Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Meurs, Illiana ^a,b   Calpe Berdiel, Laura ^a   Habets, Kim L L ^a   Zhao, Ying ^a   Korporaal, Suzanne J A ^a   Mommaas, A Mieke ^b   Josselin, Emmanuelle ^c   Hildebrand, Reeni B ^a   Ye, Dan ^a   Out, Ruud ^a   Kuiper, Johan ^a   Van Berkel, Theo J C ^a   Chimini, Giovanna ^c   Van Eck, Miranda ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER A7; CARRIER PROTEIN; CD19 ANTIGEN; CD68 ANTIGEN; CHOLESTEROL; ERYTHROPOIETIN RECEPTOR; FRIEND OF GATA 1 PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; PHOSPHOLIPID; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR TAL1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; ABC TRANSPORTER; ABCA7 PROTEIN, MOUSE; LIPID; LOW DENSITY LIPOPROTEIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROGENESIS; BONE MARROW TRANSPLANTATION; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DISEASE PREDISPOSITION; ERYTHROPOIESIS; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE FUNCTION; HEMATOPOIESIS; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; LIPID BLOOD LEVEL; LIPID METABOLISM; LIPID STORAGE; MACROPHAGE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPLEEN SIZE; SPLEEN WEIGHT; SPLENOMEGALY; T LYMPHOCYTE SUBPOPULATION; WILD TYPE; ANIMAL; ATHEROSCLEROSIS; BLOOD; FOAM CELL; GENE INACTIVATION; GENETICS; MALE; METABOLISM; PATHOLOGY; UPREGULATION;

ANIMALIA; MUS;

ANIMALS; ATHEROSCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; BONE MARROW TRANSPLANTATION; FOAM CELLS; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; LIPID METABOLISM; LIPIDS; MACROPHAGES; MALE; MICE; RECEPTORS, LDL; UP-REGULATION;

EID: 84863296386     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030984     Document Type: Article

References (41)

1. Glomset JA, (1968) The plasma lecithins:cholesterol acyltransferase reaction. J Lipid Res 9: 155-167.
2. von Eckardstein A, Nofer JR, Assmann G, (2001) High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport. Arterioscler Thromb Vasc Biol 21: 13-27.
3. Higgins CF, (1992) ABC transporters: from microorganisms to man. Annu Rev Cell Biol 8: 67-113.
4. Rye KA, Barter PJ, (2004) Formation and metabolism of prebeta-migrating, lipid-poor apolipoprotein A-I. Arterioscler Thromb Vasc Biol 24: 421-428.
5. Remaley AT, Stonik JA, Demosky SJ, Neufeld EB, Bocharov AV, et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem Biophys Res Commun 280: 818-823.
6. Brooks-Wilson A, Marcil M, Clee SM, Zhang LH, Roomp K, et al. (1999) Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat Genet 22: 336-345.
7. Bodzioch M, Orso E, Klucken J, Langmann T, Bottcher A, et al. (1999) The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat Genet 22: 347-351.
8. Rust S, Rosier M, Funke H, Real J, Amoura Z, et al. (1999) Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat Genet 22: 352-355.
9. Serfaty-Lacrosniere C, Civeira F, Lanzberg A, Isaia P, Berg J, et al. (1994) Homozygous Tangier disease and cardiovascular disease. Atherosclerosis 107: 85-98.
10. Wang N, Lan D, Chen W, Matsuura F, Tall AR, (2004) ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci U S A 101: 9774-9779.
11. Kennedy MA, Barrera GC, Nakamura K, Baldan A, Tarr P, et al. (2005) ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. Cell Metab 1: 121-131.
12. Schmitz G, Kaminski WE, Orso E, (2000) ABC transporters in cellular lipid trafficking. Curr Opin Lipidol 11: 493-501.
13. Van Eck M, Pennings M, Hoekstra M, Out R, Van Berkel TJ, (2005) Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis. Curr Opin Lipidol 16: 307-315.
14. Kaminski WE, Orso E, Diederich W, Klucken J, Drobnik W, et al. (2000) Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7). Biochem Biophys Res Commun 273: 532-538.
15. Ikeda Y, Abe-Dohmae S, Munehira Y, Aoki R, Kawamoto S, et al. (2003) Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release. Biochem Biophys Res Commun 311: 313-318.
16. Broccardo C, Osorio J, Luciani MF, Schriml LM, Prades C, et al. (2001) Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter. Cytogenet Cell Genet 92: 264-270.
17. Iwamoto N, Abe-Dohmae S, Sato R, Yokoyama S, (2006) ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis. J Lipid Res 47: 1915-1927.
18. Langmann T, Klucken J, Reil M, Liebisch G, Luciani MF, et al. (1999) Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages. Biochem Biophys Res Commun 257: 29-33.
19. Klucken J, Buchler C, Orso E, Kaminski WE, Porsch-Ozcurumez M, et al. (2000) ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. Proc Natl Acad Sci U S A 97: 817-822.
20. Abe-Dohmae S, Ikeda Y, Matsuo M, Hayashi M, Okuhira K, et al. (2004) Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein. J Biol Chem 279: 604-611.
21. Hayashi M, Abe-Dohmae S, Okazaki M, Ueda K, Yokoyama S, (2005) Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7. J Lipid Res 46: 1703-1711.
22. Wang N, Lan D, Gerbod-Giannone M, Linsel-Nitschke P, Jehle AW, et al. (2003) ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux. J Biol Chem 278: 42906-42912.
23. Linsel-Nitschke P, Jehle AW, Shan J, Cao G, Bacic D, et al. (2005) Potential role of ABCA7 in cellular lipid efflux to apoA-I. J Lipid Res 46: 86-92.
24. Kim WS, Fitzgerald ML, Kang K, Okuhira K, Bell SA, et al. (2005) Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels. J Biol Chem 280: 3989-3995.
25. Ye D, Meurs I, Ohigashi M, Calpe-Berdiel L, Habets KL, et al. (2010) Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice. Biochem Biophys Res Commun 395: 387-394.
26. Hara A, Radin NS, (1978) Lipid extraction of tissues with a low-toxicity solvent. Anal Biochem 90: 420-426.
27. Meurs I, Hoekstra M, van Wanrooij EJ, Hildebrand RB, Kuiper J, et al. (2005) HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes. Exp Hematol 33: 1309-1319.
28. Wellington CL, Brunham LR, Zhou S, Singaraja RR, Visscher H, et al. (2003) Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1. J Lipid Res 44: 1470-1480.
29. Van Eck M, Singaraja RR, Ye D, Hildebrand RB, James ER, et al. (2006) Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol 26: 929-934.
30. van Eck M, Bos IS, Kaminski WE, Orso E, Rothe G, et al. (2002) Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. Proc Natl Acad Sci U S A 99: 6298-6303.
31. Li AC, Binder CJ, Gutierrez A, Brown KK, Plotkin CR, et al. (2004) Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. J Clin Invest 114: 1564-1576.
32. Pennings M, Meurs I, Ye D, Out R, Hoekstra M, et al. (2006) Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion development. FEBS Lett 580: 5588-5596.
33. Ranalletta M, Wang N, Han S, Yvan-Charvet L, Welch C, et al. (2006) Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol 26: 2308-2315.
34. Kockx MM, (1998) Apoptosis in the atherosclerotic plaque: quantitative and qualitative aspects. Arterioscler Thromb Vasc Biol 18: 1519-1522.
35. Kockx MM, De Meyer GR, Muhring J, Jacob W, Bult H, et al. (1998) Apoptosis and related proteins in different stages of human atherosclerotic plaques. Circulation 97: 2307-2315.
36. Jehle AW, Gardai SJ, Li S, Linsel-Nitschke P, Morimoto K, et al. (2006) ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages. J Cell Biol 174: 547-556.
37. Young SG, Fielding CJ, (1999) The ABCs of cholesterol efflux. Nat Genet 22: 316-318.
38. Hamon Y, Broccardo C, Chambenoit O, Luciani MF, Toti F, et al. (2000) ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. Nat Cell Biol 2: 399-406.
39. McNeish J, Aiello RJ, Guyot D, Turi T, Gabel C, et al. (2000) High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. Proc Natl Acad Sci U S A 97: 4245-4250.
40. Kam HY, Ou LC, Thron CD, Smith RP, Leiter JC, (1999) Role of the spleen in the exaggerated polycythemic response to hypoxia in chronic mountain sickness in rats. J Appl Physiol 87: 1901-1908.
41. Kaminski WE, Piehler A, Schmitz G, (2000) Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene. Biochem Biophys Res Commun 278: 782-789.