The roles of ubiquitin and 26S proteasome in human obesity

Metabolism: Clinical and Experimental

Volumn 58, Issue 11, 2009, Pages 1643-1648

  Chang, Tsui Ling ^a   Chang, Chai Jan ^b   Lee, Wen Ying ^c   Lin, Miaw Ning ^a   Huang, Yu Wen ^a   Fan, Kang ^d  

^a NATIONAL UNIVERSITY OF TAINAN   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHI MEI MEDICAL CENTER   (Taiwan)

^d BioIntl   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

26S PROTEASOME; BIOLOGICAL MARKER; IMMUNOGLOBULIN; PROTEASOME; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN; UNCLASSIFIED DRUG; ATP DEPENDENT 26S PROTEASE; CHYMOTRYPSIN; IMMUNOGLOBULIN G;

ADULT; ARTICLE; BODY MASS; CANCER GROWTH; CARDIOVASCULAR DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; HUMAN; INFLAMMATION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; RISK ASSESSMENT; TAIWAN; BLOOD; CHEMISTRY; ENZYME LINKED IMMUNOSORBENT ASSAY; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; WESTERN BLOTTING;

ADULT; BLOTTING, WESTERN; BODY MASS INDEX; CHYMOTRYPSIN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTES; FEMALE; HUMANS; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; PROTEASOME ENDOPEPTIDASE COMPLEX; UBIQUITIN; YOUNG ADULT;

EID: 70449719261     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2009.05.020     Document Type: Article

References (30)

1. Renehan A.G., and Howell A. Preventing cancer, cardiovascular disease, and diabetes. Lancet 365 (2005) 1449-1451
2. Vainio H., and Bianchini F. International Agency for Research in Cancer. Weight control and physical activity (2002), IARC Press, Lyon, France
3. Calle E.E., and Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4 (2004) 579-591
4. Renehan A.G., Frystyk J., and Flyvbjerg A. Obesity and cancer risk: the role of the insulin-IGF axis. Trends Endocrinol Metab 17 (2006) 328-336
5. Maison P., Balkau B., Souberbielle J.C., et al., Study Group. Evidence for distinct effects of GH and IGF-I in the metabolic syndrome. Diabet Med 24 (2007) 1012-1018
6. Glickman M.H., and Ciechanover A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 82 (2002) 373-428
7. Marx J. Cell biology. Ubiquitin lives up to its name. Science 297 (2002) 1792-1794
8. Hershko A., and Ciechanover A. The ubiquitin system. Annu Rev Biochem 67 (1998) 425-479
9. Haas A.L., and Siepmann T.J. Pathways of ubiquitin conjugation. FASEB J 11 (1997) 1257-1268
10. Groll M., Ditzel L., Lowe J., et al. Structure of 20S proteasome from yeast at 2.4 A resolution. Nature 386 (1997) 463-471
11. Peters J.M. Proteasomes: protein degradation machines of the cell. Trends Biochem Sci 19 (1994) 377-382
12. Peters J.M., Franke W.W., and Kleinschmidt J.A. Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm. J Biol Chem 69 (1994) 7709-7718
13. Wang Q., Young P., and Walters K.J. Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition. J Mol Biol 348 (2005) 727-739
14. Groll M., Koguchi Y., Huber R., et al. Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor. J Mol Biol 311 (2001) 543-548
15. Nussbaum A.K., Dick T.P., Keilholz W., et al. Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1. Proc Natl Acad Sci USA 95 (1998) 12504-12509
16. Adams J., Palombella V.J., Sausville E.A., et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res 59 (1999) 2615-2622
17. Cooke P.S., Holsberger D.R., Cimafranca M.A., et al. The F box protein S phase kinase-associated protein 2 regulates adipose mass and adipocyte number in vivo. Obesity (Silver Spring) 15 (2007) 1400-1408
18. Neels J.G., and Olefsky J.M. Cell signaling. A new way to burn fat. Science 312 (2006) 1756-1758
19. Medina E.A., Afsari R.R., Ravid T., et al. Tumor necrosis factor-{alpha} decreases Akt protein levels in 3T3-L1 adipocytes via the caspase-dependent ubiquitination of Akt. Endocrinology 146 (2005) 2726-2735
20. Daino H., Matsumura I., Takada K., et al. Induction of apoptosis by extracellular ubiquitin in human hematopoietic cells: possible involvement of STAT3 degradation by proteasome pathway in interleukin 6-dependent hematopoietic cells. Blood 95 (2000) 2577-2585
21. Akarsu E., Pirim I., Capoglu I., et al. Relationship between electroneurographic changes and serum ubiquitin levels in patients with type 2 diabetes. Diabetes Care 24 (2001) 100-103
22. Tanahashi N., Murakami Y., Minami Y., et al. Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis. J Biol Chem 275 (2000) 14336-14345
23. Meister S., Schubert U., Neubert K., Herrmann K., Burger R., Gramatzki M., et al. Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition. Cancer Res 67 (2007) 1783-1792
24. Patel M.B., Proctor K.G., and Majetschak M. Extracellular ubiquitin increases in packed red blood cell units during storage. J Surg Res 135 (2006) 226-232
25. Moller D.E. Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol Metab 11 (2000) 212-217
26. Kern P.A., Ranganathan S., Li C., et al. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 280 (2001) E745-E751
27. Ishibashi Y., Hanyu N., Suzuki Y., et al. Quantitative analysis of free ubiquitin and multi-ubiquitin chain in colorectal cancer. Cancer Lett 211 (2004) 111-117
28. Kumatori A., Tanaka K., Inamura N., et al. Abnormally high expression of proteasomes in human leukemic cells. Proc Natl Acad Sci USA 87 (1990) 7071-7075
29. Nowis D., McConnell E.J., Dierlam L., et al. TNF potentiates anticancer activity of bortezomib (Velcade) through reduced expression of proteasome subunits and dysregulation of unfolded protein response. Int J Cancer 121 (2007) 431-441
30. Kang Y., Chen X., Lary J.W., et al. Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin. J Mol Biol 369 (2007) 168-176