, K.4
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23
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0035979275
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Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
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Roberts A.W., Robb L., Rakar S., Hartley L., Cluse L., Nicola N.A., Metcalf D., Hilton D.J., Alexander W.S. Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc. Natl. Acad. Sci. USA. 98:2001;9324-9329.
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(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9324-9329
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Roberts, A.W.1
Robb, L.2
Rakar, S.3
Hartley, L.4
Cluse, L.5
Nicola, N.A.6
Metcalf, D.7
Hilton, D.J.8
Alexander, W.S.9
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24
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0037415694
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SOCS3: An essential regulator of LIF receptor signaling in trophoblast giant cell differentiation
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Takahashi Y., Carpino N., Cross J.C., Torres M., Parganas E., Ihle J.N. SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation. EMBO J. 22:2003;372-384.
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(2003)
EMBO J.
, vol.22
, pp. 372-384
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Takahashi, Y.1
Carpino, N.2
Cross, J.C.3
Torres, M.4
Parganas, E.5
Ihle, J.N.6
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25
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0035910753
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CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestional inflammation
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Suzuki A., Hanada T., Mitsuyama K., Yoshida T., Kamizono S., Hoshino T., Kubo M., Yamashita A., Okabe M., Takeda K., et al. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestional inflammation. J. Exp. Med. 193:2001;471-481.
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(2001)
J. Exp. Med.
, vol.193
, pp. 471-481
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Suzuki, A.1
Hanada, T.2
Mitsuyama, K.3
Yoshida, T.4
Kamizono, S.5
Hoshino, T.6
Kubo, M.7
Yamashita, A.8
Okabe, M.9
Takeda, K.10
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26
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0035667907
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Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
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Shouda T., Yoshida T., Hanada T., Wakioka T., Oishi M., Miyoshi K., Komiya S., Kosai K., Hanakawa Y., Hashimoto K., et al. Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. J. Clin. Invest. 108:2001;1781-1788.
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(2001)
J. Clin. Invest.
, vol.108
, pp. 1781-1788
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Shouda, T.1
Yoshida, T.2
Hanada, T.3
Wakioka, T.4
Oishi, M.5
Miyoshi, K.6
Komiya, S.7
Kosai, K.8
Hanakawa, Y.9
Hashimoto, K.10
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27
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0037037586
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A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis
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Atsumi T., Ishihara K., Kamimura D., Ikushima H., Ohtani T., Hirota S., Kobayashi H., Park S.J., Saeki Y., Kitamura Y., Hirano T. A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. J. Exp. Med. 196:2002;979-990.
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(2002)
J. Exp. Med.
, vol.196
, pp. 979-990
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Atsumi, T.1
Ishihara, K.2
Kamimura, D.3
Ikushima, H.4
Ohtani, T.5
Hirota, S.6
Kobayashi, H.7
Park, S.J.8
Saeki, Y.9
Kitamura, Y.10
Hirano, T.11
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28
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0038614944
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SOCS3 regulates the plasticity of gp130 signaling
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This paper also showed that, without SOCS3, IL-6 can now activate STAT1 in addition to STAT3.
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Lang R., Pauleau A.L., Parganas E., Takahashi Y., Mages J., Ihle J.N., Rutschman R., Murray P.J. SOCS3 regulates the plasticity of gp130 signaling. Nat. Immunol. 4:2003;546-550 This paper also showed that, without SOCS3, IL-6 can now activate STAT1 in addition to STAT3.
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(2003)
Nat. Immunol.
, vol.4
, pp. 546-550
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-
Lang, R.1
Pauleau, A.L.2
Parganas, E.3
Takahashi, Y.4
Mages, J.5
Ihle, J.N.6
Rutschman, R.7
Murray, P.J.8
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29
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0037600741
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IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
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This paper demonstrates that SOCS3 is necessary to inhibit IL-6 signaling in macrophages. Without SOCS3, macrophages now can be suppressed not only by IL-10 but also by IL-6.
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Yasukawa H., Ohishi M., Mori H., Murakami M., Chinen T., Aki D., Hanada T., Takeda K., Akira S., Hoshijima M., et al. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat. Immunol. 4:2003;551-556 This paper demonstrates that SOCS3 is necessary to inhibit IL-6 signaling in macrophages. Without SOCS3, macrophages now can be suppressed not only by IL-10 but also by IL-6.
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(2003)
Nat. Immunol.
, vol.4
, pp. 551-556
-
-
Yasukawa, H.1
Ohishi, M.2
Mori, H.3
Murakami, M.4
Chinen, T.5
Aki, D.6
Hanada, T.7
Takeda, K.8
Akira, S.9
Hoshijima, M.10
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30
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0037938816
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SOCS3 negatively regulates IL-6 signaling in vivo
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SOCS3 is shown to be an important negative regulator in macrophages.
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Croker B.A., Krebs D.L., Zhang J.G., Wormald S., Willson T.A., Stanley E.G., Robb L., Greenhalgh C.J., Forster I., Clausen B.E., et al. SOCS3 negatively regulates IL-6 signaling in vivo. Nat. Immunol. 4:2003;540-545 SOCS3 is shown to be an important negative regulator in macrophages.
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(2003)
Nat. Immunol.
, vol.4
, pp. 540-545
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-
Croker, B.A.1
Krebs, D.L.2
Zhang, J.G.3
Wormald, S.4
Willson, T.A.5
Stanley, E.G.6
Robb, L.7
Greenhalgh, C.J.8
Forster, I.9
Clausen, B.E.10
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31
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0035898315
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Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation
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Ernst M., Inglese M., Waring P., Campbell I.K., Bao S., Clay F.J., Alexander W.S., Wicks I.P., Tarlinton D.M., Novak U., et al. Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation. J. Exp. Med. 194:2001;189-203.
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(2001)
J. Exp. Med.
, vol.194
, pp. 189-203
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Ernst, M.1
Inglese, M.2
Waring, P.3
Campbell, I.K.4
Bao, S.5
Clay, F.J.6
Alexander, W.S.7
Wicks, I.P.8
Tarlinton, D.M.9
Novak, U.10
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32
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0036796060
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Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
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This paper shows that a gp130 mutant lacking SHP-2 and SOCS3 binding sites induces gastrointestinal inflammatory diseases.
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Tebbutt N.C., Giraud A.S., Inglese M., Jenkins B., Waring P., Clay F.J., Malki S., Alderman B.M., Grail D., Hollande F., et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat. Med. 8:2002;1089-1097 This paper shows that a gp130 mutant lacking SHP-2 and SOCS3 binding sites induces gastrointestinal inflammatory diseases.
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(2002)
Nat. Med.
, vol.8
, pp. 1089-1097
-
-
Tebbutt, N.C.1
Giraud, A.S.2
Inglese, M.3
Jenkins, B.4
Waring, P.5
Clay, F.J.6
Malki, S.7
Alderman, B.M.8
Grail, D.9
Hollande, F.10
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