Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells

Brain Research

Volumn 1517, Issue , 2013, Pages 1-15

  Saint Pol, Julien ^a,b,c   Candela, Pietra ^a,b,c   Boucau, Marie Christine ^a,b,c   Fenart, Laurence ^a,b,c   Gosselet, Fabien ^a,b,c,d  

^a UNIV LILLE   (France)

^b EA 2465   (France)

^c IMPRT IFR114   (France)

^d UNIVERSITÉ D'ARTOIS   (France)

Author keywords

A peptide; ABCA1; ABCB1; Blood brain barrier; Cholesterol; Oxysterol

Indexed keywords

24 HYDROXYCHOLESTEROL; 26 HYDROXYCHOLESTEROL; AMYLOID BETA PROTEIN; APOLIPOPROTEIN A1; BETA ACTIN; LIVER X RECEPTOR AGONIST; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; OXYSTEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; COW; ENDOTHELIUM CELL; GENE EXPRESSION; GLIA CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

AMYLOID BETA-PEPTIDES; ANIMALS; ANIMALS, NEWBORN; ANTICHOLESTEREMIC AGENTS; APOLIPOPROTEIN A-I; ATP BINDING CASSETTE TRANSPORTER 1; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARY PERMEABILITY; CATTLE; CHOLESTEROL; CHOLESTEROL, HDL; COCULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HYDROCARBONS, FLUORINATED; HYDROXYCHOLESTEROLS; NEUROGLIA; PROTEIN TRANSPORT; RATS; SULFONAMIDES; TRITIUM; UP-REGULATION;

BOVINAE; MURINAE;

EID: 84878494268     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.04.008     Document Type: Article

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