CHIP E3 ligase regulates mammalian senescence by modulating the levels of oxidized proteins

Mechanisms of Ageing and Development

Volumn 132, Issue 5, 2011, Pages 269-272

  Sisoula, Christina ^a   Gonos, Efstathios S ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

Author keywords

CHIP ligase; Human fibroblasts; MEFS; Oxidative stress; Premature senescence; UPS

Indexed keywords

ACETYLCYSTEINE; BINDING PROTEIN; CARBOXY TERMINAL SEQUENCE OF HSP 70 INTERACTING PROTEIN; GREEN FLUORESCENT PROTEIN; HEAT SHOCK PROTEIN 70; PROTEIN P16; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CELL LEVEL; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; SENESCENCE;

ANIMALS; CELL AGING; CELLS, CULTURED; FIBROBLASTS; GENE SILENCING; MICE; MICE, KNOCKOUT; OXIDATION-REDUCTION; UBIQUITIN-PROTEIN LIGASES;

MAMMALIA; MUS;

EID: 79957684292     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2011.04.003     Document Type: Article

References (18)

1. Al-Ramahi I., Lam Y.C., Chen H.K., de Gouyon B., Zhang M., Perez A.M., Branco J., de Haro M., Patterson C., Zoghbi H.Y., Botas J. CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation. J. Biol. Chem. 2006, 281:26714-26724.
2. Ballinger C.A., Connell P., Wu Y., Hu Z., Thompson L.J., Yin L.Y., Patterson C. Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol. Cell. Biol. 1999, 19:4535-4545.
3. Bence N.F., Sampat R.M., Kopito R.R. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 2001, 292:1552-1555.
4. Chen Q.M., Bartholomew J.C., Campisi J., Acosta M., Reagan J.D., Ames B.N. Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. Biochem. J. 1998, 332:43-50.
5. Chondrogianni N., Trougakos I.P., Kletsas D., Chen Q.M., Gonos E.S. Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status. Aging Cell 2008, 7:717-732.
6. Connell P., Ballinger C.A., Jiang J., Wu Y., Thompson L.J., Hohfeld J., Patterson C. The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat. Cell Biol. 2001, 3:93-96.
7. Dantuma N.P., Lindsten K., Glas R., Jellne M., Masucci M.G. Short-lived green fluorescent proteins for quantification of ubiquitin/proteasome-dependent proteolysis in living cells. Nat. Biotechnol. 2000, 18:538-543.
8. Dikshit P., Jana N.R. The co-chaperone CHIP is induced in various stresses and confers protection to cells. Biochem. Biophys. Res. Commun. 2007, 357:761-765.
9. Jana N.R., Dikshit P., Goswami A., Kotliarova S., Murata S., Tanaka K., Nukina N. Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes. J. Biol. Chem. 2005, 280:11635-11640.
10. Marques C., Guo W., Pereira P., Taylor A., Patterson C., Evans P.C., Shang F. The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones. FASEB J. 2006, 20:741-743.
11. McClellan A.J., Tam S., Kaganovich D., Frydman J. Protein quality control: chaperones culling corrupt conformations. Nat. Cell Biol. 2005, 7:736-741.
12. Meacham G.C., Patterson C., Zhang W., Younger J.M., Cyr D.M. The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat. Cell Biol. 2001, 3:100-105.
13. Min J.N., Whaley R.A., Sharpless N.E., Lockyer P., Portbury A.L., Patterson C. CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control. Mol. Cell Biol. 2008, 28:4018-4025.
14. Murata S., Chiba T., Tanaka K. CHIP: a quality-control E3 ligase collaborating with molecular chaperones. Int. J. Biochem. Cell Biol. 2003, 35:572-578.
15. Neckers L., Neckers K. Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update. Expert Opin. Emerg. Drugs 2005, 10:137-149.
16. Neefjes J., Dantuma N.P. Fluorescent probes for proteolysis: tools for drug discovery. Nat. Rev. Drug Discov. 2004, 3:58-69.
17. Sisoula C., Trachana V., Patterson C., Gonos E.S. CHIP-dependent p53 regulation occurs specifically during cellular senescence. Free Rad. Biol. Med. 2011, 50:157-165.
18. Stebbins C.E., Russo A.A., Schneider C., Rosen N., Hartl F.U., Pavletich N.P. Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent. Cell 1997, 89:239-250.