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Volumn 72, Issue Part A, 2014, Pages 54-60

Alzheimer's and ABC transporters - new opportunities for diagnostics and treatment

Author keywords

ABC transporter; ABCA7; ABCB1; ABCC1; Alzheimer's disease; Amyloid beta; BBB; Blood brain barrier; Choroid plexus; Glymphatic system; Neurodegeneration; PET

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER A1; ABC TRANSPORTER A7; AMYLOID BETA PROTEIN; BEXAROTENE; BREAST CANCER RESISTANCE PROTEIN; DESMETHYLLOPERAMIDE C 11; EFAVIRENZ; HERBACEOUS AGENT; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 1; PACLITAXEL; PERFORIN; PIRENZEPINE; THIETHYLPERAZINE; TRACER; UNCLASSIFIED DRUG; VERAPAMIL C 11;

EID: 84909578898     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.04.001     Document Type: Review
Times cited : (69)

References (118)
  • 1
    • 0345791510 scopus 로고    scopus 로고
    • Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein
    • Abe-Dohmae S., et al. Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein. J. Biol. Chem. 2004, 279:604-611.
    • (2004) J. Biol. Chem. , vol.279 , pp. 604-611
    • Abe-Dohmae, S.1
  • 2
    • 84893206590 scopus 로고    scopus 로고
    • TGF-beta1 regulation of multidrug resistance P-glycoprotein in the developing male blood-brain barrier
    • Baello S., et al. TGF-beta1 regulation of multidrug resistance P-glycoprotein in the developing male blood-brain barrier. Endocrinology 2014, 155:475-484.
    • (2014) Endocrinology , vol.155 , pp. 475-484
    • Baello, S.1
  • 3
    • 46649085260 scopus 로고    scopus 로고
    • Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA
    • Bartels A.L., et al. Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA. J. Neural Transm. 2008, 115:1001-1009.
    • (2008) J. Neural Transm. , vol.115 , pp. 1001-1009
    • Bartels, A.L.1
  • 4
    • 33745920161 scopus 로고    scopus 로고
    • Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo
    • Bateman R.J., et al. Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo. Nat. Med. 2006, 12:856-861.
    • (2006) Nat. Med. , vol.12 , pp. 856-861
    • Bateman, R.J.1
  • 5
    • 42449149172 scopus 로고    scopus 로고
    • Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling
    • Bauer B., et al. Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling. Mol. Pharmacol. 2008, 73:1444-1453.
    • (2008) Mol. Pharmacol. , vol.73 , pp. 1444-1453
    • Bauer, B.1
  • 6
    • 84855960602 scopus 로고    scopus 로고
    • 11C]verapamil and tariquidar at the human blood-brain barrier: a comparison with rat data
    • 11C]verapamil and tariquidar at the human blood-brain barrier: a comparison with rat data. Clin. Pharmacol. Ther. 2012, 91:227-233.
    • (2012) Clin. Pharmacol. Ther. , vol.91 , pp. 227-233
    • Bauer, M.1
  • 7
    • 58149129243 scopus 로고    scopus 로고
    • Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain
    • Boche D., et al. Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain. Brain 2008, 131:3299-3310.
    • (2008) Brain , vol.131 , pp. 3299-3310
    • Boche, D.1
  • 8
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. (Berl.) 1991, 82:239-259.
    • (1991) Acta Neuropathol. (Berl.) , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 9
    • 0037333666 scopus 로고    scopus 로고
    • Staging of brain pathology related to sporadic Parkinson's disease
    • Braak H., et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging 2003, 24:197-211.
    • (2003) Neurobiol. Aging , vol.24 , pp. 197-211
    • Braak, H.1
  • 10
    • 80052672466 scopus 로고    scopus 로고
    • Beta-amyloid downregulates MDR1-P-glycoprotein (Abcb1) expression at the blood-brain barrier in mice
    • Brenn A., et al. Beta-amyloid downregulates MDR1-P-glycoprotein (Abcb1) expression at the blood-brain barrier in mice. Int. J. Alzheimers Dis. 2011, 2011:690121.
    • (2011) Int. J. Alzheimers Dis. , vol.2011 , pp. 690121
    • Brenn, A.1
  • 11
    • 21644461778 scopus 로고    scopus 로고
    • Crystal structure of BMP-9 and functional interactions with pro-region and receptors
    • Brown M.A., et al. Crystal structure of BMP-9 and functional interactions with pro-region and receptors. J. Biol. Chem. 2005, 280:25111-25118.
    • (2005) J. Biol. Chem. , vol.280 , pp. 25111-25118
    • Brown, M.A.1
  • 12
    • 78650659385 scopus 로고    scopus 로고
    • Apical-to-basolateral transport of amyloid-beta peptides through blood-brain barrier cells is mediated by the receptor for advanced glycation end-products and is restricted by P-glycoprotein
    • Candela P., et al. Apical-to-basolateral transport of amyloid-beta peptides through blood-brain barrier cells is mediated by the receptor for advanced glycation end-products and is restricted by P-glycoprotein. J. Alzheimers Dis. 2010, 22:849-859.
    • (2010) J. Alzheimers Dis. , vol.22 , pp. 849-859
    • Candela, P.1
  • 13
    • 84889593832 scopus 로고    scopus 로고
    • ATP-binding cassette transporters P-glycoprotein and breast cancer related protein are reduced in capillary cerebral amyloid angiopathy
    • Carrano A., et al. ATP-binding cassette transporters P-glycoprotein and breast cancer related protein are reduced in capillary cerebral amyloid angiopathy. Neurobiol. Aging 2014, 35:565-575.
    • (2014) Neurobiol. Aging , vol.35 , pp. 565-575
    • Carrano, A.1
  • 14
    • 84875958482 scopus 로고    scopus 로고
    • Association of ATP-binding cassette transporter variants with the risk of Alzheimer's disease
    • Cascorbi I., et al. Association of ATP-binding cassette transporter variants with the risk of Alzheimer's disease. Pharmacogenomics 2013, 14:485-494.
    • (2013) Pharmacogenomics , vol.14 , pp. 485-494
    • Cascorbi, I.1
  • 15
    • 84879016468 scopus 로고    scopus 로고
    • Reassessing cerebrospinal fluid (CSF) hydrodynamics: a literature review presenting a novel hypothesis for CSF physiology
    • Chikly B., Quaghebeur J. Reassessing cerebrospinal fluid (CSF) hydrodynamics: a literature review presenting a novel hypothesis for CSF physiology. J. Bodyw. Mov. Ther. 2013, 17:344-354.
    • (2013) J. Bodyw. Mov. Ther. , vol.17 , pp. 344-354
    • Chikly, B.1    Quaghebeur, J.2
  • 16
    • 84883307543 scopus 로고    scopus 로고
    • Association of GWAS top hits with late-onset Alzheimer disease in Korean population
    • Chung S.J., et al. Association of GWAS top hits with late-onset Alzheimer disease in Korean population. Alzheimer Dis. Assoc. Disord. 2013, 27:250-257.
    • (2013) Alzheimer Dis. Assoc. Disord. , vol.27 , pp. 250-257
    • Chung, S.J.1
  • 17
    • 27644489474 scopus 로고    scopus 로고
    • P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model
    • Cirrito J.R., et al. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J. Clin. Invest. 2005, 115:3285-3290.
    • (2005) J. Clin. Invest. , vol.115 , pp. 3285-3290
    • Cirrito, J.R.1
  • 18
    • 84862777666 scopus 로고    scopus 로고
    • ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models
    • Cramer P.E., et al. ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models. Science 2012, 335:1503-1506.
    • (2012) Science , vol.335 , pp. 1503-1506
    • Cramer, P.E.1
  • 19
    • 84885730661 scopus 로고    scopus 로고
    • Cerebrospinal fluid secretion by the choroid plexus
    • Damkier H.H., et al. Cerebrospinal fluid secretion by the choroid plexus. Physiol. Rev. 2013, 93:1847-1892.
    • (2013) Physiol. Rev. , vol.93 , pp. 1847-1892
    • Damkier, H.H.1
  • 20
    • 84861539923 scopus 로고    scopus 로고
    • ABCG2- and ABCG4-mediated efflux of amyloid-beta peptide 1-40 at the mouse blood-brain barrier
    • Do T.M., et al. ABCG2- and ABCG4-mediated efflux of amyloid-beta peptide 1-40 at the mouse blood-brain barrier. J. Alzheimers Dis. 2012, 30:155-166.
    • (2012) J. Alzheimers Dis. , vol.30 , pp. 155-166
    • Do, T.M.1
  • 21
    • 84880712325 scopus 로고    scopus 로고
    • A phase 3 trial of semagacestat for treatment of Alzheimer's disease
    • Doody R.S., et al. A phase 3 trial of semagacestat for treatment of Alzheimer's disease. N. Engl. J. Med. 2013, 369:341-350.
    • (2013) N. Engl. J. Med. , vol.369 , pp. 341-350
    • Doody, R.S.1
  • 22
    • 84881374105 scopus 로고    scopus 로고
    • Association between the ABCG2 C421A polymorphism and Alzheimer's disease
    • Feher A., et al. Association between the ABCG2 C421A polymorphism and Alzheimer's disease. Neurosci. Lett. 2013, 550:51-54.
    • (2013) Neurosci. Lett. , vol.550 , pp. 51-54
    • Feher, A.1
  • 23
    • 0037073670 scopus 로고    scopus 로고
    • Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels
    • Fukumoto H., et al. Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels. J. Biol. Chem. 2002, 277:48508-48513.
    • (2002) J. Biol. Chem. , vol.277 , pp. 48508-48513
    • Fukumoto, H.1
  • 24
    • 67349154520 scopus 로고    scopus 로고
    • Genetic analysis of coding SNPs in blood-brain barrier transporter MDR1 in European Parkinson's disease patients
    • Funke C., et al. Genetic analysis of coding SNPs in blood-brain barrier transporter MDR1 in European Parkinson's disease patients. J. Neural Transm. 2009, 116:443-450.
    • (2009) J. Neural Transm. , vol.116 , pp. 443-450
    • Funke, C.1
  • 25
    • 84894047141 scopus 로고    scopus 로고
    • Development of purine-derived (18)F-labeled pro-drug tracers for imaging of MRP1 activity with PET
    • Galante E., et al. Development of purine-derived (18)F-labeled pro-drug tracers for imaging of MRP1 activity with PET. J. Med. Chem. 2014, 57:1023-1032.
    • (2014) J. Med. Chem. , vol.57 , pp. 1023-1032
    • Galante, E.1
  • 26
    • 58149131290 scopus 로고    scopus 로고
    • Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood-brain barrier: use of an in vitro model
    • Gosselet F., et al. Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood-brain barrier: use of an in vitro model. Brain Res. 2009, 1249:34-42.
    • (2009) Brain Res. , vol.1249 , pp. 34-42
    • Gosselet, F.1
  • 27
    • 85019235785 scopus 로고    scopus 로고
    • Effects of oxysterols on the blood-brain barrier: implications for Alzheimer's disease
    • (PMID: 24275140)
    • Gosselet F., et al. Effects of oxysterols on the blood-brain barrier: implications for Alzheimer's disease. Biochem. Biophys. Res. Commun. 2013, (PMID: 24275140).
    • (2013) Biochem. Biophys. Res. Commun.
    • Gosselet, F.1
  • 28
    • 84901653647 scopus 로고    scopus 로고
    • Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis
    • (PMID 24619111)
    • Gotzl J.K., et al. Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis. Acta Neuropathol. 2014, (PMID 24619111).
    • (2014) Acta Neuropathol.
    • Gotzl, J.K.1
  • 29
    • 84879409744 scopus 로고    scopus 로고
    • Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing
    • Gruber J., et al. Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing. Biotechnol. Adv. 2013, 31:563-592.
    • (2013) Biotechnol. Adv. , vol.31 , pp. 563-592
    • Gruber, J.1
  • 30
    • 0033615580 scopus 로고    scopus 로고
    • The presenilins in Alzheimer's disease - proteolysis holds the key
    • Haass C., De Strooper B. The presenilins in Alzheimer's disease - proteolysis holds the key. Science 1999, 286:916-919.
    • (1999) Science , vol.286 , pp. 916-919
    • Haass, C.1    De Strooper, B.2
  • 31
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy J., Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci. 1991, 12:383-388.
    • (1991) Trends Pharmacol. Sci. , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 32
    • 79951933153 scopus 로고    scopus 로고
    • ABC transporters in the CNS - an inventory
    • Hartz A.M., Bauer B. ABC transporters in the CNS - an inventory. Curr. Pharm. Biotechnol. 2011, 12:656-673.
    • (2011) Curr. Pharm. Biotechnol. , vol.12 , pp. 656-673
    • Hartz, A.M.1    Bauer, B.2
  • 33
    • 77951078680 scopus 로고    scopus 로고
    • Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease
    • Hartz A.M., et al. Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease. Mol. Pharmacol. 2010, 77:715-723.
    • (2010) Mol. Pharmacol. , vol.77 , pp. 715-723
    • Hartz, A.M.1
  • 34
    • 84878954091 scopus 로고    scopus 로고
    • Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-beta from the mouse brain
    • Hawkes C.A., et al. Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-beta from the mouse brain. Aging Cell 2013, 12:224-236.
    • (2013) Aging Cell , vol.12 , pp. 224-236
    • Hawkes, C.A.1
  • 35
    • 84864922525 scopus 로고    scopus 로고
    • Improving the prediction of clinical outcomes from genomic data using multiresolution analysis
    • Hennings-Yeomans P.H., Cooper G.F. Improving the prediction of clinical outcomes from genomic data using multiresolution analysis. IEEE/ACM Trans. Comput. Biol. Bioinform. 2012, 9:1442-1450.
    • (2012) IEEE/ACM Trans. Comput. Biol. Bioinform. , vol.9 , pp. 1442-1450
    • Hennings-Yeomans, P.H.1    Cooper, G.F.2
  • 36
    • 84905293445 scopus 로고    scopus 로고
    • Reduced Alzheimer's disease pathology by St. John's Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice
    • Hofrichter J., et al. Reduced Alzheimer's disease pathology by St. John's Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice. Curr. Alzheimer Res. 2013, 10:1057-1069.
    • (2013) Curr. Alzheimer Res. , vol.10 , pp. 1057-1069
    • Hofrichter, J.1
  • 37
    • 79955484414 scopus 로고    scopus 로고
    • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
    • Hollingworth P., et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat. Genet. 2011, 43:429-435.
    • (2011) Nat. Genet. , vol.43 , pp. 429-435
    • Hollingworth, P.1
  • 38
    • 47149112621 scopus 로고    scopus 로고
    • Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial
    • Holmes C., et al. Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 2008, 372:216-223.
    • (2008) Lancet , vol.372 , pp. 216-223
    • Holmes, C.1
  • 39
    • 84874017631 scopus 로고    scopus 로고
    • Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci
    • Holton P., et al. Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci. Ann. Hum. Genet. 2013, 77:85-105.
    • (2013) Ann. Hum. Genet. , vol.77 , pp. 85-105
    • Holton, P.1
  • 40
    • 84865123660 scopus 로고    scopus 로고
    • A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta
    • 147ra111
    • Iliff J.J., et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci. Transl. Med. 2012, 4:147ra111.
    • (2012) Sci. Transl. Med. , vol.4
    • Iliff, J.J.1
  • 41
    • 84874637845 scopus 로고    scopus 로고
    • Brain-wide pathway for waste clearance captured by contrast-enhanced MRI
    • Iliff J.J., et al. Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J. Clin. Invest. 2013, 123:1299-1309.
    • (2013) J. Clin. Invest. , vol.123 , pp. 1299-1309
    • Iliff, J.J.1
  • 42
    • 84887399490 scopus 로고    scopus 로고
    • Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain
    • Iliff J.J., et al. Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain. J. Neurosci. 2013, 33:18190-18199.
    • (2013) J. Neurosci. , vol.33 , pp. 18190-18199
    • Iliff, J.J.1
  • 43
    • 78650524176 scopus 로고    scopus 로고
    • An investigation into the role of P-glycoprotein in Alzheimer's disease lesion pathogenesis
    • Jeynes B., Provias J. An investigation into the role of P-glycoprotein in Alzheimer's disease lesion pathogenesis. Neurosci. Lett. 2011, 487:389-393.
    • (2011) Neurosci. Lett. , vol.487 , pp. 389-393
    • Jeynes, B.1    Provias, J.2
  • 44
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
    • Juliano R.L., Ling V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim. Biophys. Acta 1976, 455:152-162.
    • (1976) Biochim. Biophys. Acta , vol.455 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 45
    • 84861318502 scopus 로고    scopus 로고
    • Genome-wide association study of Alzheimer's disease
    • Kamboh M.I., et al. Genome-wide association study of Alzheimer's disease. Transl. Psychiatry 2012, 2:e117.
    • (2012) Transl. Psychiatry , vol.2 , pp. e117
    • Kamboh, M.I.1
  • 46
    • 0033890964 scopus 로고    scopus 로고
    • Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7)
    • Kaminski W.E., et al. Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7). Biochem. Biophys. Res. Commun. 2000, 273:532-538.
    • (2000) Biochem. Biophys. Res. Commun. , vol.273 , pp. 532-538
    • Kaminski, W.E.1
  • 47
    • 80053386106 scopus 로고    scopus 로고
    • Beta amyloid effects on expression of multidrug efflux transporters in brain endothelial cells
    • Kania K.D., et al. Beta amyloid effects on expression of multidrug efflux transporters in brain endothelial cells. Brain Res. 2011, 1418:1-11.
    • (2011) Brain Res. , vol.1418 , pp. 1-11
    • Kania, K.D.1
  • 48
    • 70349451693 scopus 로고    scopus 로고
    • Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications
    • Kannan P., et al. Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications. Clin. Pharmacol. Ther. 2009, 86:368-377.
    • (2009) Clin. Pharmacol. Ther. , vol.86 , pp. 368-377
    • Kannan, P.1
  • 49
    • 84870584668 scopus 로고    scopus 로고
    • Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains
    • Karch C.M., et al. Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains. PLoS One 2012, 7:e50976.
    • (2012) PLoS One , vol.7 , pp. e50976
    • Karch, C.M.1
  • 50
    • 80052657824 scopus 로고    scopus 로고
    • Host response transcriptional profiling reveals extracellular components and ABC (ATP-binding cassette) transporters gene enrichment in typhoid fever-infected Nigerian children
    • Khoo S.K., et al. Host response transcriptional profiling reveals extracellular components and ABC (ATP-binding cassette) transporters gene enrichment in typhoid fever-infected Nigerian children. BMC Infect. Dis. 2011, 11:241.
    • (2011) BMC Infect. Dis. , vol.11 , pp. 241
    • Khoo, S.K.1
  • 51
    • 13544251745 scopus 로고    scopus 로고
    • Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels
    • Kim W.S., et al. Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels. J. Biol. Chem. 2005, 280:3989-3995.
    • (2005) J. Biol. Chem. , vol.280 , pp. 3989-3995
    • Kim, W.S.1
  • 52
    • 39749104095 scopus 로고    scopus 로고
    • Role of ATP-binding cassette transporters in brain lipid transport and neurological disease
    • Kim W.S., et al. Role of ATP-binding cassette transporters in brain lipid transport and neurological disease. J. Neurochem. 2008, 104:1145-1166.
    • (2008) J. Neurochem. , vol.104 , pp. 1145-1166
    • Kim, W.S.1
  • 53
    • 78751635081 scopus 로고    scopus 로고
    • Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort
    • Kim S., et al. Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort. Neurology 2011, 76:69-79.
    • (2011) Neurology , vol.76 , pp. 69-79
    • Kim, S.1
  • 54
    • 84874612598 scopus 로고    scopus 로고
    • Deletion of Abca7 increases cerebral amyloid-beta accumulation in the J20 mouse model of Alzheimer's disease
    • Kim W.S., et al. Deletion of Abca7 increases cerebral amyloid-beta accumulation in the J20 mouse model of Alzheimer's disease. J. Neurosci. 2013, 33:4387-4394.
    • (2013) J. Neurosci. , vol.33 , pp. 4387-4394
    • Kim, W.S.1
  • 55
    • 84876779726 scopus 로고    scopus 로고
    • MDR1 C3435T polymorphism and interaction with environmental factors in risk of Parkinson's disease: a case-control study in Japan
    • Kiyohara C., et al. MDR1 C3435T polymorphism and interaction with environmental factors in risk of Parkinson's disease: a case-control study in Japan. Drug Metab. Pharmacokinet. 2013, 28:138-143.
    • (2013) Drug Metab. Pharmacokinet. , vol.28 , pp. 138-143
    • Kiyohara, C.1
  • 56
    • 34250904098 scopus 로고    scopus 로고
    • Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs
    • Ko K.M., Leung H.Y. Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. Chin. Med. 2007, 2:3.
    • (2007) Chin. Med. , vol.2 , pp. 3
    • Ko, K.M.1    Leung, H.Y.2
  • 57
    • 80053387416 scopus 로고    scopus 로고
    • Cerebral amyloid-beta proteostasis is regulated by the membrane transport protein ABCC1 in mice
    • Krohn M., et al. Cerebral amyloid-beta proteostasis is regulated by the membrane transport protein ABCC1 in mice. J. Clin. Invest. 2011, 121:3924-3931.
    • (2011) J. Clin. Invest. , vol.121 , pp. 3924-3931
    • Krohn, M.1
  • 58
    • 18144379540 scopus 로고    scopus 로고
    • ABCA5 resides in lysosomes, and ABCA5 knockout mice develop lysosomal disease-like symptoms
    • Kubo Y., et al. ABCA5 resides in lysosomes, and ABCA5 knockout mice develop lysosomal disease-like symptoms. Mol. Cell. Biol. 2005, 25:4138-4149.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 4138-4149
    • Kubo, Y.1
  • 59
    • 35148859731 scopus 로고    scopus 로고
    • MDR1-P-glycoprotein (ABCB1) mediates transport of Alzheimer's amyloid-beta peptides - implications for the mechanisms of Abeta clearance at the blood-brain barrier
    • Kuhnke D., et al. MDR1-P-glycoprotein (ABCB1) mediates transport of Alzheimer's amyloid-beta peptides - implications for the mechanisms of Abeta clearance at the blood-brain barrier. Brain Pathol. 2007, 17:347-353.
    • (2007) Brain Pathol. , vol.17 , pp. 347-353
    • Kuhnke, D.1
  • 60
    • 0035112889 scopus 로고    scopus 로고
    • Beta-Amyloid efflux mediated by p-glycoprotein
    • Lam F.C., et al. beta-Amyloid efflux mediated by p-glycoprotein. J. Neurochem. 2001, 76:1121-1128.
    • (2001) J. Neurochem. , vol.76 , pp. 1121-1128
    • Lam, F.C.1
  • 61
    • 84887067817 scopus 로고    scopus 로고
    • The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy
    • Lehtinen M.K., et al. The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy. J. Neurosci. 2013, 33:17553-17559.
    • (2013) J. Neurosci. , vol.33 , pp. 17553-17559
    • Lehtinen, M.K.1
  • 62
    • 84874019107 scopus 로고    scopus 로고
    • Pregnane X receptor upregulates ABC-transporter Abcg2 and Abcb1 at the blood-brain barrier
    • Lemmen J., et al. Pregnane X receptor upregulates ABC-transporter Abcg2 and Abcb1 at the blood-brain barrier. Brain Res. 2013, 1491:1-13.
    • (2013) Brain Res. , vol.1491 , pp. 1-13
    • Lemmen, J.1
  • 63
    • 34247123807 scopus 로고    scopus 로고
    • Structure and function of ABC transporters
    • Linton K.J. Structure and function of ABC transporters. Physiology (Bethesda) 2007, 22:122-130.
    • (2007) Physiology (Bethesda) , vol.22 , pp. 122-130
    • Linton, K.J.1
  • 64
    • 84903814370 scopus 로고    scopus 로고
    • A complex association of ABCA7 genotypes with sporadic Alzheimer disease in Chinese Han population
    • (PMID 24113560)
    • Liu L.H., et al. A complex association of ABCA7 genotypes with sporadic Alzheimer disease in Chinese Han population. Alzheimer Dis. Assoc. Disord. 2013, (PMID 24113560).
    • (2013) Alzheimer Dis. Assoc. Disord.
    • Liu, L.H.1
  • 65
    • 23044500398 scopus 로고    scopus 로고
    • Drug resistance in brain diseases and the role of drug efflux transporters
    • Löscher W., Potschka H. Drug resistance in brain diseases and the role of drug efflux transporters. Nat. Rev. Neurosci. 2005, 6:591-602.
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 591-602
    • Löscher, W.1    Potschka, H.2
  • 66
    • 0036046427 scopus 로고    scopus 로고
    • Does caffeine intake protect from Alzheimer's disease?
    • Maia L., de Mendonca A. Does caffeine intake protect from Alzheimer's disease?. Eur. J. Neurol. 2002, 9:377-382.
    • (2002) Eur. J. Neurol. , vol.9 , pp. 377-382
    • Maia, L.1    de Mendonca, A.2
  • 67
    • 80053499640 scopus 로고    scopus 로고
    • PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo
    • Mairinger S., et al. PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo. Curr. Drug Metab. 2011, 12:774-792.
    • (2011) Curr. Drug Metab. , vol.12 , pp. 774-792
    • Mairinger, S.1
  • 68
    • 84898447902 scopus 로고    scopus 로고
    • Plasma phospholipids identify antecedent memory impairment in older adults
    • (PMID: 24608097)
    • Mapstone M., et al. Plasma phospholipids identify antecedent memory impairment in older adults. Nat. Med. 2014, 20:415-418. (PMID: 24608097).
    • (2014) Nat. Med. , vol.20 , pp. 415-418
    • Mapstone, M.1
  • 69
    • 84863296386 scopus 로고    scopus 로고
    • Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1
    • Meurs I., et al. Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1. PLoS One 2012, 7:e30984.
    • (2012) PLoS One , vol.7 , pp. e30984
    • Meurs, I.1
  • 70
    • 42149161677 scopus 로고    scopus 로고
    • Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease
    • Meyer E.P., et al. Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:3587-3592.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 3587-3592
    • Meyer, E.P.1
  • 71
    • 85027951376 scopus 로고    scopus 로고
    • Maternal transmission of Alzheimer's disease: prodromal metabolic phenotype and the search for genes
    • Mosconi L., et al. Maternal transmission of Alzheimer's disease: prodromal metabolic phenotype and the search for genes. Hum. Genomics 2010, 4:170-193.
    • (2010) Hum. Genomics , vol.4 , pp. 170-193
    • Mosconi, L.1
  • 72
    • 68249161945 scopus 로고    scopus 로고
    • 11C-verapamil in the brain: studies of healthy humans
    • 11C-verapamil in the brain: studies of healthy humans. J. Nucl. Med. 2009, 50:1267-1275.
    • (2009) J. Nucl. Med. , vol.50 , pp. 1267-1275
    • Muzi, M.1
  • 73
    • 40849102300 scopus 로고    scopus 로고
    • LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model
    • Nazer B., et al. LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model. Neurobiol. Dis. 2008, 30:94-102.
    • (2008) Neurobiol. Dis. , vol.30 , pp. 94-102
    • Nazer, B.1
  • 74
    • 84889872057 scopus 로고    scopus 로고
    • Development, maintenance and disruption of the blood-brain barrier
    • Obermeier B., et al. Development, maintenance and disruption of the blood-brain barrier. Nat. Med. 2013, 19:1584-1596.
    • (2013) Nat. Med. , vol.19 , pp. 1584-1596
    • Obermeier, B.1
  • 75
    • 61349095974 scopus 로고    scopus 로고
    • Noninvasive and quantitative assessment of the function of multidrug resistance-associated protein 1 in the living brain
    • Okamura T., et al. Noninvasive and quantitative assessment of the function of multidrug resistance-associated protein 1 in the living brain. J. Cereb. Blood Flow Metab. 2009, 29:504-511.
    • (2009) J. Cereb. Blood Flow Metab. , vol.29 , pp. 504-511
    • Okamura, T.1
  • 76
    • 84890471966 scopus 로고    scopus 로고
    • Increased efflux of amyloid-beta peptides through the blood-brain barrier by muscarinic acetylcholine receptor inhibition reduces pathological phenotypes in mouse models of brain amyloidosis
    • Paganetti P., et al. Increased efflux of amyloid-beta peptides through the blood-brain barrier by muscarinic acetylcholine receptor inhibition reduces pathological phenotypes in mouse models of brain amyloidosis. J. Alzheimers Dis. 2014, 38:767-786.
    • (2014) J. Alzheimers Dis. , vol.38 , pp. 767-786
    • Paganetti, P.1
  • 77
    • 48749105927 scopus 로고    scopus 로고
    • Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's disease
    • Pahnke J., et al. Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's disease. Curr. Alzheimer Res. 2008, 5:396-405.
    • (2008) Curr. Alzheimer Res. , vol.5 , pp. 396-405
    • Pahnke, J.1
  • 78
    • 67649518011 scopus 로고    scopus 로고
    • Alzheimer's disease and blood-brain barrier function - why have anti-beta-amyloid therapies failed to prevent dementia progression?
    • Pahnke J., et al. Alzheimer's disease and blood-brain barrier function - why have anti-beta-amyloid therapies failed to prevent dementia progression?. Neurosci. Biobehav. Rev. 2009, 33:1099-1108.
    • (2009) Neurosci. Biobehav. Rev. , vol.33 , pp. 1099-1108
    • Pahnke, J.1
  • 79
    • 84875414010 scopus 로고    scopus 로고
    • Aquaporin water channels in the nervous system
    • Papadopoulos M.C., Verkman A.S. Aquaporin water channels in the nervous system. Nat. Rev. Neurosci. 2013, 14:265-277.
    • (2013) Nat. Rev. Neurosci. , vol.14 , pp. 265-277
    • Papadopoulos, M.C.1    Verkman, A.S.2
  • 80
    • 80053652475 scopus 로고    scopus 로고
    • LRP1 mediates bidirectional transcytosis of amyloid-beta across the blood-brain barrier
    • Pflanzner T., et al. LRP1 mediates bidirectional transcytosis of amyloid-beta across the blood-brain barrier. Neurobiol. Aging 2011, 32(2323):e1-e11.
    • (2011) Neurobiol. Aging , vol.32 , Issue.2323 , pp. e1-e11
    • Pflanzner, T.1
  • 81
    • 84859425248 scopus 로고    scopus 로고
    • Cellular prion protein participates in amyloid-beta transcytosis across the blood-brain barrier
    • Pflanzner T., et al. Cellular prion protein participates in amyloid-beta transcytosis across the blood-brain barrier. J. Cereb. Blood Flow Metab. 2012, 32:628-632.
    • (2012) J. Cereb. Blood Flow Metab. , vol.32 , pp. 628-632
    • Pflanzner, T.1
  • 82
    • 0030685764 scopus 로고    scopus 로고
    • Perivascular spaces in the basal ganglia of the human brain: their relationship to lacunes
    • Pollock H., et al. Perivascular spaces in the basal ganglia of the human brain: their relationship to lacunes. J. Anat. 1997, 191(Pt 3):337-346.
    • (1997) J. Anat. , vol.191 , pp. 337-346
    • Pollock, H.1
  • 83
    • 84863895905 scopus 로고    scopus 로고
    • Enhanced brain amyloid-beta clearance by rifampicin and caffeine as a possible protective mechanism against Alzheimer's disease
    • Qosa H., et al. Enhanced brain amyloid-beta clearance by rifampicin and caffeine as a possible protective mechanism against Alzheimer's disease. J. Alzheimers Dis. 2012, 31:151-165.
    • (2012) J. Alzheimers Dis. , vol.31 , pp. 151-165
    • Qosa, H.1
  • 84
    • 84893833082 scopus 로고    scopus 로고
    • Differences in amyloid-beta clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling
    • Qosa H., et al. Differences in amyloid-beta clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling. Neuropharmacology 2014, 79:668-678.
    • (2014) Neuropharmacology , vol.79 , pp. 668-678
    • Qosa, H.1
  • 85
    • 0041968944 scopus 로고    scopus 로고
    • Subcellular localization and activity of multidrug resistance proteins
    • Rajagopal A., Simon S.M. Subcellular localization and activity of multidrug resistance proteins. Mol. Biol. Cell 2003, 14:3389-3399.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 3389-3399
    • Rajagopal, A.1    Simon, S.M.2
  • 86
    • 84875922261 scopus 로고    scopus 로고
    • Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E 4, and the risk of late-onset Alzheimer disease in African Americans
    • Reitz C., et al. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E 4, and the risk of late-onset Alzheimer disease in African Americans. JAMA 2013, 309:1483-1492.
    • (2013) JAMA , vol.309 , pp. 1483-1492
    • Reitz, C.1
  • 87
    • 34548433951 scopus 로고    scopus 로고
    • The neuroprotective effects of caffeine: a prospective population study (the Three City Study)
    • Ritchie K., et al. The neuroprotective effects of caffeine: a prospective population study (the Three City Study). Neurology 2007, 69:536-545.
    • (2007) Neurology , vol.69 , pp. 536-545
    • Ritchie, K.1
  • 88
    • 84878494268 scopus 로고    scopus 로고
    • Oxysterols decrease apical-to-basolateral transport of Ass peptides via an ABCB1-mediated process in an in vitro blood-brain barrier model constituted of bovine brain capillary endothelial cells
    • Saint-Pol J., et al. Oxysterols decrease apical-to-basolateral transport of Ass peptides via an ABCB1-mediated process in an in vitro blood-brain barrier model constituted of bovine brain capillary endothelial cells. Brain Res. 2013, 1517:1-15.
    • (2013) Brain Res. , vol.1517 , pp. 1-15
    • Saint-Pol, J.1
  • 89
    • 84888865974 scopus 로고    scopus 로고
    • Incidence of dementia with Lewy bodies and Parkinson disease dementia
    • Savica R., et al. Incidence of dementia with Lewy bodies and Parkinson disease dementia. JAMA Neurol. 2013, 70:1396-1402.
    • (2013) JAMA Neurol. , vol.70 , pp. 1396-1402
    • Savica, R.1
  • 90
    • 84865861409 scopus 로고    scopus 로고
    • Mitochondrial DNA polymorphisms specifically modify cerebral beta-amyloid proteostasis
    • Scheffler K., et al. Mitochondrial DNA polymorphisms specifically modify cerebral beta-amyloid proteostasis. Acta Neuropathol. 2012, 124:199-208.
    • (2012) Acta Neuropathol. , vol.124 , pp. 199-208
    • Scheffler, K.1
  • 91
    • 0037457802 scopus 로고    scopus 로고
    • Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
    • Schinkel A.H., Jonker J.W. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv. Drug Deliv. Rev. 2003, 55:3-29.
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , pp. 3-29
    • Schinkel, A.H.1    Jonker, J.W.2
  • 92
    • 31744448129 scopus 로고    scopus 로고
    • Mechanisms to explain the reverse perivascular transport of solutes out of the brain
    • Schley D., et al. Mechanisms to explain the reverse perivascular transport of solutes out of the brain. J. Theor. Biol. 2006, 238:962-974.
    • (2006) J. Theor. Biol. , vol.238 , pp. 962-974
    • Schley, D.1
  • 93
    • 84860213054 scopus 로고    scopus 로고
    • ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice
    • Schumacher T., et al. ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice. PLoS One 2012, 7:e35613.
    • (2012) PLoS One , vol.7 , pp. e35613
    • Schumacher, T.1
  • 94
    • 1542778656 scopus 로고    scopus 로고
    • Choroid plexus, aging of the brain, and Alzheimer's disease
    • Serot J.M., et al. Choroid plexus, aging of the brain, and Alzheimer's disease. Front. Biosci. 2003, 8:s515-s521.
    • (2003) Front. Biosci. , vol.8 , pp. s515-s521
    • Serot, J.M.1
  • 95
    • 77956313661 scopus 로고    scopus 로고
    • ABCG2 reduces ROS-mediated toxicity and inflammation: a potential role in Alzheimer's disease
    • Shen S., et al. ABCG2 reduces ROS-mediated toxicity and inflammation: a potential role in Alzheimer's disease. J. Neurochem. 2010, 114:1590-1604.
    • (2010) J. Neurochem. , vol.114 , pp. 1590-1604
    • Shen, S.1
  • 96
    • 33644775686 scopus 로고    scopus 로고
    • Targeting multidrug resistance in cancer
    • Szakacs G., et al. Targeting multidrug resistance in cancer. Nat. Rev. Drug Discov. 2006, 5:219-234.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 219-234
    • Szakacs, G.1
  • 97
    • 67349212434 scopus 로고    scopus 로고
    • P-glycoprotein and breast cancer resistance protein restrict apical-to-basolateral permeability of human brain endothelium to amyloid-beta
    • Tai L.M., et al. P-glycoprotein and breast cancer resistance protein restrict apical-to-basolateral permeability of human brain endothelium to amyloid-beta. J. Cereb. Blood Flow Metab. 2009, 29:1079-1083.
    • (2009) J. Cereb. Blood Flow Metab. , vol.29 , pp. 1079-1083
    • Tai, L.M.1
  • 98
    • 20044365400 scopus 로고    scopus 로고
    • Effect of MDR1 haplotype on risk of Parkinson disease
    • Tan E.K., et al. Effect of MDR1 haplotype on risk of Parkinson disease. Arch. Neurol. 2005, 62:460-464.
    • (2005) Arch. Neurol. , vol.62 , pp. 460-464
    • Tan, E.K.1
  • 99
    • 77956826011 scopus 로고    scopus 로고
    • Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7
    • Tanaka N., et al. Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7. J. Lipid Res. 2010, 51:2591-2599.
    • (2010) J. Lipid Res. , vol.51 , pp. 2591-2599
    • Tanaka, N.1
  • 100
    • 79960700354 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7
    • Tanaka N., et al. HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7. Atherosclerosis 2011, 217:407-414.
    • (2011) Atherosclerosis , vol.217 , pp. 407-414
    • Tanaka, N.1
  • 101
    • 84887368280 scopus 로고    scopus 로고
    • CLN3 loss disturbs membrane microdomain properties and protein transport in brain endothelial cells
    • Tecedor L., et al. CLN3 loss disturbs membrane microdomain properties and protein transport in brain endothelial cells. J. Neurosci. 2013, 33:18065-18079.
    • (2013) J. Neurosci. , vol.33 , pp. 18065-18079
    • Tecedor, L.1
  • 102
    • 82455210226 scopus 로고    scopus 로고
    • The Virchow-Robin spaces: delineation by magnetic resonance imaging with considerations on anatomofunctional implications
    • Tsutsumi S., et al. The Virchow-Robin spaces: delineation by magnetic resonance imaging with considerations on anatomofunctional implications. Childs Nerv. Syst. 2011, 27:2057-2066.
    • (2011) Childs Nerv. Syst. , vol.27 , pp. 2057-2066
    • Tsutsumi, S.1
  • 103
    • 84863393540 scopus 로고    scopus 로고
    • Blood-brain barrier P-glycoprotein function in Alzheimer's disease
    • van Assema D.M., et al. Blood-brain barrier P-glycoprotein function in Alzheimer's disease. Brain 2012, 135:181-189.
    • (2012) Brain , vol.135 , pp. 181-189
    • van Assema, D.M.1
  • 104
    • 84875319920 scopus 로고    scopus 로고
    • Blood-brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene
    • van Assema D.M., et al. Blood-brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene. EJNMMI Res. 2012, 2:57.
    • (2012) EJNMMI Res. , vol.2 , pp. 57
    • van Assema, D.M.1
  • 105
    • 33846983228 scopus 로고    scopus 로고
    • Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE Study
    • van Gelder B.M., et al. Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE Study. Eur. J. Clin. Nutr. 2007, 61:226-232.
    • (2007) Eur. J. Clin. Nutr. , vol.61 , pp. 226-232
    • van Gelder, B.M.1
  • 106
    • 84896479748 scopus 로고    scopus 로고
    • The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies
    • Vann Jones S.A., O'Brien J.T. The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies. Psychol. Med. 2014, 44:673-683.
    • (2014) Psychol. Med. , vol.44 , pp. 673-683
    • Vann Jones, S.A.1    O'Brien, J.T.2
  • 107
    • 84896759904 scopus 로고    scopus 로고
    • Age-specific incidence rates for dementia and Alzheimer disease in NIA-LOAD/NCRAD and EFIGA families: National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) and Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA)
    • Vardarajan B.N., et al. Age-specific incidence rates for dementia and Alzheimer disease in NIA-LOAD/NCRAD and EFIGA families: National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) and Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA). JAMA Neurol. 2014, 71:315-323.
    • (2014) JAMA Neurol. , vol.71 , pp. 315-323
    • Vardarajan, B.N.1
  • 108
    • 84887235001 scopus 로고    scopus 로고
    • ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status
    • Vasquez J.B., et al. ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status. Neurosci. Lett. 2013, 556:58-62.
    • (2013) Neurosci. Lett. , vol.556 , pp. 58-62
    • Vasquez, J.B.1
  • 109
    • 84873726158 scopus 로고    scopus 로고
    • Alzheimer's disease genes and cognition in the nondemented general population
    • Verhaaren B.F., et al. Alzheimer's disease genes and cognition in the nondemented general population. Biol. Psychiatry 2013, 73:429-434.
    • (2013) Biol. Psychiatry , vol.73 , pp. 429-434
    • Verhaaren, B.F.1
  • 110
    • 0036797713 scopus 로고    scopus 로고
    • Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
    • Vogelgesang S., et al. Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans. Pharmacogenetics 2002, 12:535-541.
    • (2002) Pharmacogenetics , vol.12 , pp. 535-541
    • Vogelgesang, S.1
  • 111
    • 2942723107 scopus 로고    scopus 로고
    • The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease
    • Vogelgesang S., et al. The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease. Curr Alzheimer Res. 2004, 1:121-125.
    • (2004) Curr Alzheimer Res. , vol.1 , pp. 121-125
    • Vogelgesang, S.1
  • 112
    • 0026928760 scopus 로고
    • Pathways of fluid drainage from the brain - morphological aspects and immunological significance in rat and man
    • Weller R.O., et al. Pathways of fluid drainage from the brain - morphological aspects and immunological significance in rat and man. Brain Pathol. 1992, 2:277-284.
    • (1992) Brain Pathol. , vol.2 , pp. 277-284
    • Weller, R.O.1
  • 113
    • 67349118757 scopus 로고    scopus 로고
    • Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy
    • Weller R.O., et al. Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy. Acta Neuropathol. 2009, 118:87-102.
    • (2009) Acta Neuropathol. , vol.118 , pp. 87-102
    • Weller, R.O.1
  • 114
    • 67449091266 scopus 로고    scopus 로고
    • Association of a polymorphism in the ABCB1 gene with Parkinson's disease
    • Westerlund M., et al. Association of a polymorphism in the ABCB1 gene with Parkinson's disease. Parkinsonism Relat. Disord. 2009, 15:422-424.
    • (2009) Parkinsonism Relat. Disord. , vol.15 , pp. 422-424
    • Westerlund, M.1
  • 115
    • 65649142529 scopus 로고    scopus 로고
    • ABCG2 is upregulated in Alzheimer's brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood-brain barrier for Abeta(1-40) peptides
    • Xiong H., et al. ABCG2 is upregulated in Alzheimer's brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood-brain barrier for Abeta(1-40) peptides. J. Neurosci. 2009, 29:5463-5475.
    • (2009) J. Neurosci. , vol.29 , pp. 5463-5475
    • Xiong, H.1
  • 116
    • 0025353908 scopus 로고
    • Interrelationships of the pia mater and the perivascular (Virchow-Robin) spaces in the human cerebrum
    • Zhang E.T., et al. Interrelationships of the pia mater and the perivascular (Virchow-Robin) spaces in the human cerebrum. J. Anat. 1990, 170:111-123.
    • (1990) J. Anat. , vol.170 , pp. 111-123
    • Zhang, E.T.1
  • 117
    • 0035112624 scopus 로고    scopus 로고
    • Atp-binding cassette transporter ABC2/ABCA2 in the rat brain: a novel mammalian lysosome-associated membrane protein and a specific marker for oligodendrocytes but not for myelin sheaths
    • Zhou C., et al. Atp-binding cassette transporter ABC2/ABCA2 in the rat brain: a novel mammalian lysosome-associated membrane protein and a specific marker for oligodendrocytes but not for myelin sheaths. J. Neurosci. 2001, 21:849-857.
    • (2001) J. Neurosci. , vol.21 , pp. 849-857
    • Zhou, C.1
  • 118
    • 62149090278 scopus 로고    scopus 로고
    • MDR1 variants and risk of Parkinson disease. Association with pesticide exposure?
    • Zschiedrich K., et al. MDR1 variants and risk of Parkinson disease. Association with pesticide exposure?. J. Neurol. 2009, 256:115-120.
    • (2009) J. Neurol. , vol.256 , pp. 115-120
    • Zschiedrich, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.