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Volumn 10, Issue 2, 2014, Pages 295-305

The pros and the cons of mTOR inhibitors in kidney transplantation

Author keywords

everolimus; kidney transplantation; mTOR; proliferation signal inhibitor; rejection; sirolimus

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR;

EID: 84893092734     PISSN: 1744666X     EISSN: 17448409     Source Type: Journal    
DOI: 10.1586/1744666X.2014.872562     Document Type: Review
Times cited : (44)

References (86)
  • 2
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall M. TOR signaling in growth and metabolism. Cell 2006;124:471-84
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.3
  • 3
    • 84863327242 scopus 로고    scopus 로고
    • The mechanisms of acute rejection revisited
    • Ponticelli C. The mechanisms of acute rejection revisited. J Nephrol 2012;25:150-8
    • (2012) J Nephrol , vol.25 , pp. 150-158
    • Ponticelli, C.1
  • 4
    • 84893096637 scopus 로고    scopus 로고
    • Immunoregulatory properties of rapamycin-conditioned monocyte-derived dendritic cells and their role in transplantation
    • Macedo C, Turquist H, Metes D, Thomson AW. Immunoregulatory properties of rapamycin-conditioned monocyte-derived dendritic cells and their role in transplantation. Transplant Res 2012;1:1-16
    • (2012) Transplant Res , vol.1 , pp. 1-16
    • Macedo, C.1    Turquist, H.2    Metes, D.3    Thomson, A.W.4
  • 5
    • 33845454157 scopus 로고    scopus 로고
    • Differential pharmacokinetic interaction of tacrolimus and cyclosporine formulations on everolimus
    • Kovarik JM, Curtis JJ, Hricik DE, et al. Differential pharmacokinetic interaction of tacrolimus and cyclosporine formulations on everolimus. Transplant Proc 2006;38: 3456-8
    • (2006) Transplant Proc , vol.38 , pp. 3456-3458
    • Kovarik, J.M.1    Curtis, J.J.2    Hricik, D.E.3
  • 6
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mtor in cancer
    • Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell 2007;12:9-22
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 7
    • 2942724235 scopus 로고    scopus 로고
    • MTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1 dependent pathways
    • Majumder PK, Febbo PG, Bikoff R, et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1 dependent pathways. Nat Med 2004;10:594-601
    • (2004) Nat Med , vol.10 , pp. 594-601
    • Majumder, P.K.1    Febbo, P.G.2    Bikoff, R.3
  • 8
    • 0036174289 scopus 로고    scopus 로고
    • Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
    • Guba M, von Breitenbuch P, Steinbauer M, et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor. Nat Med 2002;8: 128-35
    • (2002) Nat Med , vol.8 , pp. 128-135
    • Guba, M.1    Von Breitenbuch, P.2    Steinbauer, M.3
  • 9
    • 79958166689 scopus 로고    scopus 로고
    • Herpes viruses and tumours in kidney transplant recipients the role of immunosuppression
    • Ponticelli C. Herpes viruses and tumours in kidney transplant recipients. The role of immunosuppression. Nephrol Dial Transplant 2011;26:1769-75
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 1769-1775
    • Ponticelli, C.1
  • 10
    • 0042967970 scopus 로고    scopus 로고
    • Tacrolimus enhances transforming growth factor-beta1 expression and promotes tumor progression
    • Maluccio M, Sharma V, Lagman M, et al. Tacrolimus enhances transforming growth factor-beta1 expression and promotes tumor progression. Transplantation 2003;76: 597-602
    • (2003) Transplantation , vol.76 , pp. 597-602
    • Maluccio, M.1    Sharma, V.2    Lagman, M.3
  • 11
    • 3242756741 scopus 로고    scopus 로고
    • Defective DNA mismatch repair in acute myeloid leukaemia/myelodysplastic syndrome after organ transplantation
    • Offman J, Opelz G, Doehler B, et al. Defective DNA mismatch repair in acute myeloid leukaemia/myelodysplastic syndrome after organ transplantation. Blood 2004;104:822-8
    • (2004) Blood , vol.104 , pp. 822-828
    • Offman, J.1    Opelz, G.2    Doehler, B.3
  • 12
    • 27644436740 scopus 로고    scopus 로고
    • Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies
    • Kauffman HM, Cherikh WS, Cheng Y, et al. Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies. Transplantation 2005;80: 883-9
    • (2005) Transplantation , vol.80 , pp. 883-889
    • Kauffman, H.M.1    Cherikh, W.S.2    Cheng, Y.3
  • 13
    • 84864245430 scopus 로고    scopus 로고
    • Sirolimus and secondary skin-cancer prevention in kidney transplantation
    • Euvrard S, Morelon E, Rostaing L, et al. Sirolimus and secondary skin-cancer prevention in kidney transplantation. N Engl J Med 2012;367:329-39
    • (2012) N Engl J Med , vol.367 , pp. 329-339
    • Euvrard, S.1    Morelon, E.2    Rostaing, L.3
  • 14
    • 0034973856 scopus 로고    scopus 로고
    • Human cytomegalovirus up-regulates the phosphatidylinositol-3-kinase (PI3-K) pathway: Inhibition of PI3-K activity inhibits viral replication and virus-induced signalling
    • Johnson RA, Wang X, Ma XL, et al. Human cytomegalovirus up-regulates the phosphatidylinositol-3-kinase (PI3-K) pathway: Inhibition of PI3-K activity inhibits viral replication and virus-induced signalling. J Virol 2001;75:6022-32
    • (2001) J Virol , vol.75 , pp. 6022-6032
    • Johnson, R.A.1    Wang, X.2    Ma, X.L.3
  • 15
    • 3042818883 scopus 로고    scopus 로고
    • HCMV activates PI (3)K monocytes and promotes monocyte motility and transendothelial migration in a dose-dependent manner
    • Smith MS, Bentz GL, Smith PM, et al. HCMV activates PI(3)K monocytes and promotes monocyte motility and transendothelial migration in a dose-dependent manner. J Leukoc Biol 2004;76:65-76
    • (2004) J Leukoc Biol , vol.76 , pp. 65-76
    • Smith, M.S.1    Bentz, G.L.2    Smith, P.M.3
  • 16
    • 33947403537 scopus 로고    scopus 로고
    • AMPK-mediated inhibition of mTOR kinase is circumvented during immediate-early times of human cytomegalovirus infection
    • Kudchodkar SB, Del Prete GQ, Maguire TG, Alwine JC. AMPK-mediated inhibition of mTOR kinase is circumvented during immediate-early times of human cytomegalovirus infection. J Virol 2007;81: 3649-51
    • (2007) J Virol , vol.81 , pp. 3649-3651
    • Kudchodkar, S.B.1    Del Prete, G.Q.2    Maguire, T.G.3    Alwine, J.C.4
  • 17
    • 84861818332 scopus 로고    scopus 로고
    • CMV late phase-induced mTOR activation is essential for efficient virus replication in polarized human macrophages
    • Poglitsch M, Weichhart T, Hecking M, et al. CMV late phase-induced mTOR activation is essential for efficient virus replication in polarized human macrophages. Am J Transplant 2012;12: 1458-68
    • (2012) Am J Transplant , vol.12 , pp. 1458-1468
    • Poglitsch, M.1    Weichhart, T.2    Hecking, M.3
  • 18
    • 84872083283 scopus 로고    scopus 로고
    • Everolimus-Treated renal transplant recipients have a more robust CMV-specific CD8+ T-cell response compared with cyclosporine-or mycophenolatetreated patients
    • Havenith SH, Yong SL, van Donselaar-van der Pant KA, et al. Everolimus-Treated renal transplant recipients have a more robust CMV-specific CD8+ T-cell response compared with cyclosporine-or mycophenolatetreated patients. Transplantation 2013;95: 184-91
    • (2013) Transplantation , vol.95 , pp. 184-191
    • Havenith, S.H.1    Yong, S.L.2    Van Donselaar-Van Der Pant, K.A.3
  • 19
    • 84881370978 scopus 로고    scopus 로고
    • PI3Kd inhibition augments the efficacy of rapamycin in suppressing proliferation of Epstein-Barr virus (EBV) + B cell lymphomas
    • Furukawa S, Wei L, Krams SM, et al. PI3Kd inhibition augments the efficacy of rapamycin in suppressing proliferation of Epstein-Barr virus (EBV) + B cell lymphomas. Am J Transplant 2013;13: 2035-43
    • (2013) Am J Transplant , vol.13 , pp. 2035-2043
    • Furukawa, S.1    Wei, L.2    Krams, S.M.3
  • 20
    • 78650826189 scopus 로고    scopus 로고
    • Anti-BK virus mechanisms of sirolimus and leflunomide alone and in combination: Toward a new therapy for BK virus infection
    • Liacini A, Seamone ME, Muruve DA, Tibbles LA. Anti-BK virus mechanisms of sirolimus and leflunomide alone and in combination: Toward a new therapy for BK virus infection. Transplantation 2010;90: 1450-7
    • (2010) Transplantation , vol.90 , pp. 1450-1457
    • Liacini, A.1    Seamone, M.E.2    Muruve, D.A.3    Tibbles, L.A.4
  • 21
    • 33744473322 scopus 로고    scopus 로고
    • Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: A systematic review and meta-Analysis of randomized trials
    • Webster AC, Lee VW, Chapman JR, Craig JC. Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: A systematic review and meta-Analysis of randomized trials. Transplantation 2006;81:1234-48
    • (2006) Transplantation , vol.81 , pp. 1234-1248
    • Webster, A.C.1    Lee, V.W.2    Chapman, J.R.3    Craig, J.C.4
  • 22
    • 84857194014 scopus 로고    scopus 로고
    • Cytomegalovirus incidence between everolimus versus mycophenolate in de novo renal transplants: Pooled analysis of three clinical trials
    • Brennan DC, Legendre C, Patel D, et al. Cytomegalovirus incidence between everolimus versus mycophenolate in de novo renal transplants: Pooled analysis of three clinical trials. Am J Transplant 2011;11: 2453-62
    • (2011) Am J Transplant , vol.11 , pp. 2453-2462
    • Brennan, D.C.1    Legendre, C.2    Patel, D.3
  • 23
    • 84872085198 scopus 로고    scopus 로고
    • Is cytomegalovirus prophylaxis dispensable in patients receiving an mTOR inhibitor-based immunosuppressioñ A systematic review and meta-Analysis
    • Andrassy J, Hoffmann VS, Rentsch M, et al. Is cytomegalovirus prophylaxis dispensable in patients receiving an mTOR inhibitor-based immunosuppressioñ A systematic review and meta-Analysis. Transplantation 2012;94:1208-17
    • (2012) Transplantation , vol.94 , pp. 1208-1217
    • Andrassy, J.1    Hoffmann, V.S.2    Rentsch, M.3
  • 24
    • 65549108756 scopus 로고    scopus 로고
    • An optn analysis of national registry data on treatment of bk virus allograft nephropathy in the united states
    • Dharnidharka VR, Cherikh WS, Abbott KC. An OPTN analysis of national registry data on treatment of BK virus allograft nephropathy in the United States. Transplantation 2009;87:1019-26
    • (2009) Transplantation , vol.87 , pp. 1019-1026
    • Dharnidharka, V.R.1    Cherikh, W.S.2    Abbott, K.C.3
  • 25
    • 26444501663 scopus 로고    scopus 로고
    • Resolution of renal allograft-Associated posttransplant lymphoproliferative disorder with the introduction of sirolimus
    • Zaltzman JS, Prasad R, Chun K, Jothy S. Resolution of renal allograft-Associated posttransplant lymphoproliferative disorder with the introduction of sirolimus. Nephrol Dial Transplant 2005;20:1748-51
    • (2005) Nephrol Dial Transplant , vol.20 , pp. 1748-1751
    • Zaltzman, J.S.1    Prasad, R.2    Chun, K.3    Jothy, S.4
  • 26
    • 20144367584 scopus 로고    scopus 로고
    • Sirolimus for Kaposi sarcoma in renal transplant recpients
    • Stallone G, Schena A, Infante B, et al. Sirolimus for Kaposi sarcoma in renal transplant recpients. N Engl J Med 2005;352:1317-23
    • (2005) N Engl J Med , vol.352 , pp. 1317-1323
    • Stallone, G.1    Schena, A.2    Infante, B.3
  • 27
    • 1442325390 scopus 로고    scopus 로고
    • The mTOR/p70S6K1 pathway regulates vascular smooth muscle cell differentiation
    • Martin KA, Rzuicidlo EM, Merenick BL. et al. The mTOR/p70S6K1 pathway regulates vascular smooth muscle cell differentiation. Am J Cell Physiol 2004;286:C507-17
    • (2004) Am J Cell Physiol , vol.286
    • Martin, K.A.1    Rzuicidlo, E.M.2    Merenick, B.L.3
  • 28
    • 81755178342 scopus 로고    scopus 로고
    • Autophagy in atherosclerosis: A potential drug target for plaque stabilization
    • Schrijvers DM, De Meyer GR, Martinet W. Autophagy in atherosclerosis: A potential drug target for plaque stabilization. Arterioscler Thromb Vasc Biol 2011;31: 2787-91
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 2787-2791
    • Schrijvers, D.M.1    De Meyer, G.R.2    Martinet, W.3
  • 29
    • 19244366021 scopus 로고    scopus 로고
    • Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-Transplant recipients
    • Eisen HJ, Tuzcu EM, Dorent R, et al. Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-Transplant recipients. N Engl J Med 2003;349:847-58
    • (2003) N Engl J Med , vol.349 , pp. 847-858
    • Eisen, H.J.1    Tuzcu, E.M.2    Dorent, R.3
  • 30
    • 0036691215 scopus 로고    scopus 로고
    • Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism
    • Morrissett JD, Abdel-Fattah G, Hogeveen R, et al. Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism. J Lipid Res 2002;43:1170-80
    • (2002) J Lipid Res , vol.43 , pp. 1170-1180
    • Morrissett, J.D.1    Abdel-Fattah, G.2    Hogeveen, R.3
  • 31
    • 0035886214 scopus 로고    scopus 로고
    • Effects of sirolimus on the metabolism of apoB100-containing lipoproteins in renal transplant patients
    • Hoogeveen R, Ballantyne CM, Pownall HJ. Effects of sirolimus on the metabolism of apoB100-containing lipoproteins in renal transplant patients. Transplantation 2001;72:1244-50
    • (2001) Transplantation , vol.72 , pp. 1244-1250
    • Hoogeveen, R.1    Ballantyne, C.M.2    Pownall, H.J.3
  • 32
    • 0842291684 scopus 로고    scopus 로고
    • Everolimus/cyclosporine interactions on bile and biliary excretion of bile salts cholesterol in rats
    • Deters S, Kirchner G, Koal T, et al. Everolimus/cyclosporine interactions on bile and biliary excretion of bile salts cholesterol in rats. Dig Dis Sci 2004;49:30-7
    • (2004) Dig Dis Sci , vol.49 , pp. 30-37
    • Deters, S.1    Kirchner, G.2    Koal, T.3
  • 33
    • 0033406881 scopus 로고    scopus 로고
    • A double blind controlled trial for the treatment of dyslipidaemia in renal allograft recipients
    • Lepre F, Rigby R, Hawley C, et al. A double blind controlled trial for the treatment of dyslipidaemia in renal allograft recipients. Clin Transplant 1999;13:520-6
    • (1999) Clin Transplant , vol.13 , pp. 520-526
    • Lepre, F.1    Rigby, R.2    Hawley, C.3
  • 34
    • 0033549840 scopus 로고    scopus 로고
    • Treatment of lipid disorders
    • Knopp RM. Treatment of lipid disorders. N Engl J Med 1999;341:498-511
    • (1999) N Engl J Med , vol.341 , pp. 498-511
    • Knopp, R.M.1
  • 35
    • 0037287596 scopus 로고    scopus 로고
    • Interactions between cyclosporine and lipid-lowering drugs: Implications for organ transplant recipients
    • Asberg A. Interactions between cyclosporine and lipid-lowering drugs: Implications for organ transplant recipients. Drugs 2003;663:367-78
    • (2003) Drugs , vol.663 , pp. 367-378
    • Asberg, A.1
  • 36
    • 0033659109 scopus 로고    scopus 로고
    • Fibrate-induce increase in urea and creatinine: Is gemfibrozil the only innocuous agent
    • Broeders N, Knoop C, Antoine M, et al. Fibrate-induce increase in urea and creatinine: Is gemfibrozil the only innocuous agent? Nephrol Dial Transplant 2000;15: 1993-9
    • (2000) Nephrol Dial Transplant , vol.15 , pp. 1993-1999
    • Broeders, N.1    Knoop, C.2    Antoine, M.3
  • 37
    • 68249101040 scopus 로고    scopus 로고
    • Posttransplant anemia: The role of sirolimus
    • Fishbane S, Cohen DJ, Coyne DW, et al. Posttransplant anemia: The role of sirolimus. Kidney Int 2009;76:376-82
    • (2009) Kidney Int , vol.76 , pp. 376-382
    • Fishbane, S.1    Cohen, D.J.2    Coyne, D.W.3
  • 38
    • 84856850359 scopus 로고    scopus 로고
    • MTOR inhibition and erythropoiesis: Microcytosis or anaemia
    • Diekmann F, Rovira J, Diaz-Ricart M, et al. mTOR inhibition and erythropoiesis: Microcytosis or anaemiä Nephrol Dial Transplant 2012;27:537-41
    • (2012) Nephrol Dial Transplant , vol.27 , pp. 537-541
    • Diekmann, F.1    Rovira, J.2    Diaz-Ricart, M.3
  • 39
    • 34547699716 scopus 로고    scopus 로고
    • Incidence of anemia in sirolimus-Treated renal transplant recipients: The importance of preserving renal function
    • Friend P, Russ G, Oberbauer R, et al. Incidence of anemia in sirolimus-Treated renal transplant recipients: The importance of preserving renal function. Transpl Int 2007;20:754-60
    • (2007) Transpl Int , vol.20 , pp. 754-760
    • Friend, P.1    Russ, G.2    Oberbauer, R.3
  • 40
    • 79952361568 scopus 로고    scopus 로고
    • Everolimus-based, calcineurin-inhibitor-free regimen in recipients of de-novo kidney transplants: An open-label, randomised, controlled trial
    • Budde K, Becker T, Arns W, et al. Everolimus-based, calcineurin- inhibitor-free regimen in recipients of de-novo kidney transplants: An open-label, randomised, controlled trial. Lancet 2011;377:837-47
    • (2011) Lancet , vol.377 , pp. 837-847
    • Budde, K.1    Becker, T.2    Arns, W.3
  • 41
    • 80955149553 scopus 로고    scopus 로고
    • Lymphocele after renal transplantation, a medical complication
    • Minetti EE. Lymphocele after renal transplantation, a medical complication. J Nephrol 2011;24:707-16
    • (2011) J Nephrol , vol.24 , pp. 707-716
    • Minetti, E.E.1
  • 42
    • 0346732907 scopus 로고    scopus 로고
    • The impact of sirolimus, mycophenolate mofetil cyclosporine, azathioprine, and steroids on wound healing in 513 kidney transplant recipients
    • Flechner SM, Zhou L, Derweesh I, et al. The impact of sirolimus, mycophenolate mofetil. cyclosporine, azathioprine, and steroids on wound healing in 513 kidney transplant recipients. Transplantation 2003;76:1729-34
    • (2003) Transplantation , vol.76 , pp. 1729-1734
    • Flechner, S.M.1    Zhou, L.2    Derweesh, I.3
  • 43
    • 67651039979 scopus 로고    scopus 로고
    • Incidence of delayed graft function and wound healing complications after deceased-donor kidney transplantation is not affected by de novo everolimus
    • Albano L, Berthoux F, Moal MC, et al. Incidence of delayed graft function and wound healing complications after deceased-donor kidney transplantation is not affected by de novo everolimus. Transplantation 2009;88:69-76
    • (2009) Transplantation , vol.88 , pp. 69-76
    • Albano, L.1    Berthoux, F.2    Moal, M.C.3
  • 44
    • 8744256458 scopus 로고    scopus 로고
    • A retrospective review of liver transplant patients treated with sirolimus from a single center: An analysis of sirolimus-related complications
    • Montalbano M, Neff GW, Yamashiki N, et al. A retrospective review of liver transplant patients treated with sirolimus from a single center: An analysis of sirolimus-related complications. Transplantation 2004;78:264-8
    • (2004) Transplantation , vol.78 , pp. 264-268
    • Montalbano, M.1    Neff, G.W.2    Yamashiki, N.3
  • 45
    • 79955634445 scopus 로고    scopus 로고
    • Everolimus and minimization of cyclosporine in renal transplantation: 24-month follow-up of the everest study
    • Ponticelli C, Salvadori M, Scolari MP, et al. Everolimus and minimization of cyclosporine in renal transplantation: 24-month follow-up of the EVEREST study. Transplantation 2011;91:e72-3
    • (2011) Transplantation
    • Ponticelli, C.1    Salvadori, M.2    Scolari, M.P.3
  • 46
    • 0345118182 scopus 로고    scopus 로고
    • Oral ulcers in kidney transplant recipients treated with sirolimus and mycophenolate mofetil
    • Van Gelder T, Ter Meulen CG, Hené R, et al. Oral ulcers in kidney transplant recipients treated with sirolimus and mycophenolate mofetil. Transplantation 2003;75:788-91
    • (2003) Transplantation , vol.75 , pp. 788-791
    • Van Gelder, T.1    Ter Meulen, C.G.2    Hené, R.3
  • 47
    • 0035884211 scopus 로고    scopus 로고
    • Oral ulcerations in a renal transplant recipient: A mycophenolate mofetil-induced complication
    • Garrigue V, Canet S, Dereure O, et al. Oral ulcerations in a renal transplant recipient: A mycophenolate mofetil-induced complicatioñ Transplantation 2001;72: 968-9
    • (2001) Transplantation , vol.72 , pp. 968-969
    • Garrigue, V.1    Canet, S.2    Dereure, O.3
  • 48
    • 0036862285 scopus 로고    scopus 로고
    • Sirolimus (rapamune) in renal transplantation
    • Johnson RW. Sirolimus (Rapamune) in renal transplantation. Curr Opin Nephrol Hypertens 2002;11:603-7
    • (2002) Curr Opin Nephrol Hypertens , vol.11 , pp. 603-607
    • Johnson, R.W.1
  • 49
    • 38549152701 scopus 로고    scopus 로고
    • Sympathetic dystrophy associated with sirolimus therapy
    • Molina MG, Diekmann F, Burgos D, et al. Sympathetic dystrophy associated with sirolimus therapy. Transplantation 2008;85: 290-2
    • (2008) Transplantation , vol.85 , pp. 290-292
    • Molina, M.G.1    Diekmann, F.2    Burgos, D.3
  • 50
    • 84885030203 scopus 로고    scopus 로고
    • Sirolimus-FKBP12.6 impairs endothelial barrier function through protein kinase C-A activation and disruption of the p120-vascular endothelial cadherin interaction
    • Habib A, Karmali V, Polavarapu R, et al. Sirolimus-FKBP12.6 impairs endothelial barrier function through protein kinase C-A activation and disruption of the p120-vascular endothelial cadherin interaction. Arterioscler Thromb Vasc Biol 2013;33:2425-31
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 2425-2431
    • Habib, A.1    Karmali, V.2    Polavarapu, R.3
  • 51
    • 2342630498 scopus 로고    scopus 로고
    • Sirolimus-Associated pulmonary toxicity
    • Pham PT, Pham PC, Danovitch G, et al. Sirolimus-Associated pulmonary toxicity. Transplantation 2004;77:1215-80
    • (2004) Transplantation , vol.77 , pp. 1215-1280
    • Pham, P.T.1    Pham, P.C.2    Danovitch, G.3
  • 52
    • 77958551746 scopus 로고    scopus 로고
    • Pneumonitis associated with mammalian target of rapamycin inhibitors in renal transplant recipients: A single-center experience
    • Errasti P, Izquierdo D, Martín P, et al. Pneumonitis associated with mammalian target of rapamycin inhibitors in renal transplant recipients: A single-center experience. Transplant Proc 2010;42:3053-4
    • (2010) Transplant Proc , vol.42 , pp. 3053-3054
    • Errasti, P.1    Izquierdo, D.2    Martín, P.3
  • 53
    • 0037356937 scopus 로고    scopus 로고
    • Thrombotic microangiopathy with sirolimus-based immunosuppression: Potentiation of calcineurin-inhibitor-induced endothelial damage
    • Robson M, Cote I, Abbs I, et al. Thrombotic microangiopathy with sirolimus-based immunosuppression: Potentiation of calcineurin-inhibitor-induced endothelial damage ? Am J Transplant 2003;3:324-7
    • (2003) Am J Transplant , vol.3 , pp. 324-327
    • Robson, M.1    Cote, I.2    Abbs, I.3
  • 54
    • 34250166544 scopus 로고    scopus 로고
    • De novo thrombotic microangiopathy. An underrated complication of renal transplantation
    • Ponticelli C. De novo thrombotic microangiopathy. An underrated complication of renal transplantation. Clin Nephrol 2007;67:335-40
    • (2007) Clin Nephrol , vol.67 , pp. 335-340
    • Ponticelli, C.1
  • 55
    • 33644914494 scopus 로고    scopus 로고
    • Calcineurin inhibitor-free immunosuppression in renal allograft recipients with thrombotic microangiopathy/ hemolytic uremic syndrome
    • Oyen O, Strøm EH, Midtvedt K, et al. Calcineurin inhibitor-free immunosuppression in renal allograft recipients with thrombotic microangiopathy/ hemolytic uremic syndrome. Am J Transplant 2006;6:412-18
    • (2006) Am J Transplant , vol.6 , pp. 412-418
    • Oyen, O.1    Strøm, E.H.2    Midtvedt, K.3
  • 56
    • 84864643813 scopus 로고    scopus 로고
    • Proteinuria after kidney transplantation
    • Ponticelli C, Graziani G. Proteinuria after kidney transplantation. Transpl Int 2012;25: 909-17
    • (2012) Transpl Int , vol.25 , pp. 909-917
    • Ponticelli, C.1    Graziani, G.2
  • 57
    • 84857050988 scopus 로고    scopus 로고
    • Everolimus as primary immunosuppression in kidney transplantation: Experience in conversion from calcineurin inhibitors
    • Sánchez-Fructuoso AI, Ruiz JC, Calvo N, et al. Everolimus as primary immunosuppression in kidney transplantation: Experience in conversion from calcineurin inhibitors. Transplantation 2012;93:398-405
    • (2012) Transplantation , vol.93 , pp. 398-405
    • Sánchez-Fructuoso, A.I.1    Ruiz, J.C.2    Calvo, N.3
  • 58
    • 84873080842 scopus 로고    scopus 로고
    • The effect of everolimus versus mycophenolate upon proteinuria following kidney transplant and relationship to graft outcomes
    • Wiseman AC, McCague K, Kim Y, et al. The effect of everolimus versus mycophenolate upon proteinuria following kidney transplant and relationship to graft outcomes. Am J Transplant 2013;13:442-9
    • (2013) Am J Transplant , vol.13 , pp. 442-449
    • Wiseman, A.C.1    McCague, K.2    Kim, Y.3
  • 59
    • 82955226337 scopus 로고    scopus 로고
    • MTOR inhibitor-Associated proteinuria in kidney transplant recipients
    • Diekmann F, Andrés A, Oppenheimer F. mTOR inhibitor-Associated proteinuria in kidney transplant recipients. Transplant Rev (Orlando) 2012;26:27-9
    • (2012) Transplant Rev (Orlando , vol.26 , pp. 27-29
    • Diekmann, F.1    Andrés, A.2    Oppenheimer, F.3
  • 60
    • 59249094511 scopus 로고    scopus 로고
    • Factors associated with proteinuria in renal transplant recipients treated with sirolimus
    • Liew A, Chiang GS, Vathsala A. Factors associated with proteinuria in renal transplant recipients treated with sirolimus. Transpl Int 2009;22:313-22
    • (2009) Transpl Int , vol.22 , pp. 313-322
    • Liew, A.1    Chiang, G.S.2    Vathsala, A.3
  • 61
    • 31544461508 scopus 로고    scopus 로고
    • Conversion from calcineurin inhibitors to sirolimus in chronic allograft dysfunction: Changes in glomerular haemodynamics and proteinuria
    • Saurina A, Campistol JM, Piera C, et al. Conversion from calcineurin inhibitors to sirolimus in chronic allograft dysfunction: Changes in glomerular haemodynamics and proteinuria. Nephrol Dial Transplant 2006;21:488-93
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 488-493
    • Saurina, A.1    Campistol, J.M.2    Piera, C.3
  • 62
    • 0034789534 scopus 로고    scopus 로고
    • Rapamycin impairs recovery from acute renal failure: Role of cell-cycle arrest and apoptosis of tubular cells
    • Lieberthal W, Fuhro R, Andry CC, et al. Rapamycin impairs recovery from acute renal failure: Role of cell-cycle arrest and apoptosis of tubular cells. Am J Physiol Renal Physiol 2001;281:F693-706
    • (2001) Am J Physiol Renal Physiol , vol.281
    • Lieberthal, W.1    Fuhro, R.2    Andry, C.C.3
  • 63
    • 33644928466 scopus 로고    scopus 로고
    • Sirolimus-Associated heavy proteinuria in a renal transplant recipient: Evidence for a tubular mechanism
    • Straathof-Galema L, Wetzels JF, Dijkman HB, et al. Sirolimus-Associated heavy proteinuria in a renal transplant recipient: Evidence for a tubular mechanism. Am J Transplant 2006;2:429
    • (2006) Am J Transplant , vol.2 , pp. 429
    • Straathof-Galema, L.1    Wetzels, J.F.2    Dijkman, H.B.3
  • 64
    • 74449084959 scopus 로고    scopus 로고
    • Tubular toxicity in sirolimus-And cyclosporine-based transplant immunosuppression strategies: An ancillary study from a randomized controlled trial
    • Franz S, Regeniter A, Hopfer H, et al. Tubular toxicity in sirolimus-And cyclosporine-based transplant immunosuppression strategies: An ancillary study from a randomized controlled trial. Am J Kidney Dis 2010;55:33
    • (2010) Am J Kidney Dis , vol.55 , pp. 33
    • Franz, S.1    Regeniter, A.2    Hopfer, H.3
  • 65
    • 60549117111 scopus 로고    scopus 로고
    • MTOR regulates expression of slit diaphragm proteins and cytoskeleton structure in podocytes
    • Vollenbröker B, George B, Wolfgart M, et al. mTOR regulates expression of slit diaphragm proteins and cytoskeleton structure in podocytes. Am J Physiol Renal Physiol 2009;296:F418
    • (2009) Am J Physiol Renal Physiol , vol.296
    • Vollenbröker, B.1    George, B.2    Wolfgart, M.3
  • 67
    • 79955538137 scopus 로고    scopus 로고
    • Sirolimus and proteinuria in renal transplant patients: Evidence for a dose-dependent effect on slit diaphragm-Associated proteins
    • Stallone G, Infante B, Pontrelli P, et al. Sirolimus and proteinuria in renal transplant patients: Evidence for a dose-dependent effect on slit diaphragm-Associated proteins. Transplantation 2011;91:997-1004
    • (2011) Transplantation , vol.91 , pp. 997-1004
    • Stallone, G.1    Infante, B.2    Pontrelli, P.3
  • 68
    • 33746530366 scopus 로고    scopus 로고
    • Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: A randomised multicentre study
    • The Rapamune US Study Group
    • Kahan BD. Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: A randomised multicentre study. The Rapamune US Study Group. Lancet 2000;356(9225): 194-202
    • (2000) Lancet , vol.356 , Issue.9225 , pp. 194-202
    • Kahan, B.D.1
  • 69
    • 9244246780 scopus 로고    scopus 로고
    • Everolimus (Certican) 12-month safety and efficacy versus mycophenolate mofetil in de novo renal transplant recipients
    • Vitko S, Margreiter R, Weimar W, et al. Everolimus (Certican) 12-month safety and efficacy versus mycophenolate mofetil in de novo renal transplant recipients. Transplantation 2004;78:1532-40
    • (2004) Transplantation , vol.78 , pp. 1532-1540
    • Vitko, S.1    Margreiter, R.2    Weimar, W.3
  • 70
    • 16244378141 scopus 로고    scopus 로고
    • Everolimus versus mycophenolate mofetil in the prevention of rejection in de novo renal transplant recipients: A 3-year randomized, multicenter, phase III study
    • Lorber MI, Mulgaonkar S, Butt KM, et al. Everolimus versus mycophenolate mofetil in the prevention of rejection in de novo renal transplant recipients: A 3-year randomized, multicenter, phase III study. Transplantation 2005;80:244-52
    • (2005) Transplantation , vol.80 , pp. 244-252
    • Lorber, M.I.1    Mulgaonkar, S.2    Butt, K.M.3
  • 71
    • 0035884710 scopus 로고    scopus 로고
    • Sirolimus allows early cyclosporine withdrawal in renal transplantation resulting in improved renal function and lower blood pressure
    • Johnson RW, Kreis H, Oberbauer R, et al. Sirolimus allows early cyclosporine withdrawal in renal transplantation resulting in improved renal function and lower blood pressure. Transplantation 2001;72(5):777-86
    • (2001) Transplantation , vol.72 , Issue.5 , pp. 777-786
    • Johnson, R.W.1    Kreis, H.2    Oberbauer, R.3
  • 72
    • 2942534405 scopus 로고    scopus 로고
    • Sirolimus-based therapy following early cyclosporine withdrawal provides significantly improved renal histology and function at 3 years
    • Mota A, Arias M, Taskinen EI, et al. Sirolimus-based therapy following early cyclosporine withdrawal provides significantly improved renal histology and function at 3 years. Am J Transplant 2004;4:953-61
    • (2004) Am J Transplant , vol.4 , pp. 953-961
    • Mota, A.1    Arias, M.2    Taskinen, E.I.3
  • 73
    • 79961039264 scopus 로고    scopus 로고
    • Efficacy and safety of early cyclosporine conversion to sirolimus with continued mmf-four-year results of the postconcept study
    • Lebranchu Y, Thierry A, Thervet E, et al. Efficacy and safety of early cyclosporine conversion to sirolimus with continued MMF-four-year results of the Postconcept study. Am J Transplant 2011;11:1665-75
    • (2011) Am J Transplant , vol.11 , pp. 1665-1675
    • Lebranchu, Y.1    Thierry, A.2    Thervet, E.3
  • 74
    • 37349034394 scopus 로고    scopus 로고
    • Reduced exposure to calcineurin inhibitors in renal transplantation
    • Ekberg H, Tedesco-Silva H, Demirbas A, et al. Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med 2007;357:2562-7
    • (2007) N Engl J Med , vol.357 , pp. 2562-2567
    • Ekberg, H.1    Tedesco-Silva, H.2    Demirbas, A.3
  • 75
    • 79961032806 scopus 로고    scopus 로고
    • The orion study: Comparison of two sirolimus-based regimens versus tacrolimus and mycophenolate mofetil in renal allograft recipients
    • Flechner SM, Glyda M, Cockfield S, et al. The ORION study: Comparison of two sirolimus-based regimens versus tacrolimus and mycophenolate mofetil in renal allograft recipients. Am J Transplant 2011;11: 1633-44
    • (2011) Am J Transplant , vol.11 , pp. 1633-1644
    • Flechner, S.M.1    Glyda, M.2    Cockfield, S.3
  • 76
    • 84863189669 scopus 로고    scopus 로고
    • Five-year results of a randomized trial comparing de novo sirolimus and cyclosporine in renal transplantation: The SPIESSER study
    • Lebranchu Y, Snanoudj R, Toupance O, et al. Five-year results of a randomized trial comparing de novo sirolimus and cyclosporine in renal transplantation: The SPIESSER study. Am J Transplant 2012;12: 1801-10
    • (2012) Am J Transplant , vol.12 , pp. 1801-1810
    • Lebranchu, Y.1    Snanoudj, R.2    Toupance, O.3
  • 77
    • 84878569533 scopus 로고    scopus 로고
    • A randomized, open-label study of sirolimus versus cyclosporine in primary de novo renal allograft recipients
    • Flechner SM, Gurkan A, Hartmann A, et al. A randomized, open-label study of sirolimus versus cyclosporine in primary de novo renal allograft recipients. Transplantation 2013;95:1233-41
    • (2013) Transplantation , vol.95 , pp. 1233-1241
    • Flechner, S.M.1    Gurkan, A.2    Hartmann, A.3
  • 78
    • 84861793711 scopus 로고    scopus 로고
    • Conversion from cyclosporine to everolimus at 4.5 months posttransplant: 3-year results from the randomized ZEUS study
    • Budde K, Lehner F, Sommerer C, et al. Conversion from cyclosporine to everolimus at 4.5 months posttransplant: 3-year results from the randomized ZEUS study. Am J Transplant 2012;12:1528-40
    • (2012) Am J Transplant , vol.12 , pp. 1528-1540
    • Budde, K.1    Lehner, F.2    Sommerer, C.3
  • 79
    • 84860431997 scopus 로고    scopus 로고
    • Donor-specific HLA antibodies in a cohort comparing everolimus with cyclosporine after kidney transplantation
    • Liefeldt L, Brakemeier S, Glander P, et al. Donor-specific HLA antibodies in a cohort comparing everolimus with cyclosporine after kidney transplantation. Am J Transplant 2012;12:1192-8
    • (2012) Am J Transplant , vol.12 , pp. 1192-1198
    • Liefeldt, L.1    Brakemeier, S.2    Glander, P.3
  • 80
    • 59649126728 scopus 로고    scopus 로고
    • Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the convert trial
    • Schena FP, Pascoe MD, Alberu J, et al. Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trial. Transplantation 2009;87:233-42
    • (2009) Transplantation , vol.87 , pp. 233-242
    • Schena, F.P.1    Pascoe, M.D.2    Alberu, J.3
  • 81
    • 84893096638 scopus 로고    scopus 로고
    • Therapeutic drug monitoring for everolimus in kidney transplant recipients based on the exposure-efficacy and safety modelling of 12-month data
    • Lorber M, Ponticelli C, Whelchel J, et al. Therapeutic drug monitoring for everolimus in kidney transplant recipients based on the exposure-efficacy and safety modelling of 12-month data. Clin Transplant 2005;45-52
    • (2005) Clin Transplant , pp. 45-52
    • Lorber, M.1    Ponticelli, C.2    Whelchel, J.3
  • 82
    • 3943072739 scopus 로고    scopus 로고
    • Everolimus and reduced-exposure cyclosporine in de novo renal-Transplant recipients: A three-year phase II, randomized, multicenter, open-label study
    • Nashan B, Curtis J, Ponticelli C, et al. Everolimus and reduced-exposure cyclosporine in de novo renal-Transplant recipients: A three-year phase II, randomized, multicenter, open-label study. Transplantation 2004;78:1332-40
    • (2004) Transplantation , vol.78 , pp. 1332-1340
    • Nashan, B.1    Curtis, J.2    Ponticelli, C.3
  • 83
    • 44449145432 scopus 로고    scopus 로고
    • A randomized trial of steroid avoidance in renal transplant patients treated with everolimus and low-dose cyclosporine
    • Montagnino G, Sandrini S, Iorio B, et al. A randomized trial of steroid avoidance in renal transplant patients treated with everolimus and low-dose cyclosporine. Nephrol Dial Transplant 2008;23:707-14
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 707-714
    • Montagnino, G.1    Sandrini, S.2    Iorio, B.3
  • 84
    • 77952945224 scopus 로고    scopus 로고
    • Everolimus plus reduced-exposure CsA versus mycophenolic acid plus standard-exposure CsA in renal-Transplant recipients
    • Tedesco Silva H Jr, Cibrik D, Johnston T, et al. Everolimus plus reduced-exposure CsA versus mycophenolic acid plus standard-exposure CsA in renal-Transplant recipients. Am J Transplant 2010;10: 1401-13
    • (2010) Am J Transplant , vol.10 , pp. 1401-1413
    • Tedesco Silva Jr., H.1    Cibrik, D.2    Johnston, T.3
  • 85
    • 73849119625 scopus 로고    scopus 로고
    • Everolimus with very low-exposure cyclosporine in de novo kidney transplantation: A multicenter, randomized, controlled trial
    • Salvadori M, Scolari MP, Bertoni E, et al. Everolimus with very low-exposure cyclosporine in de novo kidney transplantation: A multicenter, randomized, controlled trial. Transplantation 2009;88: 1194-202
    • (2009) Transplantation , vol.88 , pp. 1194-1202
    • Salvadori, M.1    Scolari, M.P.2    Bertoni, E.3
  • 86
    • 84884821314 scopus 로고    scopus 로고
    • Review of combination therapy with mTOR inhibitors and tacrolimus minimization after transplantation
    • Peddi VR, Wiseman A, Chavin K, Slakey D. Review of combination therapy with mTOR inhibitors and tacrolimus minimization after transplantation. Transplant Rev (Orlando) 2013;27:97
    • (2013) Transplant Rev (Orlando , vol.27 , pp. 97
    • Peddi, V.R.1    Wiseman, A.2    Chavin, K.3    Slakey, D.4


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